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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Berkala Epidemiologi Jurnal Farmasi Klinik Indonesia Pharmacon Sinkron : Jurnal dan Penelitian Teknik Informatika Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JFIOnline Jurnal Kesehatan PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan
Endang Darmawan
Fakultas Farmasi Universitas Ahmad Dahlan, Jl. Prof. Dr. Soepomo S.H., Janturan Umbulharjo, Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Assessing Direct Medical Costs and Quality of Life In Elderly Patients Using High-Alert Medications at Wongsonegoro Hospital Supadmi, Woro; Endang Darmawan; Rizky Budi Santoso; Sri Sulistyorini
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 2: September 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i2.30368

Abstract

High Alert Medications (HAM) are drugs that pose a significant risk of causing harm to patients if used incorrectly. This study aimed to evaluate the direct medical costs and quality of life of elderly patients aged 60 years and above using HAM at Wongsonegoro Hospital. An observational prospective cohort study design was employed, utilizing both secondary and primary data collection methods. Secondary data included patient demographics, medication usage, and direct medical costs obtained from hospital records and the finance department. Primary data on quality of life were gathered using the European Quality of Life 5 Dimensions (EQ-5D-5L) questionnaire. A total of 25 elderly patients were identified as users of HAM, with a gender distribution of 48% male and 52% female; 64% of these patients were aged between 60 and 70 years. The most prevalent medical condition among participants was diabetes mellitus, affecting 44% of one group and 32% of another. Sodium Chloride (NaCl) 500 mL infusion at a concentration of 3% was the most frequently administered medication (27.5%). The average direct medical cost for elderly patients using HAM was IDR 4,255,050. Additionally, the quality of life assessment revealed that 20% of patients experienced significant challenges in self-care activities. These findings highlight the impact of HAM on healthcare costs and quality of life among elderly patients, emphasizing the need for careful monitoring and management strategies to mitigate risks associated with high-alert medications.
Pharmacist counseling improves medication compliance of schizophrenia patients Pranata, Meki; Perwitasari, Dyah Aryani; Noerhidayati, Elly; Iskak, Iskak; Darmawan, Endang; Angella, Widi
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.25912

Abstract

Schizophrenia is a disorder characterized by abnormal behavior, impaired thinking, disorganized speech, and a reduced ability to perceive reality. One of the key factors influencing the success of schizophrenia therapy is patient adherence. Pharmacy plays a crucial role in the treatment of schizophrenia patients. This study aimed to determine the effect of pharmacist counseling on drug adherence of schizophrenia patients from the first month to the second month. The method used in this study was a one-group pre-test and post-test design that used quasi-experimental research. The subjects of this study were schizophrenia patients in the outpatient installation of Prof.Dr.Soerojo Mental Hospital, Magelang. This study used the Medication Adherence Rating Scale (MARS) questionnaire to measure the level of adherence and drug use monitoring sheet (pill count) to monitor the amount of patient medication. The population in this study was calculated using the Lameshow formula. Data analysis was performed using the chi-square test and the Wilcoxon test. After analyzing data of 108 patients, it was found that there was a significant difference between before and after counseling conducted by pharmacists on medication adherence in schizophrenia patients, with a significance value of p <0.05. Counseling conducted by pharmacists has a good impact on patient medication adherence and monitoring the amount of medication taken. These results indicate the effect of counseling conducted by pharmacists on adherence to taking medication and the monitoring of the amount of medication taken by patients.
ANALYSIS OF TUBERCULOSIS PATIENT CHARACTERISTICS OF GORONTALO CITY HOSPITAL USING K-MEANS CLUSTERING METHOD: Analisis Karakteristik Pasien Tuberkulosis Rumah Sakit Kota Gorontalo Menggunakan Metode K-Means Clustering Hariadi Wijaya, Made; Nur Rahmatiya Abas, Siti; Fahrian Hipmi, Ahmad; Darmawan, Endang; Supadmi, Woro; Surono, Sugiyarto
Jurnal Berkala Epidemiologi Vol. 13 No. 2 (2025): Jurnal Berkala Epidemiologi (Periodic Epidemiology Journal)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jbe.V13I22025.147-155

