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All Journal Jurnal Psikologi Perseptual Adi Widya : Jurnal Pengabdian Masyarakat Jurnal Kesehatan Prima Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Biomedika Jurnal Psikohumanika Budimas : Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Kesehatan Tambusai Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) Jurnal Pengabdian Mandiri Conference on Innovation in Health, Accounting, and Management Sciences Proceeding Jurnal Medicare

Gunawan, Lucia Sincu

Fakultas Ilmu Kesehatan, Universitas Setia Budi, Jl. Letjen Sutoyo,Mojosongo, Surakarta

Author-ID : 2437970

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Uji Kadar Anti-HBs pada Balita Penerima Imunisasi Dasar Lucia Sincu Gunawan; Ratna Herawati
Biomedika Vol 10 No 2 (2017): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Hepatitis B merupakan masalah kesehatan global, diperkirakan sekitar 2 miliar penduduk dunia pernah terpapar virus Hepatitis B (HBV). Angka prevalensi infeksi HBV di Asia Pasifik cukup tinggi, yaitu melebihi 8% dan penularannya umumnya terjadi secara vertikal (pada periode perinatal) dan horizontal (pada masa anak-anak) sehingga risiko menjadi infeksi yang kronis menjadi cukup besar. Pencegahan dengan vaksinasi merupakan strategi terpenting untukmenurunkan risiko infeksi virus hepatitis B kronis dan komplikasinya. Antibodi anti-HBs berdasarkan pengukuran antibodi Anti HBs secara in vitro dengan menggunakan test diagnostik laboratorium secara imunologis. Titer antibodi hepatitis B ini dikatakan protektif bila titernya lebih dari 10mIU/ml. Pada penelitian ini dilakukan pemeriksaan kadar anti-HBs secara semi kuantitatif pada anak balita penerima imunisasi dasar yang lengkap, menggunakan rapid test dan dilakukan pengenceran pada serum dengan serokonversi positif. Diperoleh serum dari 23 balita yang memenuhi syarat dan dari hasil pemeriksaan anti-HBs didapatkan 20 anak (87%) dengan serokonversi positif dan 3 anak (13%) dengan serokonversi negatif. Untuk serum dengan serokonversi positif, maka selanjutnya dilakukan pemeriksaan serum dengan pengenceran, hasilnya 4 sampel (20%) negatif pada pengenceran 1:2, 3 sampel (15%) positif sampai pengenceran 1:2 saja, 5 sampel (25%) positif sampai pada pengenceran 1:4, 4 sampel (20%) positif pada pengenceran 1:6, 2 sampel(10%) positif pada pengenceran 1:8 dan 2 sampel (10%) tetap positif pada pengenceran 1:10.

Perbandingan Hasil Pemeriksaan Hemoglobin Metode Azidemet Hemoglobin dan Cyanide-Free Estu Sami Asih; Diah Pramudianti; Lucia Sincu Gunawan
Biomedika Vol 11 No 1 (2018): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Hemoglobin (Hb) adalah komponen utama sel darah merah atau eritrosit yang terdiri dari heme dan globin. Pemeriksaan Hb otomatis dapat dilakukan diantaranya dengan metode Azidemet Hb pada alat Point Of Care Testing (POCT) dan metode Cyanide-free pada alat Hematology Analyzer. Penelitian untuk mengetahui perbedaan hasil pemeriksaan Hb metode Azidemet Hb dan Cyanide- free. Penelitian bersifat observasi analitik cross sectional, dilakukan pada 78 sampel menggunakan alat Quick Chek dan Cell Dyn Ruby di Instalasi Patologi Klinik Rumah Sakit Umum Daerah (RSUD) dr. Moewardi di Surakarta pada bulan Mei - Juni 2017, digunakan uji perbedaan Independent Sample T-Test dan Paired Sample T-Test dengan signifikansi 0,05 dan interval kepercayaan (IK) Karakteristik subjek penelitian mean ± Standard Deviation (SD) umur 51,6 ± 12,89 tahun, perempuan 50 (64,1 %), laki-laki 28 (35,9 %). Hasil mean ± SD kadar Hb metode Azidemet Hb (darah kapiler), Cyanide-free (darah vena), dan Azidemet Hb (darah vena) adalah 11,75 ± 1,65 g/dl, 11,57 ± 1,77 g/dl, dan 11,43 ±1,65 g/dl. Tidak ada perbedaan yang signifikan (p = 0,51) hasil pemeriksaan Hb metode Azidemet Hb (darah kapiler) dan Cyanide-free (darah vena). Ada perbedaan yang signifikan (p = 0,01) hasil pemeriksaan Hb metode Azidemet Hb (darah vena) dan Cyanide-free (darah vena). Metode Azidemet Hb disarankan hanya digunakan untuk sampel darah kapiler, perlu penelitian lebih lanjut dengan metode dan jenis sampel yang lain. Kata kunci : Hemoglobin, metode Azidemet Hb, metode Cyanide-free

