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Diuretic Activity and Acute Toxicity of Combination Eurycoma longifolia Extract and Irbesartan Nurmeilis Nurmeilis; Dyah A Woro; Atiek Soemiati; Anis Khoirunisa
Indonesian Journal of Pharmaceutical Science and Technology Vol 2, No 1 (2015)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Microwave-Assisted Claisen-Schmidt Condensation Reaction of Ethyl p-methoxycinnamate to Synthesize p-Methoxystyryl Ketone Derivatives and Evaluate Anti-inflammatory Activity of Synthetic Products Ismiarni Komala; Supandi Supandi; Nurmeilis Nurmeilis; Yardi Yardi; Ofa Suzanti Betha; Nurkhyati Putri Indriyani; Moethia Moethia; Muhamad Beny Setiawan; Ghilman Dharmawan; Putri Hayati Nufus; Noni Tri Utami
Journal of Mathematical and Fundamental Sciences Vol. 53 No. 1 (2021)
Publisher : Institute for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2021.53.1.6

The rhizome of Kaempferia galanga has been known to contain ethyl p-methoxycinnamate (EPMC) (1) as a main component, which has anti-inflammatory properties. Previously we have reported the structural modification of EPMC (1) to form another ester, nitrostyrene, and cinnammamide derivatives and then studied their structure-activity relationships as anti-inflammatory agent. In continuing our research, in this paper, we report the microwave-assisted Claisen-Schmidt condensation of EPMC (1) to synthesize a series of p-methoxystyryl ketones followed by a study of their anti-inflammatory activity. The reaction begins with microwave-assisted cleavage oxidation of hydrolyzed product of EPMC, p-methoxycinnamic acid (2) with Ca(NO3)2 for the synthesis of p-methoxybenzaldehyde (3). Furthermore, 3 was reacted with acetophenone, ethyl methyl ketone and acetone via microwave-assisted Claisen-Schmidt condensation for the synthesis of (E)-1-(4-methoxyphenyl)-3-phenylprop-2-en-1-one (5a) (E)-1-(4-methoxyphenyl)pent-1-en-3-one (5b) and (E)-4-(4-methoxyphenyl)but-3-en-2-one (5c), respectively. The reaction products were characterized using spectroscopic techniques and were then tested for anti-inflammatory activity using in vitro anti-denaturation of protein assay. It was found that converting EPMC (1) to 5a and 5b reduced anti-inflammatory activity, while 5c retained anti-denaturation activity with an IC50 of 72.8 µg/ml.

Cytotoxic Activity of the Indonesian Fern Angiopteris angustifolia C. Presl and Liverwort Mastigophora diclados (Birs. ex Web) Nees Against Breast Cancer Cell Lines (MCF-7) Ismiarni Komala; Stevani Sitorus; Fitri Ratna Dewi; Nurmeilis Nurmeilis; Laifa Annisa Hendarmin
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 1, May 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i1.22645

Breast cancer is the most frequent cancer among women worldwide, and it is also the main cause of death from cancer. Fern Angiopteris angustifolia C. Presl and Liverwort Mastigophora diclados (Birs.ex Web) Nees are the plants that grow in Indonesia that are limited explored for their phytochemical and biological activity. This study aims to evaluate the cytotoxic effect of ethanolic extracts leaves of A. angustifolia and M. diclados against breast cancer cell lines (MCF-7). The MTT assay was used to determine cytotoxic activity, which revealed that the ethanol extract of A. Angustifolia and M. diclados exhibited cytotoxic activity with an IC50 value of 121.8 ± 13.3 and 29.2 ±1.4 µg /mL, respectively.

