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All Journal Indonesian Journal of Urology JURNAL KESEHATAN INDRA HUSADA Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI) Ophthalmologica Indonesiana
Hendriati
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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THE EFFECT OF ORAL VITAMIN D ON TUMOR NECROSIS FACTOR-? EXPRESSION IN TRABECULAR MESHWORK OF WISTAR GLAUCOMA MODEL: Oral Presentation - Experimental Study - Resident ERINA, RIKHA; Ariesti, Andrini; Hendriati
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/vrszrr85

Abstract

Introduction & ObjectivesElevated intraocular pressure (IOP) is a risk factor for the development and progression of glaucomathat can induces inflammation in the trabecular meshwork through the production of proinflammatorycytokines such as TNF-?. Inflammation induce mechanical stress and changes in theextracellular matrix in the trabecular meshwork, resulting in hypertonicity and resistance toaqueous humor outflow. Vitamin D can modulate cytokine production by suppressing TH1 cellexpression and inducing TH2 cell expression. The production of pro-inflammatory cytokines can besuppressed by the presence of vitamin D. MethodsAn experimental study of 30 wistar glaucoma model were divided into 3 groups, non treatmentgroup ( A and B) and the oral vitamin D (1200 IU/kg/day) group (C) for 14 days. TNF-? expressionsin trabecular meshwork were measured by immunohistochemical staining. Group A was measuredon day 3, while group B and C were measured on day 14. The differences between the three groupswere analyzed statistically using one way ANOVA test. Significantly different if the p<0.05. ResultsThe mean expression of TNF- ? in the trabecular meshwork of wistar glaucoma model in group A, B,and C was 22,2 ± 2,51%, 39,1 ± 3.98%, 34.2 ± 3,19 % respectively. There was significantlydifference in TNF-? expressions between the three groups (p<0.001). ConclusionVitamin D per oral can decrease TNF-? expression in the trabecular meshwork of wistar glaucomamodel on day 14 . Studies in wistar and humans are still needed to assess the effect of vitamin D onothers pro-inflammatory cytokines in glaucoma.
Modified Hughes Tarsoconjunctival Flap Procedure for Lower Eyelid Defect: Poster Presentation - Case Series - Resident aulia; hendriati; mardijas efendi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/fqfns990

Abstract

Introduction : Hughes procedure of tarsoconjunctival flap is a method of choice in reconstructing full thickness inferior eyelid defect that involves >50% of eyelid margin to restore anatomical integrity, function, and cosmetic of the eyelid. The modified Hughes procedure includes sparing of the marginal upper lid tarsus and removal of the levator muscle aponeurosis from the tarsoconjunctival flap.This article reports 2 patients who underwent modified Hughes procedure after basal cell carsinoma excision. Case Illustration : Two patients underwent inferior eyelid reconstruction using modified Hughes procedure. After wide excision of the tumor, tarsoconjunctival flap was made to reconstruct posterior lamella of the eyelid. Subsequently, anterior lamella of the eyelid were reconstructed using full thickness skin graft and advancement flap, respectively. Both patient then underwent second surgery, tarsus flap release, 6-8 week after the first surgery. Discussion : A tarsoconjunctival flap from the upper eyelid replaces the posterior lamella, whereas a skin graft, a skin flap, or a skin-muscle flap restores the anterior lamella. After surgery, tarsal flap apposition, skin flap/graft, and stitches were intact. After tarsus flap release, wound healing was good. Tumor biopsy showed basal cell carcinoma. Conclusion : Modified Hughes procedure is a treatment of choice in reconstructing full thickness inferior eyelid defect involving >50% of eyelid margin. Full thickness skin graft and advancement flap to reconstruct anterior lamella of the eyelid is choosen after considering skin color and texture similarity and laxity of eyelid and cheek.
EVALUATION OF PAIN SCALE ON CIRCUMCISION PATIENTS UNDER LIDOCAINE HYDROCHLORIDE LOCAL ANESTHESIA Aulia Achmad, Baraz; Manela, Citra; Zulfiqar, Yevri; Hendriati; Effendi, Rinal; Myh, Etriyel
Indonesian Journal of Urology Vol 32 No 2 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i2.924

Abstract

Objective: Evaluating the pain scale of circumcision patients under lidocaine hydrochloride local anesthesia. Material & Methods: An observational descriptive research was carried out on 30 children with a body weight of 20-29 kilograms from February 2023-April 2023. Circumcision was performed under 2 ampoules of 2% lidocaine as local anesthesia. Data consisted of pain onset measure using a stopwatch and the pain scale were obtained through the Wong-Baker Face Pain Rating Scale (WBFPRS), these variables were recorded when pain occurs post-local anesthesia effects ends. Results: The average onset of pain is 47.73 minutes with the fastest onset of pain was 20 minutes and the longest onset of pain was 72 minutes. The average pain scale as measured by the WBFPRS is 2.33. Conclusion: The average pain scale in this study was less than 3 which indicated that the pain felt did not interfere with activities. Keywords: Circumcision, pain, anesthesia, lidocaine.
Clinical Characteristics and Management of Steroid-Induced Glaucoma Pattih Primasakti; Lucyana; Fitratul Ilahi; Hendriati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 5 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i5.1285

