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All Journal Jurnal Teknologi Dan Industri Pangan VALENSI ILMU KELAUTAN: Indonesian Journal of Marine Sciences Jurnal Sains Materi Indonesia Microbiology Indonesia Majalah Ilmiah Ekonomi Komputer Jurnal Penelitian Hasil Hutan Agrointek Majalah Kulit, Karet, dan Plastik Jurnal Industri Hasil Perkebunan Indonesian Journal of Chemical Science INDONESIAN JOURNAL OF ESSENTIAL OIL Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Indonesian Journal of Chemistry Biosaintifika: Journal of Biology & Biology Education Jurnal Pascapanen dan Bioteknologi Kelautan dan Perikanan Jurnal Ilmu Kefarmasian Indonesia Jurnal Penelitian Hasil Hutan Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pijar MIPA Makara Journal of Science

Tun Tedja Irawadi

Chemistry Department, Faculty Of Mathematics And Natural Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia

Author-ID : 2463595

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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PENENTUAN KONDISI PROSES PRODUKSI SURFAKTAN MES UNTUK APLIKASI EOR PADA BATUAN KARBONAT Mira Rivai; Tun Tedja Irawadi; Ani Suryani; Dwi Setyaningsih
AGROINTEK Vol 5, No 1 (2011)
Publisher : Agroindustrial Technology, University of Trunojoyo Madura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21107/agrointek.v5i1.1933

Surfactant injection is one of the ways to lessen oil remains left in reservoir. This is done by injecting an active surface substance into reservoir until the tension of water-oil interface can be degraded. Reducing interfacial tension results in a reduced capillary pressure on pore stricture area of reservoir rocks until the oil caught in the pores can be pushed and produced. In order to make this process function optimally, an appropriate surfactant that fits the condition and formation of water and reservoir is needed. This study was conducted to get the best time of sulfonation process for producing MES surfactant with lower interfacial tension for EOR application at carbonate rock and to determine purification process of MES surfactant. Results showed that the best time of sulphonation to produce MES surfactant was from the third hour to the fourth hour. The selected purification process was conducted without methanol addition.

DIVERSIFIKASI PRODUK FARMASI DARI MINYAK LAWANG DENGAN PENDEKATAN SINTESIS KIMIA Imanuel Berly Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas'ud
INDONESIAN JOURNAL OF ESSENTIAL OIL Vol 1, No 1 (2016)
Publisher : Institut Atsiri Universitas Brawijaya

Indonesia merupakan negara yang terkenal dengan jenis–jenis tumbuhan penghasil minyak atsiri namun penggunaannya tidak banyak digunakan untuk diolah menjadi produk jadi seperti obat–obatan. Salah satu minyak atsiri yang sangat potensial dan diproduksi di wilayah Indonesia Timur khususnya Maluku dan Papua adalah minyak lawang. Tujuan yang ingin dicapai adalah membuat produk farmasi analog kurkumin dari minyak lawang dengan jalur sintesis kimia. Terdapat beberapa tahapan proses yang dilakukan, mulai dari proses isolasi safrol dari minyak lawang, proses isomerisasi safrol, proses oksidasi isosafrol dan tahapan proses reaksi kondensasi. Safrol diisolasi dari minyak lawang menggunakan metode kimia (NaOH) dan menghasilkan safrol 17,21%. Proses isomerisasi safrol menghasilkan isosafrol menggunakan sistem bebas pelarut dengan katalis alkali KOH pada suhu 120oC selama 6 jam diperoleh rendemen 77,56%. Piperonal diperoleh dari reaksi oksidasi isosafrol menggunakan oksidator KMnO4 sebanyak 65,63%. Produk analog kurkumin simetris (1,5-bis-benzo[1,3]dioxol-5-yl-penta-1,4-dien-3-one) yang diperoleh dari reaksi kondensasi antara piperonal dengan aseton. Rendemen produk menggunakan metode gelombang mikro pada daya 140 watt selama 2 menit adalah 53,3% (t.l=180 oC) dan metode konvensional selama 3 jam adalah 78,43% (t.l=191 oC). Produk analog kurkumin tidak simetris (5-benzo[1,3]dioxol-5-yl-1-phenyl-penta-2,4-dien-1-one) disintesis menggunakan dua tahapan reaksi kondensasi. Tahapan kondensasi yang pertama antara piperonal dengan asetaldehid menggunakan katalis basa dan metanol selama 3 jam diperoleh produk intermediate (3-benzo[1,3]dioxol-5-yl-propenal) 70,28%. Reaksi kondensasi tahap kedua antara produk intermediate dengan asetofenon menggunakan metode gelombang mikro pada daya 140 watt selama 2 menit diperoleh rendemen 82,82% (t.l = 104 oC) dan metode konvensional selama 3 jam diperoleh 99,55% (t.l = 111 oC).