Intervensi Promosi Kesehatan Melalui Edukasi Gizi Oleh Kader Desa Dalam Pencegahan Stunting Raihana Alkaff; Yuli Amran; Milza Nasrul Rosad; Nurmeilis Nurmeilis
Shihatuna : Jurnal Pengabdian Kesehatan Masyarakat Vol 2 No 1 (2022) : Juni
Publisher : FKM UIN Sumatera Utara Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30829/shihatuna.v2i1.11652

The Indonesian government makes stunting one of the priority health problems that must be addressed seriously and in 2017 set 100 priority districts for stunting prevention. From October to December 2019, Syarif Hidayatullah State Islamic University (UIN) Jakarta held a health promotion intervention program through nutrition education for pregnant women, breastfeeding mothers and mothers of toddlers in Gianyar Regency, Bali. The results of the evaluation of the intervention program by the UIN Syarif Hidayatullah Jakarta team showed a significant increase in the knowledge of 65.8% of pregnant women, breastfeeding mothers and mothers of toddlers in 6 villages in Gianyar Regency. However, the increase in knowledge scores was still around 12.33 points from the initial score of 62.28. This shows that there is still a need for special attention to efforts to increase public knowledge about stunting prevention through effective behavior change communication.Optimizing the role of “Leadership” in stunting prevention management programs at the village/sub-district level is very necessary in ensuring the suitability of stunting prevention programs such as the transfer of information (relay) related to stunting prevention programs that have been carried out at the time of the change of leadership. In addition, communication skills to change behavior and use of health promotion media tools in stunting prevention are needed as basic materials to support optimizing the role of cadres in providing counseling in supporting the role of midwives/health centers in the community

Efek antihipertensi Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa blimbing L.) dengan Metode Non-invasiv Suci Ahda Novitri; Nurmeilis Nurmeilis Nurmeilis; Dea Raudya Kamal
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 2, No 1 (2020)
Publisher : UIN Syarif Hidayatullah Jakarta

Daun belimbing wuluh digunakan sebagai obat tradisional untuk menurunkan tekanan darah oleh masyarakat Indonesia. Oleh karena itu, untuk menguji aktivitas tersebut, dilakukan penelitian terhadap ekstrak etanol daun belimbing wuluh (Averrhoa blimbii L.) pada tikus jantan galur Sprague-Dawley yang diinduksi dengan NaCl 2% dan Prednison 1,5 mg/KgBB. . Penelitian ini menggunakan metoda non-invasiv (CODA non-invasive blood pressure) dengan rancangan pre-test dan post-test matched control group. Tiga puluh ekor tikus dibagi menjadi 6 kelompok yaitu kelompok normal, kontrol negatif (NaCMC 5%), kontrol positif (kaptopril 2,5 mg/kgBB) dan tiga kelompok uji (ekstrak etanol 70% daun belimbing wuluh 50, 100 dan 200 mg/KgBB). Pemberian NaCl 2% dan Prednison 1,5 mg/KgBB dilakukan selama 14 hari dan dilanjutkan dengan pemberian ekstrak uji selama 7 hari secara oral. Pada hari ke-0, ke-14, dan ke-21 dilakukan pengukuran tekanan darah sistol, diastol dan heart rate tikus. Data yang diperoleh dianalisis dengan One Way ANOVA atau Kruskal Walis dan Paired T-test.Hasil penelitian menunjukkan ekstrak uji (50, 100 dan 200 mg/KgBB) dapat menurunkan tekanan darah sistol dan diastol secara bermakna terhadap kontrol negatif (p≤0,05), namun penurunan heart rate tidak ada perbedaan yang bermakna. Pada dosis 100 mg/kgBB, presentase penurunan tekanan darah sistolik tertinggi yaitu 31,69% dan diastolik 33,31%. Berdasarkan hasil penelitian tersebut, ekstrak uji memiliki efek antihipertensi.

Gambaran Karakteristik Pasien dan Penggunaan Obat Dispepsia Di Klinik A Daerah Bekasi Timur Intan Suri; Marvel Marvel; Nurmeilis Nurmeilis
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 2, No 2 (2020)
Publisher : UIN Syarif Hidayatullah Jakarta