Abstract

Background: Tuberculosis (TBC) is a major health problem in Indonesia, especially in Gorontalo, with high spread due to poor ventilation, overcrowding, and unhealthy lifestyles. Purpose: To analyze the characteristics of TB patients in one of Gorontalo City's hospitals using K-Means Clustering. Methods: Data including age, gender, TBC history, HIV status, diabetes history, hypertension, drug resistance, drug side effects, and treatment results were analyzed for the number of clusters using the K-Means method because it is effective in grouping data based on similarity, easy to implement, and works well on large datasets. Results: The analysis resulted in three clusters. Cluster 0 (219 individuals): majority female (63.50%), mean age 45.37 years, low address score (0.49), low resistance and therapy (6.40%), no comorbidities, all experienced side effects (100%), and survival rate 4.10%. Cluster 1 (150 individuals): mean age 52.21 years, higher address score (0.77), resistance 7.30%, therapy 5.30%, comorbidities 100%, all experienced adverse events, and survival rate 4.70%. Cluster 2 (98 individuals): mean age 48.58 years, address score 0.65, very low resistance and therapy (2%), no side effects, 42.90% had comorbidities, and the highest survival rate (12.20%). Conclusion: Three clusters were obtained from the analysis using K-Means. Clustering supports specific interventions such as comorbidity management or intensive surveillance, improving TB control programs in Gorontalo.
MENINGKATKAN KERJA FUNGSI GINJAL DENGAN KONSUMSI TEPUNG GANYONG (Canna edulis Kerr.) Fariah, Grin; Darmawan, Endang
Media Farmasi: Jurnal Ilmu Farmasi Vol. 10 No. 2: September 2013
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v10i2.1168

Abstract

Gout adalah peradangan akibat adanya endapan kristal asam urat pada sendi dan jari. Ganyong dengan kandungan karbohidrat yang tinggi dapat meningkatkan fungsi kerja ginjal yang diujikan pada tikus yang mengalami hiperurisemia dengan melakukan diet fiber. Hiperurisemia adalah keadaan di mana terjadi peningkatan asam urat di dalam darah darah. Tujuan dari penelitian ini adalah untuk mempelajari pengaruh konsumsi tepung ganyong pada tikus yang menderita penyakit gout terhadap fungsi ginjal. Penetapan kadar kreatinin plasma tikus menggunakan metode Jaffe (Creatinine FS). Perlakuan pemberian suspensi tepung ganyong tersebut dilakukan pada hari ke-1, 3,dan 7. Data kadar kreatinin rata-rata antar kelompok perlakuan dianalisis secara statistik menggunakan uji Kruskall-Wallis (non parametrik) dan dilanjutkan dengan uji Mann Whitney (p<0,05). Hasil penelitian menunjukkan bahwa pemberian tepung ganyong selama 7 hari dapat menurunkan kadar kreatinin rata-rata pada tikus yang diinduksi dengan kalium oksonat (p<0,05). Hal ini ditunjukan oleh nilai AUC kelompok pemberian tepung ganyong dosis 0,75; 1,5; 2,5 g/kgBB (p.o.) adalah secara berturut-turut sebesar 26,67 ± 3,96, 28,10 ± 4,80, dan 23,41 ± 4,84 (p<0,05),Secara keseluruhan dapat disimpulkan bahwa pemberian tepung ganyong selama 7 hari dapat menurunkan kadar kreatinin plasma tikus yang diinduksi dengan kalium oksonat, lebih lanjut dapat memperbaiki fungsi kerja ginjal.
KONSELING FARMASIS MERUBAH PERILAKU PASIEN HIPERTENSI RAWAT JALAN DI POLIKLINIK PENYAKIT DALAM RUMAH SAKIT PKU MUHAMMADIYAH BANTUL, INDONESIA Alfian, Riza; Akrom, Akrom; Darmawan, Endang
Media Farmasi: Jurnal Ilmu Farmasi Vol. 11 No. 1: Maret 2014
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v11i1.1399