Korelasi antara Neutrophyl Lymphocyte Ratio dengan Stadium Kanker pada Pasien Kanker Payudara Irma Ningsih Yuvita Fallo; Rina A. Sidharta; Lucia Sincu Gunawan
Biomedika Vol 11 No 2 (2018): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Kanker payudara merupakan salah satu kanker penyebab kematian pada wanita. Banyak wanita yang menyadari terserang kanker payudara setelah kanker masuk pada stadium lanjut, sehingga tidak ada proses deteksi dini yang dapat meningkatkan peluang kesembuhan dengan tata laksana di awal penyakit. Stadium kanker payudara meliputi; Stadium I, II, IIIA, IIIB dan IV. Peningkatan Neutrophi lLymphocyte Ratio (NLR) dikaitkan dengan peningkatan kematian pada keganasan kanker payudara.Tujuan penelitian ini adalah untuk mengetahui korelasi antara NLR dengan stadium kanker pada pasien kanker payudara. Teknik pengambilan sampel pada penelitian ini adalah concecutive sampling. Pasien diambil sesuai dengan kriteria inklusi dan eksklusi, diurutkan sampai jumlah sampel terpenuhi. Besar sampel pada penelitian ini adalah 55 sampel. Waktu penelitian dilakukan pada bulan April – Juni 2018 di Rumah Sakit Umum Daerah Dr. Moewardi di Surakarta. Sumber data penelitian ini adalah data sekunder yang diperoleh dari rekam medis laboratorium Patologi Klinik danlaboratorium Patologi Anatomi pasien yang terdiagnosis kanker payudara dan teknik analisis data menggunakan uji Kolmogorov Smirnov kemudian dilanjutkan dengan uji Spearman. Hasil penelitian yang diperoleh menunjukkan correlation coefficient (r) sebesar 0,350, probabilitas (p) sebesar 0,009. Maka, nilai ini menunjukkan korelasi yang lemah, positif dan bermakna antara NLR dengan stadium kanker payudara. Perlu dilakukan penelitian selanjutnya menggunakan data primer, sehingga dapat mengetahui faktor-faktor yang mempengaruhi peningkatan NLR. Kata Kunci : Neutrophyl Lymphocyte Ratio, Stadium kanker, Kanker payudara

Seroprevalensi, Pengetahuan, dan Sikap Preventif Hepatitis B Virus (HBV) Pada Mahasiwa Ahli Teknologi Laboratorium Medik di Surakarta Rumeyda Chitra Puspita; Lucia Sincu Gunawan
Biomedika Vol 12 No 1 (2019): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Health workers, especially students of the Medical Laboratory Technology (MLT) have a greater risk of contracting hepatitis B virus infection from exposure to body fluids when doing clinical labs. The importance of seroprevalence, knowledge and attitudes greatly influences students when doing practicum as a preventive measure for hepatitis B infection. This study aims to identify MLT student’s seroprevalence, knowledge and preventive attitudes towards hepatitis B virus infection. This research is a quantitative descriptive study using a cross-sectional study design carried out in one of the health universities in Surakarta in October - November 2018. Subjects were taken using total sampling techniques with a total of 71 students study in D-IV Medical Laboratory Technology. Data collection was done by questionnaire about knowledge, and preventive attitude of hepatitis B infection in students and blood samples collected and screened with HBsAg examination. Data analysis using computerization with SPSS version 21. The results showed that MLT students had good knowledge of 80.3%, good preventive attitudes of 97.2%, and seroprevalence of 1.4% of students with positive HBsAg. Knowledge and preventive attitudes of MLT students fall into the good category. Seroprevalence of D-IV MLT students showed poor results. It is expected that the higher education institution to carry out HBsAg examination as a college entry requirement, so that it can reduce work risks and can improve work safety as medical personnel.

