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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Berkala Epidemiologi Jurnal Farmasi Klinik Indonesia Pharmacon Sinkron : Jurnal dan Penelitian Teknik Informatika Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JFIOnline Jurnal Kesehatan PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan

Endang Darmawan

Fakultas Farmasi Universitas Ahmad Dahlan, Jl. Prof. Dr. Soepomo S.H., Janturan Umbulharjo, Yogyakarta

Author-ID : 250034

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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AMBARAN FUNGSI HATI PASIEN SKIZOFRENIA YANG MENGKONSUMSI RISPERIDONE DENGAN LORAZEPAM Kurniati, Tripeni; Darmawan, Endang; Anggriani, Hesti
Jurnal Farmasi Indonesia Vol 10, No 1 (2018)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v10i1.579

Treatment with risperidone 1.5-6.0 mg/day provides good benefits for schizophrenia treatment, severe psychiatric disorder with long-term disability potential and limited availability of treatment options. According to the average percentage of patients with abnormal liver function tests, patients with clinically significant improvement (> 3 times of the normal upper limit for SGPT, aspartate aminotransferase.Abnormalities that are commonly without any symptom occur within 6 weeks of antipsychotic use (Correll et al., 2015). The purpose of this study is to analyze the liver function of schizophrenic in-patients who take risperidone and lorazepam in Amino Gondohutomo’s psychiatric hospital of Central of Java Province. The research subjects were 132 schizophrenic diagnosed patients who take risperidone and combination of risperidone and lorazepam. We used Chi Square Tests, Paried T Tests and One Sample Test.Based on the research results, it can be concluded that there is a correlation between readmisi and age group, in age group > 29 years more risk relapse than age group <29 years. Also, it can be concluded the combination of risperidone and lorazepam at risk 0,933 times will increase SGOT than get treatment with risperidone only and therapy the combination of risperidone and lorazepam at risk twice will increase SGPT rather than receive treatment with risperidone only.

Treatment with risperidone 1.5-6.0 mg/day provides good benefits for schizophrenia treatment, severe psychiatric disorder with long-term disability potential and limited availability of treatment options. According to the average percentage of patients with abnormal liver function tests, patients with clinically significant improvement (> 3 times of the normal upper limit for SGPT, aspartate aminotransferase.Abnormalities that are commonly without any symptom occur within 6 weeks of antipsychotic use (Correll et al., 2015). The purpose of this study is to analyze the liver function of schizophrenic in-patients who take risperidone and lorazepam in Amino Gondohutomoâ€™s psychiatric hospital of Central of Java Province. The research subjects were 132 schizophrenic diagnosed patients who take risperidone and combination of risperidone and lorazepam. We used Chi Square Tests, Paried T Tests and One Sample Test.Based on the research results, it can be concluded that there is a correlation between readmisi and age group, in age group > 29 years more risk relapse than age group <29 years. Also, it can be concluded the combination of risperidone and lorazepam at risk 0,933 times will increase SGOT than get treatment with risperidone only and therapy the combination of risperidone and lorazepam at risk twice will increase SGPT rather than receive treatment with risperidone only.

COST OF ILLNESS DIABETES MELITUS TIPE 2 DAN KOMPLIKASINYA PADA PESERTA JAMINAN KESEHATAN NASIONAL (JKN) DI RAWAT JALAN RUMAH SAKIT CONDONG CATUR YOGYAKARTA Putri, Rr. Erni Kusuma; Darmawan, Endang; Perwitasari, Dyah Aryani
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.8915

