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All Journal Indonesian Journal of Urology Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Cancer Majalah Obstetri dan Ginekologi Majalah Kesehatan FKUB Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Majalah Patologi Indonesia JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Layanan Masyarakat (Journal of Public Service) Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka

Sjahjenny Mustokoweni, Sjahjenny

Departemen Patologi Anatomi Fakultas Kedokteran Universitas Airlangga, Surabaya

Author-ID : 2391614

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The Role of Human Papillomavirus in Bowenoid Papulosis Yuli Wahyu Rahmawati; Dwi Murtiastutik; Sjahjenny Mustokoweni
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Human Papillomavirus (HPV) infection can be associated with a variety of cutaneous as well as mucosal manifestations. Some types of HPV are associated with increased risk of epithelial malignancies; these have been divided into low-risk and high-risk types based on their oncogenic potential. Bowenoid papulosis (BP) strongly associated with high risk type. Purpose: To provide information to health workers, in order to be more concern about BP.Review: The term BP refers to multifocal papular lesions on the genitalia with histological features similar to squamous cell carcinoma (SCC) in situ or Bowen’s Disease (BD). Its clinical manifestation is characterized by multiple brownish or erythematous papules located in the anogenital region, affecting mostly young adults with an active sex life. Clinically, it must be differentiated from seborrheic keratosis, and melanocytic nevus. Bowenoid papulosis is strongly associated with HPV 16.Conclusion: The natural course of BP is unpredictable, the lesions may increase, decrease, and even disappear spontaneously. Progression to an invasive SCC has been estimated in 2.6% of cases, HPV type 16 is the most frequent causative agent of BP.

PREVALENCE OF HUMAN PAPILLOMAVIRUS GENOTYPES IN LOW AND HIGH GRADE SQUAMOUS INTRAEPITHELIAL LESIONS AT CERVICAL TISSUE Rizki Eko Prasetyo; Gondo Mastutik; Sjahjenny Mustokoweni
Folia Medica Indonesiana Vol. 53 No. 4 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Airlangga

HPV infection is known to cause cervical cancer. This study aimed to identify the variant of HPV genotypes of cervical precancerous lesions from low grade squamous intraepithelial lesion (LSIL) and high grade squamous intraepithelial lesion (HSIL). This was an explorative study using formalin fix paraffin embedded (FFPE) from cervical precancerous lesions at Dr. Soetomo Hospital, Surabaya. DNA was extracted from FFPE and hybridized for HPV genotyping using Ampliquality HPV Type Express kit (AB ANALITICA) by reverse line blot techniques. The results showed that there were variants of HPV genotype in LSIL. The variants were HPV16 (8/15), HPV18 (3/15), HPV52 (1/15), HPV6+31 (1/15), HPV6+18 (1/15), and HPV72+68 (1/15), and in HSIL which were HPV16 (4/10), HPV18 (2/10), HPV59 (1/10), HPV6+45 (1/10), HPV61+26 (1/10), and HPV16+31 (1/10). The characteristics of infection in LSIL were single infection of high-risk (hr) HPV and multiple infection of low-risk (lr)+hr HPV, and in HSIL were single infection of HPVhr, multiple infection of HPVhr+hr and HPVlr+hr. In conclusion, HPV prevalence in cervical precancerous lesions is single infection by HPV16 (48%), HPV18 (20%), HPV52 (4%), HPV59 (4%), and multiple infection by HPV6+31, HPV6+18, HPV6+45, HPV16+31, HPV61+26, HPV72+68 is 4%.

The Role of HIF-1alpha in Regional Lymph Nodes Metastasis in Colorectal Adenocarcinoma Ladyna Rumapar; Sjahjenny Mustokoweni; Alphania Rahniayu
Folia Medica Indonesiana Vol. 54 No. 1 (2018): March
Publisher : Faculty of Medicine, Universitas Airlangga

Colorectal carcinoma has high morbidity and mortality rate worldwide, in which over 90% are adenocarcinoma. Colorectal carcinoma is one of the most cancer that metastasize to the lymph node. Angiogenesis have an important role in tumor growth and metastasis. Hypoxia is the trigger factor for angiogenesis. Hypoxia induced factor-1 (HIF-1) is one critical protein directly reacting to hypoxia. HIF-1alpha, a HIF-1 subunit, is an important regulator of angiogenesis. This study analyzed HIF-1a expression in colorectal adenocarcinoma with and without regional lymph node metastasis. This study was to prove that HIF-1a has a role in regional lymph node metastasis in colorectal adenocarcinoma. An analytical observational study was conducted on thirty formalin fixed paraffin-embedded colorectal adenocarcinoma tissues from Anatomic Pathology Laboratory of Dr. Soetomo Hospital. Detection of HIF-1alpha expressions were performed with immunohistochemistry method, using HIF-1alpha antibody. It were statistically analyzed using Mann-Whitney and Kruskal- Wallis methods. There were no significant differences in the expression of HIF-1alpha in colorectal adenocarcinoma with or without lymph node (LN) metastasis (p>0.05). As a conclusion, this study showed that HIF-1alpha has no role in LN metastasis in colorectal adenocarcinoma.

