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All Journal Journal of Food and Pharmaceutical Science Jurnal Penelitian Farmasi Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Pharmacology and Clinical Pharmacy Research JURNAL PENDIDIKAN TAMBUSAI Majalah Farmasetika Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Food and Pharmaceutical Sciences Jurnal Manajemen Rekayasa (Journal of Engineering Management) Jurnal Medika: Medika Jurnal Bakti Nusantara Medical Sains : Jurnal Ilmiah Kefarmasian
Deni Anggraini
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Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Sosialisasi Bahaya Konsumsi Gula Berlebihan dan Dampaknya bagi Kesehatan Masyarakat di Kota Pekan Baru Anggraini, Deni; Sinata, Novia; Agistia, Nesa; Almurdani, M.; Sandra, Alya Dwi; Al-Fadillah, Annsisya Shafira; Azhar, Gustika; Yadi, Hervi; Kurnia, Lisa; Nadia, Putri; Astaharie, Shinta Angelia; Adela, Syarifah Nur; Pratiwi, Wulan Iska; Zikrinnissa, Zikrinnissa
Jurnal Bakti Nusantara Vol. 2 No. 2 (2024): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v2i2.70

Abstract

Telah dilakukan sosialisasi bahaya konsumsi gula berlebihan dan dampaknya bagi kesehatan masyarakat di Kota Pekan Baru. Kegiatan yang melibatkan peserta berjumlah 60 orang dilakukan di Stadion Utama Riau. Metode yang digunakan dalam sosialisasi ini adalah demonstrasi dan diskusi serta pembagian leaflet kepada masyarakat. Pengukuran efektivitas kegiatan sosialisasi ini dilakukan dengan memberikan tes berbentuk kuisoner yang diberikan sebelum kegiatan sosialisasi sebagai tes awal (pretest) dan tes akhir setelah sosialisasi (post-test). Hasil yang diperoleh dari kegiatan ini adalah telah terjadi peningkatan pemahaman peserta tentang bahaya konsumsi gula berlebihan dan dampaknya bagi kesehatan setelah kegiatan dilaksanakan. Analisis sosiodemografi yang melihat kategori umur, jenis kelamin, tingkat pendidikan, status pekerjaan, dan penghasilan peserta menunjukkan bahwa kenaikan pengetahuan yang signifikan terjadi pada peserta yang berusia 17-25 tahun, peserta jenis kelamin perempuan, peserta yang berpendidikan tinggi, peserta yang bekerja, dan berpenghasilan tinggi. Pengetahun yang baik akan bahaya konsumsi gula berlebihan dan dampaknya bagi kesehatan masyarakat akan dapat membantu mengurangi jumlah kasus penyakit degeneratif yang semakin banyak terjadi.
IMPROVED SOLUBILITY NOVEL MULTICOMPONENT CRYSTALS OF FENOFIBRIC ACID-ACETYLSALISYLIC ACID Anggraini, Deni; Novita, Gressy; Wulandari, Intan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1690

Abstract

Solubility is an important physicochemical property of active pharmaceutical ingredients. Poor water solubility of active pharmaceutical ingredients leads to low bioavailability; therefore, efforts are needed to improve the solubility of active pharmaceutical ingredients. The goal of this study was to prepare and characterize novel multicomponent crystals of fenofibric acid (FA) using acid acetylsalicylic (ACE) as a coformer and to evaluate the solubility enhancement when prepared for multicomponent crystal formation.  Solid characterization of the novel multicomponent crystals was performed using powder X-ray diffraction (XRD), differential scanning diffraction (DSC), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), polarized microscopy, and solubility tests. Multicomponent crystals were prepared by the solvent drop grinding method using a few drops of an ethanol pro analyzer. The results showed that the solubility of multicomponent crystalline fenofibric acid was 4.7 times greater than that of pure fenofibric acid. Differential Scanning Calorimetry characterization results show the novel multicomponent crystals  with a sharp endothermic peak at 136,65 oC. The PXRD diffractograms show no new diffraction peaks and a decrease  in intensity. FT-IR spectroscopic analysis showed no new functional groups, and most of the transmittance peaks of the multicomponent crystals were superimposed between the peaks of fenofibric acid and acetylsalicylic acid. The novel multicomponent crystals fenofibric acid with acetylsalicylic acid as a coformer can improve the solubility of fenofibric acid  Keywords: Acetylsalicylic acid ; Fenofibric acid ; Multicomponent crystals ; Solubility  
Edukasi Penggunaan Tanaman Herbal Terhadap Penderita Diabetes di Desa Empat Balai, Kampar Rasyid, Wildan; Pratiwi, Wirahma Indah; Djohari, Meiriza; Anggraini, Deni; Mora, Enda; Almurdani, M.; Ikhtiarudin, Ihsan; Harpirabi, T.; Jasma, Jasma; Tami, Tami; Sukma, Sukma
Jurnal Medika: Medika Vol. 4 No. 3 (2025)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/w8yeem10