Type 2 diabetes mellitus is a chronic disease that requires lifelong therapy and high service costs so that the use of antidiabetic drugs affects the patient's therapeutic costs. The purpose of this study was to determine the cost of outpatient type 2 diabetes mellitus therapy for National Health Insurance (JKN) participants in Condong Catur Hospital Yogyakarta. The research method used is observational. The parameters measured are calculating the average direct medical costs (drug costs, doctor's examination and consultation fees, laboratory costs, medical treatment costs), and comparison between the costs of oral drugs, insulin, oral and insulin. The results of normality tests with Shapiro-Wilk (microvascular, microvascular and macrovascular), Kolmogorrov-Smirnov (macrovascular) p<0.05 indicate that data are not normally distributed, the results of the Kruskal Wallis test of the three groups (microvascular, macrovascular, microvascular and microvascular) show that differences are not normally distributed significant (p = 0.001).The results showed that the microvascular group therapy costs Rp 3,164,733.58 per month, the macrovascular group Rp 9,984,566.85 per month, the microvascular and macrovascular groups Rp 11,260,372.39 per month. The cost of therapy is based on the microvascular group drug Rp. 408,567.78 per month, the macrovascular group Rp. 1,245,987.48 per month, the microvascular and macrovascular groups Rp. 1,786,270.68 per month so that statistically from the three complications groups show significant differences p = 0,001 (p <0,005). The difference in the difference between the total real costs and the total INA-CBG's rates, the microvascular group Rp -38,741.14 per patient, the macrovascular group Rp -10,914.03 per patient, while in the microvascular and macrovascular group Rp 3,272.90 per patient shows that from to three groups of complications were not significantly different p = 0.207 (p> 0.005). Statistically it can be concluded that the cost of therapy based on antidiabetic drugs in the three groups of complications shows a significant difference. There is no significant difference in the difference between the real costs in the three groups of complications

Hubungan Indeks Massa Tubuh dengan Keparahan dan Mortalitas Pasien Covid-19 Hasanah, Uswatun; Ramdani, Dewi; Darmawan, Endang; Sugiyarto, Sugiyarto
Jurnal Kesehatan Vol 13 No 2 (2022): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v13i2.3051

Covid-19 is a novel viral disease resulting in many casualties around the world, including in Indonesia. By the 19th of January 2022, the death rate is 3.36% higher than the worldâ€™s, i.e., 1.64%. Covid-19 -related death is caused by several factors; one of them is body mass index (BMI). A patientâ€™s BMI affects the clinical condition as well as the severity of the case. Increasing BMI is believed to be a risk and mortality factor for Covid-19 patients. This research aimed at identifying the relationship between BMI and the severity as well as mortality of Covid-19 patients. From March 2020 to June 2021, as many as 345 in-patients at RSU Haji Surabaya were studied using the retrospective cohort research method. The data were analyzed using Chi-square with <0.05 significance value to see the relationship amongst its test variables. The results indicated that there was no significant relationship between body mass index and severity and mortality in Covid-19 patients. Therefore, it can be concluded that the severity and mortality of Covid-19 patients in Indonesia were not dependent only on the increase in BMI.Â

K-Medoids Algorithm to Clustering COVID-19 Patients with Various Age Levels at Hospitals in Yogyakarta Province Insani, Pratamasari Noor; Darmawan, Endang; Sugiyarto, Sugiyarto
Sinkron : jurnal dan penelitian teknik informatika Vol. 8 No. 2 (2024): Article Research Volume 8 Issue 2, April 2024
Publisher : Politeknik Ganesha Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33395/sinkron.v8i2.13551

COVID-19 causes a wide spectrum of symptoms, such as mild upper respiratory infection or life-threatening sepsis. From 20.2% of cases of COVID-19 progressed to severe disease with a mortality rate of 3.1% where 60%-90% of patients with comorbidities were hospitalized. The purpose of this study was to find out that cluster analysis using K-Medoids can distinguish COVID-19 patients at various age levels which analytical method has sensitivity and specificity values in analyzing clustering in COVID-19 patients. This study uses a cohort retrospective design conducted at five hospitals in Yogyakarta Province. The study used patient medical record data from March 2020 – September 2021 with a total of 916 patient data that met the inclusion criteria. Cluster analysis will be carried out using Google Colaboratory with the Python programming language. The clustering results are divided into 2 cluster groups where cluster 1 consists of 558 patients and cluster 2 consists of 358 patients with various age levels. The test resulted in 2 clusters with a DBI value of 5,191631. The results of statistical tests showed that there was a significant relationship (p-value = 0,023) between age, recovery rate, and patient mortality. From the test results, it can be seen that ages 50 to 59 years are suspected of COVID-19