Bone Tuberculosis: Clinical Profile of 40 Patients in Dr. Soetomo General Hospital Surabaya Yonatan Esli Alexander Tidja; Sjahjenny Mustokoweni; Tania Ardiani Saleh
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 11 No. 1 (2020): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V11I12020.1-5

Introduction: Bone and joint tuberculosis are specific infection inflammation of Mycobacterium tuberculosis, mostly affected bone and joint confirmed by acceleration of vascular supply to vertebrae and growth line of long bone. The aim of this study is to know clinical profile of bone and joint tuberculosis’ patients. Methods: This study was conducted using descriptive observational method, samples were tested by observation descriptive test. Results: The average ages of bone and joint tuberculosis hospitalized patients of RSUD Dr. Soetomo Surabaya are 35-44 years. There are 22 cases on male (55%) and 18 cases on female (45%) with 29 subjects of Hb’s abnormal number (72.5%), 15 subjects of abnormal leucocytes (37.5%), 20 subjects of abnormal thrombocyte (50%), 34 subjects of abnormal ESR (94.4%), 20 patients of abnormal C-reactive protein (54.1%), 11 subjects of abnormal serum creatinine (28.9%), 13 subjects of abnormal sodium level (35.1%), 15 patients of abnormal potassium level (40.5%), and 16 patients of abnormal chloride level (43.2%). There are 16 subjects with smoking history (40%), 29 subjects of positive tuberculosis history (72.5%), 6 subjects with positive tuberculosis family history (15%), 30 subjects of pain as main problems (75%), 5 subjects of swelling or pus as main problems (12.5%), 5 subjects of extremities disability as main problems (12.5%). Dominant location of infection is vertebrae (95%) which are suffered by 38 subjects with thoracal as the main level of infection, suffered by 15 subjects (50%). Other levels of infection are lumbal with 12 subjects (40%), cervical with 3 subjects (10%), and pelvis or thigh with 2 subjects (5%). Conclusion: From 40 subjects, bone and joint tuberculosis mostly suffered by elderly, male risks more than female. Most of hematology tests results were abnormal. Most subjects suffered abnormal C-reactive protein. Most subjects’ hematology tests were BUN, creatinine serum, and electrolyte normal. Number of subjects with smoking habits was dominant. Most subjects were having tuberculosis history but negative family history. Most subjects complained about pain with vertebrae level thoracal as dominant location of infection.

EARLY DETECTION OF BREAST CANCER AT PUBLIC HEALTH CENTER IN REJOSO, NGANJUK Gondo Mastutik; Sjahjenny Mustokoweni
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 6 No. 1 (2022): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v6i1.2022.61-68

The objective was to convey knowledge about procedures for early detection of breast cancer and screening of breast cancer as an effort to reduce the number of cases of advanced breast cancer. The activity was held at the Public Health Center in Rejoso, Nganjuk and was attended by 71 participants. The participants' understanding was measured by a questionnaire containing questions about breast cancer risk factors and knowledge about breast cancer. Questionnaires were given as pre-test and post-test. After attending the lecture presentation, there was an increase in understanding of 11%. Participants in this activity based on the risk factors of not having children and x-ray radiation, all of them do not have a risk of developing breast cancer. Furthermore, based on data on breastfeeding less than 6 months, aged more than 25 years, had a tumor in the breast, and had a family suffering from breast cancer, the participants in this activity had a risk of breast cancer that were 16.67%, 88.1%, 7.14%, and 14.29% respectively.This activity can increase public understanding of procedures for early detection of breast cancer so that people can carry out breast self-examinations at home every month. In this activity, participants can perform breast examinations by medical personnel so that they can help the community to carry out free breast examinations at community health centers.