Perubahan gaya hidup dan pola makan menjadi salah satu penyebab terjadinya gangguan saluran pencernaan. Gangguan pencernaan yang paling banyak diderita adalah dispepsia. Dalam hal ini banyak faktor risiko yang menyebabkan terjadinya kekambuhan dispepsia. Penelitian ini bertujuan untuk mengetahui gambaran karakteristik pasien dan penggunaan obat dispepsia di klinik A daerah Bekasi Timur. Penelitian ini dilakukan dengan metode cross sectional dengan metode pengambilan data secara retrospektif melalui rekam medik pasien. Pemilihan sampel dengan menggunakan teknik total sampling dimana terdapat 200 sampel yang memenuhi kriteria inklusi dalam penelitian. Hasil penelitian menunjukkan Karakteristik pasien dispepsia di Klinik A Daerah Bekasi Timur yang dominan adalah berjenis kelamin perempuan (60%), berada pada rentang umur ≥ 56 tahun (27,5%), tanpa ada penyakit penyerta (76,5%), jenis penyakit penyerta hipertensi (46,42%), frekuensi kedatangan pasien 1 kali (64,5%), dan penggunaan obat dispepsia dengan 3 kombinasi (57%). Dari hasil uji statistik dihasilkan pernyataan bahwa jenis kelamin, umur tidak mempunyai hubungan yang bermakna dengan frekuensi dispepsia (p > 0,05). Penyakit penyerta mempunyai hubungan yang bermakna dengan frekuensi dispepsia (p < 0,05). Jenis kelamin, umur, penyakit penyerta tidak mempunyai hubungan yang bermakna dengan penggunaan obat dispepsia (p > 0,05). Frekuensi dispepsia mempunyai hubungan yang bermakna dengan obat dispepsia (p < 0,05).

The Effect of Health Education Video Based on Islamic Purification Jurisprudence on Handwashing Intention Nurmeilis; Nurrika, Dieta; Anggraeni, Yuni; Alkaff, Raihana Nadra; Sukmayanti, Zanastia
TEKNOLOGI MEDIS DAN JURNAL KESEHATAN UMUM Vol 7 No 2 (2023): Medical Technology and Public Health Journal September 2023
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mtphj.v7i2.4939

This study aimed to determine the effectiveness of health education videos based on Islamic purification fiqh on students’ intention to wash their hands using and buying clay soap by applying the theory of planned behavior. A two-armed pre-post intervention was conducted in Banten from February to August 2022. Participants were randomly assigned to an intervention or a control group. The total sample of this research is 187 respondents. This study found that the intention to wash hands using clay soap before and after the short video educational media intervention increased by 4.3%, and the intention to buy it increased by 4.8%. In the three variables that construct the intention to wash hands using clay soap, only the subjective norm variable is related to the behavioural intention to use clay soap. Religious reasons have the potential to increase handwashing behaviour using clay soap. Short video educational media interventions targeting Generation Z can be carried out to increase the intention to practice handwashing.

Analisis Pola Peresepan Obat Berdasarkan Perbedaan Status Penjamin (BPJS dan Non-BPJS) Rahayu, Retno Tri; Marvel, Marvel; Nurmeilis, Nurmeilis; Dhilasari, Estu Mahanani
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol 7, No 1 (2025)
Publisher : UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.39009

Evaluasi penggunaan obat merupakan aspek krusial dalam pelayanan farmasi klinik di fasilitas kesehatan. Tujuan penelitian ini adalah menganalisis hubungan antara status penjamin (BPJS dan non-BPJS) dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kementerian Kesehatan Republik Indonesia (Kemenkes RI) di sebuah klinik di daerah Kroya (Provinsi Jawa Tengah) pada tahun 2020. Indikator peresepan yang digunakan mencakup rerata jumlah obat per lembar resep, persentase peresepan antibiotik untuk ISPA non-pneumonia (batuk-pilek) dan diare non-spesifik, serta peresepan injeksi untuk myalgia. Penelitian ini menggunakan desain cross-sectional dengan data diperoleh secara retrospektif dari resep dan buku rawat jalan pasien. Sampel dipilih menggunakan teknik total sampling, menghasilkan 2.206 sampel resep yang dianalisis. Hasil penelitian menunjukkan perbedaan yang bermakna secara statistik (p<0,05) antara penjamin BPJS dan non-BPJS dalam semua indikator peresepan yang dievaluasi. Perbedaan ini terlihat pada rerata jumlah obat yang diresepkan (BPJS: 2,91; non-BPJS; 3,42), persentase peresepan antibiotik pada ISPA non-pneumonia (BPJS: 41,5%; non-BPJS: 63,1%), persentase peresepan antibiotik pada diare non-spesifik (BPJS: 39,8%; non-BPJS: 68,1%), dan persentase peresepan injeksi pada myalgia (BPJS: 0,0%; non-BPJS: 4,1%). Terdapat hubungan yang signifikan antara status penjamin dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kemenkes RI.