THE COMPARISON OF THE EFFICACY OF CEFTRIAXONE AND COMBINATION OF AMPICILLIN-CHLORAMPHENICOL OF CHILDREN WITH PNEUMONIA OF PKU MUHAMMADIYAH HOSPITAL IN BANTUL Astuti Wulandari, Nur; Darmawan, Endang; Umam Kurniawan, Nurcholid
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 1 No. 1 (2022): JANUARY
Publisher : Transpublika Publisher

Pneumonia is an infectious disease that occurs in the lungs caused by various microorganisms. Patients of children with pneumonia in Indonesia experienced an increase in 2013. Antibiotics therapy is the main therapy for patients with pneumonia. This study aims to compare of the efficacy of ceftriaxone and combination of ampicillin-chloramphenicol of children with pneumonia of PKU Muhammadiyah hospital in Bantul. The study design was a randomized controlled trial with prospective Open trial do in March 2018 to June 2018. The outcomes used were tightness, cough, retraction, temperature, respiration rate, and length of stay. Research data were analyzed using Chi Square test, Fisher test, independent t test and Mann Whitney test. The results of the study of ceftriaxone (n=26) and ampicillin chloramphenicol groups (n=26) showed that the percentage of patients who had not experienced tightness was 82.7%, not cough 7.7%, and there was no retraction of 76.9% with p<0.05. The mean ±SD temperature of the ceftriaxone group was 36.5±0.12 and the ampicillin chloramphenicol group was 36.57±0.09 with a p<0.05. The mea n±SD respiration rate of the ceftriaxone group was 27.9±3.22 and the ampicillin chloramphenicol group was 27.92±2.62 with a p <0.05. The mean ±SD length of stay in the ceftriaxone group was 4.5±0.81 and the ampicillin chloramphenicol group was 4.26±0.66 with a p<0.05. Conclusions showed that there was no significant difference between the effectiveness of ceftriaxone and ampicillin chloramphenicol on fever, spasms, cough, retraction, temperature, respiration rate and length of stay.

EVALUATION OF THE SECURITY OF THE USE OF GUAJAVA PSIDIUM EXTRACT CAPSULE ON HEART FUNCTION IN DENGUE FEVER AND DENGUE HEMORAGIC FEVER PATIENTS IN TYPE C HOSPITAL Agamasi, Amalia; Darmawan, Endang; Akrom
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 1 No. 1 (2022): JANUARY
Publisher : Transpublika Publisher

There are 126,675 DHF sufferers in 34 provinces and 1,229 of them died, while the Incidence Rate (IR) in Central Java is 47.9 per 100,000 population. Based on the safety of Psidium guajava Linn on the liver by calculating the lethal dose average showed that there were no deaths from the two experimental models of Swiss mice and Wistar mice in the dose range up to 2,000 mg/kg BB. Safety tests in rats proved lethal dose 50 (LD50) of guava leaf extract more than 5 g/kg. This study aims to determine the effect of psidii capsules containing guava leaf extract (Psidium guajava Linn.) toward levels (SGOT and SGPT) of DF and DHF patients in PKU Muhammadiyah Wonosobo Hospital. This study belongs to perspective cohort analytic observational using blood plasma patients of PKU Muhammadiyah Wonosobo Hospital of 37 patients in the period of March to August 2018 which were divided into two groups, namely standard therapy + guava leaf extract capsules and the group receiving standard therapy only. Dosage of Psidium guajava 3x2 capsules for 3 to 4 days. Examination of SGOT and SGPT levels used UV-vis spectrophotometry. General linear model was used for analyzing the data. The average SGOT level after treatment was 64 U/L in DF and 99 at DHF while the SGPT levels were 30 U/L and 35 U/L. Average levels of SGOT and SGPT decreased. There were no differences in SGOT and SGPT mean of DF and DHF patients in the two groups after giving guava leaf extract capsules with p>0.05. In SGOT mean, there was an increase in SGOT after giving guava leaf extract probably because there were patients who had chronic liver disorders. Keywords: Dengue Fever, Dengue Hemorrhagic Fever, Guava extract capsule, SGOT SGPT