Korelasi Ekspresi ezrin dan CD44 dengan Respons Kemoterapi pada Pasien Osteosarkoma CHRISTIAN BAMBANG SULISTIO; SJAHJENNY MUSTOKOWENI; NILA KURNIASARI
Indonesian Journal of Cancer Vol 11, No 3 (2017): July - September 2017
Publisher : National Cancer Center - Dharmais Cancer Hospital

Osteosarcoma is the most common malignant bone tumor in children and young adults. The process of metastasis and recurrence involves several proteins, including ezrin, and CD44 that are shown to be involved in tumor growth,metastasis and recurrence. To analyse the corelation of ezrin and CD44 expression with chemotherapy responsse in osteosarcoma patient. Cross sectional method on paraffin block of Osteosarcoma in Anatomic Pathology Laboratory of RSUD dr Soetomo, (January 1, 2010 - December 31, 2015). There were 17 out of 26 cases of amputated osteosarcoma which are met the inclusion criteria were performed immunohistochemical staining with ezrin and CD44 antibodies. The corellation of ezrin and CD44 expression with chemotherapy responsse was analyzed using Spearman’s rho test. The coeficient correlation in this experiment p<0.05, there was no corellation of ezrin expression with chemotherapy responsse of osteosarcoma. There was no correlation of CD44 expression with chemotherapy responsse in osteosarcoma. There was no correlation of ezrin and CD44 expression with chemotherapy responsse of osteosarcoma. There was no corellation of ezrin and CD44 expression with chemotherapy responsse of osteosarcoma.ABSTRAKOsteosarkoma merupakan tumor ganas tulang, sering terjadi pada anak-anak dan dewasa muda. Proses metastasis dan rekurensi melibatkan beberapa protein, di antaranya ezrin dan CD44 yang terbukti ikut serta dalam pertumbuhan tumor, metastasis, dan rekurensi. Penelitian ini bertujuan menganalisis hubungan antara ekspresi ezrin dan CD44 dengan respons kemoterapi. Penelitian ini menggunakan metode cross sectional blok parafin osteosarkoma di Laboratorium Patologi Anatomi RSUD Dr. Soetomo (1 Januari 2010–31 Desember 2015). Sebanyak 17 kasus sesuai kriteria inklusi dari 26 kasus osteosarkoma yang telah diamputasi dilakukan seleksi serta pemeriksaan imunohistokimia dengan antibodi ezrin danCD44. Hubungan ekspresi antara ezrin dan CD44 dengan respons kemoterapi dianalisis menggunakan uji Spearman’srho. Pada penelitian ini, nilai koefisien korelasi p<0,05 sehingga tidak terdapat hubungan antara ekspresi ezrin denganrespons kemoterapi pada osteosarkoma, di mana nilai p=0,868 (p>0,05). Tidak terdapat hubungan antara ekspresi CD44 dengan respons kemoterapi pada osteosarkoma di mana nilai p = 0,740 (p> 0,05).Tidak terdapat korelasi antaraekspresi ezrin dengan CD44 dengan respons kemoterapi osteosarkoma, nilai p=0,113 (p>0,05). Tidak terdapat hubungan antara ekspresi ezrin dan CD44 dengan respons kemoterapi pada pasien osteosarkoma.

Perbedaan Ekspresi Foxp3+ dan Cd8+ Tumor Infiltrating Lymphocytes Karsinoma Payudara pada Berbagai Stadium T Anisia Indiralia; Alphania Rahniayu; Sjahjenny Mustokoweni
Indonesian Journal of Cancer Vol 12, No 1 (2018): Jan - Mar
Publisher : National Cancer Center - Dharmais Cancer Hospital

