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All Journal Widya Warta Krida Rakyat Psikodimensia: Kajian Ilmiah Psikologi Universa Medicina DIKEMAS (Jurnal Pengabdian Kepada Masyarakat) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JMK Jurnal Manajemen dan Kewirausahaan Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Buana Farma Dharmas Education Journal (DE_Journal) Psycho Idea Vision Science and Eye Health Journal MEDICINUS Joong-Ki
Andi Cahyadi
Universitas Widya Mandala Surabaya
Religion Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Risk factors of tumor lysis syndrome in childhood acute lymphoblastic leukemia Andarsini, Mia Ratwita; Hartono, Audylia; Cahyadi, Andi; Larasati, Maria Christina Shanty; Asmara, Almeir Pradhipta Andras
Universa Medicina Vol. 43 No. 3 (2024)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2024.v43.265-271

Abstract

BackgroundAcute lymphoblastic leukemia (ALL) is the most common childhood hematologic malignancy. Treatment failure in ALL can be caused by severe and life-threatening complications, including tumor lysis syndrome (TLS). Delay in identifying risk factors and establishing the diagnosis of TLS by clinicians can be fatal. This study aimed to determine the risk factors for TLS in children with ALL. MethodsThis was a retrospective cross-sectional study on 81 children aged 0 to 18 years with ALL. Tumor lysis syndrome comes in two forms: laboratory and clinical. Laboratory TLS occurs if uric acid levels >normal values, potassium >6mEq/L, phosphate >6.5mg/dl, and calcium <7mg/dl. Clinical TLS includes an increase in serum creatinine, the presence of heart attacks, sudden death, and seizures. Risk factors for TLS include age, nutritional status, leukocyte count, presence of organ infiltration, presence of mediastinal mass, uric acid level, renal function, and type of chemotherapy regimen. Risk factors were analyzed using simple and multiple logistic regression analyses. A value of p<0.05 indicates a significant risk factor. ResultsTwenty seven patients (33.3%) experienced TLS. Adjusted OR analysis showed that the presence of organ infiltration (aOR 5.42; 95% CI 1.45-20.27; p=0.012), leukocyte count (aOR 8.70; 95% CI 1.67-45.13; p=0.010), and decreased kidney function (aOR 12.21; 95% CI 1.09-136.89; p=0.042) were significant risk factors for TLS. ConclusionDecreased renal function, leukocyte count, and organ infiltration were significant risk factors for TLS. We suggest more vigilant assessment and monitoring to recognize and treat those patients who are at risk of TLS.
ANALISIS PENGARUH PEMASARAN DIGITAL YANG BERDAMPAK TERHADAP PENINGKATAN VOLUME PENJUALAN DISTRIBUTOR ALAT KESEHATAN Cahyadi, Andi; Sitanggang, Maura Linda; Hatta, Iha Haryani
Dharmas Education Journal (DE_Journal) Vol 4 No 2 (2023): DE_Journal
Publisher : Fakultas Keguruan dan Ilmu Pendidikan Univesitas Dharmas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56667/de_journal.v4i2.1162

Abstract

Tujuan penelitian ini dilakukan dalam rangka menganalisa pengaruh pendidikan digital marketing terhadap kepuasan customer yang berdampak langsung pada peningkatan volume penjualan. Secara teori peningkatan penggunaan internet seharusnya dapat menjadi peluang untuk melakukan promosi melalui tools digital maketing, tetapi kasus yang terjadi di perusahaan PT. X yaitu penurunan volume penjualan. Metode yang digunakan menggunakan metode analitik deskriptif. Teknik pengumpulan datanya menggunakan kuisioner. Populasi dan sampel penelitian sebanyak 85 responden, dan metode sampling yang digunakan yaitu purposive sampling sesuai kriteria inklusi dan eksklusi. Hasil penelitian menunjukkan bahwa sosial media, email marketing memiliki pengaruh signifikan terhadap kepuasan pelanggan dan website tidak memiliki pengaruh terhadap kepuasan pelanggan. Kepusaan pelanggan memiliki pengaruh signifikan terhadap peningkatan volume penjualan sedangkan email marketing dan sosial media tidak berpengaruh terhadap peningkatan volume penjualan.
Subconjunctival Hemorrhage as a Sign of Intraocular Retinoblastoma Progression to Orbital Retinoblastoma Jatikusuma, Anas; Lutfi, Delfitri; Cahyadi, Andi; Heriyawati
Vision Science and Eye Health Journal Vol. 4 No. 3 (2025): Vision Science and Eye Health Journal
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/vsehj.v4i3.2025.95-99

