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All Journal HAYATI Journal of Biosciences VALENSI CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Sains dan Teknologi Jurnal Pendidikan Biologi Indonesia Jurnal Kimia Riset Menara Ilmu Jurnal Media Sains Journal of Health Sciences and Medicine Journal of Multidisciplinary Applied Natural Science

I. A. R. Astiti Asih

Program Studi Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Udayana

Author-ID : 2421099

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Environmental Science Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics

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EFEK EKSTRAK GLIKOSIDA FLAVONOID BUAH TERONG BELANDA TERHADAP AKTIVITAS SUPEROKSIDA DISMUTASE DAN KADAR MALONDIALDEHID PADA JARINGAN HATI TIKUS WISTAR DI BAWAH KONDISI STRES I. A. R. A. Asih; A. A. N. G. W. Pramantha; S. R. Santi
Jurnal Kimia (Journal of Chemistry) Vol. 15, No.2, Juli 2021
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JCHEM.2021.v15.i02.p11

Senyawa kimia yang dihasilkan oleh tumbuh-tumbuhan semakin banyak dieksploitasi dan diteliti sebagai bahan obat-obatan. Terong belanda merupakan tanaman yang termasuk ke dalam keluarga Solanaceae, yang kaya nutrisi serta bermanfaat untuk membantu metabolisme seperti meningkatkan imunitas tubuh sehingga dapat mencegah stres oksidatif karena kandungan glikosida flavonoidnya. Ekstraksi dilakukan dengan cara maserasi. Analisis in vivo menggunakan rancangan randomized post-test only control group design dengan 24 ekor tikus Wistar sebagai hewan uji. Hewan uji dibagi menjadi empat kelompok perlakuan, dan diberikan ekstrak dengan dosis 50 mg/kgBB setelah perenangan selama 90 menit. Hasil menunjukkan bahwa pemberian ekstrak glikosida flavonoid mampu mengobati stres oksidatif dengan menurunkan kadar malondialdehid (MDA) sebesar 14,71% lebih rendah dan meningkatkan aktivitas superoksida dismutase (SOD) sebesar 53,47% lebih tinggi pada jaringan hati tikus di bawah kondisi stres dibandingkan tanpa diberikan ekstrak glikosida secara signifikan (p<0,05). Kata kunci : MDA, SOD, Solanum betaceum Cav, tikus Wistar Chemical compounds produced by plants have been increasingly exploited and researched as medicinal ingredients. Terong belanda is a plant that belongs to the Solanaceae family, which is rich in nutrients and beneficial for supporting metabolism, such as increasing the body's immunity so that it can prevent oxidative stress, because it contains flavonoid glycoside. Extraction was done by maceration and fractionation. In vivo analysis used a randomized post-test only control group design with 24 Wistar rats as test animals. The test animals were divided into four treatment groups and given the glycoside extract at a dose of 50 mg/kg BW after swimming for 90 minutes. The results showed that the administration of flavonoid glycoside extract was able to treat oxidative stress by reducing malondialdehyde (MDA) levels by 14.71% lower and increasing superoxide dismutase (SOD) activity by 53.47% higher of the rat liver tissue under stress conditions than the one without significantly given the extract (p <0.05). Keywords : MDA, SOD, Solanum betaceum Cav, Wistar rat

ISOLASI DAN IDENTIFIKASI SENYAWA ISOFLAVON DARI KACANG KEDELAI (Glycine max) I. A. R. Astiti Asih
Jurnal Kimia (Journal of Chemistry) Vol. 3, No. 1 Januari 2009
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

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Isolation and identification of flavonoid compound from soy bean (Glycine max) have been conducted inthis research. Extraction of 1740.83 g of soy bean powder with methanol yielded 17.82 g yellowish brown of crudemethanol extract. The crude extract was then hydrolysed with 2N HCl. Following partition of hydrolysed productwith n-hexane gave 2.61g of n-hexane extract. Phytochemical testing of n-hexane extract gave positive result forflavonoid compound. The n-hexane extract was then subjected to column chromatography for purification.Identification of fraction which contained flavonoid using UV-Vis showed two band peaks at 312.9 nm dan 268.2nm. Further identification using chemical shift including sodium hydroxide, sodium acetate, sodium acetate:borateacid, aluminium chloride, aluminium chloride-concentrated chloride acid suggested that the compound isolated wasisoflavone without any free hydroxyl group and ortho dihydroxy group at ring A. Thr infra red spectra of isolateindicated the presence of characteristic functional group such as aromatic CH, aliphatic C-H, C=O, aromatic C=C,and C-O

