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All Journal Jurnal Kedokteran Syiah Kuala Majalah Patologi Indonesia Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Jurnal Kedokteran STM (Sains dan Teknologi Medik) Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Glosains: Jurnal Sains Global Indonesia
Mariedina, Causa Trisna
Department Of Pathology Anatomy, Faculty Of Medicine, Universitas Sumatera Utara, Medan, North Sumatera, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Analisis Ekspresi Estrogen Receptor (ER) dan Progesteron Receptor (PR) pada Tipe dan Grading Histopatologik Karsinoma Endometrium Causa Trisna Mariedina; Soekimin Soekimin; Delyuzar Delyuzar
Majalah Patologi Indonesia Vol 26 No.3, September 2017
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Latar belakangKarsinoma endometrium merupakan tumor ganas organ reproduksi wanita yang paling sering dijumpai, dengan insidennya yang terus meningkat, terutama pada wanita-wanita postmenopause di negara-negara berkembang. Perkembangan karsinoma endometrium sangat erat kaitannya dengan hormon estrogen. Paparan estrogen dalam waktu panjang tanpa dihalangi efek progesteron dapat meningkatkan risiko terjadinya karsinoma endometrium. Epitel glandular endometrium merupakan lokasi keganasan yang sangat responsif terhadap hormon, dalam hal ini akan diekspresikan melalui estrogen receptor (ER) dan progesterone receptor (PR). ER dan PR yang akan berikatan dengan hormon estrogen dan progesteron pada jaringan endometrium relatif akan berkurang jumlahnya pada karsinoma endometrium, dan hilangnya reseptor-reseptor tersebut merupakan bagian dari karsinogenesis endometrium. Beberapa parameter histopatologi, seperti tipe dan grading histopatologi akan mempengaruhi ekspresi reseptor-reseptor tersebut. Tujuan penelitian ini untuk menganalisis ekspresi ER dan PR pada tipe dan grading histopatologik karsinoma endometrium.MetodePenelitian ini merupakan penelitian deskriptif analitik dengan pendekatan secara cross sectional. Sampel penelitian adalah blok parafin jaringan endometrium yang didiagnosa secara histopatologi sebagai karsinoma endometrium. Sampel dipulas dengan imunohistokimia ER dan PR. Uji statistik dilakukan untuk menganalisis ekspresi ER dan PR pada tipe dan grading histopatologik.HasilEkspresi ER pada tipe endometrioid (78,8%) dan kasus low grade (90,2%) sedang ekspresi PR pada tipe endometrioid (82,7%) dan kasus low grade (90,2%).KesimpulanEkspresi ER dan PR dapat digunakan untuk membedakan antara tipe dan grading histopatologik low grade pada karsinoma endometrium.
Comparison of Buccal Mucosal Epithelial Cell Analysis of Communities Around and Outside the Medan City Waste Landfill T.Kemala Intan; Zulham Yamamoto; Causa Trisna Mariedina; Indryani Rachman; Matsumoto Toru
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 2 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i2.696

Abstract

Background: People living around waste final processing sites (TPAs) have the potential to experience chronic exposure to environmental pollution that can have an impact on health. Exposure to various pollutants from waste processing activities has the potential to cause cellular damage, including in buccal mucosal epithelial cells that can be used as biomarkers of cytogenetic damage. Objective: This study aims to examine the damage to buccal mucosal epithelial cells in people living around the Medan City Landfill and compare it with people who do not live in the area. Methods: This study used a cross-sectional design involving 100 respondents divided into two groups: the community living around the landfill (50 subjects) and the control group not living near the landfill (50 subjects). Buccal mucosal epithelial cells were collected using the cytobrush technique and stained using the Papanicolaou method. Analysis was carried out on the frequency of pyknosis, karyorrhexis, and karyolysis as cytogenetic biomarkers, with adjustment for potential confounders including sex, age, and duration of residence, then compared between the two groups. Results: The results showed that the frequency of buccal mucosal epithelial cells exhibiting pyknosis, karyorrhexis, and karyolysis in the community living around the landfill did not show a statistically significant difference compared to the control group (p > 0.05 for all cytogenetic endpoints). Conclusion: There was no significant difference in the frequency of cytogenetic endpoints (pyknosis, karyorrhexis, and karyolysis) of buccal mucosal epithelial cells between people living around the Medan City Landfill and those who did not. These findings indicate no evidence of significant genotoxicity based on the analyzed cytogenetic parameters in the studied population. However, continued environmental monitoring and longitudinal studies with larger sample sizes are recommended to detect subclinical cellular changes at earlier stages.
Hubungan Ekspresi Imunohistokimia p16INK4a terhadap subtipe dan grading histopatologi pada karsinoma sel skuamosa penis Marisi Cintya Debby Sihotang; T. Kemala Intan; Ibnu Alferraly; Causa Trisna Mariedina; Joko S. Lukito
Majalah Patologi Indonesia Vol. 35 No. 2, Mei 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i2.687