Background: Breast carcinoma, the most common malignancy in women, are often accompanied by tumor infiltrating lymphocytes (TIL) which has controversial clinical relevance. TIL is thought to reflect the host’s immune response to malignant tumors. FOXP3, specific biomarker of Treg, is an important transcription factors that develops and functions in the maintenance of self tolerance, including inhibition of CD8+ cytotoxic T cell function. Aim: To analyze the differences and the correlation between FOXP3+ and CD8+ TIL in breast carcinoma with different T staging. Methods: An analytical observational research, performed on 44 paraffin block of breast carcinoma of various stages T (AJCC 7th ed) in anatomical pathology installation of RSUD Dr. Soetomo, used FOXP3+ and CD8+ antibodies. The immunoexpression are evaluated on stromal area, then analyzed statistically, period January 1, 2014 – December 31, 2016. Result: Showed significant differences in FOXP3+ expression between T1-T4, T2-T3, T2-T4, T3-T4. There were significant differences in CD8+ expression between T2-T3, T2-T4. There is a correlation between the expression of FOXP3+ and CD8+ in T1 and all T (p < 0.05). Conclusion: There was significant difference in FOXP3+ and CD8+ TIL of breast carcinoma with increasing T stage. There was correlation between FOXP3+ and CD8+ TIL expression of breast carcinoma at all T and T1 stage. ABSTRAKPendahuluan: Karsinoma payudara adalah keganasan terbanyak wanita dan sering didapatkan adanya tumor infiltrating lymphocytes (TIL) dengan relevansi klinis yang masih kontroversial. TIL sering dianggap mencerminkan respon imun inang terhadap tumor ganas. FOXP3, biomarker spesifik Treg, merupakan faktor transkripsi yang penting dalam perkembangan dan berfungsi dalam pemeliharaan self tolerance, termasuk penghambatan fungsi sel T sitotoksik CD8+. Metode: Penelitian observasional analitik terhadap 44 sampel blok parafin karsinoma payudara berbagai stadium T (AJCC edisi ketujuh) di instalasi Patologi Anatomi RSUD Dr. Soetomo Surabaya menggunakan antibodi FOXP3 dan CD8, dihitung pada area stroma tumor, kemudian dilakukan uji statistik periode 1 Januari 2014 – 31 Desember 2016. Hasil: Terdapat perbedaan bermakna ekspresi FOXP3+ antara T1 dan T4, T2 dan T3, T2 dan T4, T3 dan T4. Terdapat perbedaan bermakna ekspresi CD8+ antara T2 dan T3, T2 dan T4. Terdapat korelasi antara tingginya ekspresi FOXP3+ dengan tinginya ekspresi CD8+ pada T1 dan semua T (p < 0,05). Kesimpulan: Terdapat perbedaan bermakna ekspresi FOXP3+ dan CD8+ TIL karsinoma payudara dengan meningkatnya stadium T. Terdapat korelasi antara ekspresi FOXP3+ dan CD8+ TIL karsinoma payudara pada semua stadium T dan T1.

PEMERIKSAAN PAP SMEAR SEBAGAI UPAYA DETEKSI DINI KANKER SERVIK DI PUSAT KESEHATAN MASYARAKAT REJOSO, NGANJUK Gondo Mastutik; Sjahjenny Mustokoweni
Jurnal Layanan Masyarakat Vol. 6 No. 2 (2022): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v6i2.2022.244-250

Tujuan kegiatan ini adalah menyampaikan informasi tentang tata cara deteksi dini kanker servik untuk menurunkan jumlah kasus kanker servik stadium lanjut. Kegiatan ini diikuti oleh 71 orang wanita di Pusat Kesehatan Masyarakat (PKM) Rejoso, Nganjuk, yang berusia 28-59 tahun. Peningkatan pemahaman peserta tentang faktor risiko kanker servik diukur dengan kuisioner yang diberikan sebagai pre-test dan post-test. Setelah mengikuti pemaparan materi, terdapat peningkatan pemahaman sebanyak 11,18%. Faktor risiko peserta terhadap kanker servik adalah melakukan hubungan seksual pada usia kurang dari 20 tahun sebanyak 29,27%, melakukan hubungan seksual dengan lebih dari satu orang termasuk apabila menikah lebih dari satu kali sebanyak 17,07%, melahirkan banyak anak yaitu > 5 kali yaitu 7,32%, sering mengalami infeksi daerah kelamin atau keputihan yaitu 21,95%, dan tidak rutin melakukan pemeriksaan pap smear yaitu 24,39%. Hasil pemeriksaan pap smear menunjukkan bahwa semua peserta kegiatan pengabdian kepada masyarakat dinyatakan normal yang meliputi papanicolau class I dan II yaitu dengan diagnosis normal smear, normal atopic smear, dan tidak terdapat lesi intra epithelial maupun keganasan. Kesimpulannya adalah kegiatan ini dapat meningkatkan pemahaman masyarakat tentang tata cara deteksi dini kanker servik. Hasil pemeriksaan pap smear pada kegiatan ini menunjukkan bahwa semua peserta dinyatakan sehat sehingga bisa mengulang pemeriksaan pap smear 2 tahun lagi.