Abstract

Diabetes mellitus is a public health problem that continues to increase, especially in rural areas that have limited access to modern health services. The use of herbal plants as alternative therapy is increasingly receiving attention because of its abundant availability and relatively low cost. In order to increase public awareness of the importance of prevention and treatment, especially with herbal ingredients for this degenerative disease, there needs to be ongoing counseling, one of which is through community service. This community service activity aims to provide education on the use of herbal plants that have the potential to lower blood sugar levels to the people of Empat Balai Village, Kuok District, Kampar Regency. The activities include counseling, interactive discussions, and demonstrations of the use of local herbal plants such as insulin leaves (Costus igneus), Moringa leaves (Moringa oleifera), Belimbing Wuluh (Averrhoa bilimbi), Pare (Momordica charantia), sambiloto, and mahkota dewa. The research method uses a qualitative approach with counseling techniques and leaflets given to 50 respondents. The results of the study showed an increase in public knowledge or insight about the use of herbal plants for diabetes sufferers with significance (p <0.5). The results of this Community Service activity show the importance of educating the community about managing diabetes naturally and increasing interest in implementing the use of herbs as a treatment support. Therefore, further efforts need to be made to increase insight and prevention related to Diabetes Mellitus by using herbal plants holistically.
IMPROVED SOLUBILITY NOVEL MULTICOMPONENT CRYSTALS OF FENOFIBRIC ACID-ACETYLSALISYLIC ACID Anggraini, Deni; Novita, Gressy; Wulandari, Intan
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1690

Abstract

Solubility is an important physicochemical property of active pharmaceutical ingredients. Poor water solubility of active pharmaceutical ingredients leads to low bioavailability; therefore, efforts are needed to improve the solubility of active pharmaceutical ingredients. The goal of this study was to prepare and characterize novel multicomponent crystals of fenofibric acid (FA) using acid acetylsalicylic (ACE) as a coformer and to evaluate the solubility enhancement when prepared for multicomponent crystal formation.  Solid characterization of the novel multicomponent crystals was performed using powder X-ray diffraction (XRD), differential scanning diffraction (DSC), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), polarized microscopy, and solubility tests. Multicomponent crystals were prepared by the solvent drop grinding method using a few drops of an ethanol pro analyzer. The results showed that the solubility of multicomponent crystalline fenofibric acid was 4.7 times greater than that of pure fenofibric acid. Differential Scanning Calorimetry characterization results show the novel multicomponent crystals  with a sharp endothermic peak at 136,65 oC. The PXRD diffractograms show no new diffraction peaks and a decrease  in intensity. FT-IR spectroscopic analysis showed no new functional groups, and most of the transmittance peaks of the multicomponent crystals were superimposed between the peaks of fenofibric acid and acetylsalicylic acid. The novel multicomponent crystals fenofibric acid with acetylsalicylic acid as a coformer can improve the solubility of fenofibric acid  Keywords: Acetylsalicylic acid ; Fenofibric acid ; Multicomponent crystals ; Solubility  
Edukasi dan Konsultasi Terkait Waktu Penggunaan Obat Antihipertensi bagi Pasien yang Menjalankan Ibadah Puasa untuk Menunjang Kesehatan Anggraini, Deni; Octaviani, Melzi; Sinata, Novia; Idzan, Nur Kamilah; Repuja, Dira; Fitri, Eliza; Safitri, Elsa; Annisa, Annisa; K, Della Yunita Sary.; Amanda, Denisya; Ezuela, Deska Z; Anggraini, Dhiva; Sari, Fatwa Aulia
Jurnal Pendidikan Tambusai Vol. 9 No. 2 (2025): Agustus
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v9i2.31482

Abstract

Puasa Ramadhan mengubah pola makan dan waktu penggunaan obat secara signifikan, terutama pada pasien dengan penyakit kronis seperti hipertensi. Edukasi penggunaan obat antihipertensi sangat penting agar pasien tetap memperoleh efek terapi optimal selama berpuasa. Kegiatan ini bertujuan untuk meningkatkan pemahaman masyrakat khususnya lansia, tentang waktu konsumsi obat antihipertensi selama bulan Ramadhan kegiatan dilaksanakan pada 15 maret 2025 di UPT PSTW Husnul Khotimah, Pekanbaru, dalam bentuk sosialisasi dan konsultasi. Hasil evaluasi menunjukkan peningkatan pemahaman peserta setelah edukasi
Inovasi Lip Cream Ekstrak Stroberi (Fragaria x ananassa): Optimasi Beeswax dan Castor Oil sebagai Antioksidan Alami Pelembab Bibir Iskandar, Benni; Zalfa Desion, Aufa; Anggraini, Deni
Majalah Farmasetika Vol 10, No 6 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v10i6.66570