STUDI AWAL PENGARUH METODE EKSTRAKSI TERHADAP RENDEMEN DAN KADAR ASIATICOSIDE DARI CENTELLA ASIATICA (L) URB Dewi Sondari; Tun Tedja Irawadi; Dwi Setyaningsih; Silvester Tursiloadi
Jurnal Sains Materi Indonesia Vol 17, No 3: APRIL 2016
Publisher : Center for Science & Technology of Advanced Materials - National Nuclear Energy Agency

STUDI AWAL PENGARUH METODE EKSTRAKSI TERHADAP RENDEMEN DAN KADAR ASIATICOSIDE DARI CENTELLA ASIATICA (L) URB. Proses ekstraksi Centella asiatica (L) Urb dengan metode maserasi, sonikasi, sokletasi dan CO2 superkritik telah dilakukan. Pengaruh proses ekstraksi terhadap rendemen dan kadar asiaticoside dari Centella asiatica (L) Urb (pegagan) telah dipelajari. Hasil dari perhitungan rendemen asiaticoside terlihat bahwa kandungan asiaticoside (% berat) dari proses ekstraksimaserasi, sonikasi, sokletasi dan CO2 superkritik berturut-turut sebagai berikut: 6,723%; 0,187%; 3.648%dan 9,24%. Rendemen asiaticoside paling tinggi diperoleh dari teknologi ekstraksi CO2 superkritik, karena teknologi ini dilakukan pada tekanan dan suhu tertentu sehingga kualitas hasil ekstraksi ditentukan oleh seberapa kritis penggunaan tekanan dan suhunya. Karena pada kondisi ini, selain mengubah densitas CO2, juga berpengaruh terhadap kelarutan dan selektivitas dari zat yang akan terekstrak. Semakin tinggi tekanan dan kelarutan, total hasil ekstraksi akan semakin tinggi. Untukmengetahui adanya senyawa asiaticoside dalam Centella asiatica (L) Urb (pegagan) digunakan analisis HPLC. Dari hasil analisis kromatogram bahwa ada dua puncak yang terdeteksi, dan secara kualitatif senyawa asiaticoside yang diperoleh denganmenggunakan ekstraksi CO2 superkritik lebih tinggi kadarnya dibanding metode ekstraksi lainnya, karena teknologi proses ekstraksi CO2 superkritik memanfaatkan kekuatan pelarut dan sifat fisik dari komponenmurni atau campuran, sehinggamudahmelakukan penetrasi ke dalam dinding material yang di ekstrak dan melarutkan komponen senyawa aktif secara selektif dengan kualitas produk tinggi dan tidakmengandung residu pelarut sehingga lebih murni.