Abstract

Introduction: Retinoblastoma is the most common intraocular malignancy of childhood. While treatable when detected early, a delayed diagnosis can lead to orbital extension, which significantly worsens the prognosis. We report an unusual case in which a subconjunctival hemorrhage signaled the progression of intraocular retinoblastoma to orbital involvement. Case Presentation: A 2-year-4-month-old child presented with a one-month history of left-eye leukocoria. Ocular ultrasound and computed tomography (CT) confirmed features of an intraocular retinoblastoma (Group E), and urgent enucleation was planned. The surgery was delayed by two months; shortly before the operation, the child developed an inferonasal subconjunctival hemorrhage that rapidly expanded. During enucleation, a reddish-brown extrascleral tumor was discovered beneath the hemorrhage, indicating orbital extension. Histopathology revealed Grade 3 retinoblastoma with optic nerve invasion (resection margin free of tumor). Adjuvant chemotherapy was initiated postoperatively. Conclusion: Subconjunctival hemorrhage can be an unusual warning sign of orbital tumor extension in retinoblastoma. This case highlights the importance of raising awareness and reducing diagnostic delays, particularly in resource-constrained settings.
Psikoedukasi Anti Bully Sebagai Upaya Preventif Tindak Perundungan Tingkat Sekolah Dasar Dani, Robik Anwar; Setyawan, yonathan; Aryono, Marcella Mariska; Wicaksono, David Ary; Cahyadi, Andi
DIKEMAS (Jurnal Pengabdian Kepada Masyarakat) Vol 9 No 1 (2025)
Publisher : Politeknik Negeri Madiun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32486/dikemas.v9i1.902

Abstract

Perilaku bullying atau perundungan adalah tindakan maladaptif yang dilakukan oleh anak-anak, sehingga perilaku tersebut tidak bisa dianggap normal, karena akan memberikan dampak negatif kepada korban. Para korban perundungan akan merasa tertekan, tidak percaya diri, takut, khawatir, dan stress ketika datang ke sekolah. Solusi yang ditawarkan untuk permasalahan yaitu dengan menawarkan kegiatan psikoedukasi anti bully di sekolah dasar yang berada di wilayah Kota Madiun dengan harapan bahwa mitra Abdimas ini memiliki pengetahuan tentang bullying dan dapat menghindari praktek bullying di sekolah. Abdimas ini akan dilaksanakan dengan metode ceramah, presentasi, modeling, role play, dan small group discussion atau diskusi kelompok. Metode ceramah dipilih karena metode ini akan membuka pemahaman para peserta kegiatan untuk lebih memahami makna bullying, jenis-jenis bullying, dampak bullying, serta bentuk-bentuk tindakan pencegahan bullying yang dapat dilakukan. Selanjutnya metode presentasi dan small group discussiong adalah motode kombinasi yang dipilih dengan pertimbangan kedua metode ini dapat merangsang keaktifan para peserta kegiatan dalam mendiskusikan beberapa permasalahn bullying yang terjadi di sekolah, serta mencari jalan keluar dalam memecahkan kasus-kasus tersebut.
ANALISIS RASIONALITAS OBAT DIABETES MELITUS TIPE II DI UPT PUSKESMAS SAKETI PERIODE JULI-DESEMBER 2023 Santi, Santi Endrawati; Maimunah, Sariyati; Cahyadi, Andi
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1374

Abstract

Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic hyperglycemia, the treatment process must be carried out rationally, including correct diagnosis, correct patient, correct drug, correct dose, correct indication and correct time interval. This study aims to determine the rationality of the use of antidiabetic drugs at the Saketi Health Center UPT in the period July-December 2023. Retrospective data collection based on medical records using the Total sampling method was carried out on 138 samples that had met the inclusion and exclusion criteria. Data analysis using univariate analysis using the Microsoft Office Excel 2010 program, data was analyzed using the 2021 Perkeni literature and the Indonesian Ministry of Health 2019 for the rationality of 138 Diabetes Mellitus (DM) patients. Patient characteristics in the form of gender, there is a percentage of women 99 (72%) and men 39 (28%), Diabetes Mellitus (DM) which often occurs in the age range of 46-65 years with 110 cases (80%) The percentage of rationality of the use of diabetes mellitus drugs in patients with the right diagnosis is 138 patients 100%, right patients 138 100%, right drug selection 26 (19%) patients, wrong drug selection 112 (81%), right indication 138 patients 100%, right dose patients 138 100% and interval time of administration 138 patients.
Comparison of Proliferation and Apoptosis in CD34+ Lymphoblasts in Pediatric Acute Lymphoblastic Leukemia: invivo and exvivo Conditions Hernaningsih, Yetti; Cahyadi, Andi; Rusanti, Rahmi; Armayani, Erawati; Juwita, Syntia Tanu; Nur‘ Aini, Farida; Tanzilia, May Fanny; Nunki, Nastasya
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 32 No. 1 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v32i1.2389