ISOLASI DAN IDENTIFIKASI SENYAWA TOKSIK PADA EKSTRAK METANOL DAUN GAHARU (Gyrinops versteegii) I Nyoman Mika Adi Santosa; Ida Ayu Raka Astiti Asih; A. A. I. A. Mayun Laksmiwati
Jurnal Kimia (Journal of Chemistry) Vol. 7, No. 2 Juli 2013
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Isolation and identification of toxic compound from methanol extract of eaglewood leaves (Gyrinops versteegii) has been done. Extraction of 869 g of dried eaglewood leaves powder produced concentrated extracts of n-hexane (21.56 g) and methanol (81.85 g). The result of toxicity test for both of concentrated extracts showed methanol extract was the most toxic with LC50 of 39.81 ppm. Partition of methanol extract gained three concentrated extracts in chloroform (2.74 g) , ethyl acetate (3.44 g) and water (15.56 g). The result of toxicity test showed chloroform extract was the most toxic with LC50 of 23.44 ppm. Chloroform extract was then separated and purified by chromatography technique and obtained three toxic fractions namely fraction of A (0.44 g), B (0.22 g) and C (0.13 g). The toxicity test showed that fraction C was the most toxic with LC50 of 34.67 ppm. The phytochemical test result showed that fraction C was belong to triterpene groups. Analysis using UV-Vis spectrophotometer gained 2 peaks at ? 245 nm and ? 416 nm, showing the possibility of the chromophore C=O and C=C, respectively. Analysis using infrared spectrophotometer showed the characteristic absorption of an -OH group, aliphatic CH, C=O and C=C on wave numbers of cm-1 3441.01; 2924.09 (-CH3) and 2854.65 (-CH2); 1743.65; and 1627.92, respectively. According to phytochemical test and spectrophotometry analysis, the isolate of fraction C was supposed to contain triterpene group compounds which has functional groups of OH, aliphatic CH, C=O and C=C.

POTENSI EKSTRAK DAUN CENDANA (Santalum album L.) SEBAGAI SENYAWA PENGHAMBAT JAMUR Candida albicans K. Swandiyasa; N. M. Puspawati; I. A. R. A. Asih
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Diseases caused by C. albicans (C. albicans) such as mouth, skin and nail diseases are still commonly found in Indonesia. This study aimed to examine antifungal activity of n-hexane, chloroform, and n-butanol extracts of Santalum album (S.album) leaves in inhibiting the growth of C. albicans and to determine the minimum inhibitory concentration of the most active extract as well as to identify their active compounds. Antifungal activity testing was carried out using disc diffusion method and identification of active compound was performed using LC-MS /MS. Extraction of 1 kg sandalwood leaf powder with methanol yielded 86.80 gram of crude methanol extract. Partiiton 40 gram of the crude methanol extract with n-hexane, chloroform, and n-buthanol gave 12.60, 6.20 and 1.20 g of extracts respectively. The antifungal activity test results revealed that n-hexane extract was the most active in inhibiting the growth of C.albicans with inhibitory diameter of 13 mm as compared to chloroform 9 mm and n-buthanol 8 mm. The active n-hexane extract which is active as an antifungal is then made various variations to obtain a minimum inhibitory. The n-hexane extract, at concentrations of 95, 90 and 85% inhibited the growth of C.albican with inhibitory diameter of 12.04, 15.8, and 13 mm respectively. While at the concentarion of 80 % showed minimum inhibitory diameter of 9.32 mm. Based on analysis mass spectra of two peaks of LC-MS / MS chromatogram with MassLynx V4.1 programe and Chemspider web database suggested the presence of benzofurazan and picolylamine compounds which may contribute to the antifungal activityof n-hexane extract of S.album. Keywords: Sandalwood (Santalum album L.), antifungal, C. albicans, n-Hexane, LC-MS/MS

PEMANFAATAN KALENG ALUMINIUM BEKAS DALAM MENANGANI PENCEMARAN AIR WIWIK SUSANAH RITA; I.A. RAKA ASTITI ASIH; WAHYU DWIDJANI S; I W. SUIRTA; I G.A. KUNTI SRI PANCA DEWI
Buletin Udayana Mengabdi Vol 7 No 2 (2008): Volume 7 No.2 – September 2008
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