Korelasi Rasio Aspartate Aminotransferase - Alanine Aminotransferase dengan Profil Hematologi pada Peminum Alkohol Lucia Sincu Gunawan
Biomedika Vol 12 No 1 (2019): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Toxicity due to alcohol is the most common cause of liver disease and ranks health resources worldwide. In developed countries, alcohol is the main cause of cirrhosis (PalP and Ray S, 2016). People who consumes a lot of alcohol will tend to have haematological dan bone marrow’s problems, where blood is produced. The bad effects of alcohol on blood cell production occur directly or indirectly. The direct effects of excessive alcohol consumption are toxic effects on the bone marrow, red blood cells, mature erythrocyte cells, leukocytes and platelets. The indirect effect of alcohol consumption is a nutritional deficiency that can disturb production and function of various blood cells. (Ifeanyi O.E, et al, 2014). In this study, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), haemoglobin, erythrocytescounts, leukocytes counts, platelet counts, haematocrit and Protrombine Time (PT) and Activated Partial Thromboplastin Time (APTT) in 30 alcoholic malesat 20-50 years old were examined. From 30 respondents, haemoglobin data, the number of erythrocytes, the number of leukocytes, the number of platelets, haematocrit, PT, aPTT, AST, ALT were obtained and the ratio was also calculated. The results of the Spearman test, the AST/ALT ratio data with haemoglobin levels (p = 0.741), AST/ALT ratio with erythrocyte count (p = 0.778), AST/ALT ratio with leukocyte count (p = 0.472), AST/ALT ratio with platelet count (p = 0.95), AST/ALT ratio with haematocrit (p = 0.88), AST/ALT ratio with PT (p = 0.757), AST/ALT ratio with aPTT (0.352). There was no significant difference between the AST/ALT ratio and the haematological profile in alcohol drinkers (p> 0.05). The importance of paying attention to diet as part of a disease prevention.

Perbedaan Derajat Aglutinasi Uji Golongan Darah Berdasarkan Teknik Penanganan Sampel dalam Pembuatan Suspensi Sel Darah Merah Lucia Sincu Gunawan; Rumeyda Chitra Puspita
Biomedika Vol 12 No 2 (2019): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Pre transfusion testing is a very essential part of blood transfusion procedure. In some types of pretransfusion test, suspension of red blood cells is required. This cell suspension is made to optimize the antigen-antibody reaction so that the on going reaction can be clearly observed. The practice of determining blood type needs a suspension of red blood cells, which its washing phase is a time-consuming. The type of sample used can be whole blood with anticoagulants or frozen blood samples. Due to time constraints, the standard procedures were modified. This study aimed to determine the differences in the degree of agglutination of blood type testing based on the handling samples’ techniques in the manufacture of red blood cell suspensions. Blood group testing was done by the tube method on venous blood samples with different sample handling techniques: frozen blood samples without anticoagulants with storage, fresh blood samples with direct addition of 0.9% NaCl, and EDTA anticoagulant blood samples with refrigerator storage 8 - 24 hours at 40C. The number of samples for each type of treatment is 30 samples, and an assessment of the degree of agglutination in the blood group test is carried out by 2 analysts. There were differences in the mean degree of aglutination between the 3 suspensi-making techniques with NaCl samples (Mean = 3.88; SD = 0.32), frozen samples (Mean = 3.93; SD = 0.25), and EDTA samples (Mean = 3.98; SD = 0.13), but the mean differences was not statistically significant (p> 0.05), so it can be concluded that the three types of samples could be used to replace one another as a comparable sample alternative in making red blood cell suspension to measure ABO cell grouping method.

