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All Journal Jurnal Kedokteran Syiah Kuala Majalah Patologi Indonesia Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Jurnal Kedokteran STM (Sains dan Teknologi Medik) Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Glosains: Jurnal Sains Global Indonesia
Mariedina, Causa Trisna
Department Of Pathology Anatomy, Faculty Of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Analisis Ekspresi Estrogen Receptor (ER) dan Progesteron Receptor (PR) pada Tipe dan Grading Histopatologik Karsinoma Endometrium Causa Trisna Mariedina; Soekimin Soekimin; Delyuzar Delyuzar
Majalah Patologi Indonesia Vol 26 No.3, September 2017
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Latar belakangKarsinoma endometrium merupakan tumor ganas organ reproduksi wanita yang paling sering dijumpai, dengan insidennya yang terus meningkat, terutama pada wanita-wanita postmenopause di negara-negara berkembang. Perkembangan karsinoma endometrium sangat erat kaitannya dengan hormon estrogen. Paparan estrogen dalam waktu panjang tanpa dihalangi efek progesteron dapat meningkatkan risiko terjadinya karsinoma endometrium. Epitel glandular endometrium merupakan lokasi keganasan yang sangat responsif terhadap hormon, dalam hal ini akan diekspresikan melalui estrogen receptor (ER) dan progesterone receptor (PR). ER dan PR yang akan berikatan dengan hormon estrogen dan progesteron pada jaringan endometrium relatif akan berkurang jumlahnya pada karsinoma endometrium, dan hilangnya reseptor-reseptor tersebut merupakan bagian dari karsinogenesis endometrium. Beberapa parameter histopatologi, seperti tipe dan grading histopatologi akan mempengaruhi ekspresi reseptor-reseptor tersebut. Tujuan penelitian ini untuk menganalisis ekspresi ER dan PR pada tipe dan grading histopatologik karsinoma endometrium.MetodePenelitian ini merupakan penelitian deskriptif analitik dengan pendekatan secara cross sectional. Sampel penelitian adalah blok parafin jaringan endometrium yang didiagnosa secara histopatologi sebagai karsinoma endometrium. Sampel dipulas dengan imunohistokimia ER dan PR. Uji statistik dilakukan untuk menganalisis ekspresi ER dan PR pada tipe dan grading histopatologik.HasilEkspresi ER pada tipe endometrioid (78,8%) dan kasus low grade (90,2%) sedang ekspresi PR pada tipe endometrioid (82,7%) dan kasus low grade (90,2%).KesimpulanEkspresi ER dan PR dapat digunakan untuk membedakan antara tipe dan grading histopatologik low grade pada karsinoma endometrium.
Comparison of Buccal Mucosal Epithelial Cell Analysis of Communities Around and Outside the Medan City Waste Landfill T.Kemala Intan; Zulham Yamamoto; Causa Trisna Mariedina; Indryani Rachman; Matsumoto Toru
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 2 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i2.696

Abstract

Background: People living around waste final processing sites (TPAs) have the potential to experience chronic exposure to environmental pollution that can have an impact on health. Exposure to various pollutants from waste processing activities has the potential to cause cellular damage, including in buccal mucosal epithelial cells that can be used as biomarkers of cytogenetic damage. Objective: This study aims to examine the damage to buccal mucosal epithelial cells in people living around the Medan City Landfill and compare it with people who do not live in the area. Methods: This study used a cross-sectional design involving 100 respondents divided into two groups: the community living around the landfill (50 subjects) and the control group not living near the landfill (50 subjects). Buccal mucosal epithelial cells were collected using the cytobrush technique and stained using the Papanicolaou method. Analysis was carried out on the frequency of pyknosis, karyorrhexis, and karyolysis as cytogenetic biomarkers, with adjustment for potential confounders including sex, age, and duration of residence, then compared between the two groups. Results: The results showed that the frequency of buccal mucosal epithelial cells exhibiting pyknosis, karyorrhexis, and karyolysis in the community living around the landfill did not show a statistically significant difference compared to the control group (p > 0.05 for all cytogenetic endpoints). Conclusion: There was no significant difference in the frequency of cytogenetic endpoints (pyknosis, karyorrhexis, and karyolysis) of buccal mucosal epithelial cells between people living around the Medan City Landfill and those who did not. These findings indicate no evidence of significant genotoxicity based on the analyzed cytogenetic parameters in the studied population. However, continued environmental monitoring and longitudinal studies with larger sample sizes are recommended to detect subclinical cellular changes at earlier stages.
Co-Authors Alferraly, T. Ibnu Basrul, Mohd. Yuwanda Betty betty betty Chrestella, Jessy Delyuzar, Delyuzar Elvira, Cindy Fitri Desimilani, Fitri Desimilani Fitri Dewi Ismida Indryani Rachman Intan, T. Kemala Kadri, Sayed Muhammad Kuncara, Dede Bisma Laksmi, Lidya Imelda Listiyaningsih, Listiyaningsih Lubis, M. Nadjib Dahlan Lukito, Joko S Lukito, Joko S. Matsumoto Toru Nadjib Dahlan Lubis Rezeki, Dewi Sri Safarianti Safarianti Sivabalan Logawathi, Satthiyabalan Soekimin Soekimin Soekimin Soekimin, Soekimin T.Kemala Intan Yamamoto, Zulham