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All Journal Jurnal Veteriner Jurnal Anestesiologi Indonesia Jurnal Kedokteran Syiah Kuala MNJ (Malang Neurology Journal) Oceana Biomedicina Journal Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Indonesian Journal of Anesthesiology and Reanimation (IJAR) Majalah Biomorfologi (Biomorphology Journal) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Jurnal Neuroanestesi Indonesia Oceana Biomedicina Journal AKSONA Jurnal Widya Medika Folia Medica Indonesiana
Rehatta, Nancy Margarita
Departemen Anestesiologi Dan Reanimasi, RSUD Dr. Soetomo – Fakultas Kedokteran Universitas Airlangga Surabaya
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Denta Journal Kedokteran Gigi Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.
Pengaruh Usia dan Jenis Kelamin pada Skala Nyeri Pasien Trigeminal Neuralgia Hanik Badriyah Hidayati; Elena Ghentilis Fitri Amelia; Agus Turchan; Nancy Margarita Rehatta; Atika; Muhammad Hamdan
AKSONA Vol. 1 No. 2 (2021): JULY 2021
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (150.957 KB) | DOI: 10.20473/aksona.v1i2.149

Abstract

Pendahuluan: Trigeminal neuralgia (TN) merupakan kondisi yang digambarkan sebagai nyeri hebat seperti tersilet pada satu sisi wajah  pada distribusi area saraf ke lima. Nyeri ini dapat mengganggu aktivitas sehari-hari pasien. Rasa nyeri merupakan fenomena subjektif yang dapat dipengaruhi oleh banyak faktor, seperti usia dan jenis kelamin. Tujuan: Mengetahui pengaruh usia dan jenis kelamin terhadap skala nyeri pasien Trigeminal Neuralgia. Metode: Data diambil dari rekam medik pasien pada periode Januari 2017 hingga Juni 2019 di RSUD Dr. Soetomo Surabaya, RS PHC Surabaya, dan RSUD Bangil Pasuruan berdasarkan kriteria inklusi dan eksklusi yang telah ditetapkan. Hasil: TN banyak ditemukan pada kelompok usia  36-64 tahun (55,55%) dan jenis kelamin perempuan (66,67%). Tidak didapatkan hubungan pengaruh usia dan jenis kelamin terhadap skala nyeri pasien (p > 0.05). Kesimpulan: Usia dan jenis kelamin merupakan faktor yang tidak dapat diubah dalam mempengaruhi nyeri. Usia dan jenis kelamin mempengaruhi nyeri melalui perubahan anatomi, hormonal, dan psikologis. Tidak ada hubungan antara usia dan jenis kelamin pada skala nyeri pasien dengan TN.  
Analisa in Silico Kunyit (Curcuma longa) sebagai Inhibitor Murine Double Minute 2 Protein untuk Terapi Glioblastoma Multiforme Benny Iswanto Pantoro; Nancy Margarita Rehatta; Siti Khaerunnisa; Anna Surgean Veterini; Yuani Setiawati
Oceana Biomedicina Journal Vol 3 No 2 (2020): Oceana Biomedicina Journal Volume 3 Issue (No) 2 July - December 2020
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v3i2.61

Abstract

Brain tumor consists of tumor which grows primarily from cells in the brain (primary brain tumor) or systemic tumor which metastasized into the brain (secondary brain tumor). From all types of primary brain tumor, Glioblastoma Multiforme is the most common and the most malignant tumor. In 85% of Glioblastoma Multiforme cases are found a molecular alteration of the tumor suppresor gene p53 pathway, which promotes current studies to focus on this pathway. One of the pathway that can be used as therapeutic model is through inhibiting the murine double minute 2 protein (MDM2), which in itself is a p53 inhibitor. Turmeric (curcuma longa) is one of the traditional plants which is commonly used as herbs and its extracts has been studied to have an anti-cancer properties. This study is an in silico study which evaluate the potential efficacy of turmeric extract as a murine double minute 2 protein inhibitor using AutoDock 4.2 based on the Lamarckian genetic algorithm principle. Docking result shows binding energy ranging from -4.81 kcal/mol to -2.34 kcal/mol, with curcumenol having the lowest binding energy and curcumin having the highest binding energy. This study may be used as a base in further study (consists of in vivo and in vitro) of turmeric extract and its effect as the therapeutic regiments for Glioblastoma Multiforme.
Pain Treatment On Trauma Patient In Dr.Soetomo General Hospital Emergency Room Khoir Amaliin; Atiya Nurrahmah; Nancy Margarita Rehatta; Choesnan Effendi
Indonesian Journal of Anesthesiology and Reanimation Vol. 1 No. 1 (2019): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.28 KB) | DOI: 10.20473/ijar.V1I12019.13-18