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ABSTRACT Community service by giving a lecture and practical work with a title: “Utilizing of Aluminum Cans used for Water Purification (Pemanfaatan Kaleng Aluminium Bekas dalam Upaya Penjernihan Air)” was be held on Wednesday, 22nd of August 2007. The participants of this activity were about 45 of the Third degree Students of SMAN Abiansemal Badung. The aim of the activity was to give information that aluminum cans can be recycled into alum (tawas), where it can be used for water purification. The result of this activity indicated that the knowledge of the students have broaden. This was showed by Their enthusiastic to give some questions and ideas. They paid attention about the environmental cleanliness, so this activity can help them to solve many environmental problems and motivate them to run a private enterprise.

PEMANFAATAN VCO DAN EKSTRAK BUNGA KENANGA DALAM PEMBUATAN SABUN ANTIBAKTERI DI DESA ABABI KECAMATAN ABANG KARANGASEM W.S. Rita; I.W. Suirta; E. Sahara; I.A.R.A. Asih
Buletin Udayana Mengabdi Vol 18 No 2 (2019): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Virgin Coconut Oil (VCO) dan ekstrak bunga kenanga dapat digunakan sebagai alternatif pengganti antibakteri sintetik dalam pembuatan sabun mandi padat transparan. Pengabdian ini bertujuan untuk membuat sabun antibakteri dengan memanfaatkan bahan aktif bakteri dari VCO dan ekstrak bunga kenanga. Sabun dibuat dengan mereaksikan VCO, minyak kelapa, asam sterat dengan suatu basa (NaOH), selanjutnya ditambahkan bahan-bahan lain seperti sukrosa dan gliserin untuk membuat sabun yang transaparan. Ekstrak kenanga ditambahkan juga sebagai bahan aktif antibakteri dan sebagai pewangi. Produk yang dihasilkan beruba sabun transparan antibakteri yang mana sabun tersebut telah memenuhi Standar Nasional Indonesia (SNI). Masyarakat yang ditargetkan pada pelatihan pembuatan sabun adalah PKK dan Kelompok Perempuan Petani di Desa Ababi, Kecamatan Abang, Kabupaten Karangasem. Hasil pelatihan menunjukkan bahwa ada peningkatan wawasan peserta tentang sabun antibakteri dan cara membuatnya. Kata kunci : Sabun, Antibakteri, Bunga Kenanga, VCO

TEKNIK VOLTAMETRI PELUCUTAN ANODIK GELOMBANG PERSEGI UNTUK PENENTUAN KADAR LOGAM Cu DALAM KANGKUNG AIR Irdhawati Irdhawati; Liana Sari; Ida Ayu Raka Astiti Asih
Jurnal Kimia Riset Vol. 1 No. 2 (2016): Desember
Publisher : Universitas Airlangga

