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All Journal Dentika Dental Journal Journal of Mathematical and Fundamental Sciences STOMATOGNATIC- Jurnal Kedokteran Gigi Jurnal Kesehatan Gigi UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Health Notions Journal of Dentomaxillofacial Science Journal Of Vocational Health Studies Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan BIOEDUKASI AloHA International Journal of Health Advancement (AIJHA) Dental Agromedis
I Dewa Ayu Ratna Dewanti
Bagian Biomedik, Fakultas Kedokteran Gigi, Universitas Jember, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Library & Information Science Mathematics Medicine & Pharmacology Nursing Physics Public Health

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PERAN TOLL LIKE RECEPTORS (TLRs) PADA INNATE IMMUNITY (The Role of Toll Like Receptors to Innate immunity) Nuzulul Hikmah; I Dewa Ayu Ratna Dewanti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 8 No 1 (2011)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

TRLS is a homologous protein located at APC membrane cell worl as a functional receptor to activate leucocyte lead to onduce mentriger responsimun innate or inflamatory respons against palogenic againt. Functional receptor is associated wuth kinase respons to produce sitokyn and microbidal subtance. The aim of the study is to examine the respons to produce sitokyn and microbidal subtance. The aim of the study is to examine the role TLRs on innate immunity it is concluded that the role of TLRS is important functional receptor which activate leucocyte to induce mentriger respons imun innate or an inflamators respons against patogenic agent.
Peningkatan Ekspresi GSH (Gluthathione) pada Monosit yang Dipapar Biji Kopi dan DMBA (7,12-dimethylbenz(a)anthrancene) I Dewa Ayu Ratna Dewanti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 13 No 1 (2016)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Background. The content of the coffee beans that are antioxidants have good potential, particularly against cancers of the oral cavity. Polyphenols in coffee beans 5% together the other ingredients in the diet, such as vitamin C, vitamin E and carotenoids, can protect the body's tissues against oxidative stress. Antioxidants can prevent a variety of diseases associated with oxidative stress, such as cancer. Objective. Research to determine the expression of GSH on monocytes were exposed to coffee beans and DMBA in vitro. Research Methods. Monocytes aspirated, added RPMI, resuspension with M 199, penstrep, fungisone. Superimposed on a cell culture plate that was given coverslip, added M 199, incubation. Add RPMI, incubation, discard lymphocytes, washing with RPMI. Add medium M 199, incubation. Cultures are washed, resuspension with M 199, treatments according to the research group. KO: Monocytes, K1: Coffee Monocytes + 10% + DMBA, K2: Coffee Monocytes + 5% + DMBA, K3: Monocytes + Coffee 10%, K4: Monocytes + coffee 5%, K5: Monocytes + DMBA. Immunocytochemistry for the analysis of GSH. Cells expressing GSH brown under a light microscope with a magnification of 400 times and counted on five visual fields. Research Result. Results of ANOVA analysis (p <0.01) showed that there were significant differences in all groups. Furthermore, the LSD test (p <0.05), the results are significant differences between all groups. Conclusion. Coffee beans can increase GSH expression on monocytes were exposed to DMBA.
SEPUTAR REAKSI HIPERSENSITIVITAS (ALERGI) Nuzulul Hikmah; I Dewa Ayu Ratna Dewanti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 7 No 2 (2010)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Introduction. Till now allergy was a piquancy to be submitted, because most all people have everexperienced it. Symptom and also allergen all kinds and varies can come from neither outside body nor in bodyx'self. Purpose of Writing. Co-signature deeper in around allergic reaction. Discussion. Allergic reaction is immunesystem trouble marked by abundant reaction from immune response. Allergic reaction entangles allergen, is causingcells discharges matters or mediator chemistry which can destroy or hurts network in vinicity. Allergen can in the formof mote, crop powder, drug or food, is acting as antigen stimulating the happening of immune responds. Allergicreaction divided to become allergic reaction type I entangling Ig E, type II Antibody-Mediated Cytotoxi ity ( Ig G),type III ( Immune Complex Disorders) and type IV (delayed hypersensitivities). Conclusion. Allergic reaction is caused[by] allergen having manifestation to vary and divided to become reaction quickly ( type I), type II, type III and typeIV.
KEJADIAN HIV/AIDS DENGAN MANIFESTASI ORAL PADA ANAK-ANAK Nuzulul Hikmah; I Dewa Ayu Ratna Dewanti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 7 No 1 (2010)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

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Abstract

Nowadays HIV/AIDS infection was increase to children in the world. In development countries include Indonesia, it was caused fourth killer to children. Oral manifestation to the children who has infected HIV have a different been compared with adult. Discussion.Candidiasis and necrotizing ulcerative gingivitis is oral lesion who was found in the children. Linear gingival erythema leukoplakia, caries and kaposis sarcoma can be an indicator of moderate and hard immunosupression. Parotis swollen, herpes simplex virus infection and recurrent aphtous stomatitis not special connected with immunosupression grade. The best of management patients was consider immunology status andexamined oral continuity. Conclusion. Oral manifestation in the childen very important to known because it was often first indication clinical so that someone had been infected of HIV.
Bagian Biomedis Fakultas Kedokteran Gigi, Universitas Jember Jember, Indonesia I Dewa Ayu Ratna Dewanti
Journal of Dentomaxillofacial Science Vol. 10 No. 1 (2011): Formerly Jurnal Dentofasial ISSN 1412-8926
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v10i1.248

