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Journal : INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY

Expression of gonadotropin-releasing hormone receptor type-II correlates with proliferation activity in tissue microarray of rare ovarian tumor Ariesaka, Kiky Martha; Kusumanto, Ardhanu; Zucha, Muhammad Ary; Anggorowati, Nungki; Wicaksono, Agil Wahyu; Yunus, Moch; Fanani, Erianto; Nuryady, Moh Mirza
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 6 No 2 (2024): Promising and valuable research towards diagnosis, prognosis and treatment of dis
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v6i2.6034

Abstract

Activation of Gonadotropin-Releasing Hormone type II Receptors (GnRHR-II) exhibits antiproliferative activity. GnRHR-II is not only expressed exclusively in the pituitary, but also in a variety of tumors. To date, the clinical relevance of GnRHR-II in ovarian tumors is unclear. In addition, there is a lack of literature addressing GnRHR-II in ovarian tumors, especially rare types. This study was conducted to investigare the correlation between GnRHR-II expression with clinicopathology and proliferative activity of rare ovarian tumors. The purpose of this study was an analytic observational study with a cross-sectional design that utilized 18 ovarian tumor samples on tissue microarray (TMA). The expression of GnRHR-II and Ki67 was assessed using immunohistochemical staining (IHC) and observed using the IHC profiler plugin ImageJ software to obtain their respective H-scores. The data was analyzed using independent t-test, ANOVA, Pearson's test, and Fisher's exact test based on data types. The value of p<0.05 was considered statistically significant. GnRHR-II is expressed in various forms in ovarian tumors, including extrapituitary expression. GnRHR-II expression was highest in the sex cord stromal tumor (SCST) group, 110.30 ± 23.89 (p<0.0001). In addition, there was also a significant difference between GnRHR-II expression with age (p<0.001) and the primary tumor (p<0.05), but not with tumor type (p=0.101). There is a correlation between GnRHR-II expression and proliferative activity (r=-0.043, p=0.866). Elevated GnRHR-II expression is significantly correlation with SCST, individuals over 40 years of age, and tumors confined to the ovary and it is correlates with lower proliferative activity, although this correlation is very weak.
Co-Authors Abdilla, Sintia Aditya, Ronal Surya Afifah, Nadiyah Hanun Afrian Eskartya Harjono Agil Wahyu Wicaksono Amalina, Haliza Amanatillah, Asti Anita Sulistyorini Anjelina, Dian Denisa Annisa, Gusnita Ayu Ardhanu Kusumanto Arisma, Bayu Jaya Noor Arya Kusuma Wardhana Aulia, Miftha Huda Awanda Putra Pratama Baihaq, Firda Bayu Jaya Noor Arisma Cindy Puspita Sari Dahlia Dian Paramita Devina Ramadhanty Wirakusuma Dhiyaulhaq, Alvira Djoko Kustono Endang Sri Redjeki Erni Dwiyanti Eryani, Salwa Al Farhah’Izzati, Nur Amalina Fauziah, Laili Indah Fa’izah, Erika Nur Firda Baihaq Fulviansyah, Zaidhan Lucano Gelaner, Nauval Akhmadian Haryono, Putri Dwinita Iftitahurroza, Hilma Tsurayya Istiqomah, Mutiara Titian izzatsaltsa maya azmi Khoirunnisa, Irmanda Kiky Martha Ariesaka Kinasih, Kannindya Sekar Kurniawati, Anerinanta Ajeng Nurul Lintang Widya Sishartami Lorenza Arinda Saputri Nur Endah Setyowati Mahendra, Alfian Ihza Marji Marji Marji Marji Marji Marji Maududi, Affan Al Mawarni, Briza Tris Mochammad Yunus, Mochammad Moh Mirza Nuryady, Moh Mirza Mohd Rafee Baharudin Muhammad, Naufalsyah Falah Nadia Rosalinda Najwa Tsaqifa ʻAzmil Umami Nanang Tri Wahyudi Nareswara, Zahra Filloa Ni’maturrohmah, Mufaizin Nungki Anggorowati Nurhikmah, Nadya Nuril Adh-har Putri Dwinita Haryono Putri, Risma Verani Arfina Putri, Salsabilla Alifah Rachmawati, Windi Chusniah Rahayu, Dinarsih Rahmayanti, Fida Ramadhani, Azzahra Agustin Sri Riski Dani Simanjuntak Robbah, Mar’aa Refina rochma, Ana vida nur Salsabilla Alifah Putri Sheikh Abdullah, Siti Rozaimah Shintia Yunita Arini, Shintia Yunita Shofa Zahrotun Naiim Silvia Trias Putri Simanjuntak, Riski Dani Soares, Domingos Solichin Solichin Solichin Solichin Suhartanti, Ajeng Sri Supriyadi Supriyadi Supriyadi Supriyadi Syifa, Tsabitah Aulawiyatus Tika Dwi Tama Tisnalia Merdya Andyastanti Tri Martiana Tristan, Muhammad Ugsang Acob, Joel Rey Wahyuda, Agus Nur Wenny Rasmawati Simamora Wibowo, Farhan Rahadi Yulinda Nur Maulidya Zaeni, Ilham Ari Elbaith Zucha, Muhammad Ary