ABSTRAK Analisis logam berat Cu(II) dilakukan dengan metode voltametri pelucutan anodik gelombang persegi. Penelitian ini bertujuan untuk mengetahui validitas metode voltametri pelucutan anodik yang digunakan dalam pengukuran kadar logam Cu(II) dalam sampel kangkung air di muara sungai Badung. Elektroda glassy carbon digunakan sebagai elektroda kerja, Ag/AgCl sebagai elektroda pembanding, dan kawat platina sebagai elektroda pembantu. Parameter yang dioptimasi meliputi waktu deposisi dan laju pindai dalam larutan standar Cu(II) 500 ppb. Validasi metode ditentukan dengan menentukan rentang konsentrasi linier, limit deteksi, keberulangan pengukuran, dan persen perolehan kembali. Teknik voltametri pelucutan anodik kemudian digunakan untuk mengukur kadar logam Cu(II) pada sampel kangkung air.Hasil optimasi pengukuran kadar logam Cu(II) yaitu waktu deposisi optimum 60 detik dan laju pindai optimum 10 mV/detik. Pengukuran validitas larutan standar logam Cu(II), rentang konsentrasi linier larutan 50 ~500 ppb dan memiliki nilai koefisien korelasi 0,9983. Limit deteksi 35 ppb, keberulangan pengukuran memiliki rasio Horwitz kurang dari 2, dan persen perolehan kembali 99,35% ± 0,4526. Hasil pengukuran sampel tanaman kangkung memiliki kandungan logam Cu(II) sebesar 4,0 ppm. Berdasarkan Keputusan Direktur Jenderal Pengawasan Obat dan Makanan batas maksimum cemaran logam dalam makanan untuk logam Cu(II) adalah 5,0 ppm. Oleh karena itu dapat diketahui bahwa kandungan logam Cu(II) tidak melebihi kadar maksimum yang diperkenankan. Kata Kunci : logam berat, voltametri pelucutan anodik gelombang persegi, kangkung airABSTRACTHeavy metal analysis of Cu(II) was measured by square wave anodic stripping voltammetry method. The aim of this research is to know the validity of square wave anodic stripping voltammetry method for determination of Cu(II) in water spinach from the estuary of Badung river. Glassy carbon, Ag/AgCl, and Pt wire electrodes were used as working electrode, reference electrode and counter electrode, respectively. Optimized parameter involved the deposition time and scan rate in standard solution Cu(II) 500 ppb. Furthermore, the validation method was examined by determination of linear concentration range, limit of detection, repetition of measurement, and percent of recovery. Moreover, the result of validation was used for observing of heavy metal Cu(II) content in water spinach. The result of optimum deposition time is 60 s. Meanwhile, the scan rate optimum is 10 mV/s. Measurement for standard solution 50 ~ 500 ppb on linear concentration range, with correlation coefficient 0,9983. Limit of detection is 35 ppb, repetition of measurement for metal has Horwitz ratio less than 2, and percent recovery of Cu(II) measurement is 99,35% ± 0,4526. The measurement of Cu(II) content in the water spinach sample contain Cu(II) 4,0 ppm. Based on Decree of Directorate General for Drug and Food Control, the treshold line for Cu(II) contamination for food is 5,0 ppm. Therefore, the water spinach sample contain Cu(II) is less than accepted value. Keyword : Heavy metal, square wave anodic stripping voltammetry, water spinach

In Vitro Evaluation Of Antioxidant Activity Of Flavonoid Compounds From Terong Belanda Ida Ayu Raka Astiti Asih; Ni Made Puspawati; Wiwik Susanah Rita
Journal of Health Sciences and Medicine Vol 1 No 2 (2017): JHSM (September 2017)
Publisher : Institute for Research and Community Services Udayana University

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Terong belanda (Solanum betaceum, cav), is a fruit that has nutrients and vitamins which are essential for health of human body and it is believed to have a potent antioxidant activity. This research aimed to evaluate in vitro antioxidant activity of flavonoid compounds isolated from Terong belanda. In vitro antioxidant activity was evaluated using DPPH method. Identification of flavonoids was done using Infrared and UV–Vis Spectrophotometers. Extraction of ten (10) kg terong belanda fruits with ethanol gave of 126.17 g peels extract, 178.44 g flesh, and 253.11 g seed extracts respectively. Phytochemical test showed both peels, flesh, and seed extracts of Terong belanda contained flavonoids. Antioxidant activity test showed peels, flesh, and seeds extracts exhibited antioxidant activity with IC50 of 68,14 ppm, 621.45 ppm, and 1162.608 ppm respectively. Separation and purification of these three active extracts using column chromatography gave each one isolate which positive flavonoid on phytochemical test. Infrared spectra of each isolate from peels, flesh, and seed were similar and each revelaed to contain the same functional groups (OH alcohol, CH aromatic, C=O, C=C, and CH aliphatic). Analysis of UV-Vis spectra and its spectra with shifting reagents of the peels isolates gave absorption at the wavelength range of 310-330 nm (Bans I ) and 245-275 nm (bands II) due to isoflavones group with a hydroxy group at C6, C7 or C7, C8 and C3', C 4 ' while flesh and seed gave absorption at 300-330 nm (bands I) and 275-295 nm (bands II) that indicated the class of flavanones with hydroxyl groups at C-2', C-5', C-6' and Oglycoside at C7 for flessh and hydroxyl group at C6, C7 or C7, C8 for the seed.

