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All Journal VALENSI JSFK (Jurnal Sains Farmasi & Klinis) Medical Technology and Public Health Journal Pharmaceutical And Biomedical Sciences Journal (PBSJ) Procedia of Social Sciences and Humanities Journal of English Literature and Linguistic Studies (JELLS) Saba : Journal of Tourism Research Jurnal Kefarmasian Indonesia
Yuni Anggraeni
UIN Syarif Hidayatullah Jakarta
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : VALENSI

 1 
Stabilitas Asiatikosida dalam Proses Pembuatan Film Penutup Luka Kitosan yang Mengandung Asiatikosida Yuni Anggraeni
Jurnal Kimia Valensi Jurnal VALENSI Volume 4, No. 2, November 2014
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3801.517 KB) | DOI: 10.15408/jkv.v0i0.3613

Abstract

Solubility Enhancement of Ethyl AcetateFraction of The Artocarpus altilis (Parkinson) Fosberg Leaves with Addition of β-Cyclodextrin-HPMC by Using Kneading Method Sabrina Sabrina; Yuni Anggraeni; Berti Puspitasaril; LBS Kardono
Jurnal Kimia Valensi Jurnal Valensi Volume 4, No.1, Mei 2014
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (153.533 KB) | DOI: 10.15408/jkv.v4i1.1077

Abstract

Abstract Ethyl acetate fraction of the Artocarpus altilis (Parkinson) Fosberg extract have a potency to treat the cardiovascular diseases have poorly solubility in water. The purpose of this study was to improve the solubility of the extract. One of method to improve the solubility of the extract by mixing with cyclodextrin polymers and their derivatives. Hydroxyl propyl methylcellulose (HPMC) as a water-soluble polymer can enhance the β-cyclodextrin (β-CD) activity. Three comparisons extract and ß-cyclodextrin were: 1:2, 1:4, and 1:6 by mixing with the addition hydroxyl propyl methylcellulose 0.12%of the total weight of extract and β-CD for each formula. The sample was prepared by kneading method. The sample characterization was used Karl Fischer titration, Scanning Electron Microscopy and solubility study.Content of total flavonoid from the extract was 32.7%. The Result showed that the addition polymer combination of β-CD + HPMC caused increasing the solubility of extract in water7.04% (F1), 19.47% (F2) and 59.92% (F3) compared to extract control with significant differences at level of confidence 95% (p ≤ 0.05). Keywords : ethyl acetate fraction of breadfruit, kneading method, β-cyclodextryn, hydroxy propyl methylcellulose, total flavonoid
Co-Authors Abdi Wira Septama Amelia, Puteri Andini Wulandari Berti Puspitasaril Citraningsih, Kinanti Dewi, Asri Kusuma Dieta Nurrika Evie Destiana Fakhrun Nisa' Fatmala, Endang Fitriyani Bakri Herdini Herdini , Herdini Iskandar Iskandar LBS Kardono Maulina Handayani Munfarikhatin, Atina Nisa', Fakhrun Nurkhasanah Nurkhasanah Nurkhasanah Nurkhasanah Nurmeilis Ofa Suzanti Betha Sabrina Dahlizar Sofa Fajriah Sukmayanti, Zanastia suryani, nelly Umar Mansur Umniyaty Mufidah Vivi Anggia, Vivi Zilhadia Zilhadia Zilhadia