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All Journal HAYATI Journal of Biosciences INDONESIAN JOURNAL OF PHARMACY Acta Pharmaceutica Indonesia Journal of Science and Applicative Technology Acta Pharmaciae Indonesia : Acta Pharm Indo JFL : Jurnal Farmasi Lampung Jurnal Kreativitas PKM Stannum : Jurnal Sains dan Terapan Kimia Jurnal Pengabdian Dharma Wacana Mejuajua Jurnal Vokasi Kesehatan Indonesian Journal of Chemical Science
Syaikhul Aziz
Program Studi Farmasi, Fakultas Sains, Institut Teknologi Sumatera, Lampung, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Analysis of Lead (Pb) Contamination in Lipstick and Eye Shadow Powder in the King Street Market in Bandar Lampung Using UV-Visible Spectrophotometer Method Alya Pinahayu Sakanthi; Syaikhul Aziz; Salsa Nabila Ahlika Ulya; Auli, Winni
Indonesian Journal of Chemical Science Vol. 13 No. 3 (2024): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v13i3.11465

Abstract

  Lipsticks and eye shadows are cosmetics frequently used by women every day. Some cosmetic products contain heavy metals like lead. This study aims to validate the UV-Visible Spectrophotometer method for analyzing lead in cosmetics and determine the lead content in lipsticks and eye shadows. Sample preparation was conducted using closed wet digestion with reflux. The samples consisted of 5 lipsticks and eye shadows from the King Street Market in Bandar Lampung. Lead content was determined using a UV-Visible spectrophotometer after method validation. Validation parameters included selectivity, linearity (correlation coefficient = 0.998), accuracy (% recovery = 99-100%), precision (%RSD = < 2% for all experiments), detection limit 0.044 µg/mL, and quantitation limit 0.148 µg/mL, all of which met validity criteria. Lead levels in lipsticks ranged from ±6,000 to 11,000 µg/gram, while in eye shadows, they ranged from ±5,000 to 10,000 µg/gram. The results indicate that lead levels in lipsticks and eye shadows exceed the BPOM RI limit of 20 µg/gram.
Quantitative Profiling of Total Flavonoid Content in Cassava Leaf (Manihot esculenta Crantz) Varieties and Isolation of Flavonoid Compounds from a High-Flavonoid Variety Aziz, Syaikhul; Siringoringo, Vinta Marito; Mulyani, Isna; Ngatinem
Journal of Science and Applicative Technology Vol. 9 No. 1 (2025): Journal of Science and Applicative Technology June Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/jsat.v9i1.2190

Abstract

Cassava (Manihot esculenta Crantz) is widely utilized across Indonesia as both a staple food and a traditional medicinal resource, and its leaves are known to contain bioactive secondary metabolites such as flavonoids. This study aimed to quantify the total flavonoid content in several cassava leaf varieties and to isolate a flavonoid compound from the variety with the highest flavonoid content. Total flavonoid content was determined using UV-Visible spectrophotometry. The isolation of flavonoid compounds was carried out using vacuum liquid chromatography (VLC) and column chromatography (CC), with thin-layer chromatography (TLC) employed to monitor the separation results. The total flavonoid content of the Gajah, UJ-3 (Thailand), UJ-5 (Katsesart), Cimanggu dan Kaspro varieties were found to be 1.029 ± 0.003 mgQE/g, 0.746 ± 0.006 mgQE/g, 0.970 ± 0.009 mgQE/g, 0.936 ± 0.004 mgQE/g and 1.220 ± 0.003 mgQE/g, respectively. The Kaspro variety exhibited the highest flavonoid content. Isolation and characterization of the flavonoid from Kaspro leaves yielded a yellowish powder with absorption maxima at 269 nm (Band II) and 334 nm (Band I). Further analysis using shift reagents identified the isolated compound as apigenin, a member of the flavone group.
Acute Toxicity Studies of Mirabilis jalapa L. Flower Extract in Mice Mulyani, Isna; Desy Purnama Sari; Muhammad F. Agustiawan; Syaikhul Aziz
Jurnal Vokasi Kesehatan Vol 4 No 1 (2025)
Publisher : Gayaku Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/juvokes.v4i1.1375

Abstract

Traditional medicine, derived from medicinal plants, has been used for generations as a form of treatment. The safety, quality, and efficacy of plants used for medicinal purposes are important considerations. Mirabilis jalapa L., also known as the four o'clock flower, is a traditional medicine with known benefits such as diuretic, anti-inflammatory, and antibacterial properties. However, its safety level remains uncertain. To address this, an acute toxicity test was conducted on the ethanol extract of Mirabilis jalapa L. flowers to determine its safety. The extraction process utilized a reflux method with 96% alcohol as a solvent, resulting in a standardized extract. Subsequent toxicity tests were performed on 12 female white mice, using doses of 300 and 2,000 mg/kg body weight. The results revealed an LD50 value exceeding 2,000 mg/kg body weight for the ethanol extract of Mirabilis jalapa L. flowers, indicating its classification as "Practically Not Toxic."
Edukasi dan Pelatihan Pembuatan Minuman Fungsional Anti Anemia di SMA 2 Muhammadiyah Bandar Lampung Nurnahari, Naura; Aziz, Syaikhul; Fauziyya, Riri; Nur Auli, Winni; Maulidia Rahayyu, Annisa; Kartika Sari Ramadhani, Untia; Azanti Putri, Refsya; Fajar Fauzi, Muh; Sekarsari Yusuf, Mubarika; Mulyani, Isna
Mejuajua: Jurnal Pengabdian pada Masyarakat Vol. 5 No. 1 (2025): Agustus 2025
Publisher : Yayasan Penelitian dan Inovasi Sumatera (YPIS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/mejuajuajabdimas.v5i1.236