Abstract

Background: Steroid-induced glaucoma (SIG) is a secondary glaucoma characterized by elevated intraocular pressure (IOP) due to steroid use. This study aimed to analyze the clinical characteristics and management of SIG patients at Dr. M. Djamil General Hospital Padang, Indonesia, from January 2019 to August 2023. Methods: A retrospective descriptive study was conducted using medical records of patients diagnosed with SIG. Data collected included age, gender, steroid type, route of administration, duration of use, IOP at diagnosis, underlying diseases, glaucoma stage, and treatment. Results: Seventeen patients were diagnosed with SIG. The majority were female (70.58%) and aged 4-39 years (58.83%). The most common underlying diseases were systemic lupus erythematosus (SLE) and allergic conjunctivitis (47%). Oral steroid administration was most frequent (76.4%), with a usage duration of 2-12 months in most cases (70.6%). IOP at diagnosis ranged from 22 to 31 mmHg in most patients (82.3% right eye, 64.7% left eye). Most patients presented with mild glaucoma (70.5%). Topical anti-glaucoma medications were the primary treatment (76.4%), with trabeculectomy performed in some cases (23.6%). Conclusion: SIG is a preventable condition. Early detection and appropriate management are crucial to prevent vision loss. The clinical characteristics identified in this study contribute to a better understanding of SIG in our population. Further research on the interplay of risk factors, genetics, and histopathology is needed to enhance our comprehension of SIG.
ANGKA KEBERHASILAN TERAPI EKSISI DAN RADIOTERAPI ADJUVAN PADA PASIEN KELOID YANG DIOPERASI DI RUMAH SAKIT UNAND Iffah Annadiyah; Fory Fortuna; Hendriati
JURNAL KESEHATAN INDRA HUSADA Vol 13 No 1 (2025): Juni 2025
Publisher : SEKOLAH TINGGI ILMU KESEHATAN INDRAMAYU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36973/jkih.v13i1.709

Abstract

Keloid is a benign fibroproliferative tumor of the dermal that extends beyond the original wound and invades adjacent dermal tissue due to an abnormal healing response from the wound in the dermis. Keloids can have a disturbing impact on individuals such as cosmetic disorders, pruritus, pain, and in severe cases, limited joint movement so that it is very necessary to be managed. One of the keloid therapies with quite promising results is surgical excision and adjuvant radiotherapy. This aim of this research was to determine the success rate of excision therapy and adjuvant radiotherapy in keloid patients operated on at Unand Hospital. This research is an observational descriptive study and uses a cross- sectional design using a total sampling technique of 12 samples. Data analysis uses univariate analysis and research data is presented in the form of a table of success rates. The Results In this study, the highest success rate was found in the 12-16 year age group, female gender, lower extremity predilection. All patients received external radiation with the highest success rate in the group of patients who were given a total dose of 20 Gy in 5 fractions, a follow-up interval of 6 months, and a distance of excision and adjuvant radiotherapy for <3x24 hours, and adhered to the fixed therapy protocol. The success of therapy is largely influenced by predilection, age, gender, radiation dose, and patient compliance with therapy.
From Handlebar to Enucleation: Management and Prosthetic Outcome of a Severe Traumatic Globe Luxation Harlin Farhani; Hendriati; Chaerena Amri; Delvi Saswita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 10 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i10.1421

Abstract

Background: Traumatic globe luxation (TGL) is a rare, severe ocular emergency involving the complete displacement of the eyeball from the orbit. It presents a profound clinical challenge, demanding a rapid and accurate assessment of complex prognostic factors to guide the difficult decision between globe salvage and primary enucleation. Case presentation: A 33-year-old male presented 18 hours after a motorcycle handlebar strike to his left orbit. The examination revealed a left globe luxation with No Light Perception (NLP) vision, a total afferent pupillary defect, and complete ophthalmoplegia. Computed tomography confirmed a closed-globe injury with a superior orbital rim fracture and a large retrobulbar hematoma, but could not delineate soft tissue integrity. Surgical exploration revealed two critical, paradoxical findings: an anatomically intact optic nerve despite its functional death, and a catastrophic avulsion of five of the six extraocular muscles. The medial, lateral, and inferior recti, along with both oblique muscles, were detached, while the superior rectus muscle was uniquely spared. Conclusion: Based on the catastrophic loss of vascular supply from the avulsed muscles, which rendered the globe biologically non-viable, a primary enucleation was performed. This case suggests that in TGL, the integrity of the extraocular musculature is a paramount prognostic indicator, potentially superseding the anatomical status of the optic nerve in determining globe viability. It highlights the necessity of intraoperative exploration to definitively assess the extent of injury and illustrates a scenario where primary enucleation is not a treatment failure, but a definitive, rehabilitation-focused therapeutic strategy.
Vitamin D Supplementation is Associated with Attenuated Ocular Surface Oxidative Stress in Mild Thyroid Eye Disease: A Preliminary Interventional Study Mardijas Efendi; Hendriati; Pattih Primasakti; Yolanda Wulandari Erwen; Rani Apriani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 12 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i12.1451