Abstract

Lip cream merupakan salah satu produk kosmetik dekoratif yang banyak diminati, namun penggunaan bahan sintetis sering menimbulkan efek samping. Oleh karena itu, penelitian ini dilakukan untuk mengembangkan Lip cream dengan bahan alami yaitu ekstrak buah stroberi (Fragaria x ananassa) yang kaya akan senyawa antosianin dan polifenol sebagai pewarna alami sekaligus antioksidan. Kombinasi beeswax dan castor oil digunakan sebagai basis karena memiliki peran penting dalam membentuk tekstur, daya lekat, serta kestabilan sediaan.Tujuan penelitian ini adalah untuk mengoptimalkan formula Lip cream berbahan dasar ekstrak stroberi dengan variasi konsentrasi beeswax dan castor oil, serta mengevaluasi karakteristik fisik pH, daya sebar, daya lekat. Penelitian menggunakan software Design Expert dengan metode Box-Behnken Design (BBD) untuk mendapatkan formula optimal. Evaluasi meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, serta uji aktivitas antioksidan dengan metode DPPH. Hasil penelitian menunjukkan bahwa kombinasi beeswax dan castor oil berpengaruh signifikan terhadap pH, daya sebar, dan daya lekat Lip cream. Formula optimal diperoleh pada perbandingan tertentu yang menghasilkan pH sesuai standar kulit bibir, daya sebar baik, dan daya lekat yang cukup. Aktivitas antioksidan ekstrak stroberi tetap terjaga dalam sediaan dengan nilai inhibisi yang diperoleh sebesar 59,97% pada konsentrasi 500µg/ml menunjukkan sediaan Lip cream ekstrak buah stroberi memiliki kemampuan menghambat radikal bebas. Kesimpulan penelitian ini adalah Lip cream berbahan ekstrak stroberi dengan kombinasi beeswax dan castor oil dapat diformulasikan secara optimal, menghasilkan sediaan yang stabil, aman, dan memiliki potensi sebagai kosmetik alami dengan aktivitas antioksidan yang bermanfaat.
Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Anggraini, Deni; Agistia, Nesa; Fernando, Armon; Yulia, Amanda; Repuja, Dira
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Abstract

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.
Increased Dissolution Rate of Solid Dispersion Fenofibric Acid PEG 6000 and In Vivo Study Anggraini, Deni; Agistia, Nesa; Fernando, Armon; Yulia, Amanda; Repuja, Dira
Journal of Food and Pharmaceutical Sciences Vol 14, No 2 (2026): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.26376

Abstract

Fenofibrate acid is a fibrate drug with high permeability but low water solubility, resulting in limited bioavailability. Solid dispersion using hydrophilic carriers is one strategy to increase solubility. The objective of this study was to improve the solubility of fenofibric acid by converting it into a solid dispersion system using PEG 6000 as a carrier. Preparation of solid dispersion systems by the melting method. The fenofibric acid PEG 6000 weight ratios were F1 (1:1), F2 (1:3), and F5 (1:5). Physicochemical characterization of the solid dispersions included DSC, PXRD, FTIR, and SEM tests, as well as dissolution and bioavailability tests with the determination of pharmacokinetic parameters. Characterization results show that fenofibric acid with PEG 6000 as a carrier still exhibits a crystalline phase but with reduced intensity, resulting in increased solubility and dissolution rate. Dissolution test show that solid dispersion F3 (1:5) dissolves faster (78.7%) than pure fenofibric acid (53.2%). after 60 minutes. Pharmacokinetic parameter determination tests showed no significant difference between pure fenofibric acid and solid dispersion. Solid dispersion of fenofibric acid with PEG 6000 as a carrier can improve the physicochemical performance and dissolution rate of fenofibric acid but pharmacokinetic parameters did not differ significantly.
Co-Authors Abdul Kadir Adela, Syarifah Nur Adris Ade Putra Agistia, Nesa Al-Fadillah, Annsisya Shafira Amanda, Denisya Anggraini, Dhiva Anita Lukman Anita Lukman Annisa Annisa Armon Fernando Astaharie, Shinta Angelia Azhar, Gustika Azizah, Nur Rahmi Azli, Echa Saskia BENNI ISKANDAR Delvi Eliza Fitri Enda Mora Ezuela, Deska Z Fitri Mulyani, Fitri Gressy Novita Harpirabi, T. Idzan, Nur Kamilah Ihsan Ikhtiarudin Indriana, Annisa Chika Ayu Jasma, Jasma K, Della Yunita Sary. Kurnia, Lisa M Almurdani Maria Susiladewi Masril Malik Meiriza Djohari, Meiriza Melanie, Claudy Friesta Melzi Octaviani Mia Audina, Mia Nabela, Nabela Nadia, Putri Nani Suhaeni Nofri Hendri Sandi Noveri Rahmawati Pratiwi, Wirahma Indah Pratiwi, Wulan Iska Rasyid, Wildan Repuja, Dira Safitri, Elsa Sandra, Alya Dwi Sari, Fatwa Aulia Sinata, Novia Siti Hafsah Suhada, Zikra Sukma, Sukma Suwinda, Elia Tami, Tami Teruna, Hilwan Y. Wiwik Sri Rahmides Wulandari, Intan Wulandari, Lydia Tri Yadi, Hervi Yulia, Amanda Zalfa Desion, Aufa Zikrinnissa, Zikrinnissa