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All Journal HAYATI Journal of Biosciences VALENSI CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Sains dan Teknologi Jurnal Pendidikan Biologi Indonesia Jurnal Kimia Riset Menara Ilmu Jurnal Media Sains Journal of Health Sciences and Medicine Journal of Multidisciplinary Applied Natural Science

I. A. R. Astiti Asih

Program Studi Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Udayana

Author-ID : 2421099

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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ANTIBACTERIAL ACTIVITY OF Samanea saman LEAF ETHANOL EXTRACT AGAINST Escherichia coli AND Staphylococcus aureus AND ITS TOTAL FLAVONOID AND PHENOLIC CONTENTS W. S. Rita; I M. D. Swantara; I. A. R. Astiti Asih; N.K. Sinarsih
Jurnal Kimia (Journal of Chemistry) Vol.12 No.2 Juli 2018
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Antibacterial activity of Samanea saman usually shows a positif correlation to the flavonoid and phenolic contents. The aim of this study was to evaluate the antibacterial activity of the ethanol extract of Samanea saman against Escherechia coli and Staphylococcus aureus and determine the total flavonoid and phenolic contents of the extract. The extraction was done by ethanol 96% at room temperature. The antibacterial assay was conducted by agar disc diffusion method. The total flavonoid and phenolic contents were determined by UV-Vis Spectrofotometer with the standard of quersetin and galic acid, respectively. The extraction of 250 g of Samanea saman leaves resulted in 24.5 g of ethanol extracts. The ethanol extract showed a moderate inhibition of 8.33 mm towards E. coli and a strong inhibition of 13.6 mm towards S. aureus at the concentration of 4%. The Minimum Inhibitory Concentration (MIC) of the extract against E. coli and S.aureus were of 3% and 0.3%”, respectively. The total flavonoid and phenolic contents were successively 1233.2991 mg QE/100g and 2544.6154 mg GAE/100g. Keywords: Escherechia coli, flavonoid and phenolic content, Samanea saman, Staphylococcus aureus

ANALISIS KANDUNGAN KAFEIN PADA KOPI DI DESA SESAOT NARMADA MENGGUNAKAN SPEKTROFOTOMETRI UV-VIS Aryanu Fahmi Arwangga; Ida Ayu Raka Astiti Asih; I Wayan Sudiarta
Jurnal Kimia (Journal of Chemistry) Vol. 10, No. 1 Januari 2016
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Coffee is one of the agriculture commodities that are cultivated by farmers. One of the compounds in the coffee is caffeine. Caffeine is one of alkaloids which contains in coffee bean. The purpose of this study was to determine the contents of caffeine in unripe coffee, pure coffee powder, and mix coffee powder by using UV-Vis spectrophotometer. Standard solutions of caffeine used were 1 ppm; 3 ppm; 6 ppm; 9 ppm; 12 ppm; and 15 ppm. Caffeine calibration curve equation was y = 0.0494x ??+ 0.01862 with a correlation coefficient (r) of 0.99714. Caffeine content in unripe coffee was 1,28±0,82 % with water content 3%, pure coffee powder 1,63±0,13 % with water content 1%, and mix coffee powder 0,87±0,01 % with water content 1%. According to SNI 01-7152-2006 maximum limit of caffeine in food and drink was 150 mg/day and 50 mg/dish.

POTENSI EKSTRAK AIR DAUN GAHARU (Gyrinops versteegii) DALAM MENURUNKAN KADAR KOLESTEROL TOTAL PADA TIKUS WISTAR HIPERKOLESTEROLEMIA I M. O. A. Parwata; I. A. R. A. Asih; I W. A. Kartika
Jurnal Kimia (Journal of Chemistry) Vol. 15, No.1, Januari 2021
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JCHEM.2021.v15.i01.p14

