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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Biotechnology Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Sistem Kesehatan Universa Medicina Paediatrica Indonesiana GIZI INDONESIA Chimica et Natura Acta BIOEDUSCIENCE Indonesian Journal of Chemistry The Indonesian Journal of Infectious Diseases FLUIDA Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Tunas Medika Jurnal Kedokteran & Kesehatan The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Bachti Alisjahbana
Infectious Diseases And Tropical Diseases Division, Department Of Internal Medicine, Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Faktor Intrinsik yang Berhubungan dengan Keberhasilan Pengobatan Tb Paru marni banowati; Ida Parwati; Hadyana Sukandar; Rovina Ruslami; Bachti Alisjahbana; Kumia Wahyudi
The Indonesian Journal of Infectious Diseases Vol. 4 No. 2 (2018): The Indonesian Journal of Infectious Diseases
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v4i2.48

Abstract

Latar belakang: Tuberkulosis (TB) merupakan penyakit infeksi yang disebabkan oleh Mycobacterium tuberculosis yang telah menginfeksi hampir sepertiga penduduk dunia. Indikator yang digunakan sebagai evaluasi pengobatan yaitu angka keberhasilan pengobatan. Tujuan dari penelitian ini adalah untuk mengevaluasi hasil pengobatan pada pasien baru TB Paru BTA positif dan faktor yang berhubungan dengan keberhasilan pengobatan TB Paru di Puskesmas Kota Bandung. Metode: Penelitian analitik-kuantitatif dengan rancangan cross sectional prospektif. Sampel dalam penelitian ini pasien baru TB paru BTA positif pada triwulan ke empat yaitu bulan Oktober, November dan Desember 2016 dari sepuluh Puskesmas di Kota Bandung yaitu UPT. Puskesmas Puter, Garuda, Ujungberung Indah,  Sukajadi, Kopo, Ibrahim Adji, Arcamanik, Mohammad Ramdan, Salam, dan Antapani. Besar sampel 77 responden yang diambil dengan teknik multistage random sampling. Analisa bivariabel dengan uji chi square. Hasil : Angka keberhasilan pengobatan TB pada fase intensif 64% (IK 95%: 73,2%-89,9%); sedangkan pada fase lanjutan sebesar 94,8% (IK 95%: 87,4%-98,0%). Berdasarkan analisis bivariabel yang berhubungan dengan keberhasilan pengobatan TB paru  adalah jumlah BTA pada pengamatan bulan ke-2 (p: 0,05) dan status HIV pada pengamatan bulan ke-5 (p: 0,007). Kesimpulan: jumlah BTA dan status HIV berhubungan dengan keberhasilan pengobatan TB Paru di Puskesmas Kota Bandung.
Protein Modelling Insight to the Poor Sensitivity of Chikungunya Diagnostics on Indonesia’s Chikungunya Virus Bevi Lidya; Muhammad Yusuf; Umi Baroroh; Korry Novitriani; Bachti Alisjahbana; Iman Rahayu; Toto Subroto
Indonesian Journal of Chemistry Vol 23, No 5 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.79301

Abstract

Sensitive detection of infectious diseases is crucial for effective clinical care. However, commercial rapid tests may be limited in their ability to detect pathogen variants across different countries. It was found that the sensitivity of a chikungunya rapid test on local strain was only 20.5% as compared to the East, Central, and South Africa (ECSA) phylogroup. Therefore, the development of geographically specific diagnostics is essential. Investigating the distinctive structural properties of a locally sourced antigenic protein is an important initiative for the development of a specific antibody. This study utilized structural bioinformatics and molecular dynamics simulations to investigate the differences between the E1-E2 antigenic proteins of the Indonesian chikungunya virus (Ind-CHIKV) and that of ECSA. The results showed that some of the mutation points are located at the antibody binding sites of Ind-CHIKV. G194S and V318R mutations were proposed as distinctive features of Ind-CHIKV, leading to weaker antibody binding compared to ECSA. It suggests that modifying the antibody to accommodate bulkier side chains at positions 194 and 318 could improve its effectiveness against Ind-CHIKV. These insights are valuable for developing a highly sensitive immunoassay for Ind-CHIKV and other regional pathogens, ultimately enhancing diagnostic capabilities in Indonesia.
Characteristics and Clinical Outcomes of COVID-19 Patients with Hyperglycemia: Retrospective Cohort Study from a COVID-19 Referral Hospital, Bandung, Indonesia Permana, Hikmat; Ikhsanawati, Annisa; Susandi, Evan; Soetedjo, Nanny Natalia Mulyani; Alisjahbana, Bachti
Althea Medical Journal Vol 10, No 4 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n4.3111