UJI TOKSISITAS EKSTRAK DAN ISOLAT DAUN SRIKAYA (Annona squamosa Linn) DAN IDENTIFIKASI SENYAWANYA Ni Luh Indra Dewi Senisk; I Made Dira Swantara; Ida Ayu Raka Astiti Asih
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 10 No 2 (2022): Cakra Kimia (Indonesian E-Journal of Applied Chemistry)
Publisher : Graduate Program of Applied Chemistry, Udayana University, Bali-INDONESIA

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ABSTRAK: Srikaya (Annona squamosa Linn) merupakan tanaman yang mengandung banyak manfaat yaitu pencegahan penyakit jantung, mencegah penyakit asma, mengatasi penyakit diabetes, mengobati masalah hipertensi mencegah dan mengobati penyakit kanker. Penelitian ini dilakukan untuk mengetahui aktivitas toksik ekstrak dan isolat daun srikaya serta identifikasi kandungan senyawanya. Metode Brine Shrimp Mortality Test (BSLT) digunakan untuk uji toksisitas dan identifikasi senyawa dengan menggunakan instrumen LC MS/MS. Maserasi 750 g serbuk daun srikaya kering menggunakan pelarut metanol menghasilkan 64,45 g ekstrak kental. Uji toksisitas ekstrak kental metanol menunjukkan nilai LC50 sebesar 26,30 ppm. Partisi 45,0 g ekstrak kental metanol menghasilkan 14,3 g ekstrak n-heksana, 2,57 g kloroform dan 9,05 g n-butanol dengan nilai LC50 berturut-turut 104,71; 52,48; dan 323,59 ppm. Pemisahan senyawa pada ekstrak kloroform dilakukan dengan kromatografi kolom menghasilkan empat fraksi dengan fraksi A menunjukkan aktivitas paling toksik dengan nilai LC50 sebesar 100,00 ppm. Analisis LC MS/MS fraksi A menunjukkan adanya senyawa (6S,7?R)-6-hydroxy-4,4,7?-trimethyl-6,7-dihydro-5H-1-benzofuran-2-one (Loliolide); Cocamidopropyl betaine; Linolenic Acid; dan 1-Dodecyl-2-azepanon (Laurocapram). ABSTRACT: Sugar apple (Annona squamosa Linn) has many benefits, i.e. preventing heart disease, preventing asthma, overcoming diabetes, treating hypertension problems, preventing and treating cancer. This research aims to find out the toxicity of sugar apple leaf extract and isolate and to identify their compounds. Brine Shrimp Mortality Test (BSLT) method was used for toxicity test and identification compounds carried out using the LC MS/MS instrument. Maceration of 750 g of dry sugar apple leaf powder using methanol as solvent yielded 64.45 g of thick extract. Toxicity test of methanol viscous extract showed an LC50 value of 26.30 ppm. Partition of 45.0 g of methanol thick extract produced 14.3 g of n-hexane extract, 2.57 g of chloroform and 9.05 g of n-butanol with LC50 values ??of 104.71; 52.48; and 323.59 ppm respectively. The separation of compounds in the chloroform extract was carried out by column chromatography resulting in four fractions with fraction A showing the highest toxicity with an LC50 value of 100.00 ppm. LC MS/MS analysis of fraction A showed the presence of compound (6S,7?R)-6-hydroxy-4,4,7?-trimethyl-6,7-dihydro-5H-1-benzofuran-2-one (Loliolide) ; Cocamidopropyl betaine; Linolenic Acid and 1-Dodecyl-2-azepanone (Laurocapram).

POTENSI EKSTRAK ETANOL DAUN PUTRI MALU (Mimosa pudica L.) SEBAGAI OBAT ALTERNATIF ANTIHIPERGLIKEMIA Desmon Tutu Bili; Ida Ayu Raka Astiti Asih; Sri Wahjuni
CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Vol 10 No 2 (2022): Cakra Kimia (Indonesian E-Journal of Applied Chemistry)
Publisher : Graduate Program of Applied Chemistry, Udayana University, Bali-INDONESIA