Abstract

Anemia adalah suatu kondisi di mana jumlah sel darah merah atau konsentrasi Hemoglobin di dalam darah lebih rendah dari normal. Berdasarkan Survei Kesehatan Nasional Indonesia 2023, prevalensi anemia pada kelompok  usia 15-24 tahun sebesar 15,5%. Anemia bisa dicegah dengan nutrisi yang tepat. Tujuan pengabdian masyarakat ini adalah mengedukasi para remaja mengenai pemanfaatan bahan alam untuk mencegah anemia serta pelatihan pembuatan minuman fungsional untuk mencegah anemia. Kegiatan ini berlangsung di SMA 2 Muhammadiyah Bandar Lampung dan melibatkan 39 siswa-siswi. Metode yang diterapkan dalam kegiatan ini meliputi ceramah dan demonstrasi. Penilaian peningkatan pengetahuan dilakukan melalui pre-test dan post-test. Evaluasi dilakukan menggunakan instrumen pre-test dan post-test yang terdiri dari 10 butir pertanyaan. Uji normalitas Shapiro-Wilk menunjukkan bahwa data berdistribusi normal (pre-test p = 0,7485; post-test p = 0,2501), sehingga dilanjutkan dengan uji paired sample t-test. Hasil analisis menunjukkan peningkatan yang signifikan secara statistik (p = 0,0008), dengan rata-rata skor meningkat dari 59,3% menjadi 80,5%.
Pelatihan Pengolahan Blondo Menjadi Cookies untuk Penanganan Stunting di CV. Buah Asa Tani, Bangunrejo, Lampung Nareswari, Tantri Liris; Aziz, Syaikhul; Septiani, Winda; Muhyi, Abdul
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 7, No 5 (2024): Volume 7 No 5 2024
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v7i5.14169

Abstract

ABSTRAK Indonesia termasuk dalam jajaran negara penghasil kelapa terbesar di dunia. Untuk memastikan bahwa produk kelapa diserap oleh petani, usaha pengolahan kelapa, seperti UMKM yang menjual kelapa atau produk kelapa, adalah sektor yang krusial. Hasil samping pembuatan Virgin Coconut Oil, yaitu blondo, belum dimanfaatkan dan menimbulkan bau menyengat ketika dibuang langsung ke lingkungan. Padahal, blondo ini diketahui memiliki kandungan protein tinggi, yang dapat digunakan untuk pencegahan stunting. Tujuan dari kegiatan pengabdian masyarakat ini berfokus pada pelatihan dan pembuatan produk berbahan hasil samping olahan VCO pada CV. Buah Asa Tani (BAT). Pelatihan dilakukan dengan metode sosialisasi, diskusi dan tanya jawab serta praktik pembuatan cookies blondo untuk karyawan CV. BAT. Sebelum dan setelah pelatihan, terhadap peserta pelatihan dilakukan evaluasi secara terstruktur menggunakan kuesioner. Pelatihan manfaat kesehatan kelapa dan stunting, cara pembuatan cookies blondo untuk karyawan CV. Buah Asa Tani telah diselenggarakan dengan seluruh peserta (100%) menunjukkan peningkatan pengetahuan dan keterampilan. Hal ini menunjukkan potensi positif dalam mengatasi masalah limbah industri kelapa sambil meningkatkan keterampilan masyarakat setempat. Kata Kunci: Blondo, VCO, Pengabdian Masyarakat, Stunting, Kue Kering  ABSTRACT One of the world's leading producers of coconuts is Indonesia. Coconut processing companies, such as UMKM that sell coconuts or coconut goods, are an essential industry to guarantee that farmers receive their share of the product. The by-product of making Virgin Coconut Oil, namely blondo, has not been utilized and causes a strong odor when thrown directly into the environment. Blondo is known to have a high protein content, which can be used for stunting prevention. The purpose of this community service activity focuses on training and making products made from by-products of VCO processing in CV. Buah Asa Tani (BAT). The training was delivered to CV BAT employees through socialization, discussion, and question-and-answer sessions, along with the practical application of baking blondo cookies. Before and after the training, the training participants were evaluated in a structured manner using a questionnaire. The community service activities carried out through training and making blondo cookies products have increased the trainees' knowledge and ability to process blondo. This shows a positive potential in addressing the coconut industry waste problem while improving the skills of the local community. Keywords: Blondo, VCO, Community Services, Stunting, Cookies
Analysis Interaction of Nicotinamide and Ascorbic Acid and Its Derivatives as Active Substances in Skin Lightening Cosmetic Products Hidayati, Pratiwi Al Fitri; Auli, Winni Nur; Aziz, Syaikhul; Zaqia, Lulu; Liswatini, Putri
Journal of Science and Applicative Technology Vol. 9 No. 2 (2025): Journal of Science and Applicative Technology December Chapter
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/jsat.v9i2.2154