THE INCREASED RISK OF RANDOM BLOOD GLUCOSE, BODY MASS INDEX AND ABDOMINAL CIRCUMFERENCE IN THE SCHIZOPHRENIC PATIENTS USING CLOZAPINE AND QUETIAPINE Hidayah, Lailatul; Darmawan, Endang; Yuliani, Santi
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 1 No. 1 (2022): JANUARY
Publisher : Transpublika Publisher

The use of atypical antipsychotics often causes an increase in blood glucose levels, body mass index (BMI) and abdominal circumference. This study aims to identify the increased risk of random blood glucose, BMI and abdominal circumference in the schizophrenic patients using clozapine and quetiapine. This cohort study involved 35 schizophrenic patients (19 patients used clozapine and 16 patients used quetiapine). The measurement of random blood glucose BMI and abdominal circumference was done in the zero month, the first month and the second month. The average of random blood glucose, BMI and abdominal circumference were analyzed using Wilcoxon and Chi-square. In the use of clozapine, there is a significant increase in the average of random blood glucose between the first month and the second month (p=0.1) with the difference of 6.37 mg/dl, there is an increase average in BMI between the first month and the second month (p=0.03) with the difference of 0.18 kg/m² and an average increase in abdominal circumference between the zero month and the first month (p=0.04) with the difference of 1.47 cm, between the first month and the second month (p=0.02) with the difference of 1.94 cm. In the use of quetiapine, a significant increase in abdominal circumference between the first month and the second month (p=0.02) with the difference 1.38 cm. The use of clozapine has more risk in increasing random blood glucose (OR 2.00: CI 95% 0.41-9.76), BMI (OR 2.78: CI 95% 0.69-11.10) and abdominal circumference (OR 3.61: CI 95% 0.89-14.64) compared to the use of quetiapine. The use of clozapine has more risk in increasing blood glucose, BMI and abdominal circumference compared to the use of quetiapine.

THE FUNCTION OF RECOMMENDATION OF A PHARMACISTS IN REDUCE PIMs (POTENTIALLY INAPPROPRIATE MEDICATIONS) OF GERIATRIC PATIENTS AT THE GENERAL HOSPITAL DR. MOEWARDI SURAKARTA Dewi Isnaini, Ratna; Darmawan, Endang; Yovita Dewi, Fransiska
PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS Vol. 1 No. 2 (2022): APRIL
Publisher : Transpublika Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55047/comorbid.v1i2.81

The prevalence of potentially inappropriate medications (PIMs) is quite high in geriatric patients. PIMs can be detected using an explicit prescription indicator (a criterion). Explicit criteria that can be used in the identification of PIMs in geriatric patients include: BEERS Criteria, STOPP Criteria, and START Criteria. This study aims to analyze drugs included in the PIMs category based on BEERS Criteria, STOPP Criteria, and START Criteria. This research is a semi-experimental study (intervening in the form of giving recommendations) with prospective data collection in the geriatric ward of Regional General Hospital Dr. Moewardi Surakarta in the period from October 2019 to January 2020. The results showed that out of 70 patients, there were 47 PIMs, PIMs based on BEERS Criteria for 20 patients (28.6%), PIMs based on STOPP Criteria for 10 patients (14.3%) and PIMs based on START Criteria for 17 patients (24.3%). Bivariate analysis showed that there was a relationship between the incidence of adverse drug events (ADEs), with recommendations that were followed up on PIMs based on BEERS Criteria with an RR value of 25 (95% CI 1,2: 520,7), P = 0.04 and PIMs based on START Criteria with an RR value of 5 (95% CI 1: 35.9), P = 0.04, whereas the results of the bivariate analysis on PIMs based on STOPP Criteria showed that there was no relationship between the incidence of ADEs with the recommendations that were followed up with a RR value of 4 (95% CI 0.13: 119.2), P = 0.50. Based on the results of univariate and bivariate statistical analysis, it can be concluded that there are still many incidents of PIMs based on BEERs Criteria, STOPP Criteria, and START Criteria and pharmacists have an important function to reduce PIMs so that the incidence of ESO due to PIMs can be minimized in the regional general hospital Dr. Moewardi Surakarta.