Abstract

Background Penile squamous cell carcinoma is a malignancy of the epithelial cells of the prepuce or glans penis, occupying 95% of all malignancies in the penis.The average patient age is 50 until 70 years. The p16INK4a immunohistochemistry is a cyclin dependent kinase inhibitor and can be expressed by human papilloma virus. Several studies have tried to relate this expression to eradicate this virus.  Methods This study use cross-sectional analytical study with 30 samples of histopathological preparations diagnosed as penile squamous cell carcinoma at H. Adam Malik Hospital Medan. Assessment of p16INK4a expression was made based on analysis of the percentage of positive tumor cells and staining intensity. Score 0: (no positive tumor cells). Score +1: (≤10% positive tumor cells). Score +2: (11–50% positive tumor cells). Score +3: (> 50% positive tumor cells). The color intensity of p16INK4a  is categorized as follows:  Score 0: (negative). Score 1: (weak). Score 2: (strong). Results The most common age was 40-49 years, the most location was in more than one region, the most subtype was HPV-associated ,the most weak positive expression was the HPV-associated subtype and the most strong positive expression was HPV-associated of squamous cell carcinoma of penile. The highest immunohistochemical expression of p16INK4a  was weakly positive at grade 3. Conclusion There is a significant relationship between p16INK4a and histopathological subtypes, but there was no significant with the grading of penile squamous cell carcinoma.    
Relationship of Immunohistochemical Expression of Protein 16 (p16) to Nasopharyngeal Carcinoma Subtype at Haji Adam Malik General Hospital Medan Very Hidayat; Lidya Imelda Laksmi; Causa Trisna Mariedina; T. Kemala Intan; Nadjib Dahlan Lubis
Majalah Patologi Indonesia Vol. 35 No. 2, Mei 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i2.689

Abstract

Introduction Nasopharyngeal carcinoma is a malignant tumor that originates from the epithelial cells of the nasopharyngeal mucosa or gland and is a malignant tumor of the head and neck area. Immunohistochemistry Protein 16 is a tumor suppressor gene (TSG), which is  a cyclin-dependent kinase (CDK) inhibitor that regulates tumor cells through the G1 phase of the often inactive cell cycle in cancer. Research on the relationship  of p16 expression to nasopharyngeal carcinoma has not been done much. Method This study used 46 slide/block samples of paraffin in Nasopharyngeal carcinoma cases that had been histopathologically diagnosed at the Anatomical Pathology Unit of H. Adam Malik Hospital Medan from January 2022 to May 2024. All clinicopathology data is taken from medical records/pathology archives. p16  expression is assessed in the nucleus and or cytoplasm of tumor cells. The assessment  of p16  expression was carried out semi-quantitatively based on the multiplication of area and intensity in the expressed tumor cells. Statistical analysis was carried out using the Eta test. Result Among the 46 nasopharyngeal carcinoma samples, 21 samples were found to have positive expressions with strong positive values in  the NKSCC subtype  as many as 14 samples (30.4%) and weak positive values in  the NKSCC subtype  as many as 7 samples (15.2%). Meanwhile, the results of immunohistochemical staining p16 were most negatively expressed, namely in  the NKSCC subtype  as many as 23 samples (50.0%) and in  the KSCC subtype  as many as 2 samples (4.3%). This variable Eta test was carried out and a p-value of 0.195 was obtained. Conclusion There was no relationship of p16  expression to the nasopharyngeal carcinoma subtype.
Co-Authors Alferraly, T. Ibnu Basrul, Mohd. Yuwanda Betty betty betty Chrestella, Jessy Delyuzar, Delyuzar Elvira, Cindy Fitri Desimilani, Fitri Desimilani Fitri Dewi Ismida Ibnu Alferraly Indryani Rachman Intan, T. Kemala Joko S. Lukito Kadri, Sayed Muhammad Kuncara, Dede Bisma Laksmi, Lidya Imelda Lidya Imelda Laksmi Listiyaningsih, Listiyaningsih Lubis, M. Nadjib Dahlan Lukito, Joko S Lukito, Joko S. Marisi Cintya Debby Sihotang Matsumoto Toru Nadjib Dahlan Lubis Rezeki, Dewi Sri Safarianti Safarianti Sivabalan Logawathi, Satthiyabalan Soekimin Soekimin Soekimin Soekimin, Soekimin T. Kemala Intan T.Kemala Intan very hidayat Yamamoto, Zulham