Conventional Radiological Profile of Metastatic Bone Disease Based on Its Histopathological Results: A 3-Year Experience Armando, Braven; Setiawati, Rosy; Edward, Mouli; Mustokoweni, Sjahjenny
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 14 No. 2 (2023): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V14I22023.76-82

Highlights:1. The incidence of MBD tends to be more frequent in older ages and in female patients.2. The radiological appearance of a lesion tends to differ depending on its primary tumor.3. Pathological fracture was present in 55.37% of the cases. AbstractIntroduction: Metastasis commonly occurs in the bone, termed metastatic bone disease (MBD). Early diagnosis and intervention are important to prolong and increase the quality of life. Although conventional radiology is less sensitive for diagnosing this disease, it remains the most cost and time-efficient screening method. This study aimed to describe the radiological profile of patients diagnosed with MBD based on its histopathological result.Methods: This was a descriptive retrospective study using medical records and digital radiological data of patients diagnosed with MBD from 2019-2021 in Dr. Soetomo General Academic Hospital, Surabaya. Variables in this study include gender, age, histopathological result, location of metastases, number of lesions, lesion density, and pathological fracture.Results: 51 patients were diagnosed with MBD during the period of the study and sorted into 121 cases based on metastases location. MBD is more frequent in older female patients, where lesion mostly originates from the breast, thyroid, and lungs, with adenocarcinoma as the most common histology. Vertebrae were the most common location of metastases. Most lesion tends to be multiple and osteolytic. However, certain lesions from different primary tumor had different predilections. Pathological fracture was present in 55.37% of cases.Conclusion: MBD needs to be suspected in patients with cancer from the breast, thyroid, and lungs as its incidence is higher. More studies about MBD profiles on a larger scale should be conducted to better represent this disease in the general population.

The Expression of E6 HPV, P53 and P16ink4a at Well, Moderately, and Poorly Differentiated Cervical Adenocarcinoma Mastutik, Gondo; Rahniayu, Alphania; Kurniasari, Nila; Rahaju, Anny Setijo; Alia, Rahmi; Mustokoweni, Sjahjenny
Folia Medica Indonesiana Vol. 55 No. 4 (2019): December
Publisher : Universitas Airlangga

The objective of this study is to analyze the expression of E6 Humanpapilloma virus (HPV), p53, and p16INK4A in cervical adenocarcinoma grade well differentiated (WD), moderately differentiated (MD), and poorly differentiated (PD). A cross sectional study conducted at Department of Anatomic Pathology, Dr. Soetomo General Academic Hospital Surabaya Indonesia using formalin fix paraffin embedded (FFPE) from cervical normal and cervical adenocarcioma grade WD, MD, and PD. The expression of E6 HPV, p53, and p16INK4A was performed by immunohistochemistry (IHC) staining. Data were analyzed with Kruskal-Wallis and continued with Mann-Withney test. The expression of E6 HPV in the cervical adenocarcinoma showed 35.9% specimens represented negative and 64.1% specimens represented positive. There was no significant difference in the expression of E6 HPV and p53 in cervical adenocarcinoma between grade WD, MD, and PD. The p16INK4A was overexpressed, shown as diffuse appearance in 89.7% of the specimens. There was a significant difference in the expression of p16INK4A between grade WD and MD with PD. In conclusion, some of cervical adecarcinoma were not caused by infection of HPV type 16 or 18 and the expression of p16INK4A might take a role in the developing of malignancy that caused by infection of HPV.

Co-Authors A.A. Ketut Agung Cahyawan W Achmad Zaki Ali Mashuri Alphania Rahniayu Andra Kusuma Putra Aniek Meidi, Aniek Aniek Meidy Utami Anisia Indiralia Anny Setijo Rahaju, Anny Setijo Arifa Mustika Arius Suwondo Armando, Braven Askandar Tjokroprawiro Ayu Maghfira Nida Putri CHRISTIAN BAMBANG SULISTIO Dana Hendrawan Putra Dina Utami Dwi Murtiastutik DYAH FAUZIAH, DYAH Eighty Mardian Eighty Mardian K, Eighty Ernawati Ernawati Ferdiansyah - Ferdiansyah Mahyudin Fetty Fatimah Gondo Mastutik Heriyawati, Heriyawati Ida Hartati Ilmiah, Khafidhotul Imam Susilo Indiralia, Anisia Irene Lingkan Parengkuan KUSUMASTUTI, ETTY HARY Ladyna Rumapar Laksmi Wulandari Lysa Veterini Markus Kore Mouli Edward Nila Kurniasari Nila Kurniasari Nunik Hapsari Susilowati Putu Garry Rahmi Alia Rahmi Alia, Rahmi Rizki Eko Prasetyo Saleh, Tania Ardiani Sari, Aditya Sita Setiawati, Rosy SULISTIO, CHRISTIAN BAMBANG Tri Nugraheni Widyanti, Sri Rejeki Willy Sandhika Yonatan Esli Alexander Tidja Yuli Wahyu Rahmawati

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