Abstract

Hipertensi  merupakan  salah satu  faktor  resiko  utama  penyakit  jantung  koroner, gagal  ginjal,  dan  stroke.  Prevalensi  hipertensi  di  Indonesia  pada  tahun  2007 mencapai  angka  32,2%.  Perilaku  adalah  merupakan  faktor  kunci  yang menghalangi pengontrolan tekanan darah sehingga membutuhkan intervensi untuk mencapai keberhasilan  terapi.Tujuan  penelitian  ini  adalah  untuk  mengetahui pengaruh  konseling  farmasis  secara  oral terhadap  perubahan  perilaku  pasien hipertensi  rawat  jalan  di  Poliklinik  Penyakit  Dalam  Rumah  Sakit  PKU Muhammadiyah  Bantul. Penelitian  ini  menggunakan  rancangan  kuasi eksperimental  dengan  pengambilan  data  secara  prospektif  pasien  rawat  jalan selama periode Januari-April 2013. Kuesioner pengukuran tingkat perilaku yang terdiri dari  9  pertanyaan  dan  sudah  divalidasi  digunakan  untuk  mengambil  data awal  pasien  sebelum  diberi  konseling  dan  data  akhir  pasien  setelah  diberikan konseling. Penelitian ini melibatkan 60 pasien yang dibagi rata menjadi 30 pasien kelompok  kontrol  dan  30  pasien  kelompok  perlakuan. Hasil  penelitian  ini menunjukkan  konseling  yang  diberikan farmasis meningkatkan  skor  domain kognitif,  afektif,  dan  psikomotorik  kelompok perlakuan  secara  signifikan (p<0,05).  Rata-rata  peningkatan  skor  domain  kognitif  antara  kelompok  kontrol 0,33± 0,61 dan kelompok perlakuan 0,60 ± 0,96 tidak berbeda signifikan (p=0,39). Rata-rata  peningkatan  skor  domain afektif  dan  psikomotorik  pasien  hipertensi kelompok kontrol berturut-turut 0,03 ± 0,61, 0,20 ± 0,41 dan kelompok perlakuan berturut-turut 0,67 ± 0,55, 0,83 ± 0,83 berbeda signifikan (p=0,00). Berdasarkan hasil  penelitian  tersebut  dapat  disimpulkan  bahwa intervensi  konseling  yang diberikan farmasis dapat merubah perilaku pasien hipertensi ke arah positif yang menunjang untuk tercapainya keberhasilan terapi psikomotorik
An overview of Covid-19 patients with and without comorbid Diabetes Mellitus at Surabaya Hajj general hospital Hasanah, Uswatun; Darmawan, Endang; Sugiyarto, Sugiyarto
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.23246

Abstract

Diabetes mellitus (DM) is one of the most common comorbidities found in patients infected with Covid-19 with severity and death. To obtain an overview of Covid-19 patients with and without comorbid DM. A retrospective cohort study, taking subjective data on Covid-19 patients with and without DM at Surabaya Hajj general hospital for the period of March 2020 to June 2021. Data analysis using the Chi-square test was to determine differences in both test variables. The death of Covid-19 patients with comorbid DM was found with the condition in which the average random blood glucose (RBG) increased by >150 mg/dl (286 mg/dl), as well as in recovered patients (197 mg/dl); meanwhile, patients without comorbid DM died with also an increase in the RBG value (166 mg/dl). Male patients were found to be more prone to get infected with Covid-19 than female patients. It can be concluded that there was no significant difference in the severity of cases in Covid-19 patients with comorbid DM and without comorbid DM. Deaths due to Covid-19 in patients with comorbid DM or without comorbid DM occurs due to the increasing blood glucose value by >150 mg/dl.
Co-Authors Agamasi, Amalia Akrom, Akrom Ananda Muhammad Naafi, Ananda Muhammad Anastasya, Yolanda Andi Namirah Muh. Syuaib AS, Andi Angella, Widi Anggriani, Hesti Annisa Hardikasari Yazin, Annisa Hardikasari Anovia, Rizka Angerti Ardyati, Sulistia Astuti Wulandari, Nur Dewi Indah Sari, Dewi Indah Dewi Isnaini, Ratna Dyah Aryani Perwitasari Evi Mulyani Fahrian Hipmi, Ahmad Farida Baroroh, Farida Grin Fariah Hariadi Wijaya, Made Insani, Pratamasari Noor Iskak, Iskak Jamhari Jamhari Jastria Pusmarani Kurniati, Tripeni Kurniawan, Nurcholid U. Kurniawan, Nurcholid Umam Kusumawati, Leny Witaning Lailatul Hidayah Maulida, Nuril Meki Pranata Mustofa Mustofa Noerhidayati, Elly Nur Rahmatiya Abas, Siti Nurul Hanifah Ramdani, Dewi Riza Alfian Rizky Budi Santoso RR. Ella Evrita Hestiandari Santi Yuliani, Santi Saputri, Ginanjar Zukhruf Sri Mulyaningsih Sri Sulistyorini Sugiyarto Sugiyarto Sugiyarto Surono, Sugiyarto Suyandra Sah Putra, Suyandra Ulfa Ismayani, Ulfa Umam Kurniawan, Nurcholid Uswatun Hasanah Woro Supadmi Yovita Dewi, Fransiska