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All Journal Jurnal Teknologi Dan Industri Pangan VALENSI ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Sains Materi Indonesia Microbiology Indonesia Majalah Ilmiah Ekonomi Komputer Jurnal Penelitian Hasil Hutan Agrointek Majalah Kulit, Karet, dan Plastik Jurnal Industri Hasil Perkebunan Indonesian Journal of Chemical Science INDONESIAN JOURNAL OF ESSENTIAL OIL Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Indonesian Journal of Chemistry Biosaintifika: Journal of Biology & Biology Education Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Jurnal Ilmu Kefarmasian Indonesia Jurnal Penelitian Hasil Hutan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pijar MIPA Makara Journal of Science JURNAL REKAYASA KIMIA & LINGKUNGAN
Tun Tedja Irawadi
Chemistry Department, Faculty Of Mathematics And Natural Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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REKAYASA PROSES SINTESIS PIPERONAL DARI KULIT LAWANG (Cinnamomum culilawan Blume) SEBAGAI PREKURSOR OBAT KANKER Imanuel Berly Delvis Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas'ud
Jurnal Penelitian Hasil Hutan Vol 34, No 3 (2016): Jurnal Penelitian Hasil Hutan
Publisher : Pusat Penelitian dan Pengembangan Hasil Hutan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2016.34.3.217-229

Abstract

Piperonal as a precursor of cancer drug (Curcumin analogues) can be synthesized from extract of lawang’s bark (Cinnamomum culilawan Blume) with multiple stages, among others: isolation of  essential oils, isolation safrole, safrole isomerization, and synthesis of piperonal. Essential oils were isolated from the bark of lawang (the water content of 46.2%) using a water distillation system with 1/3 volume of high boiler for five hours. Isolation of safrole from lawang bark oils was performed using NaOH solution and purified using reduced pressure distillation system at a temperature of 90-123°C / 1 mmHg. The safrole isomerization was undergone using alkali catalyst (KOH) without solvent at a temperature of 120°C for 8 hours. Oxidation of isosafrol was performed using KMnO4 in acidic conditions using a KTF tween 80 at a temperature below 30°C, and purified using silica gel. Results of isolation yield 0.94% with 14 components were determined through GC-MS, including 67.35% eugenol, safrole 13.96%, 12.61% methyl eugenol, 4-terpineol sineol 1.79% and 1.55%. The isolated safrole yield of 17.21% with purity testing and identification using FTIR, 1H- NMR and GCMS confirmed the product was safrole. The isomerization obtained yield of 77.56% with GC analysis indicated compounds of  cis-isosafrole and trans-isosafrole. The results of  oxidation obtained yield of  65.63% with a purity of 100% by GCMS and the 1H-NMR indicated the product is piperonal.
UJI AKTIVITAS ANTIBAKTERI FRAKSI ETIL ASETAT DAUN TANAMAN BANDOTAN (Ageratum conyzoides L) Taufan H Sugara; Tun Tedja Irawadi; Irma Herawati Suprapto; Muhammad Hanafi
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 1 No 1 (2016): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1008.791 KB) | DOI: 10.36387/jiis.v1i1.34

Abstract

Pemanfaatan tanaman bandotan (Ageratum conyzoides L.) untuk penyembuhan luka dan gangguan pencernaan seringkali dikaitkan dengan aktivitas antibakteri yang dimiliki. Namun demikian, informasi tentang aktivitas antibakteri tanaman ini masih sebatas pada fraksi polar dan non polar saja. Oleh karena itu, tujuan dari penelitian ini adalah untuk mengetahui aktivitas antibakteri fraksi semi polar daun tanaman bandotan terhadap bakteri Staphylococcus aureus and Eschirichia coli. Hasil uji fitokimia menunjukkan bahwa ekstrak etil asetat daun tanaman bandotan mengandung senyawa flavonoid, steroid, p-hidrokuinon dan terpenoid. Fraksinasi ekstrak etil asetat dengan eluen kloroform : metanol (9:1) menghasilkan 8 fraksi dengan jumlah rendemen berturut-turut sebanyak 15,14g; 22,21g; 21,19g; 20,44g; 5,79g; 4,50g; 1,40g; 1,43g; dan 0,93g. Ekstrak etil asetat dan seluruh fraksi yang terkandung di dalamnya menunjukkan aktivitas antibakteri berspektrum luas dengan daya hambat yang tergolong dalam kategori kuat.  Rata-rata daya hambat ekstrak etil asetat dan fraksi 1-8 terhadap S. aureus berturut-turut sebesar 14mm; 12mm; 12,5mm; 15,5mm; 16mm; 12mm; 11,5mm; 10mm; 9,5mm. Sedangkan rata-rata daya hambat ekstrak etil asetat dan fraksi 1-8 terhadap E. coli berturut-turut sebesar 11mm; 11,5mm; 11mm; 11,5mm; 13mm; 14mm; 10,5mm; 10mm; 9,5mm.Kata kunci: Daun tanaman bandotan, ekstrak etil asetat, antibakteri.
Isolasi dan Elusidasi Struktur Kimia Antimikroba yang Dihasilkan Oleh Aktinomisetes Laut Rofiq Sunaryanto; Bambang Marwoto Irawadi; Tun Tedja Irawadi; Zainal Alim Mas’ud; Liesbetini Hartoto
Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Vol 5, No 1 (2010): Juni 2010
Publisher : Balai Besar Riset Pengolahan Produk dan Bioteknologi Kelautan dan Perikanan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15578/jpbkp.v5i1.422