Abstract

Ascorbic acid and its derivatives with nicotinamide are often used as skin lightening, anti-aging, and anti-pigmentation agents. Combining these two active substances may increase the risk of instability due to degradation. This research was conducted to determine the effect of nicotinamide concentration on the degradation process of ascorbic acid and its derivatives, and to determine the degradation products formed using liquid chromatography-mass spectrometry (LC-MS). The study was conducted by combining nicotinamide concentrations ranging from 5 to 15 micrograms per milliliter with incubation times of 1, 2, 3, and 24 hours to react with ascorbic acid and its derivatives. The spectral shape and maximum wavelength were analyzed using a UV-Vis spectrophotometer. Samples that showed changes in chemical structure were subsequently analyzed by LC-MS to identify degradation products. The results showed that only the combination of ascorbic acid and nicotinamide shifted the maximum wavelength and generated a new peak at 310 nm after 24 hours of incubation. Nicotinamide can accelerate the degradation process of ascorbic acid. The LC-MS analysis results show that the degradation products formed from the combination of ascorbic acid and nicotinamide samples are dehydroascorbic acid and 3-hydroxy-2-pyrone. These findings highlight the importance of incorporating stabilizing agents into cosmetic formulations containing unstable active ingredients, such as ascorbic acid, to ensure product stability during storage and use.
Comparative solvent evaluation for protein extraction from Channa striata and development of a stable capsule formulation for nutritional supplementation Salim, Prayoga Drajat Pangestu; Karim, Dewi Damayanti Abdul; Aziz, Syaikhul
Acta Pharmaciae Indonesia Vol 13 No 1 (2025): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2025.13.1.16152

Abstract

Background: Channa striata is a protein-rich freshwater fish with therapeutic potential, yet systematic optimization of extraction methods and stable formulation development remain limited. Objective: To compare protein extraction efficiency using three solvents (1% HCl, 0.9% NaCl, and distilled water) and develop optimized capsule formulations. Methods: Protein was extracted at 1:4 (w/v) ratio and quantified using the Lowry method at 595 nm. The method was verified for linearity (R = 0.998), accuracy (98-102%), and precision (RSD <2%). Extracts were formulated into capsules at 0, 300, 400, and 500 mg (F0-F3) and evaluated for quality parameters and 28-day stability at -4°C, 24°C, and 40°C. Data were analyzed using one-way ANOVA with Duncan's post-hoc test. Results: The 1% HCl yielded highest protein content (4.947 ± 0.071 mg/mL) and extraction efficiency (21.390%) compared to 0.9% NaCl and distilled water (p <0.05). All formulations met pharmaceutical standards. Notably, F3 maintained protein retention >95% across all storage conditions (97.1-99.3%), while F0-F2 failed this criterion. Conclusion: The 1% HCl demonstrated optimal extraction efficiency. F3 (500 mg) exhibited superior stability and dissolution characteristics, representing a promising candidate for C. striata-based nutritional supplements.
Co-Authors Abdul Muhyi Akbar Dana Alya Pinahayu Sakanthi Arif Azhari Azrifitria, Azrifitria Budipramana, Krisyanti Chairul . Cresentia Aurora Mizuki Damayanti Abdul Karim, Dewi Dana, Akbar Debora Silalahi Elfahmi Elfahmi, Elfahmi Evanggeulista, Arnanda Fajar Fauzi, Muh Fauziyya, Riri Firly Shalsha Billa Frangky Sangande Hamdiyah Fuola Zeri Hasibuan Hidayati, Pratiwi Al Fitri Isna Mulyani Jannah, Aryn Fatkhul Kartika Sari Ramadhani, Untia Liswatini, Putri Maulidia Rahayyu, Annisa Meiriska Maharani Surya Nugroho Mendrofa, Alexander Yoel Harazachi Muhammad F. Agustiawan Muhammad Raffi Zakaria Muhammad Yogi Saputra Muhyi, Abdul Murni Sari Ngatinem Nur Adliani Nurnahari, Naura Rahmat Kurniawan Refsya Azanti Putri Rissyelly Rissyelly Rizki Nisfi Ramdhini Rizki Nisfi Ramdhini Salim, Prayoga Drajat Pangestu Salsa Nabila Ahlika Ulya Sekarsari Yusuf, Mubarika Sena Maulana Shindy Martha Rahayu Siringoringo, Vinta Marito Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Tantri Liris Nareswari Welldone Sartika Winda Septiani Winda Septiani Winni Nur Auli Yodha, Agung Wibawa Mahatva Zaqia, Lulu