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All Journal Jurnal Kedokteran Syiah Kuala Majalah Patologi Indonesia Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Jurnal Kedokteran STM (Sains dan Teknologi Medik) Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Mariedina, Causa Trisna
Department Of Pathology Anatomy, Faculty Of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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HSP70 EXPRESSION AND BETHESDA CLASSIFICATION IN BUCCAL MUCOSAL CELLS OF RESIDENTS NEAR MEDAN LANDFILL: EKSPRESI HSP70 DAN KLASIFIKASI BETHESDA PADA SEL MUKOSA BUKAL PENDUDUK SEKITAR TPA MEDAN Ramadansyah; Intan, T. Kemala; Lubis, Nadjib Dahlan; Mariedina, Causa Trisna
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 25 No. 1 (2026): Januari 2026
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/ibnusina.v25i1.1056

Abstract

Chronic exposure to pollutants generated from landfill environments may induce oxidative and genotoxic stress in oral epithelial cells, while Heat Shock Protein 70 (HSP70) functions as a key cellular chaperone involved in maintaining proteostasis and mediating adaptive responses to environmental stressors. This study aimed to evaluate the association between HSP70 expression and the Bethesda 2014 cytological classification in buccal mucosal cells of residents living in proximity to the Terjun landfill in Medan, Indonesia. A cross-sectional analytical design was employed involving 100 adult participants, comprising 24 individuals residing within ≤1–3 km of the landfill and 76 residing ≥3 km away. Buccal epithelial samples were collected using sterile cytobrushes, examined using Papanicolaou staining, and assessed immunocytochemically for HSP70 expression using the Immunoreactive Score (IRS), categorized as low (≤4) or high (>4). Statistical analysis was performed with Fisher’s Exact Test at a significance level of p<0.05. The results demonstrated that 98% of samples were classified as NILM and 2% as ASC-US, with high cytoplasmic HSP70 expression identified in 5% of samples, predominantly among the exposed group; however, a statistically significant association was observed between HSP70 expression and Bethesda classification. In conclusion, the overall low HSP70 expression with slight elevation among exposed individuals suggests early adaptive epithelial responses to chronic pollutant exposure, supporting the potential role of HSP70 as a noninvasive biomarker for monitoring environmentally induced epithelial stress.
Co-Authors Alferraly, T. Ibnu Basrul, Mohd. Yuwanda Betty betty betty Chrestella, Jessy Delyuzar, Delyuzar Elvira, Cindy Fitri Desimilani, Fitri Desimilani Fitri Dewi Ismida Intan, T. Kemala Kadri, Sayed Muhammad Kuncara, Dede Bisma Laksmi, Lidya Imelda Listiyaningsih, Listiyaningsih Lubis, M. Nadjib Dahlan Lukito, Joko S Lukito, Joko S. Nadjib Dahlan Lubis Ramadansyah Rezeki, Dewi Sri Safarianti Safarianti Sivabalan Logawathi, Satthiyabalan Soekimin Soekimin Soekimin Soekimin, Soekimin