Abstract

Isolasi senyawa aktif dari aktinomisetes laut yang memiliki aktivitas antimikroba telah dilakukan. Isolasi aktinomisetes dilakukan dengan pengenceran dan praperlakuan sampel dengan cara pemanasan dan pengasaman. Sampel diambil dari sedimen laut di 6 titik lokasi Pantai Anyer, Banten. Dari total 29 isolat yang diperoleh, isolat A32 merupakan isolat terpilih untuk penelitian lebih lanjut. Isolat A32 memiliki aktivitas antimikroba terhadap Staphylococcus aureus ATCC25923 dan Candida albican BIOMCC00122. Elusidasi struktur kimia menggunakan ESI-LCMS, 1 HNMR, dan COSY menunjukkan bahwa senyawa aktif tersebut memiliki bobot molekul 501,2 g/mol dan rumus molekul C26H35N3O7. Diduga senyawa ini termasuk dalam golongan makrolakton virginiamycin yaitu Madumycin I.
Optimasi Produksi Hydroxy Octadecadienoic Acid (HODE) dari Kapang Endofit Culvularia lunata BioMCC FE-00283 dengan Metode Respon Permukaan ERWAHYUNI ENDANG PRABANDARI; TUN TEDJA IRAWADI; WAHONO SUMARYONO; KHASWAR SYAMSU
JURNAL ILMU KEFARMASIAN INDONESIA Vol 9 No 1 (2011): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1692.642 KB)

Abstract

Hydroxyl octadecadienoic acid (HODE) is an oxidized aliphatic fatty acid from the oxylipins group, which shows bioactivity and can be produced by Curvularia lunata BioMCC FE-00283 by submerged fermentation. Glucose, monosodium glutamate, and corn oil were media components that showed significant effect toward HODE production by C. lunata BioMCC FE-00283. Composition optimization of these three medium components was carried out by Response surface methodology (RSM). A full factorial central composite design (CCD) was used to explain the interaction effect between media components. Maximum HODE production as predicted by the quadratic model have chromatogram area of 4540000, which was verified experimentally to be 1091338 ± 152489. Eventhough experimental veriiication showed lower result compared to the model prediction, however it was higher compared to the HODE production using basal media with unoptimized composition of carbon, nitrogen, and inducer which only have chromatogram area of 295045 ± 71200. The verification also showed that optimization increased HODE production by 3.7 fold compared to that produced by the unoptimized media.
Performance of Zinc-Difattyalkyldithyocarbamate as Anti-Friction/Anti-Wear Lubricant Additives Komar Sutriah; Zainal Alim Mas’ud; Tun Tedja Irawadi; Mohammad Khotib
Indonesian Journal of Chemistry Vol 14, No 1 (2014)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (592.03 KB) | DOI: 10.22146/ijc.21271

