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Masfufatun
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Journal : Hang Tuah Medical Journal

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Efek Sinergis Vitamin C Dalam Meningkatkan Kinerja Antijamur Madu Apis dorsata Terhadap Biofilm Candida albicans Untuk Terapi Kandidiasis MASFUFATUN; ZAHRA, FATIMATUZ; AGUSTIN ANGRAENI, DWI PUTRI; NUZULA, FIRDAUSI
Hang Tuah Medical Journal Vol 22 No 1 (2024): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i1.698

Abstract

Honey is a natural ingredient produced by bees from flower nectar that has antimicrobial, antioxidant, anti-inflammatory, good wound healing effects, and bacteriostatic. This study aims to determine the synergistic effect of vitamin C in improving the antifungal performance of Apis dorsata honey against Candida albicans biofilm for candidiasis therapy. This research design is true experimental with a post-test only control group design approach using the microtiter plate assay method to measure the Optical Density (OD) value of the biofilm matrix. The test of the synergistic effect of Vitamin C on Honey was carried out by adding vitamin C to honey concentrations of 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, and 50%. Furthermore, the MBIC50 value between honey and the combination of honey and vitamin C was compared. The results showed that both honey and the combination of honey and vitamin C were each able to decrease the growth of C. albicans biofilm matrix against A. dorsata honey at various concentrations. The results of the Minimum Biofilm Inhibitory Concentration 50% (MBIC50) value in A. dorsata honey and the combination of A. dorsata honey and vitamin C were 84.27% and 63.56% respectively. Based on this study, it can be concluded that vitamin C can increase the antifungal performance of A. dorsata by lowering the MBIC50 value. Thus, the combination of vitamin C and honey can be used as an alternative therapy for candidiasis.
Efektivitas Ekstrak Etanol Rimpang Temulawak Sebagai Antibiofilm Terhadap Candida Albicans Penyebab Kandidiasis WASILATUN NAJAHAH; MASFUFATUN
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.693

Abstract

Curcuma (Curcuma xanthorrhiza Roxb) is a type of herbal plant that can be used to control infections from C. albicans, because it contains alkaloids, flavonoids, phenolics, saponins, triterpennoids, and glycosides. The purpose of this study is to analyze the effectiveness of temulawak rhizome ethanol extract as an antibiofilm against Candida alibicans, which causes candidiasis. The research design used is purely experimental with a post test control group only design approach. The extraction method used is maceration with 96% ethanol solvent, the antibiofilm activity test uses the microtiter plate biofilm assay method. The measurement of Optical Density (OD) of the antibiofilm activity test results was carried out with a microplate reader at a wavelength of 595nm. The data was analyzed using SPSS for Windows V29.02. The results showed that Temulawak ethanol extract (Curcuma xanthorrhiza Roxb) had a significant effect on the formation of C. albicans biofilm (p<0.05) with the highest inhibition at a concentration of 1.56%, and the smallest value at a concentration of 50%. The MBIC50 value was determined by probit analysis, so that the concentration of Temulawak ethanol extract (Curcuma xanthorrhiza Roxb) which can inhibit 50% of the formation of C. albicans biofilm is located at a concentration of 0.031%. Thus, it can be concluded that Temulawak rhizome ethanol extract has antibiofilm effectiveness against C. albicans, which causes candidiasis at the stage of biofilm formation. Thus, ethanol extract of temulawak rhizome has the potential to be used as an herbal medicine for the treatment of infectious diseases caused by C. albicans biofilm.
Co-Authors AGUSTIN ANGRAENI, DWI PUTRI Amanda, Izrania Tria Aryanti, Novina Ayly Soekanto Devi Dwi Rianti, Emilia Diah Setijowati, Eva Dwi Cahyani, Herawati Eko Wirawan Budianto, Nugroho Fatimatuz Zahra, Fatimatuz Febtarini Rahmawati Firdausi Nuzula Furkani Listyawati, Agusniar Haru Setiawan Kartika Ishartadiati Kurniawan Gondo, Harry Listyawati, Agusniar Furkani Lusiani Tjandra Maria Juliati Kusumaningtyas Masfufatun Masfufatun Nisjmatul Ma’rifah, Renda Noer Kumala Indahsari, Noer Kumala Purbowati , Rini Putu Oky Ari Tania Ratnasari, Diana Tri Rini Purbowati Sukma Sahadewa, Sukma Viona Rindu Pristia WASILATUN NAJAHAH Wulandari, Atik Sri