Abstract

Introduction: Uncontrolled pain has many negative effects to the body. The Guideline of Pain Management has been specifically arranged, but assessment and pain treatment in the Emergency Room (ER) have not adequate yet. Integrated pain assessment before and after treatment is very important in monitoring pain management effectiveness. Objective: The aim of this study was to determine pain score of emergency patients before and after treatment. This study was also conducted to record the treatment timing that was given by the paramedics in the emergency room. Method and Material: This study was a description research with 40 trauma patients as samples in the ER at Dr. Soetomo Hospital. Patient's pain level was measured twice, before the treatment and an hour after that. The pain level was measured using Visual Analog Scale (VAS). Patients were given ketorolac 30mg intravenous as the treatment. Result and Discussion: There were2.5% of the patients VAS 1 and the other 12.5% VAS 10. An hour after treatment 20% of the ER patients were free of pain and the rest 7.5% VAS 6. The average of VAS before the treatment were 6.38 ± 2.1and an hour after later they decreased to 2.23 ± 1.7. There were only 67.5% of the ER patients that were treated in the 1st hour, 17.5% of them were treated in the 2nd hour, the other 10% were treated in the 3rd hour, and the last 5% of them were treated in the 4th hour. Conclusion:The average value of pain was decreased when one hour after administration of pain therapy by paramedics, but therapy at different times showed no difference in the level of pain reduction that can be inferred.
Effectivity Comparison of Ketamine and Morphine as Post-Operative Analgesic in Spinal Surgery Nenden Suliadiana Fajarini; Nancy Margarita Rehatta; Arie Utariani
Indonesian Journal of Anesthesiology and Reanimation Vol. 1 No. 2 (2019): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (325.95 KB) | DOI: 10.20473/ijar.V1I22019.43-51

Abstract

Introduction: Patients who undergo spinal procedure, experience the post-operative pain as the major problem. From the Visual Analog Scale (VAS), patients scale their pain around 8. An inadequate pain management could fasten the healing process and reduce patient life quality. Opioid group as the gold standard still inflicts several problems, such as respiratory depression. Moreover, the combination NSAID and opioid which used to suppress the side effect, still burden the healthcare cost. In a research of analgesic, through the discovery of N-Methyl D Aspartate receptor, researchers found an explanation of the ketamine effect in relieve chronic and intense pain which safer and cheaper. Method and Material: This research using single blind randomized control trial. Comparing 0.25mg/kg ketamine IV followed by ketamine 0,1mg/kg/h for the intervention group and 0.02mg/kg/h of morphine for the control group to manage the first 24 hours pain sensation. If patient VAS was more than 4, patient would get additional 0.5mg/kg ketamine (intervention group) and 25μg fentanyl (control group). Result and Discussion: From 17 patients each groups, the VAS values were better in control group rather than on intervention group. Low dose ketamine can't be compared with morphine to manage post spinal procedure pain. There were no hemodynamic changes, respiratory rate depression, loss of consciousness and hallucination, nystagmus, vomiting and hyper salivation. Even though 11.8% of the subject were nausea. The morphine group tends to experience hemodynamic changes and loss of consciousness in the first 12 hours but still within normal range. In the control group, 47.1 % patients were having nausea in the first hour, but only 17.6% of them who actually vomited. Conclusion: The analgesic effect of morphine is higher than ketamine, but the amount effect of ketamine is lower than morphine so that ketamine is more effective and safer given in the room.
Description of Gastric Acidity (pH) with Simple Method in Lipopolysaccharide Induced Mice Anna Surgean Veterini; Bambang Wahjuprajitno; Nancy Margarita Rehatta; Heni Rachmawati; Subijanto Marto Soedarmo; I Ketut Sudiana; Widodo Jatim P; Annis Catur Adi; Rachmad Suhanda; Sarmanu Sarmanu; Widjiati Widjiati
Jurnal Veteriner Vol 24 No 1 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.1.55