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ABSTRAK: Penelitian ini bertujuan untuk mengetahui potensi ekstrak etanol daun putri malu (Mimosa pudica L) sebagai antihiperglikemia melalui penurunan kadar glukosa darah dan malondialdehide (MDA) tikus putih galur Wistar yang diinduksi streptozotocin. Uji penurunan glukosa darah dan malondialdehide menggunakan 24 ekor tikus Wistar yang dibagi menjadi 6 kelompok yaitu tiga kelompok kontrol dan tiga kelompok perlakuan dengan beragam dosis ekstrak daun putri malu. Dosis yang digunakan pada masing-masing kelompok perlakuan adalah 50, 100, dan 150 mg/kg BB. Kondisi hiperglikemia pada hewan uji dibuat dengan induksi streptozotocin dosis 40 mg/kg BB. Hasil penelitian menunjukkan bahwa ekstrak etanol daun putri malu dapat menurunkan kadar glukosa darah tikus Wistar hiperglikemik dengan dosis 50, 100, 150 mg/kgBB sebesar 45.97, 62.07, 75.27 mg/dL dan penurunan kadar malondialdehide sebesar 2.59, 5.01, 6.01 ?M terhadap kontrol negatif. Perbedaan penurunan rerata kadar glukosa darah dan MDA ini dianalisis dengan metode One Way ANOVA dan didapatkan hasil bahwa semua data dari setiap kelompok memiliki perbedaan yang signifikan. Hasil Analisis LC-MS/MS ekstrak etanol daun putri malu teridentifikasi 8 senyawa. Dari 8 senyawa yang teridentifikasi, luteolin dan apigenin merupakan senyawa yang diketahui berperan sebagai antihiperglikemia. ABSTRACT: The purposes of this research are to determine the potential of Mimosa leaves (Mimosa pudica L) ethanol extract as the antihyperglycemic agent by reducing blood glucose and malondialdehyde (MDA) levels of streptozotocin-induced white rats of Wistar strain. Tests for reducing blood glucose and malondialdehyde used 24 Wistar rats which were divided into 6 groups, namely three control groups and three treatment groups with various doses of mimosa leaf extract. The doses used in each treatment group were 50, 100, and 150 mg/kg BW. Hyperglycemic conditions in test animals were made by induction of streptozotocin at a dose of 40 mg/kg BW. The results showed that the ethanol extract of mimosa leaves could reduce blood glucose levels of hyperglycemic Wistar rats with doses of 50, 100, 150 mg/kg BW by 45.97, 62.07, 75.27 mg/dL and a decrease in malondialdehyde levels by 2.59, 5.01, 6.01 µM against negative controls. The difference in the average decrease in blood glucose and MDA levels was analyzed by the One Way ANOVA method and the results showed that all data from each group had significant differences. The results of the LC-MS/MS analysis of the ethanol extract of the mimosa leaves identified 8 compounds. Of the 8 compounds identified, luteolin and apigenin are compounds known to act as antihyperglycemic agents.

Co-Authors A. A. N. G. W. Pramantha Adnyana , I Made Dwi Mertha Ana Malia Anak Agung Istri Agung Mayun Laksmiwati Aryanu Fahmi Arwangga Desmon Tutu Bili E. Sahara Egi Azikin Maulana Eti Meirina Brahmana Eti Meirina Brahmana Henny Puspa Dewi Giri I Gede D. Yudha Partama I Gusti Ayu Kunti Sri Panca Dewi I Gusti Bagus Teguh Ananta I K. D. Yasa I M. Adi Setiawan I M. O. A. Parwata I Made Dira Swantara I Made Wisnu Adhi Putra I Nyoman Mika Adi Santosa I Nyoman Suarsana I W. A. Kartika I W. G. Gunawan I Wayan Sudiarta I Wayan Suirta I. A. Gede Widihati Ida Bagus Swardana Irdhawati Irdhawati James Sibarani Jeane, Magda Juniari, Tjokorda Istri Trisna K. Swandiyasa Ketut Ratnayani Liana Sari Made Arsa Mahardika Aprilia Iflahah Manuntun Manurung Mariance Thomas Miftakul Sururi N. K. D. M.S. Wahyuni N. M. Desi Ariani N. P. Widya Astuti N. W. Bogoriani N.K. Sinarsih Ni Kadek Dyan Mustika Sri Wahyuni Ni Luh Gede Sudaryati Ni Luh Indra Dewi Senisk Ni Luh Yuli Damayanti Ni Made Puspawati Ni Made Suaniti Ni Made Yuliari Ni Putu Widayanti Ni Wayan Oktarini A.C.Dewi Putu Lakustini Cahyaningrum Putu Suarya Putut Dewantha Jenar S. R. Santi Sri Rahayu Santi Sri Wahjuni W. S. Rita W. S. Rita W.S. Rita WAHYU DWIDJANI S Wiwik Susana Rita WIWIK SUSANAH RITA Yudha Taufantri

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