Abstract

Dithyocarbamate is an organosulphur compound that has long been known and widely applied in various fields, including in agriculture and industry. Several variants of synthesized vegetable oil-based Zinc-difattyalkyldithyocarbamate were tested its anti-friction/anti-wear performance on four ball machine using the method of ASTM-D2783. Anti-friction/anti-wear test to six of additive variants of Zinc-difattyalkyldithyocarbamate at doses of 1.2% indicated that all variants of the product has welding point value higher than the lube base oil lubricant HVI 60, and from US Steel 136 standard for Hydraulic lubricants, but only two additive variants of Zinc-bis(lauryl palmityl)dithyocarbamate and Zinc-bis(lauryl oleyl)dithyocarbamate which has a larger load wear index value than the standard, and meet the criteria as an additive extreme pressure according to US steel 136 standard. Zinc-bis(lauryl palmityl)dithyocarbamate is an additive variant with the best performance, meet bi-functional lubricant additives criteria, as anti-friction/anti-wear and antioxidant additive.
SYNTHESIS OF ZINC-DIFATTYALKYLDITHIOCARBAMATES AND THEIR ANTIOXIDANT ACTIVITIES Komar Sutriah; Zainal Alim Mas’ud; Tun Tedja Irawadi
Indonesian Journal of Chemistry Vol 12, No 2 (2012)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (444.768 KB) | DOI: 10.22146/ijc.21362

Abstract

Zinc-difattyalkyldithiocarbamates are organosulfur compounds with many functions, including as an antioxidant in a lubrication system. They were synthesized by reacting secondary fatty amine with ZnCl2 and CS2 giving result zinc-difattyalkyldithiocarbamates of around 77-87%. The synthesized products were characterized using infrared (IR) spectroscopic techniques. The IR spectra of zinc-difattyalkyldithiocarbamates showed sharp bands at 1450-1550 cm-1 for thioureida v (C-N), 950-1050 cm-1 for v (C-S), and in the far-red area 300-400 cm-1 for sulfur-metal bond. Products recovery was evaluated by AAS and the purity was analyzed by HPLC. Seven variants of zinc-difattyalkyldithiocarbamates were obtained. Antioxidant activity was evaluated by rancimat test regarding their induction time. At 125 ppm levels all variants showed higher value in each of their induction time as compared to those of butylated hydroxyanisole and butylated hydroxytoluene, commercial antioxidants No.1, and commercial antioxidants no.2. Three variants, i.e. Zn-bis(dilauryl)dithiocarbamate, Zn-bis(laurylpalmityl)dithiocarbamate, and Zn-bis(laurylstearyl)dithiocarbamate had higher values in their induction time than the other variants. The values are 16.67, 26.54, and 16.11 h, respectively.
Reaction Products of Crude Palm Oil-based Fatty Acids and Monoethanolamine as Corrosion Inhibitors of Carbon Steel Ali, Mohamad Makrus; Irawadi, Tun Tedja; Darmawan, Noviyan; Khotib, Mohammad; Mas’ud, Zainal Alim
Makara Journal of Science Vol. 23, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Herein we report the application of the reaction products of crude palm oil-based fatty acids and monoethanolamine as sustainable corrosion inhibitors in acidic environments for carbon steels. Reaction products were identified based on FTIR analysis as a mixture of 2-aminoethyl fatty esters and N-(2-hydroxyethyl) fatty amides. Corrosion inhibition effect of these compounds was evaluated by potentiodynamic polarization techniques in 0.5 M HCl. The mixture of fatty esters and fatty amides showed promising potential as an alternative corrosion inhibitor. Inhibition efficiency was found to be 80% at 80 ppm. Thermodynamic and kinetic parameters obtained from the tafel plot displayed an increase in activation energy with a higher inhibitor concentration that led to the decrease in the corrosion rate. Furthermore, physisorption interaction was found to be the main process of the inhibitor’s adsorption on metal surfaces and obeyed the adsorption model of the Langmuir isotherm.
Isolation and Characterization of Cellulose Whiskers from Lampung Sugarcane Bagasse, Indonesia Afifi, Muhammad Ridho; Aini, Zahratul; Irawadi, Tun Tedja; Purwaningsih, Henny
Jurnal Pijar Mipa Vol. 20 No. 5 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i5.9371

