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All Journal HAYATI Journal of Biosciences Jurnal Pendidikan dan Pembelajaran Khatulistiwa (JPPK) Prosiding Seminar Biologi Indonesian Journal of Biotechnology Jurnal Teknologi Laboratorium Biosaintifika: Journal of Biology & Biology Education Jurnal Labora Medika Gorontalo Journal of Public Health Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Borneo Journal of Medical Laboratory Technology Narra J Quality : Jurnal Kesehatan Prosiding University Research Colloquium Jurnal Kefarmasian Indonesia
Sri Darmawati
Muhammadiyah Semarang University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : Biosaintifika: Journal of Biology

 1 
Antibacterial Activity of Various Extracts of Averrhoa bilimbi against Multidrug Resistant Bacteria Prastiyanto, Muhammad Evy; Wardoyo, Fandhi Adi; Wilson, Wildiani; Darmawati, Sri
Biosaintifika: Journal of Biology & Biology Education Vol 12, No 2 (2020): August 2020
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v12i2.23600

Abstract

The multi-drug resistance (MDR) bacteria is a global health problem that causes high mortality every year. Therefore, novel antibacterial agents are needed from natural biological sources. This research aimed to investigate the antibacterial activities of various crude extracts of Averrhoa bilimbi against MDR bacteria. The antibacterial activity was calculated based on the use agar well diffusion assay and the minimum bactericidal concentration (MBC) using Mueller–Hinton broth in a microdilution method. Bacteria from wells were subcultured using inoculating loop onto a 5% sheep BAP. The best antibacterial activity, calculated as the most widely inhibitory zone and the smallest MBC values. The ethanolic extract showed antibacterial activity against the all MDR bacterial test in the agar well diffusion assay (10-14.5 mm inhibition diameter). The MBC of water extract against ESβL + CR Pseudomonas aeruginosa showed the best antibacterial activity (12.5 mg/mL). The fruit of bilimbi was shown to be potentially developed as antibacterial agents, especially for MDR strains. Further in vivo research and discovery of action mode are needed to shed light on their antibacterial effects. This study can provide new information about the benefits of bilimbi as a source of natural antibacterial againts MDR-bacteria
Antibacteria Activity Peel and Seed Extracts of Rambutan (Nephelium lappaceum L.) Against MDR Bacteria Causing Urinary Tract Infections Mukaromah, Ana Hidayati; Cahyaningrum, Dea Galuh; Putri, Desty Ratna; Jannah, Erni M; Rinaldi, Muhamad Rizqi; Wardoyo, Fandhi Adi; Ariyadi, Tulus; Hikmah, Annisa Nurul; Darmawati, Sri
Biosaintifika: Journal of Biology & Biology Education Vol 15, No 3 (2023): December 2023
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v15i3.39568

Abstract

Multidrug-resistant (MDR) - Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) are the main causes and have become serious problems in urinary tract infections, so antibacterial agents derived from biological materials are needed. ESBL-E. coli and ESBL-K. pneumoniae bacteria are resistant to extracts from rambutan peels and seeds, but there is no knowledge of the use of different solvents, such as n-hexane, chloroform, or ethanol. The objective of this research was to assess the antibacterial activity of rambutan peels and seed extracts (n-hexane, chloroform, and ethanol) against MDR bacteria that cause urinary tract infections (UTI). The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) values for antibacterial activity were calculated using agar well diffusion and dilution procedures. The results demonstrated that the ethanol extract of rambutan peels had inhibitory zones against MDR K. pneumoniae and E. coli that varied from 9.00 to 14.13 mm. 15.625 mg/mL For MDR E. coli and 3.90 mg/mL for MDR K. pneumoniae, respectively, the MIC value was determined. The MBC value was 62.50 mg/mL for MDR K. pneumoniae and 31.25 mg/mL for MDR E. coli. Conclusion: Of the six rambutan peel and seed extracts, the ethanol extract has greater potential as an antibacterial agent. It is advised that more in-vivo studies be done to understand how the antibacterial activity operates.The benefits of research for the science are providing alternative solutions to antibiotic resistance, to further advancing the field of antimicrobial research, and reducing the risk of bacterial infections.
Co-Authors A.A. Ketut Agung Cahyawan W Afriansyah, M. Ardi Ana Hidayati Mukaromah Anak Agung Wiradewi Lestari Aprilia Indra Kartika, Aprilia Indra Batara, Murni Budi Santosa Budi Santosa BUDI SETIADI DARYONO Cahyaningrum, Dea Galuh Daryono, Budi S. Edward Kurnia Setiawan Limijadi, Edward Kurnia Setiawan Endang Tri Wahyuni Maharani Ernanto, Aditya Rahman Ethica, Stalis N. Fandhi Adi Wardoyo Felim, Jethro Fuad, Hayatun Hariutami, Desi Hidayani, Al Hikmah, Annisa Nurul Jannah, Erni M La’lang, Marselaonety LANGKAH SEMBIRING Listiyanti, Apriliya Manufandu, Anjar Richardo Mardiyah Hayati Masashi Kawaichi, Masashi Maulida, Gita Rossa NANIK RAHMANI Nasruddin, N Nur Hidayah Palimbongan, Junita Rensa Permana, Atna Prastiyanto, Muhammad E. Prastiyanto, Muhammad Evy Prastiyanto, Muhammad Evy Putri, Desty Ratna Retnaningrum, Endah Rinaldi, Muhamad Rizqi Rosnita . Rustiyarso . Salsabila, Nia Silvestre, Richard David Sri Sinto Dewi Stalis Norma Ethica Sulistyaningtyas, Ayu Rahmawati Susanti, A.Meryam Syaiful Anwar Trianes, Juwy Tulus Ariyadi Wayan T. Artama Wayan T. Artama Widya Asmara Wilson, Wildiani Zilda, Dewi S. Zuraida Zuraida