Abstract

Background: COVID-19 often causes severe complications in patients with metabolic disorders such as diabetes mellitus. Conversely, inflammation caused by infection may also trigger insulin resistance, resulting in hyperglycemia and is related to the disease severity. This study aimed to describe the characteristics and clinical outcomes of COVID-19 patients with hyperglycemia at one of the COVID-19 referral hospitals in Bandung, Indonesia.Methods: This retrospective cohort study used secondary data from medical records of COVID-19 patients admitted to Dr. Hasan Sadikin General Hospital Bandung, Indonesia from March 2020 to March 2021. This study included all patients with confirmed COVID-19, aged >18 years, and had at least one blood glucose test at admission. Patients were grouped based on three possible types of hyperglycemia, namely diabetes mellitus, reactive hyperglycemia, and steroid-induced hyperglycemia; then their characteristics and disease outcomes were compared. Results: This study identified 1,114 patients’ medical records and included 1,013 data in the analysis. Hyperglycemia occurred in 45.1% of COVID-19 patients. The most common hyperglycemia types were diabetes mellitus (55.7%), reactive hyperglycemia (37.4%), and steroid-induced hyperglycemia (7%). The steroid-induced hyperglycemia group had similar characteristics as the diabetes group. The reactive hyperglycemia group exhibited a metabolic syndrome pattern resembling pre-diabetic conditions. The highest rates of severe disease and mortality were seen in the steroid-induced hyperglycemia group, followed by the diabetes group.Conclusions: There is an elevated prevalence of hyperglycemia in COVID-19 patients with diabetes. The steroid-induced hyperglycemia group has the most unfavorable outcomes. These observations emphasize the importance of identifying hyperglycemic conditions to improve management and outcomes.
In Silico-Predicted Cytokeratin Fragment 21-1 (Cyfra 21-1) Immunogenic Epitopes for The Early Detection of Nasopharyngeal Carcinoma Depamede, Brian Umbu Rezi; Alisjahbana, Bachti; Depamede, Sulaiman Ngongu; Hafidhoh, Sanny; Nururrohmah, Siti; Tryawan, Ilham Ngongu; Yusuf, Muhammad
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.51749

Abstract

Nasopharyngeal Carcinoma, an aggressive cancer in the head and neck region is mostly diagnosed at an advanced stage and thus has a poor prognosis. Cytokeratin Fragment 21-1 (CYFRA 21-1) is one of the oncomarkers discovered in saliva. For developing a diagnostic kit, CYFRA 21-1 antibodies and immunogens are needed. Natural CYFRA 21-1 immunogen is difficult to obtain, so it must be made in-silico using bioinformatics. We aim to predict CYFRA 21-1 immunogenic epitope to produce antibodies polyclonal against CYFRA 21-1, which can be used to develop NPC diagnostics. The immunogenic epitopes were predicted and chosen based on antigenicity, surface accessibility, and hydrophilicity, then characteristic was analyzed and evaluated. The epitope candidates were compared with other saliva protein biomarkers to find if there were cross-reactions. CYFRA 21-1 consists of 57 amino acids, where two immunogenic epitopes (C3 and D2) were chosen. The Ramachandran Plot of both epitopes shows that 100% of the amino acids were in the favoured area. Epitopes C3 and D2 have no cross-reaction with other protein biomarkers. The predicted immunogenic epitopes have the potential as antigen to produce antibodies for developing saliva-based immunodiagnostics to early diagnose NPC patients.
Comparison Between Evendo Score and Baveno VII Criteria for Predicting Esophageal Varices in Cirrhosis Patients Bestari, Muhamad Begawan; Alisjahbana, Bachti; Baskoro, Toni
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 25, No 3 (2024): VOLUME 25, NUMBER 3, December, 2024
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/25320243-8

Abstract

Background: The EVendo score and Baveno VII criteria are non-invasive methods in predicting the presence of esophageal varices in patients with cirrhosis. The EVendo score is more practical to use in daily practice than the Baveno VII criteria because it does not require a liver stiffness measurement. This study aims to compare the performance of the EVendo score with the Baveno VII criteria for predicting the presence of esophageal varices in patients with liver cirrhosis.Methods: This study was diagnostic study with cross-sectional approach on cirrhosis patients who had previously undergone upper gastrointestinal endoscopy who had laboratory examination data and liver stiffness measurement values. Based on the existing data, calculation and comparison of the diagnostic value of the EVendo score and the Baveno VII criteria were carried out. The research was conducted at dr. Hasan Sadikin based on patient data from April 2017 to May 2023.    Results: The Evendo score had a sensitivity of 80.5%, specificity 50%, PPV 84.6%, NPV 42.9%, positive likelihood ratio 1.61, and negative likelihood ratio 0.39. The Baveno VII criteria had a sensitivity of 95.1%, specificity of 25%, PPV 81.2%, NPV 42.9%, positive likelihood ratio 1.27, and negative likelihood ratio 0.2.Conclusion: The results of this study show that the EVendo score and Baveno VII criteria have high sensitiviy but low specificity for predicting esophageal varices in patients with liver cirrhosis.  
Challenges and opportunities to improve tuberculosis care for Indonesian children Graham, Stephen M.; Dwihardiani, Bintari; Felisia, Felisia; Koesoemadinata, Raspati Cundarani; Putri, Nina Dwi; Alisjahbana, Bachti; Lestari, Trisasi; Yani, Finny Fitry; Triasih, Rina
Paediatrica Indonesiana Vol. 65 No. 1 (2025): January 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.1.2025.1-9