Abstract

The gastrointestinal acidity/pH can considerably influence the stability and absorption of oral medications. As a result, understanding the circumstances for drug delivery requires knowledge of gastrointestinal pH. Mice injected with lipopolysaccharide (LPS) are used in the most well-studied animal models of sepsis. However, information on gastrointestinal pH in sepsis mice is still insufficient. This study was conducted to identify gastric pH values in mice induced by lipopolysaccharide. The LPS was injected intraperitoneally as well as 0.9% NaCl as control groups. Treated groups (LPS) consisted of four groups and the control group (0.9% NaCl) consisted of four groups. Ten mice were used in each group. Gastric pH measurement was conducted using pH meter Lutron PH-201. Based on this study, the factors that influenced gastric pH in sepsis animal models were the LPS doses and the time after LPS injection. The results of gastric pH measurement in sepsis mice did not show a decrease in the pH compared to the normal conditions. The dose of LPS significantly influences the gastric pH change.
Analgesic Profile in Intensive Observation Room (Ruang Observasi Intensif/ ROI) Dr. Soetomo General Hospital Surabaya Bunga Priscilla Rotua Manurung; Maulydia Maulydia; Maftuchah Rochmanti; Nancy Margarita Rehatta
JAI (Jurnal Anestesiologi Indonesia) Vol 15, No 1 (2023): Jurnal Anestesiologi Indonesia
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.49869

Abstract

Introduction: Pain is a condition that the majority of critical care patients will possibly suffer at some point during their stay in the intensive care unti (ICU). In both medical and surgical ICU patients, the incidence of considerable pain is still 50% or greater. Analgesic administration is considered one of the most effective pain managements. While useful, it can cause detrimental effects if not used according to its indications and regulations.Objective: To obtain the analgesic profile used in intensive observation room (ruang observasi intensif/ROI) Dr. Soetomo General Hospital Surabaya.Methods: This study is a retrospective descriptive study with 537 medical records met the inclusion criteria.Result: The most frequent analgesic used is metamizole (44.41%) and paracetamol (16.08%) while ketamine was used the least (0.24%). Most commonly used analgesic adjuvants is phenytoin (6.12%). The amount of single drug administration (52.70%) is more frequent than multimodal analgesic (47.30%). Metamizole with paracetamol is the most popular analgesic combination (20.74%), followed by metamizole with tramadol (14.17%), and metamizole with fentanyl (12.99%). The most common procedures recorded are obstetrics and gynaecological (29.98%), cranial and general surgery with the same result (21.42%), and orthopaedic (12.29%). 205 samples with Wong-Baker FACES Pain Ratings Scales stated that there is an increase in patients who do not experience pain after administration of analgesics (N=25 to N=132), patients that underwent mild pain decreased (N=134 to N=65), and patients with moderate and severe pain also decreased (N=43 to N=8 and N=3 to N=0 respectively).Conclusion: Non-opioid analgesic dominates the analgesic profile in ROI Dr. Soetomo General Hospital Surabaya compared to opioids that generally used the most worldwide. Giving analgesics to patients has been proven successful in reducing the pain degree. 
RETRACTION : PREVALENCE OF DEPRESSION IN FIRST-YEAR MEDICAL STUDENTS AT AIRLANGGA UNIVERSITY, INDONESIA Izzah, Dina Arini; Yitnamurti, Suksmi; Rehatta, Nancy Margarita
Journal of Community Medicine and Public Health Research Vol. 2 No. 1 (2021): Journal of Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.494 KB) | DOI: 10.20473/jcmphr.v2i1.26477

Abstract

Depression is a mental disorder with a relatively high prevalence rate in medical students around the world. Medical students are often faced with a variety of pressures ranging from academic to social stress so that the prevalence of depression in medical students tends to be higher than general population. Therefore, this study aimed to find out the prevalence of depression in medical students at Airlangga University. This research was a descriptive cross-sectional study. The sample used was 86 first-year medical students at Airlangga University, Indonesia in the academic year of 2017/2018. The data collection was carried out using Beck Depression Inventory II questionnaires as a measurement instrument. The data was analyzed by descriptive univariate using SPSS 16.0. From 86 samples obtained from first-year students, 37.20% of them experienced mental conditions that were considered abnormal (mean score of 10.14 ± 7.093), starting from mild mood disturbance (23.26%) to the most severe category, severe depression (1.16%). There was no extreme depression category in this study. Furthermore, mean score of male subjects is 8.57 ± 6.120 while mean score of female subjects is 10.64 ± 7.351. This study revealed that the prevalence of depression in first-year medical students at Airlangga University in the second semester of academic year 2017/2018  is quite high, which is more than one third of the total respondents while the prevalence in female subjects is higher than in male subjects.
Naja Kaouthia Snake Bite: Case Report Ahmad, Bahtiar; Rehatta, Nancy Margarita
JAI (Jurnal Anestesiologi Indonesia) Vol 16, No 3 (2024): JAI (Jurnal Anestesiologi Indonesia)
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jai.v0i0.59758