Reaksi transfer hidrogenasi minyak jarak kastor serta aplikasinya sebagai bahan pelunak kompon karet Santi Puspitasari; Adi Cifriadi; Krisnawati Krisnawati; Tun Tedja Irawadi
Majalah Kulit, Karet, dan Plastik Vol 32, No 2 (2016): Majalah Kulit, Karet, dan Plastik
Publisher : Center for Leather, Rubber, and Plastic Ministry of Industry, Indonesia

Rubber plasticizer is used to improve rubber processability so as to shorten time and reduce energy consumption during compounding. In general, rubber plasticizer is nonrenewable and environmentally harmful petroleum derivatives due to the carcinogenic property. Environmentally friendly plasticizer can be produced by transfer hydrogenation of vegetable oil. The research was aimed to synthesize new rubber plasticizer from transfer hydrogenation of castor oil using diimide compound which was generated in situ by oxidation of hydrazine hydrate and hydrogen peroxide as well as the application of the new rubber plasticizer obtained on natural and synthetic rubbers compounding. The result showed that the optimum condition of transfer hydrogenation was achieved at a capacity of 1000 ml oil/batch, 40oC for 5 hours, and ratio hydrazine hydrate to hydrogen peroxide at 1:2 due to the hydrogenated castor oil (HCO) had the highest degree of hydrogenation and neutral pH. The application of 10 phr HCO had significant effect on the compounding of EPDM 6250 which was shown by shortest time and lowest energy of compounding, and also by the highest minimum torque modulus. In addition, the crosslink density of rubber vulcanizate which was formed during accelerated sulfur vulcanization was affected both by the addition of HCO and the saturation of the rubber being used.Keywords: environmentally friendly plasticizer, castor oil, diimide hydrogenation, rubber.

Isolasi Dan Penapisan Aktinomisetes Laut Penghasil Antimikroba Rofiq Sunaryanto; Bambang Marwoto; Tun Tedja Irawadi; Zainal Alim Mas'ud; Liesbetini Hartoto
ILMU KELAUTAN: Indonesian Journal of Marine Sciences Vol 14, No 2 (2009): Jurnal Ilmu Kelautan
Publisher : Marine Science Department Diponegoro University

Telah diiakukan isolasi dan penapisan aktinomisetes laut yang mampu menghasilkan senyawa antimikroba. Isolasi diiakukan ditiga tempat berbeda yaitu di Pantai Barat Banten, Pantai Utara Cirebon, dan Pantai Selatan Yogyakarta. Isolasi dilakukan dengan dua metode pre-treatment yaitu dengan metode pengasaman dan metode pemanasan. Dari hasil isolasi diperolehjumlah total isolat sebanyak 50 isolat. Setelah diiakukan penapisan diperoleh 4 isolat yang mampu menghambat Eschereschia coli, 5 isolat mampu menghambat Streptococcus aereus, 4 isolat mampu menghambat Bacillus subtilis, 4 isolat mampu menghambat Pseudomonas aeroginosa, 5 isolat mampu menghambat Candida albican, dan 4 isolat mampu menghambatAspergillus niger. Hasil identifikasi morfologi dan DNA dari salah satu isolat yang memiliki aktivitas antibakteri paling kuat (isolat A11) adalah Streptomyces sp. Secara morfologi isolat A11 memiliki hifa yang bercabang dengan kantong spora pada ujung hifa. Minimum Inhibition Concentration (MIC) isolat A11 terhadap Bacillus subtilis sebesar 120,86 μg/ml.Kata kunci: Isolasi, penapisan, aktinomisetes laut, antimikrobaIsolation and screening of antimicrobial-producing marine actinomycetes has been conducted on isolates taken from West Banten, North Cirebon, and South Yogyakarta Coasts. Two methods pretreatments were applied i.e. acid and heat shock method. The research 50 isolates. The screening reavealed four isolates which has ability to inhibi Eschereschia coli, 5 isolates could inhibited Streptococcus aereus, 4 isolates could inhibited Bacillus subtilis, 4 isolates could inhibited Pseudomonas aeroginosa, 5 isolats could inhibited Candida albican, and 4 isolatescould inhibited Aspergillus niger. Result of identification morphology and DNA of isolate A11 it’s Streptomyces sp. Morphology of isolate A11 haves branching hyphae with spore sack at the end of hyphae. The Minimum Inhibition Concentration (MIC) of isolate A11 to Bacillus subtilis was 120,86 μg /ml.Key words: Isolation, Screening, Marine Actinomycetes, Antimicrobial.

