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All Journal Sains Olahraga : Jurnal Ilmiah Ilmu Keolahragaan BIOTIK: Jurnal Ilmiah Biologi Teknologi dan Kependidikan Jurnal Dunia Farmasi Majalah Farmasetika FORTE JOURNAL Jurnal Farmasi Sains dan Praktis Journal of Pharmaceutical and Sciences. Jurnal Pengabdian Masyarakat Ilmu Kesehatan
Khairani Fitri
Program Studi Farmasi, Fakultas Farmasi Dan Kesehatan, Institut Kesehatan Helvetia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Uji Aktivitas Antibakteri Ekstrak Etanol Daun Seroja (Nelumbo nucifera Gaertn.) terhadap Escherichia coli dan Staphylococcus aureus Khairani Fitri; Tetty Noverita Khairani; Ruth Mayana Rumanti; Sri Handayani; Mintaria Halawa
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1809

Abstract

Introduction: The increasing occurrence of bacterial infections and antimicrobial resistance has encouraged the investigation of medicinal plants as potential sources of antibacterial compounds. Lotus (Nelumbo nucifera Gaertn.) leaves contain several classes of secondary metabolites that may contribute to antibacterial activity. Objective: This study evaluated the antibacterial activity of lotus leaf ethanol extract against Escherichia coli and Staphylococcus aureus and identified the major classes of secondary metabolites present in the extract. Methods: This laboratory experimental study used lotus leaf extract prepared by maceration with 96% ethanol. The simplicia was characterized and subjected to phytochemical screening. Antibacterial activity was evaluated using the paper-disc diffusion method on Mueller–Hinton agar at extract concentrations of 10%, 15%, and 20%, with clindamycin as the positive control and dimethyl sulfoxide as the negative control. Each treatment was tested in triplicate. Inhibition-zone diameters were analyzed using one-way analysis of variance followed by Tukey's HSD test. Results: The lotus leaf material contained alkaloids, flavonoids, saponins, tannins, steroids, and triterpenoids. Against E. coli, the mean inhibition-zone diameters at concentrations of 10%, 15%, and 20% were 13.60, 15.40, and 16.60 mm, respectively; the corresponding values against S. aureus were 14.56, 15.21, and 18.13 mm. Differences among treatments were statistically significant for both test bacteria (p<0.001). Conclusion: Lotus leaf ethanol extract exhibited concentration-dependent antibacterial activity against E. coli and S. aureus, with the strongest inhibition observed at 20%. Further studies should determine the minimum inhibitory and bactericidal concentrations and characterize the active antibacterial constituents.
Uji Aktivitas Antibakteri Ekstrak Metanol Bunga Tapak Dara (Catharanthus roseus) Terhadap Bakteri Streptococcus pneumoniae dan Bakteri Klebsiella pneumoniae Tetty Noverita Khairani; Khairani Fitri; Loura Novilla; Fahma Shufyani; Liza Fiska
Journal of Pharmaceutical and Sciences Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v5i2.162

Abstract

Background: Pneumonia is an acute infection of the lung tissue (alveoli) which can be caused by bacteria, viruses, and fungi. Most are caused by bacteria. Symptoms include high fever accompanied by coughing up phlegm, rapid breathing (breathing frequency >50 breaths/minute), shortness of breath, and other symptoms (headache, restlessness and decreased appetite). Objective: to determine the antibacterial activity and the best concentration of the methanol extract of the vinca flower against Streptococcus pneumoniae and Klebsiella pneumoniae bacteria. Methods: This study was experimental research design, namely experimental activities that determined the independent and dependent variables, also the research parameters. The research phase included sampling, making simplicia, making extracts, testing the characteristics of simplias and extracts, testing the inhibition of vinca flower extract against pathogenic bacteria (Streptococcus pneumoniae and Klebsiella pneumoniae) with a comparison of doxycycline antibiotics.. Result: the methanol extract of the vinca flower had antibacterial activity against Streptococcus pneumoniae and Klebsiella pneumoniae bacteria. Where the antibacterial activity test of the methanol extract of the vinca flower on Streptococcus pneumoniae bacteria showed an average inhibition zone of each concentration, namely: 10% (12.6 mm), 15% (13.26 mm), 20% (15.26 mm). And the bacteria Klebsiella pneumoniae showed the average inhibition zone of each concentration was 10% (12.86 mm), 15% (13.71 mm), 20% (15.86 mm). Conclusion: was vinca flower extract has antibacterial activity and the best concentration to inhibit Streptococcus pneumoniae and Klebsiella pneumoniae bacteria is a concentration of 20%.
Co-Authors Abadi, Hafizhatul Amalia Juliani Hasibuan Anak Agung Gede Sugianthara Bellina Elizabeth Dolok Saribu Betari Khairani Lubis Bustami Bustami Deni Rahman Marpaung Fahma Shufyani Faizah Rahman Hanafis Sastra Winata Ihsanul Hafiz Indra Ginting Jacob Tarigan Jashima Ukhtia Khairani, Tetty Noverita Leny Leny Leny, Leny Liza Fiska Loura Novilla Luthvia Luthvia Mandike Ginting Mintaria Halawa Muhammad Amin Nasution Muhammad Amin Nasution Muhammad Andry Muhammad Fauzan Lubis Mutiara Sinaga Nidia Rizka Nina Mardiana (F01108057) Noni Alvianti Nova Rianti Marbun Nuzulul Safitri Ratna Kumala Reanza Musmulya Putri Ruth Mayana Rumanti Sri Handayani Tetty Noverita Khairani Tetty Noverita Khairani Tetty Noverita Khairani Tetty Noverita Khairani Tetty Noverita Khairani Tety Noverita Khairani Ulfa Melyza Vivi Eulis Diana Wiwik Rismadayanti