Radikal bebas berlebih dalam tubuh dapat menimbulkan berbagai macam penyakit degenerative yang berbahaya, salah satunya dapat menyebabkan hiperkolesterolemia. Senyawa yang memiliki aktivitas antioksidan dapat meredam radikal bebas yang merusak sel dalam tubuh. Gaharu (Gyrinops versteegii) banyak dimanfaatkan sebagai obat tradisional karena aktivitasnya sebagai senyawa antioksidan. Penelitian ini bertujuan untuk menentukan potensi ekstrak air daun gaharu (Gyrinops versteegii) dalam menurunkan kadar kolesterol total dalam darah tikus wistar yang hiperkolesterolemia. Metode penelitian yang digunakan adalah One-group Pretest-Posttest Design, untuk mengetahui penurunan kadar kolesterol total pada darah tikus. Hasil penelitian menunjukan bahwa ekstrak air daun gaharu dengan dosis 50, 100 dan 200 mg/kgBB dapat menurunkan kadar kolesterol total dalam darah tikus wistar yang hiperkolesterolemia dengan nilai rata-rata secara berturut-turut yaitu: 34,6 ; 43 ; dan 72,2 mg/dL. Kata kunci: Gyrinops versteegii, hiperkolesterolemia, kolesterol total. ABSTRACT Excessive free radicals in the body can cause various kinds of dangerous degenerative diseases, which one of them is hypercholesterolemia. Compounds having antioxidant activity can reduce free radicals that damage cells in the body. Agarwood (Gyrinops versteegii) is widely used as traditional medicine because of its activity as an antioxidant compound. The purpose of this study was to determine the potential of water extract of agarwood (Gyrinops versteegii) leaves in reducing the total cholesterol in the blood of hypercholesterolemic wistar rats. The research method used was One-group Pretest-Posttest Design, to determine clearly the decrease in total cholesterol in the blood of rats. The results of the study after treatment showed that the water extract of agarwood leaves at a dose of 50, 100, and 200 mg/kg BW could reduce the total cholesterol levels in the blood of hypercholesterolemic wistar rats by an average value of 34.6; 43; and 72.2 mg/dL, respectively. Keywords: Gyrinops versteegii, hypercholesterolemia, total cholesterol.

ISOLASI SENYAWA SITOTOKSIK DARI DAUN ANDONG (Cordyline terminalis Kunth) N. W. Bogoriani; Sri Rahayu Santi; I. A. R. Astiti Asih
Jurnal Kimia (Journal of Chemistry) Vol. 1, No. 1 Januari 2007
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (70.785 KB)

Isolation and identification one of cytotoxic fraction have been conducted from the leaves of Andong(Cordyline terminalis Kunth). The fraction having LC50 values of 41,64 ppm contains saponin. Major isolate (7.5 mgwhite amorphous solid) was obtained after a series of chromatographic separations (gravity column chromatography,and preparative high performance liquid chromatography). Identification of the isolate using mass spectrometry withpositive electrospray showed MW of 866 as calculated from the ion peaks m/z 889[M + Na]+, and 867[M + H]+.The ion peaks at m/z 721[(M + H) - 146]+, 703[(M + H) - 164]+, 575[(M + H) - 292]+, 557[(M + H) - 310]+ , 429[(M+ H) - 438]+, and 411 [(M + H) - 456]+ of its fragments indicate the presence of three sugars (two terminal sugarsand one central sugar) from methylpentose moiety with MW 164 eash linked to an agyicone of MW of 428. Protonmagnetic resonance spectrum of the isolate in pyridine-d5 showed characteristic proton signals for three steroidmethyls (two angular methyls and one secondary methyl) at d 1.37 (s), 0.84 (s) and 1.02 (d, J = 6.6 Hz); anexomethylene group at d 4.79 ppm and 4.71 (each br s); an ethylene group at d 5.52 ppm (br d, J = 5.4 Hz); signalsof the protons linked to C26 at d 4.01 and 4.44 ppm (each d, J = 12.0 Hz), and three anomeric protons at d 6.43 ppm(br s); 5.56 ppm (br s) and 4.57 ppm (d, J = 7.0 Hz). From the above data it can be indicated that the isolate resultedis spirostan steroidal saponin.

ISOLASI DAN IDENTIFIKASI SENYAWA GOLONGAN TRITERPENOID DARI EKSTRAK n- EKSANA DAUN KEPUH (Sterculia foetida L.) SERTA UJI AKTIVITAS ANTIRADIKAL BEBAS I. A. R. Astiti Asih; I W. G. Gunawan; N. M. Desi Ariani
Jurnal Kimia (Journal of Chemistry) Vol. 4, No. 2 Juli 2010
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.943 KB)

Kepuh leaves can be used as traditional medicine to cure various diseases. Maseration of ± 1000 g drypowder of Kepuh leaves with n-hexane as the solvent resulted in 2,10 g n-hexane concentrated extract. Separation ofthis extract with column chromatography gained two yellow amorphous crystal isolates of F3.1 and F3.2 with 0,0195 gand 0,0032 g in weight, respectively.The result of phytochemical test of isolate F3.1 with Liebermann-Burchard reagent showed that the isolatepositively contained triterpenoid. Identification of isolate F3.1 with spectrophotometer UV-Vis showed one broadpeak at 265 nm. The transition occured probably was n *, that was caused by C=O chromophor. Infraredspectrum showed characteristic groups of OH at 3294,42 cm-1, aliphatic CH at 2924,09 cm-1 and 2854,65 cm-1, C=Oat 1743,65 cm-1, bending CH2 and bending CH3 at 1458,18 cm-1 and 1381,03 cm-1 and alcoholic CO at 1172,72 cm-1.Free antiradical activity test against isolate F3.1 was carried out by spectroscopy UV-Vis method. Isolate F3.1 hadcharacteristic as a free antiradical with DPPH damping percentage at the 5th minute was 85,33% and at the 60thminute was 88,52%.According to phytochemical tests and spectrophotometry analysis, isolates from kepuh leaves was expectedto contain true triterpenoid group compounds with free antiradical activity OH group, aliphatic CH, C=O andalcoholic C-O as the functional groups.