KAJIAN MANFAAT EKONOMIS PENERAPAN KONSEP PRODUKSI BERSIH PADA INDUSTRI KARET REMAH BERBASIS KARET RAKYAT Tanto Pratondo Utomo; Anas Miftah Fauzi; Tun Tedja Irawadi; Muhammad Romli; Amril Aman; Suharto Honggokusumo
Majalah Ilmiah Ekonomi Komputer 2007: Majalah Ilmiah Ekonomi Komputer Edisi Agustus
Publisher : Majalah Ilmiah Ekonomi Komputer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1076.352 KB)

Tujuan penelitian ini adalah menganalisis manfaat ekonomis penerapan konsep produksi bersihberdasarkan altematif terpilih untuk perbalkan proses pada industri karet remah yang dapal meningkatkanefisiensi dan mengurangi resiko pencemaran dan dapat diterapkan pada penyedia bahan baku (petani karet,KUD, dan pedagang pengumpul) dan pengolahan bokar menjadi karet remah (pabrik karet remah). Hasilpenelitian menunjukkan bahwa penerapan konsep produksi bersih pada industri karet remah berbasis karetrakyat yang diterapkan pada tahap penyediaan bahan baku dan pada tahap pengolahan bokar menjadi karetremah menghasilkan keuntungan ekonomis dengan (1) penghematan air sebanyak 18,5 m3110n karet kering;(2) penghematan energi senilai Rp. 7.91011on karet kering; (3) tidak diperlukan investasi untuk peralatanpenghilangan bau (malodour); (4) dihindari terjadinya kerugian akibat proses penggantungan selama 14 harisenilai Rp. 70/kg bokar; dan (5) tahapan proses pengolahan bokar menjadi karet remah lebih singkat dengantidak digunakannya mesin hammer-mills. Dampak ekonomis yang bersifat menambah biaya adalah (1)diperlukan investasi tambahan untuk resirkulasi air; (2) investasi fasilitas penggilingan bokar; dan (3) investasibiaya pengolahan Iimbah berupa serum hasil pengpresan bokar pada tingkat petani karet.Kata kunci: produksi bersih, bokar, karet remah, manfaat ekonomis

REKAYASA PROSES SINTESIS PIPERONAL DARI KULIT LAWANG (Cinnamomum culilawan Blume) SEBAGAI PREKURSOR OBAT KANKER Imanuel Berly Delvis Kapelle; Tun Tedja Irawadi; Meika Syahbana Rusli; Djumali Mangunwidjaja; Zainal Alim Mas'ud
Jurnal Penelitian Hasil Hutan Vol 34, No 3 (2016): Jurnal Penelitian Hasil Hutan
Publisher : Pusat Penelitian dan Pengembangan Hasil Hutan

Piperonal as a precursor of cancer drug (Curcumin analogues) can be synthesized from extract of lawang’s bark (Cinnamomum culilawan Blume) with multiple stages, among others: isolation of essential oils, isolation safrole, safrole isomerization, and synthesis of piperonal. Essential oils were isolated from the bark of lawang (the water content of 46.2%) using a water distillation system with 1/3 volume of high boiler for five hours. Isolation of safrole from lawang bark oils was performed using NaOH solution and purified using reduced pressure distillation system at a temperature of 90-123°C / 1 mmHg. The safrole isomerization was undergone using alkali catalyst (KOH) without solvent at a temperature of 120°C for 8 hours. Oxidation of isosafrol was performed using KMnO4 in acidic conditions using a KTF tween 80 at a temperature below 30°C, and purified using silica gel. Results of isolation yield 0.94% with 14 components were determined through GC-MS, including 67.35% eugenol, safrole 13.96%, 12.61% methyl eugenol, 4-terpineol sineol 1.79% and 1.55%. The isolated safrole yield of 17.21% with purity testing and identification using FTIR, 1H- NMR and GCMS confirmed the product was safrole. The isomerization obtained yield of 77.56% with GC analysis indicated compounds of cis-isosafrole and trans-isosafrole. The results of oxidation obtained yield of 65.63% with a purity of 100% by GCMS and the 1H-NMR indicated the product is piperonal.