Abstract

Background: Thyroid eye disease (TED) is an autoimmune orbitopathy where inflammation drives significant oxidative stress, contributing to patient morbidity. Malondialdehyde (MDA), a lipid peroxidation product, is a key biomarker of this oxidative damage. While vitamin D has known systemic immunomodulatory effects, its capacity to mitigate local oxidative stress on the ocular surface in TED is poorly understood. This study aimed to investigate the association between oral vitamin D supplementation and tear film MDA levels in patients with mild TED. Methods: A prospective, single-center, quasi-experimental pre-post study without a control group was conducted on 15 patients diagnosed with mild, active TED (Clinical Activity Score ≤3). Participants received 1000 IU of oral cholecalciferol (Vitamin D3) daily for 21 consecutive days. The primary outcome was the change in tear film MDA concentration, measured by ELISA. Secondary outcomes included serum 25-hydroxyvitamin D [25(OH)D] levels and clinical ocular surface parameters (Ocular Surface Disease Index [OSDI], Tear Break-Up Time [TBUT], Schirmer's I test). Results: A statistically significant reduction in mean tear film MDA levels was observed, decreasing from a baseline of 8.69 ± 4.15 ng/L to 5.70 ± 1.56 ng/L post-intervention (p<0.001). This was accompanied by a significant increase in mean serum 25(OH)D levels from 18.2 ± 5.9 ng/mL to 29.8 ± 6.4 ng/mL (p<0.001). Significant improvements were also noted in OSDI scores (p=0.002) and TBUT (p=0.005). The reduction in tear film MDA showed a significant negative correlation with the increase in serum 25(OH)D (r = -0.68, p=0.005). Conclusion: In this preliminary, uncontrolled study, short-term oral vitamin D supplementation was associated with a significant attenuation of ocular surface oxidative stress in patients with mild TED. These findings provide initial biochemical evidence for the potential localized benefits of vitamin D and support the need for larger, placebo-controlled randomized trials to validate its role as a safe adjunctive therapy for managing the ocular surface component of this disease.
Balancing Efficacy and Tolerability: A Prospective Cohort Study of Oral and Intravenous Methylprednisolone for Active Graves' Ophthalmopathy in an Indonesian Tertiary Care Center Mardijas Efendi; Hendriati; Pattih Primasakti; Yolanda Wulandari Erwen
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 12 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i12.1466

Abstract

Background: In managing active, moderate-to-severe Graves' Ophthalmopathy (GO), a notable gap often exists between treatment efficacy in controlled trials and effectiveness in real-world practice. High-dose corticosteroids are standard, but the choice between intravenous (IV) and oral routes involves a complex trade-off between efficacy, tolerability, and practicality, particularly in diverse populations. Methods: This single-center, pragmatic, prospective cohort study was conducted at a tertiary hospital in Indonesia from March 2023 to March 2024. Thirty-six GO patients were treated with either IV pulse or daily oral methylprednisolone based on a shared clinical decision-making process. The primary outcome was the change in proptosis. To address the non-randomized design and control for selection bias, a propensity score-adjusted Analysis of Covariance (ANCOVA) was used to compare treatment effectiveness. Results: Baseline analysis revealed that patients selected for IV therapy had significantly more severe proptosis. Both unadjusted and adjusted analyses showed that each regimen resulted in a significant reduction in proptosis from baseline (p < 0.01). In the primary, propensity score-adjusted analysis, no statistically significant difference was detected in the degree of proptosis reduction between the IV and oral groups. However, the tolerability profiles were profoundly different; patients in the oral group experienced a significantly higher incidence of adverse events, including dyspepsia (66.7%) and Cushingoid features (55.6%), compared to a single case of transient hypokalemia in the IV group. Conclusion: In this real-world setting, after statistically controlling for baseline severity, both IV and oral methylprednisolone demonstrated comparable effectiveness in reducing proptosis. However, the intravenous route was associated with a vastly superior safety profile. These findings underscore the critical importance of tolerability in clinical decision-making and support the continued recommendation of IV pulse therapy as the first-line treatment.
Changes in Retinal Ganglion Cell (RGC) and Retinal Nerve Fiber Layer (RNFL) Thickness in Children with Type 1 Diabetes Mellitus at Dr. M. Djamil General Hospital, Padang, Indonesia lonanda, Gama Agusto; Kemala Sayuti; Havriza Vitresia; Hendriati; Andrini Ariesti; Weni Helvinda
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 8 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i8.1047