Abstract

Background: Snakebites prevalent globally, pose a severe threat, especially in resource-limited regions. The impact is substantial, affecting millions annually, with a significant number of fatalities.Case: A 37-year-old man experienced deterioration leading to cardiac arrest after being bitten by a Naja Kaouthia snake. Adequate management in the intensive care unit (ICU), including antivenom administration, restored the patient's condition to return of spontaneous circulation (ROSC).Discussion: Snake venom causes various symptoms, from tissue damage to breathing and heart issues. Treating with antivenom, specifically from horses, can neutralize the venom's effects, as shown in studies. This treatment is effective for Naja Kaouthia bite.Conclusion: Quick treatment with antivenom partially neutralized the venom, showing how important antivenom is for treating snakebites.
Comparison General Anesthesia And Combined Scalp Block With Ropivacaine 0.5% On Mean Arterial Pressure, Heartrate And Fentanyl Consumption During Craniotomy. Rudi Iskandar Suryadani; Hamzah Hamzah; Nancy Margarita Rehatta; Arie Utariani
JURNAL WIDYA MEDIKA Vol. 6 No. 1 (2020): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v6i1.2499

Abstract

Surgical craniotomy such as skin incisions, head pinning, periosteal-dural contact, dura closure, bones and skin can cause of nociceptive stimulation. These actions are stimuli to the nerves that can stimulate stress response. The stress response to surgery is characterized by increased secretion of the pituitary hormone and activation of the sympathetic nervous system. Hypothalamic activation of the sympathetic autonomic nervous system results in increased secretion of catecholamines from the adrenal medulla and the release of norepinephrine from the presynaptic nerve terminal. Objectives: This study is a single blind experimental, 14 patients with ages 18-60 years physical status ASA (American Society of Anesthesiologists) 1-3, with elective craniotomy surgery. This study was divided into two groups of subjects, group A with seven craniotomy subjects with general anesthesia and group B with seven craniotomy subjects combined with scalp block using ropivacaine 0.5%. Data collected then analyzed with SPSS. We found a decrease in MAP (Mean Arterial Pressure) and heart rate in the scalp block group during scalp incision (MAP p=0.002; HR p=0.029), periosteal contact (MAP p=0.025; HR p=0.039) significantly, as well as the use of fentanyl during surgery was significantly decreased (p=0.0001). General anesthesia with scalp block is more effective in reducing the increase in MAP, heart rate and fentanyl consumption during craniotomy.
Co-Authors , Nabilah A. Himendra Wargahadibrata Abdul Kadir Munsy Agustina Salinding Ahmad, Bahtiar Amelia, Elena Ghentilis Fitri Anna Surgean Veterini Annis Catur Adi Atika atika Atiya Nurrahmah Aulia Rahmi Bambang Wahjuprajitno Benny Iswanto Pantoro Bunga Priscilla Rotua Manurung Candra Dwantara Ramadhan Cecilia Felicia Chandra Choesnan Effendi Dina Arini Izzah Eddy Rahardjo Elena Ghentilis Fitri Amelia Elizeus Hanindito Erwin Astha Triyono Feriawan Tan Fitri Amelia, Elena Ghentilis Fundhy Sinar Ikrar Prihatanto, Fundhy Sinar Ikrar Hamzah Hamzah Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Harijono, Bambang HENI RACHMAWATI HERAWATI, LILIK Izzah, Dina Arini Karimah, Azimatul Khoir Amaliin Lila Tri Harjana Lucky Andriyanto Maulydia, Maulydia Mohammad Sofyan Harahap Muhammad Hamdan Muhammad Hamdan Nabilah Nenden Suliadiana Fajarini Prananda Surya Airlangga Prattama Santoso Utomo Rachmad Suhanda Rizkiya, Putri Rochmanti, Maftuchah Rochmanti Rudi Iskandar Suryadani S.Pd. M Kes I Ketut Sudiana . Sarmanu, Sarmanu Semedi, Bambang Pujo Sinaga, Nur Flora Nita TB Siti Khaerunnisa Subijanto Marto Soedarmo Subijanto Marto Soedarmo Suksmi Yitnamurti Sulistiawan, Soni Sunarso Sulistiawan, Soni Sunarso Tan, Feriawan Tatang Bisri Tedyanto, Eric Hartono Teguh Sylvaranto Turchan, Agus Utariani, Arie Widijiati Widijiati Widjiati Widjiati Widodo Jatim P Widodo Jatim Pudjirahardjo Windhu Purnomo Yitnamurti, Suksmi Yoga Pamungkas Susani Yuani Setiawati