Perbedaan Jumlah Retikulosit Sebelum dan Sesudah Pemberian Tablet Tambah Darah Zefika Lutfi Ivana; Lucia Sincu Gunawan
Biomedika Vol 12 No 2 (2019): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Anemia is a condition where the number of red blood cells in the body is not fulfilled. Iron deficiency anemia in young women has to be taken seriously because it can cause the development disturbance. Reticulocyte is a parameter commonly used to determine the success of therapy in iron deficiency anemia, which showed the body’s physiologic response by enhancing the red blood cells production. This study aimed to find out the differences of reticulocyte count before and after administration of iron tablets on female students at Setia Budi University Surakarta. Using Randomized Control Trial, this study separated the subject randomly into control group and treatment group which received iron tablets for 7 days. The subjects were 40 female students at Setia Budi University in Surakarta. Reticulocyte count examination was carried out at the Setia Budi University Hematology Laboratory, using manual calculations with Brillant Cresyl Blue supravital staining. Data normality was tested with Saphiro Wilk and Independent t test were performed before and after 7 days administration of iron tablets between 2 groups. Reticulocyte count before supplementation in the treatment and control groups showed no significant difference (p = 0.084). After administration of iron tablets, reticulocyte count showed a significant difference (p = 0.005) between the control group and the treatment group. Effect Size exhibited p = 1.509 which meant that the effect of iron tablets supplementation was quite large. This study concluded there were significant differences in the reticulocytes count before and after the administration of iron tablets to the students of Setia Budi University, Surakarta. It is very important to take iron tablets regularly at recommended dose to prevent anemia in women of childbearing age.

Erythrocyte Morphology in Women of Reproductive Age (WORA) with Anemia Alex Jekson Tukira; Lucia Sincu Gunawan; Edy Prasetya
Biomedika Vol 13 No 1 (2020): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v13i1.613

Anemia is a decrease in the number of erythrocytes in the blood circulation or the level of hemoglobin that is less than normal. The three major body mechanisms that cause anemia are excessive destruction of erythrocytes, blood loss, and decreased erythrocyte production. Based on the Basic Health Research (Riskesdas) in 2013, the prevalence of anemic women of reproductive age (WORA) aged 15-44 years in Indonesia was 35.3%. Anemia is classified based on the morphology of erythrocytes, including hypochromic microcytic, normocytic normochromic, and macrocytic. Erythrocyte morphology can be observed using peripheral blood smear examination. The objective of this study was to determine the morphology of erythrocytes in anemic women of reproductive age. This study belongs to descriptive research. The population of the study was 136 women of reproductive age, covering the students of D-IV in Medical Laboratory Technology at Setia Budi University. Forty-one respondents suffering from anemia were taken using a purposive sampling technique. The types of anemia were determined with examination using an Easy Touch hemoglobinometer with the Hb level of less than 12g/dL. Preparation of peripheral blood smear examination using EDTA venous blood and stained with Giemsa. Microscopic examination was performed with 1000x objective magnification. The peripheral blood smear reading showed the erythrocyte morphology that includes normocytic normochromic (38 samples or 93%), microcytic hypochromic (three samples or 7%), and poikilocytosis consisting of teardrop cells, target cells, ellipstocytes, and stomatocytes (five samples or 18%). Further study is required to investigate the correlation of erythrocyte index and peripheral blood smear in anemia.

Co-Authors Afif Afghohani, Afif Alex Jekson Tukira Alfiana, Ina Ana Ines Kisnaini Anak Agung Gede Sugianthara Anita Nurfaiz Contriwati Indricuan Dewantara, Mahardira Dewi, Yulia Ratna Diah Pramudianti Dwi Nur Indah Sari Dwi Nur Indah Sari, Dwi Nur Indah Edy Prasetya Edy Prasetya Emma, Ismawatie Estu Sami Asih Hafizah, Dila Auli Ilham Kuncahyo, Ilham Irma Ningsih Yuvita Fallo Ismawatie, Emma Iswandi Iswandi KARSANTO, NARINDRO Kartinah Wiryosoenjoyo Khairunnisa, Salma Shabrina Khofifah Tasha Widya Martha Kunti Dewi Saraswati Livrança, Expedito José Oliveira Mactildis Yosefeni Mariandini Talnoni Mahayana, Argoto Narimo Narimo, Narimo Nur Hidayati Prasasti, Anin Prilya Shanty Andrianie Puspita, Rumeyda Chitra Putri, Hana Maylinda Rahmawati, Juvita Tri Rany Reynaldy Rina A. Sidharta RM Narindro Karsanto Rosita Yuniati, Rosita Rumeyda Chitra Puspita Rumeyda Chitra Puspita Soebiyanto, Soebiyanto Stevanus Zulkarnaen Wijaya Wara Sugiyarmasto Sugiyarmasto, Sugiyarmasto Sumardiyono Sumardiyono Sunardi Sunardi Sutopo, Salsa Tri Aprilia Putri Wahyuningsih, Sandra Tri Wiryosoendjoyo, Kartinah Yustinus Joko Dwi Nugroho Zefika Lutfi Ivana

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