Abstract

Sugarcane bagasse, the fibrous residue from sugar production, is an abundant agricultural waste in Indonesia, especially in Lampung, one of the country’s leading sugarcane-producing provinces. Its high lignocellulosic content makes it a promising alternative source of cellulose. However, effective extraction and conversion into high-value products such as cellulose whiskers require optimized chemical processes. This study aims to isolate cellulose from sugarcane bagasse using alkali and peroxide treatments and convert it into cellulose whiskers through hydrolysis using sulfuric acid (H₂SO₄) at varying concentrations (4–12 M). The objective is to evaluate the optimal acid concentration that produces cellulose whiskers with desirable morphology and crystallinity. Cellulose isolation was achieved through sequential NaOH and H₂O₂ treatments, significantly reducing lignin and hemicellulose content and yielding α-cellulose at 88.37%. Hydrolysis of the purified cellulose was then performed with H₂SO₄. The resulting materials were characterized using FTIR, SEM, XRD, and TGA. FTIR confirmed the removal of non-cellulosic components, while SEM showed that only 10 M H₂SO₄ produced well-defined whiskers with nanoscale dimensions (200–700 nm in length and 10–50 nm in diameter). Lower acid concentrations resulted in incomplete hydrolysis, while excessive degradation occurred at 12 M. XRD analysis revealed an increase in crystallinity to 86.7%, indicating the removal of amorphous regions and successful formation of crystalline whiskers. TGA analysis showed different thermal degradation patterns between isolated cellulose and whiskers, supporting structural transformation. Cellulose whiskers can subsequently be utilized as a reinforcing material in the fabrication of plastic films for water–oil separation and dye adsorption applications in laboratory experiments.
The Heat Resistant Capabilities of Bioplastic Composites on Sago Hampas Starch-Al2O3 Amatullah, Afra Najiyah; Kemala, Tetty; Irawadi, Tun Tedja
Jurnal Rekayasa Kimia & Lingkungan Vol 17, No 2 (2022): Jurnal Rekayasa Kimia & Lingkungan (December, 2022)
Publisher : Chemical Engineering Department, Syiah Kuala University, Banda Aceh, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23955/rkl.v17i2.25520

Abstract

Sago hampas are a waste with a high starch content. The starch from sago hampas can be used as a raw material for bioplastics. However, because bioplastics have a lower heat resistance than conventional plastics, additives are required to increase heat resistance. Aluminum oxide can be used as a metal compound that acts as an additive to increase heat resistance. Bioplastics were created using a weight percentage of 0, 1, 3, and 5% Al2O3. DTA was used to determine the melting point of bioplastics, as well as their mechanical properties, density, and water resistance. The best results were identified using FTIR and SEM. The results showed that adding Al2O3 at 1, 3, and 5% increased the heat resistance of bioplastics with melting points of 270, 274, and 280 oC. Except for mechanical properties, the best results were obtained with a melting point of 280 oC, tensile strength of 3.41 Mpa, elongation of 38.66%, density of 5.52 g cm-3, and 80.28% water resistance for bioplastics with 5% Al2O3 that suitable on Indonesian National Standard 7188.7:2016. The FTIR analysis revealed that bioplastics containing Al2O3 experienced physical interactions. Morphological analysis revealed that Al2O3 was evenly distributed on the bioplastic's surface.
Co-Authors . Muntamah A.A. Ketut Agung Cahyawan W Adi Cifriadi Afifi, Muhammad Ridho Ahmad Zakaria Aini, Zahratul Ali, Mohamad Makrus Amatullah, Afra Najiyah Amril Aman Anas Miftah Fauzi Ani Suryani Awan Purnawan BAMBANG MARWOTO Bambang Marwoto Bambang Marwoto Irawadi Cifriadi, Adi Dewi Sondari Djumali Mangunwidjaja Djumali Mangunwidjaja Dwi Setyaningsih ERWAHYUNI ENDANG PRABANDARI ERWAHYUNI ENDANG PRABANDARI Henny Purwaningsih Inda Iliyin Irma Herawati Suprapto Jorion Romengga Jorion Romengga Kapelle, Imanuel B. D. Khaswar Syamsu Komar Sutriah Komar Sutriah Krisnawati Krisnawati Krisnawati, Krisnawati LIESBETINI HARTOTO Liesbetini Hartoto Liesbetini Hartoto M. Syamsul Maarif Mas’ud, Zainal Alim Meika Syahbana Rusli Mira Rivai Mohamad Rafi Mohammad Khotib Muhammad Agus Muljanto Muhammad Hanafi Muhammad Romli dan Suprihatin Andes Ismayana Noviyan Darmawan Pamungkas, Wahyu Widji Puspitasari, Santi Retno Djulaika Rofiq Sunaryanto ROFIQ SUNARYANTO Rofiq Sunaryanto Santi Puspitasari Silvester Tursiloadi Sr Sugiarti Sugara, Taufan H Suharto Honggokusumo Suprapto, Irma Herawati Tanto Pratondo Utomo Taufan H Sugara Tetty Kemala Wahono Sumaryono Widia Citra Anggundari, Widia Citra Yandra Arkeman YOPI YOPI Zainal Alim Mas'ud Zainal Alim Mas'ud Zainal Alim Mas'ud ZAINAL ALIM MAS'UD Zainal Alim Mas’ud Zainal Alim Mas’ud Zainal Alim Mas’ud Zainal Alim Mas’ud