PEMODELAN KERANGKA ADAPTIVE THRESHOLD UNTUK MEMONITOR PRODUKSI MINYAK SAWIT NASIONAL BERBASIS STATISTICAL PROCESS CONTROL DAN ARTIFICIAL NEURAL NETWORK-BACKPROPAGATION Wahyu Widji Pamungkas; Syamsul Maarif; Tun Tedja Irawadi; Yandra Arkeman
Jurnal Industri Hasil Perkebunan Vol 11, No 2 (2016)
Publisher : Balai Besar Industri Hasil Perkebunan

Indonesia is the largest exporter of palm oil in the world, as the largest producer Indonesia still havemany problems. The problem caused by incomparable between the growth of upstream and downstreampalm oil industries. This impact to low added value of palm oil, then Indonesia exports palm oil in crudeform. On the other hand, On the other hand , orientation export of this commodity is also prone of barrier,because Indonesia was not the price setter of this commodity in the international market. Therefore it isimportant to monitor and predict the development of national palm oil production volume in order to takegood anticipation. This research develop a framework model adaptive threshold to monitor the growing ofnational palm oil production volume with techniques of statistical process control (SPC) and back propagationartificial neural network (ANN - BP) methods. Historical data production volume period from 1967 to 2015was used as a base of the behavior as data to determine the threshold and prediction volume for nextperiods. The formation of the threshold value was based on the behavior of the historical data, which areoriented by the epicenter of the average value in the last two periods .Through mapping of data historicalperiod values, existing and forecast values with adaptive threshold can show tolerant level for the threshold.Furthermore, based on the analysis, it is known that the prediction of 2016 to 2018 period, there will behappen the dynamics production volume of national palm oil within tolerance threshold. The values of thesepredictions generated from the simulation model predictions of ANN-BP with the level very good of validationmodel, demonstrated the level of squared errors is very small1 in the MSE = 0.00021136 with a degree ofoutput correlation and the target is very strong2 with R Validation is 99.98 percent.Keywords: adaptive threshold, statistical process control, artificial neural network, national palm oilproduction.

Cyclo (Tyrosyl-Prolyl) Produced by Streptomyces sp.: Bioactivity and Molecular Structure Elucidation ROFIQ SUNARYANTO; BAMBANG MARWOTO; LIESBETINI HARTOTO; ZAINAL ALIM MAS'UD; TUN TEDJA IRAWADI
Microbiology Indonesia Vol. 5 No. 2 (2011): June 2011
Publisher : Indonesian Society for microbiology

Determination of bioactivity by minimum inhibitory concentration (MIC) methods and molecular structure identification of antibiotic produced by Streptomyces sp. have been carried out. The antibiotic was produced by liquid culture using Streptomyces sp. isolate. Purification of antibiotic was carried out by silica gel column chromatography and preparative HPLC. Molecular structure identification was carried out using ESI-MS, 1H NMR, 13C NMR, and 13C DEPT NMR. Pure antibiotic showed inhibition activity to Gram-negative and Gram-positive bacteria. MIC to Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC27853 , Staphylococcus aureus ATCC25923, and Bacillus subtilis ATCC66923 were 27.0, 68.7, 80.2, and 73.7 μg mL-1 , respectively. Identification using ESI-MS showed that the molecular weight of this antibiotic was 260 g mol-1 , and molecular formula was C14H16N2O3 . Elucidation of molecular structure using 1HNMR, 13C NMR, and 13C DEPT NMRshowed that antibiotic was cyclo(tyrosyl-prolyl).