PENGARUH RASIO MOLAR MINYAK JELANTAH DENGAN METANOL DAN SUHU REAKSI DALAM REAKSI TRANSESTERFKASI TERKATALIS CaO/ZEOLIT ALAM TERHADAP YIELD BIODIESEL Ana Malia; Putu Suarya; Ida Ayu Raka Astiti Asih; I Made Wisnu Adhi Putra
Jurnal Kimia (Journal of Chemistry) Vol. 10, No. 1 Januari 2016
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

The research of transesterification reaction catalyzed by CaO/natural zeolite has been carried out. This work was aimed to obtain the high yield of biodiesel. The supporting process of CaO on natural zeolite (CaO/ZAA) was done by using wet impregnation method and characterization of CaO/ZAA was performed using XRD, FTIR and the determination of specific surface area of natural zeolite as CaO supporter was performed by BET method. This research aims to study the influence of transesterification reaction which was executed by varying molar ratio of oil to methanol and reaction temperature. Analysis of functional groups and minerals using FTIR and XRD, respectively, showed no significant changes before and after the impregnation of CaO on natural zeolites. CaO supported on natural zeolite was undetected by FTIR. Instead, it was detected by the vibration of carbonate groups as the result of the CO2 absorption by CaO and the result of surface area analysis using BET method showed that the greater the size of natural zeolite, the smaller the specific surface area of catalyst. The result analysis using BET method showed that the spesific surface area of 200 mesh sized natural zeolite as CaO supporter was 9.993 m2/g. The simple gravimetric test revealed that the amount of CaO supported on 200 mesh sized natural zeolite was 0.2155 g/g. It was concluded that CaO/ZAA 200 mesh was the most suitable catalyst which was then used in the production of biodiesel. The transesterification result showed that the highest biodiesel yield of 98.34% was gained at molar ratio of oil to methanol of 1:15 and at the temperature of 60 oC. The GC-MS analysis indicated that the main components of the biodiesel were methyl palmitate and methyl oleate.

PENENTUAN KADAR 8-HIDROKSI-2’-DEOKSIGUANOSIN (8-OHdG) DALAM URIN TIKUS SETELAH TERPAPAR ETANOL DAN ASAP ROKOK Mahardika Aprilia Iflahah; Ni Made Suaniti; Ida Ayu Raka Astiti Asih
Jurnal Kimia (Journal of Chemistry) Vol. 8, No. 1 Januari 2014
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Urinary level of 8-OHdG in rats after exposure to ethanol and smoke have been investigated for 15 days with TLC-Spectrophotodensitometer. Ethanol and smoke exposure to could increase the number of Reactive Oxygen Species (ROS), which could lead to a state called oxidative stress. 8-OHdG compound is the result of DNA oxidation by ROS in the body in the form of guanine nucleotide. This 8-OHdG is a water-soluble compound excreted in urine easily. In this study, exposure of ethanol and smoke both singly and combined had an effect on the level of 8-OHdG. Urinary level of 8-OHdG in the control group; groups exposed to ethanol, smoke, and ethanol-smoke were (0,00 ± 0,00)%, (0,33 ± 0,08)%, (0,25 ± 0,10)%, and (0,57 ± 0,27)% respectively.

PEMANFAATAN ZAT WARNA ALAM DARI EKSTRAK KULIT AKAR MENGKUDU (Morinda citrifolia Linn) PADA KAIN KATUN Mariance Thomas; Manuntun Manurung; I. A. Raka Astiti Asih
Jurnal Kimia (Journal of Chemistry) Vol. 7, No. 2 Juli 2013
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

The research about utilization of natural dyes from root bark extract of Morinda citrifolia on cotton fabric has been done. The extraction of root bark morinda was done by using water and methanol as solvent with ratio of 1:20 (w/v) (10 g sample : 200 mL solvent). The extract obtained from water was blackish brown, while from methanol solvent was reddish brown. The extract obtained was used to dye cotton fabric with addition of 1.00 g whiting as a mordant. Extracts of both solvents can dye cotton fabrics with varied colors : yellow, red, and red purple. Mordant can strengthen the bond between the fiber and dyes and sharpen the fabric color. Endurance test by using 0.5% detergent water to soak for 15 minutes, showing the colour of fabric without mordant easily fade, whereas the colour with mordant of whiting do not easily fade.