Abstract

The proliferation and apoptosis assays have been utilized in numerous studies to develop new substances such as antineoplastic agents. Commonly, it was performed in ex-vivo conditions using the culture method. However, the cytotoxic or cytostatic effects observed ex vivo often differ from those in vivo. This study investigated differences in proliferation and apoptosis of lymphoblast between in vivo and ex vivo conditions of childhood ALL. This study was conducted on new childhood acute lymphoblastic leukemia (ALL) patients. Nineteen (19) subjects were recruited, comprising of 10 with favorable and 9 with unfavorable outcomes. The negative control came from 8 healthy children volunteers. All patients under went leukemia immunophenotyping, including CD34, to identify the phenotype. Bone marrow mononuclear cells (BMMCs) of patient groups were analyzed using apoptosis and proliferation assays, as well as the negative control group, and then compared to the in vivo condition. 12 out of 19 BMMC were cultured for 48 hours, and proliferation and apoptosis assays were performed in ex vivo conditions. The results showed that the proliferation, apoptosis, and apoptosis/proliferation (A/P) ratio of the patients in the ex vivo group were significantly higher than the in vivo group with p =0.000, p =0.050, and p =0.000, respectively. The proliferation was higher for patient groups than the control group, with p =0.001 and p =0.004, respectively. The apoptosis rates of the patient group were higher than the control group, with p =0.000 and p =0.002, respectively. The proliferation and apoptosis of lymphoblasts ex vivo are higher than in vivo.
Career Plan Strategy: Pendampingan Perencanaan Karir dan Peningkatan Entrepreneur skill pada siswa SMP Cahyadi, Andi; Aryono, Marcella Mariska; Wibisono, Haris
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 5 No. 4 (2024): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN) Edisi September - Desembe
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v5i4.4783

Abstract

Salah satu tugas perkembangan masa remaja adalah mempersiapkan karir mereka untuk masa depan yang lebih baik. Namun faktanya remaja seringkali belum memiliki arah yang jelas setelah lulus sekolah. Padahal, masa remaja adalah periode krusial untuk merencanakan masa depan, termasuk karir. Peneliti terdahulu menyatakan, banyak remaja yang belum merancang karir secara matang. Akibatnya, banyak lulusan bekerja tidak sesuai dengan bidang studinya. Berdasarkan hasil analisa lapangan yang dilakukan, ditemukan bahwa siswa-siswi di SMPK Slamet Riyadi Ponorogo kurang memiliki kesesuaian antara pekerjaan yang diinginkan dengan jurusan kuliah yang diinginkan. Permasalahan lain adalah beberapa siswa menginginkan menjadi entrepreneur, namun mereka belum bisa menjelaskan secara spesifik apa bisnis yang mereka inginkan. Responden dalam kegiatan ini adalah siswa kelas 8 dan 9 SMPK Slamet Riyadi ponorogo yang terdiri dari 32 siswa. Metode yang digunakan dalam kegiatan ini adalah adanya asesmen awal, pelatihan dan pendampingan. Hasil dari kegiatan ini adalah para siswa mendapatkan pemahaman yang lebih komprehensif terkait dengan pembuatan rancangan karir dan rencana bisnis. Berdasarkan hasil pre dan post test menyatakan terdapat peningkatan pemahaman yang signifikan secara statistik pada skor rata-rata pemahaman siswa SMP Katolik Slamet Riyadi baik dalam perencanaan karir maupun keterampilan kewirausahaan. Peningkatan skor dari 25,31 menjadi 30,13 untuk perencanaan karir, dan dari 23,25 menjadi 30,06 untuk keterampilan kewirausahaan. Hasil tersebut menunjukkan betapa pentingnya pelatihan dan pendampingan perencanaan karir dan bisnis diusia dini agar mereka lebih awal dapat merancang massa depan yang lebih baik.
The Influence of Motivation, Entrepreneurial Commitment, and Business Networks on the Sustainability of MSMEs Prasetyo, Vinsensius Widdy Tri; Cahyadi, Andi
JMK (Jurnal Manajemen dan Kewirausahaan) Vol 9 No 3 (2024): September
Publisher : Universitas Islam Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32503/jmk.v9i3.5147