Abstract

Background: Type 1 diabetes mellitus (DM) is a chronic metabolic disorder that causes hyperglycemia and increases the risk of morbidity and mortality. Diabetic retinopathy, a microvascular complication that often occurs in DM patients, can cause visual impairment and even blindness. Regular eye examinations are important for early detection of diabetic retinopathy. Optical coherence tomography (OCT) is a non-invasive method that can be used to measure the thickness of retinal layers, including RGC and RNFL. It is thought that thinning of the retinal layer can be a sensitive biomarker in detecting diabetic retinopathy in type 1 DM patients. This study aims to determine changes in RGC and RNFL thickness in children with type 1 DM. Methods: This cross-sectional design analytical observational study was conducted at the eye polyclinic of Dr. M. Djamil General Hospital Padang in November 2023-March 2024. A total of 46 eyes from 46 people, divided into two groups: the type 1 DM group and the control group, were recruited in this study. RGC thickness was measured using AS-OCT GC-IPL thickness analysis and RNFL with optic disc RNFL thickness analysis. Data analysis was carried out using the unpaired T-test. Results: The results showed RGC depletion in the type 1 DM group (RGC 83.48 ± 3.75) compared to the control group (RGC 86.70 ± 4.87) with a value of p = 0.016 (p < 0.05). There was no statistical difference in RNFL thickness between the type 1 DM group (RNFL 102 ± 11.80) and the control group (RNFL 100.96 ± 10.97) with a value of p = 0.581 (p> 0.05). Conclusion: This study found RGC thinning in type 1 DM patients, but did not find differences in RNFL thickness between the two groups. This RGC depletion is thought to be caused by apoptosis of retinal neuronal cells due to chronic hyperglycemia. Examination of RGC thickness with OCT can be developed as an early detection of diabetic retinopathy in children with type 1 DM.
Impact of Open-Angle Glaucoma Severity on Vision-Related Quality of Life: A Cross-Sectional Study in a Single Center in Indonesia Rino Agustian Praja; Andrini Ariesti; Hendriati; Muhammad Hidayat; Irayanti; Julita
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1171

Abstract

Background: Glaucoma is a progressive optic neuropathy characterized by the gradual loss of retinal ganglion cells (RGCs) and their axons, leading to irreversible visual field loss. This study aimed to investigate the relationship between the severity of primary open-angle glaucoma (POAG) and vision-related quality of life (VRQoL) in a single center in Indonesia. Methods: A cross-sectional study was conducted at the eye polyclinic of Dr. M. Djamil General Hospital, Padang, Indonesia, from June to August 2024. A total of 54 patients with POAG were included and categorized into mild, moderate, and severe groups based on their cup-to-disc ratio and visual field index (VFI). VRQoL was assessed using the Indonesian version of the National Eye Institute Visual Function Questionnaire (NEI-VFQ 25). Results: The mean VRQoL score was significantly lower in the severe group (60.63 ± 13.04) compared to the moderate (81.79 ± 10.42) and mild (85.04 ± 10.52) groups (p = 0.000). A strong negative correlation was observed between glaucoma severity and VRQoL (r = -0.667, p = 0.000). The social functioning subscale showed the strongest correlation with severity (r = -0.573, p = 0.000). Conclusion: The severity of POAG significantly impacts VRQoL, with more severe disease associated with lower QoL scores. The social functioning domain appears to be particularly affected. These findings underscore the importance of comprehensive glaucoma management that addresses not only clinical parameters but also the patient's overall quality of life.
Co-Authors Andrini Ariesti Ariesti Andrini Ariesti, Andrini Aulia Aulia Achmad, Baraz Chaerena Amri Citra Manela Delvi Saswita ERINA, RIKHA Etriyel Myh Fortuna, Fory Freegaito, Adhycahyo Harlin Farhani Helvinda Weni Hidayat Muhammad Iffah Annadiyah Ilahi, Fitratul Irayanti Julita Kemala Sayuti Lili Irawati lonanda, Gama Agusto Lucyana Mandela, Kelvin Mardijas Efendi Muhammad Hidayat Pattih Primasakti Pratama Yogi Rani Apriani Rinal Effendi Rino Agustian Praja Vitresia, Havriza Wati Rinda Weni Helvinda Yolanda Wulandari Erwen Zulfiqar, Yevri