AKTIVITAS ANTIBAKTERI DAN KOMPONEN KIMIA MINYAK ATSIRI TEMU KUNCI (Boesenbergia rotunda L. Mansf) TERHADAP BAKTERI PENYEBAB JERAWAT Mulyaningsih, Sri; Anastasya, Yolanda; Darmawan, Endang
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.1924

Essential oil of fingerroot (Boesenbergia rotunda L. (Mansf)) have antibacterial activity against Staphylococcus but was not specific against acne-causing bacteria. The aim of this study was to determine its chemical content and antibacterial activity of the fingerroot oil against S. aureus, S. epidermidis, and Propionibacterium acnes that cause acne. The essential oil was isolated by steam and water distillation. The organoleptic, yield, and refractive index were observed. Gas chromatography-mass spectrometry (GC-MS) carried out the identification of essential oil components. Antibacterial activity of the oil was determined with the diffusion method. Broth microdilution methods was used for determination of the minimum inhibitory concentration (MIC) and minimum bactericide concentration (MBC). Fingerroot essential oil was clear in color, aromatic odor, chelate taste, and slightly bitter with a yield of 1.19%. The refractive index was 1.4785 ± 0.0001. GC-MS identification showed 5 main components of fingerroot oil were camphor (28.70%), ocimene (24.71%), eucalyptol (16.26%), geraniol (14.81%), and methyl cinnamate (4.16%). The diameter of the zone of inhibition of bacterial growth was greatest at 20% concentration of fingerroot oil, followed by 10%, 5%, and 2.5%. MIC value of fingerroot oil against S. aureus and S. epidermidis was 0.625% and against P. acnes was 1.25%. The MBC value of fingerroot oil was doubled as the MIC value. The great antibacterial activity of fingerroot essential oil makes it potential to be developed into anti-acne preparations.

Co-Authors Agamasi, Amalia Akrom, Akrom Ananda Muhammad Naafi, Ananda Muhammad Anastasya, Yolanda Andi Namirah Muh. Syuaib AS, Andi Angella, Widi Anggriani, Hesti Annisa Hardikasari Yazin, Annisa Hardikasari Anovia, Rizka Angerti Ardyati, Sulistia Astuti Wulandari, Nur Dewi Indah Sari, Dewi Indah Dewi Isnaini, Ratna Dyah Aryani Perwitasari Evi Mulyani Fahrian Hipmi, Ahmad Farida Baroroh, Farida Grin Fariah Hariadi Wijaya, Made Insani, Pratamasari Noor Iskak, Iskak Jamhari Jamhari Jastria Pusmarani Kurniati, Tripeni Kurniawan, Nurcholid U. Kurniawan, Nurcholid Umam Kusumawati, Leny Witaning Lailatul Hidayah Maulida, Nuril Meki Pranata Mustofa Mustofa Noerhidayati, Elly Nur Rahmatiya Abas, Siti Nurul Hanifah Ramdani, Dewi Riza Alfian Rizky Budi Santoso RR. Ella Evrita Hestiandari Santi Yuliani, Santi Saputri, Ginanjar Zukhruf Sri Mulyaningsih Sri Sulistyorini Sugiyarto Sugiyarto Sugiyarto Surono, Sugiyarto Suyandra Sah Putra, Suyandra Ulfa Ismayani, Ulfa Umam Kurniawan, Nurcholid Uswatun Hasanah Woro Supadmi Yovita Dewi, Fransiska

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