Hubungan Karakteristik Sosiodemografi dengan Hasil Terapi Tuberkulosis Paru di RSUD Banyumas Shavira, Rurynta Ferly; Restinia, Mita; Nurmeilis, Nurmeilis; Maula, Charisma Soffa
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.29973

Pulmonary tuberculosis (TB) is one of the infectious diseases caused by Mycobacterium tuberculosis and is one of the highest causes of morbidity and mortality rates with a low level of treatment outcome. Indonesia is the second country in the world with the largest tuberculosis burden. This study aims to determine the relationship of sociodemographic characteristics with the results of pulmonary tuberculosis therapy at Banyumas Regional Public Hospital for the period 2019-2021. This study used a case-control method. The inclusion criteria in this study were new pulmonary tuberculosis patients at the Banyumas Regional Public Hospital and patients aged ≥18 years, both male and female. Multi-drug resistance (MDR) TB patients and patients with incomplete medical record data were excluded. There were 166 patients enrolled in this study. Data analysis was performed by univariate analysis and bivariate analysis by chi-square test. The results showed that the sociodemographic characteristics were dominated by male patients (57,2%), patients aged <65 years (66,3%), patients weighing <55 kg (53%), not graduating from college (94%), currently working (64,5%), married (68,7%), have health insurance (94%), and close distance (<10 km) to the hospital (53%). The conclusion is that gender ((P=0,028; OR 2,112; 95%Cl(1,129 – 3,951)), age (P=0,014; OR 2,413; 95% Cl (1,242 – 4,689)), body weight (P=0,000; OR 3,306; 95%Cl (1,748 – 6,252)), and distance from the patient's house to the hospital (P=0,020; OR 2,190; 95% CI (1,176 – 4,077)) have a significant relationship with the outcome of pulmonary TB therapy at Banyumas Regional Public Hospital.

Analisis Pola Peresepan Obat Berdasarkan Perbedaan Status Penjamin (BPJS dan Non-BPJS) Retno Tri Rahayu; Marvel Marvel; Nurmeilis Nurmeilis; Estu Mahanani Dhilasari
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.39009

Evaluasi penggunaan obat merupakan aspek krusial dalam pelayanan farmasi klinik di fasilitas kesehatan. Tujuan penelitian ini adalah menganalisis hubungan antara status penjamin (BPJS dan non-BPJS) dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kementerian Kesehatan Republik Indonesia (Kemenkes RI) di sebuah klinik di daerah Kroya (Provinsi Jawa Tengah) pada tahun 2020. Indikator peresepan yang digunakan mencakup rerata jumlah obat per lembar resep, persentase peresepan antibiotik untuk ISPA non-pneumonia (batuk-pilek) dan diare non-spesifik, serta peresepan injeksi untuk myalgia. Penelitian ini menggunakan desain cross-sectional dengan data diperoleh secara retrospektif dari resep dan buku rawat jalan pasien. Sampel dipilih menggunakan teknik total sampling, menghasilkan 2.206 sampel resep yang dianalisis. Hasil penelitian menunjukkan perbedaan yang bermakna secara statistik (p<0,05) antara penjamin BPJS dan non-BPJS dalam semua indikator peresepan yang dievaluasi. Perbedaan ini terlihat pada rerata jumlah obat yang diresepkan (BPJS: 2,91; non-BPJS; 3,42), persentase peresepan antibiotik pada ISPA non-pneumonia (BPJS: 41,5%; non-BPJS: 63,1%), persentase peresepan antibiotik pada diare non-spesifik (BPJS: 39,8%; non-BPJS: 68,1%), dan persentase peresepan injeksi pada myalgia (BPJS: 0,0%; non-BPJS: 4,1%). Terdapat hubungan yang signifikan antara status penjamin dengan pola peresepan penggunaan obat berdasarkan indikator peresepan Kemenkes RI.

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