Selection of Carbon and Nitrogen Source for 8-Hydroxy 9, 12-Octadecadienoic Acid Production using Endophytic Fungi Curvularia lunata BioMCC FE-00283 ERWAHYUNI ENDANG PRABANDARI; TUN TEDJA IRAWADI; WAHONO SUMARYONO; KHASWAR SYAMSU
Microbiology Indonesia Vol. 5 No. 4 (2011): December 2011
Publisher : Indonesian Society for microbiology

Hydroxyoctadecadienoic acid (HODE) is one of hydroxy fatty acids that has anticancer activity. HODE was previously produced by chemical synthesis or bioconversion from linoleic acid. This is the first paper reported production of HODE by Curvularia lunata an endophytic fungi of Cibotium barometz. Various carbon and hydrogen sources have been tested for their effects on the production of HODE by C. lunata. Glucose, lactose, maltose, xylose, and sucrose were used as carbon sources, while yeast extract, monosodium glutamate, urea, and NH4Cl were used as nitrogen sources. Fermentation was done using 100 ml medium in 250 ml Erlenmeyer flask at 150 rpm, 28 oC for 10 days. HODE products were analyzed by high pressure liquid chromatography using C18 coloumn and eluted by gradient system of acetonitril-water from 15% to 100%. Glucose and monosodium glutamate were found to be the best carbon and nitrogen source. The optimum concentration of glucose and monosodium glutamate for the production of HODE were 10 mg L-1 and 12 mg L-1 respectively.

Co-Authors . Muntamah A.A. Ketut Agung Cahyawan W Adi Cifriadi Afifi, Muhammad Ridho Ahmad Zakaria Aini, Zahratul Ali, Mohamad Makrus Amril Aman Anas Miftah Fauzi Ani Suryani Awan Purnawan BAMBANG MARWOTO Bambang Marwoto Bambang Marwoto Irawadi Cifriadi, Adi Dewi Sondari Djumali Mangunwidjaja Djumali Mangunwidjaja Dwi Setyaningsih ERWAHYUNI ENDANG PRABANDARI ERWAHYUNI ENDANG PRABANDARI Henny Purwaningsih Inda Iliyin Irma Herawati Suprapto Jorion Romengga Jorion Romengga Kapelle, Imanuel B. D. Khaswar Syamsu Komar Sutriah Komar Sutriah Krisnawati Krisnawati Krisnawati, Krisnawati Liesbetini Hartoto LIESBETINI HARTOTO Liesbetini Hartoto M. Syamsul Maarif Mas’ud, Zainal Alim Meika Syahbana Rusli Mira Rivai Mohamad Rafi Mohammad Khotib Muhammad Agus Muljanto Muhammad Hanafi Muhammad Romli dan Suprihatin Andes Ismayana Noviyan Darmawan Pamungkas, Wahyu Widji Puspitasari, Santi Retno Djulaika Rofiq Sunaryanto ROFIQ SUNARYANTO Rofiq Sunaryanto Santi Puspitasari Silvester Tursiloadi Sr Sugiarti Sugara, Taufan H Suharto Honggokusumo Suprapto, Irma Herawati Tanto Pratondo Utomo Taufan H Sugara Wahono Sumaryono Widia Citra Anggundari, Widia Citra Yandra Arkeman YOPI YOPI Zainal Alim Mas'ud Zainal Alim Mas'ud Zainal Alim Mas'ud ZAINAL ALIM MAS'UD Zainal Alim Mas’ud Zainal Alim Mas’ud Zainal Alim Mas’ud Zainal Alim Mas’ud

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