SUPLEMEN EKSTRAK DAUN SIRIH, Piper betle, Lin DALAM MENURUNKAN KADAR MALONDIALDEHID PADA TIKUS WISTAR I W. Suirta; I. A. R. A. Asih
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Betel leaf extract supplements, Piper betle Lin , was made by extracting maceration of betel leaves with ethanol 96%. Phytochemical screening of betle leaf extract obtained secondary metabolites such as : terpenoids, steroids, phenolics, and saponins . The results of the antioxidant activity test test showed that n-hexane fraction was more reactive as an antioxidant (IC50 26,73 mg/L) than the diethyl ether fraction (IC50 114,54 mg/L). The MDA analysis showed that the betel leaves have a very good ability to reduce MDA levels. The concentration of MDA with addition of allopurinol (as positive control) was 0,41±0,0021?L/mL, while with addition of betel leaves the level was 0,44±0,0021?L/mL. The structure identification obtained active antioxidant compounds such as: cavicol, eugenol, caryophilene and isoeugenol. Keywords : betel leaf, malondialdehyde, Piper betle, wistar rat

ISOLASI DAN IDENTIFIKASI SENYAWA GOLONGAN FLAVONOID DARI MADU K ELENGKENG (Nephelium longata L.) Ida Ayu Raka Astiti Asih; Ketut Ratnayani; Ida Bagus Swardana
Jurnal Kimia (Journal of Chemistry) Vol. 6, No. 1 Januari 2012
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.213 KB)

The determination of anti free radical activity on longan honey (Nephelium longata L.) by DPPH method using UV-Vis sphectrophotometry and identification of chemical compound in non polar and semi polar fraction have been done. Longan honey was diluted with methanol and then partied by n-hexane and ethyl acetate. The absorbance was measured at 497 nm, 517 nm, and 537 nm for the DPPH concentration of : 0,001%, 0,002%, 0,003%, and 0,004% and the chemical compound was identified by phytochemical method.The result showed that part of n-hexane and ethyl acetate probably consist of chemical compound of isoflavone and value of anti free radical activity on longan honey in semi polar fraction was higher than in non polar fraction which were 91,71% and 77,68% at DPPH concentration of 0,001% (b/v).

Co-Authors A. A. N. G. W. Pramantha Adnyana , I Made Dwi Mertha Ana Malia Anak Agung Istri Agung Mayun Laksmiwati Aryanu Fahmi Arwangga Desmon Tutu Bili E. Sahara Egi Azikin Maulana Eti Meirina Brahmana Eti Meirina Brahmana Henny Puspa Dewi Giri I Gede D. Yudha Partama I Gusti Ayu Kunti Sri Panca Dewi I Gusti Bagus Teguh Ananta I K. D. Yasa I M. Adi Setiawan I M. O. A. Parwata I Made Dira Swantara I Made Wisnu Adhi Putra I Nyoman Mika Adi Santosa I Nyoman Suarsana I W. A. Kartika I W. G. Gunawan I Wayan Sudiarta I Wayan Suirta I. A. Gede Widihati Ida Bagus Swardana Irdhawati Irdhawati James Sibarani Jeane, Magda Juniari, Tjokorda Istri Trisna K. Swandiyasa Ketut Ratnayani Liana Sari Made Arsa Mahardika Aprilia Iflahah Manuntun Manurung Mariance Thomas Miftakul Sururi N. K. D. M.S. Wahyuni N. M. Desi Ariani N. P. Widya Astuti N. W. Bogoriani N.K. Sinarsih Ni Kadek Dyan Mustika Sri Wahyuni Ni Luh Gede Sudaryati Ni Luh Indra Dewi Senisk Ni Luh Yuli Damayanti Ni Made Puspawati Ni Made Suaniti Ni Made Yuliari Ni Putu Widayanti Ni Wayan Oktarini A.C.Dewi Putu Lakustini Cahyaningrum Putu Suarya Putut Dewantha Jenar S. R. Santi Sri Rahayu Santi Sri Wahjuni W. S. Rita W. S. Rita W.S. Rita WAHYU DWIDJANI S Wiwik Susana Rita WIWIK SUSANAH RITA Yudha Taufantri

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