Abstract

No abstract for editorial
Optimization and Evaluation of the Accuracy of the C-Reactive Protein Detection Range in a Rapid Test Based on Lateral Flow Immunoassay with Two Clinical Cut-Offs Rukmi, Ai; Darmawati, Sri; Alisjahbana, Bachti; Depamede, Sulaiman Ngongu; Pambudi, Sabar; Yuwita, Anita
BIOEDUSCIENCE Vol 10 No 2 (2026): BIOEDUSCIENCE
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/jbes/20220

Abstract

Background: C-Reactive Protein (CRP) is an important biomarker for infection and inflammation; however, quantitative assessment using ECLIA is costly and requires adequate laboratory facilities and trained personnel. This study aims to optimize antibody concentration and conjugate volume, and to evaluate the accuracy of the detection range of an LFIA-based CRP rapid test at two clinical cut-offs (10 and 40 mg/L). Methods: Experimental research was conducted by optimizing antibody concentrations on the T1 and T2 lines, optimizing CGC volume, and testing sensitivity, specificity, and the correlation between color intensity and Image. Results: The optimal antibody concentrations were obtained at T1 of 0.075 mg/mL and T2 of 0.025 mg/mL with a CGC volume of 2 µL. Sensitivity and specificity were 95.7% and 100% at T1, and 83.3% and 95.5% at T2. Conclusions: The developed CRP rapid test has adequate diagnostic performance as a semi-quantitative screening tool in primary healthcare facilities.
Co-Authors Afandi, Ressa Novita Agnes Rengga Indrati Ahmad Sulaeman Amaylia Oehadian Andre van der Venn Angèle JGMGerver-Jansen Angky Tririni Anita Yuwita Anna Alisjahbana Annisa Ikhsanawati, Annisa Ardini S. Raksanagara Ardini S. Raksanagara, Ardini S. Baskoro, Toni Basti Andriyoko Bestari, Muhamad Begawan Bevi Lidya Bevi Lidya Budi Santoso Budiman , Budiman Clara M Kusharto Depamede, Brian Umbu Rezi Dewi Kartika Turbawaty Dhiya Salsabila Dick van Soolingen Dida Ahmad Gurnida Dwi Agustian Dwihardiani, Bintari Edhyana Sahiratmadja Endang Sutedja Eva Mardiana Hidayat Evan Susandi Fauzian Giansyah Febriani, Ulfah Dwi Felisia . Finny Fitry Yani Gumilang, Manik Intan Guntur Darmawan Hadyana Sukandar Hafidhoh, Sanny Hendra Subroto, Hendra Henriette A Delemarre–van de Waal Henry Chandra Herry Garna Hesti Lina Wiraswati Hidayat, Eva Mardiana Hikmat Permana Hikmat Permana Hinta Meijerink Hofiyah Djauhari Ida Parwati Ida Parwati Iman Rahayu Irvan Afriandi Jeffery Malachi Candra Jose RL Batubara Juhariah Juhariah Julia Hartati Koesoemadinata, Raspati C. Korry Novitriani Krishna Yana Krisnian, Tharani Kumia Wahyudi Kusumawardhani, R.N. Yasmin Lelly Yuniarti Leonardus Wiydatmoko marni banowati Menik Herdwiyanti Muhamad Zulchoir Rasyid Muhammad Yusuf Muhammad Yusuf Muhammad Yusuf Nanan Sekarwana Nanny Natalia Mulyani Soetedjo Ni Sayu Dewi B. Nina Dwi Putri Nisa Fauziah Novi Jayanti Nuni Sulastri Nurizzatun Nafsi Nurul Hidayah Chairunnisa Nururrohmah, Siti Nury Fitria Dewi obin sarwita Panji Fortuna Hadisoemarto Parse, Rocci Jack Prayudi Santoso Putri Vidyaniati Ratna Yulistya Ningrum Reinout van Crevel Reinout van Crevel Ressa Novita Afandi Resvi Livia Rina Triasih Rocci Jack Parse Rovina Ruslami Rovina Ruslami, Rovina Rukmi, Ai Sabar Pambudi Santoso, Ida Parwati Sari Syahruni Setyaningrum, Sinta Siti Soidah Sofia Imaculata Sri Darmawati Stephen M. Graham, Stephen M. Sulaiman Ngongu Depamede Suparman Hardinsyah, Suparman Susan Margaret McAllister Susandi, Evan Susantina Prodjosoewojo Syndi Nurmawati Teow Sheng Hao Tharani Krisnian Tjahjani M. Sudiro Tony Sadjimin Toto Subroto Trinugroho Heri Fadjari, Trinugroho Heri Trisasi Lestari, Trisasi Tryawan, Ilham Ngongu Tya Listiaty Ulfah Dwi Febriani Umi Baroroh Uun Sumardi, Uun Willem J Gerver Wirawan, Chevie Woro Indri Padmosiwi Yana, Krishna Yani Triyani Yanti Mulyana Yeva Rosana Yovita Hartantri Yulniar Tasli Yuwita, Anita