Abstract

Business continuity as an important concept in determining the decision to continue business operations. The key to business sustainability includes economic and non-economic benefits for individuals, the economy and society. To survive, the pecel chili industry in Madiun City must have motivation, commitment, and business networks in running a business. The purpose of this article is to examine the important role of motivation, entrepreneurial commitment, and business networks and their influence on business sustainability, a study on Sambal Pecel MSMEs in Madiun City. This study uses a quantitative method to prove the influence of the variables studied. The unit of analysis for this study was the Sambal Pecel in the Madiun City area with a total of 57 Sambal Pecel respondents. Entrepreneurial motivation, entrepreneurial commitment, and business networks have an important role in the sustainability of Sambal Pecel in Madiun City. This is as evidenced by the results of multiple linear regression analysis which has proven the results of the significant influence of entrepreneurial motivation, entrepreneurial commitment, and business networks on the sustainability of the Sambal Pecel in Madiun City.
Lansia Tangguh: Pendampingan Lansia Benteng Gading Mater Dei Madiun Aryono, Marcella Mariska; Cahyadi, Andi; Wicaksono, David Ary; Dani, Robik Anwar; Setyawan, Yonathan
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 5 No. 1: November 2025
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joongki.v5i1.13789

Abstract

Pada usia Indonesia yang hampir mencapai 80 tahun saat ini, bangsa ini telah mencapai tahap di mana populasinya berangsur-angsur menua. Sesuai perkiraan Kementerian Kesehatan, pada tahun 2025 jumlah penduduk di Indonesia yang akan dicap lanjut usia adalah sekitar 1,2 milyar. Lansia merupakan kelompok usia yang memiliki ketergantungan terhadap kelompok usia produktif. Dengan presentase yang cukup besar, secara tak langsung, memiliki dampak sosial dan ekonomi, baik bagi individu, keluarga, maupun lingkungan sosial. Lansia merupakan kelompok penduduk yang rentan dan sedikitnya ada tiga faktor utama yang menyebabkan kelompok lansia rentan, yaitu tidak lagi produktif secara ekonomi, masalah kesehatan, dan membutuhkan pendamping sebagai pengasuh. Permasahan ini juga terjadi pada para lansia di Paguyuban Benteng Gading Mater Dei Madiun. Meskipun mereka memiliki cukup banyak kesibukan dalam kegiatan gereja, namun tidak sedikit yang juga masih mengeluhkan permasalahan-permasalahan yang terjadi pada masa lansia ini. Oleh karena itu, program pendampingan ini dilakukan sehingga dapat membuat para lansia ini menjadi Lansia yang Tangguh sehingga dapat mampu menghadapi permasalahan-permasalahan di masa lansia. Kegiatan pendampingan yang telah dilakukan tersebut mendapatkan respon yang positif dari para lansia yang ada di Paguyuban Lansia Benteng Gading Mater Dei Madiun. Pendampingan ini sangat mengedukasi dan sangat bermanfaat bagi para lansia agar mereka dapat menjadi lansia yang Tangguh sehingga tidak merasakan kesepian dan stress dikarenakan tinggal sendirian.
Co-Authors Apollo - Armayani, Erawati Aryono, Marcella Mariska Asmara, Almeir Pradhipta Andras Bambang Permono David Ary Wicaksono Endrawati, Santi Haris Wibisono Hartono, Audylia Herdina Tyas Leylasari Heriyawati IDG Ugrasena Iha Haryani Hatta Jatikusuma, Anas Juwita, Syntia Tanu Larasati, Maria Christina Shanty Lutfi, Delfitri Maimunah, Sariyati Maria Christina Shanty Larasati Mia Ratwita Andarsini Muhammad Faizi Nengcy Erlina Tasik Rerung Nunki, Nastasya Nur Rochmah Nur‘ Aini, Farida Prasetyo, Vinsensius Widdy Tri Rahmi Rusanti, Rahmi Riefka Cahyanita Rahayuning Tyas Robik Anwar Dani Setyawan, Yonathan Sitanggang, Maura Linda Tanzilia, May Fanny Yetti Hernaningsih