Abstract

Neem is one of the traditional medicine known by society as immunomodulator. On the other hand, 80% of oralinfection diseases is caused by C. albicans. This research is aimed to explain the phagocytosis activities on wistarrats which were inoculated with C. albicans and fed with neem leaves. There are 5 groups, namely control group(KO)with no treatment, the other treatment groups were classified into 4 groups. First group (KP1)was inoculatedwith C. albicans only. KP2 was fed with 50 mg/day/kg BW aqueous extracts from neem leaves, then inoculated withC. albicans start from day 8-21. KP3 was fed with 100 mg/day/kg BW aqueous extract from neem leaves, theninoculated with C. albicans start from day 8-21. KP4 was fed with 200 mg/day/kg BW aqueous extract from neemleaves, then inoculated with C. albicans start from day 8-21. On day 22, the tongue was swabbed for each group,then cut for immunohistochemistry preparation. The study that there was significant difference showed that therewere different results computed using anova, HSD test, and linier regression. The conclusion was neem leavesincreased the phagocytosis activity of wistar rats, inoculated with C.albicans.
TNFα and IL-10 Expression in Dental Pulp after Administration of Gouramy Bone Paste (Osphronemus gouramy) and Calcium Hidroxide Sunana Ageng Hikmawati; Dheamira Rosida; I Dewa Ayu Ratna Dewanti; Erawati Wulandari
Aloha International Journal of Health Advancement (AIJHA) Vol 3, No 6 (2020): June
Publisher : Alliance oh Health Activists (AloHA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/aijha30602

Abstract

Mechanical trauma causes pulp exposure and make the invasion of pathogenic microorganisms into the dental tissue. This condition causes pulp inflammation characterized by the release of pro-inflammatory cytokine tumor necrosis factor-α (TNF-α) and anti-inflammatory cytokine interleukin-10 (IL-10). Gouramy bone paste (Osphronemus gouramy) contains amino acids, omega-3, omega-6, and flavonoids which is thought to accelerate healing of inflamed pulp tissue that triggers decreased TNF-α expression and increased IL-10 expression. This study aims to analyze the expression of TNF-α and IL-10 in dental pulp after administration of Gouramy bone paste (Osphronemus gouramy) and calcium hydroxide. The sample size consisted of 24 Rattus novergicus which were divided into 3 groups i.e (K1) without the application of direct pulp capping material, (K2) with the application of calcium hydroxide, and (K3) with the application of gouramy bone paste. Data measured are the number of inflammatory cells (neutrophils, macrophages, and lymphocytes) that express TNF-α and IL-10 on the 4th and 7th days histologically by immunohistochemical methods. Statistical test results showed that administration of gouramy bone paste in dental pulp decreased TNF-α expression and increased IL-10 expression more than those without gouramy bone paste with a significant difference (p
Kejadian Stunting Berdasarkan Jenis Kelamin Dan Usia Di Wilayah Kerja Puskemas Kalisat Imania Zulfa; Ristya Widi Endah Yani; I Dewa Ayu Ratna Dewanti
STOMATOGNATIC - Jurnal Kedokteran Gigi Vol 20 No 2 (2023)
Publisher : Fakultas Kedokteran Gigi Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/stoma.v20i2.44016

Abstract

Stunting is a chronic condition characterized by the poor condition of the child or the inhibition of the child's linear growth due to the accumulation of various factors that occur over a long time. This situation can be seen based on the z-score of height according to age less than -2 standard deviation (SD) which is classified as short and very short. To find out the incidence of stunting by gender and age in the working area of the Kalisat Health Center in 2020. Descriptive research using secondary data from patient KIA data in February 2020. From the research that has been done, it can be concluded that the incidence of stunting in toddlers is mostly male and toddlers aged 24-36 months.
IgG AND CD4+ Responses Post Immunization With Cidr1α-Pfemp1 Recombinant Protein Istinaroh, Nurul; Sulistyaningsih, Erma; Dewanti, I Dewa Ayu Ratna
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 2 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i2.7658

Abstract

Malaria vaccine is urgently needed to eradicate malaria. The complexity of Plasmodium sp life cycle and host immunity to malaria have become the forces for developing peptide-based malaria vaccines using recombinant technology. The CIDR1α-PfEMP1 (cysteine-rich interdomain region 1α of Plasmodium falciparum erythrocyte membrane protein 1) is vital in malaria pathogenicity, making it a malaria vaccine candidate. This study investigated the IgG and CD4+ responses generated after the CIDR1α-PfEMP1 recombinant protein immunization in Wistar rats. The rats were divided into a control group, injected with 0.9% NaCl, and a treatment group, subcutaneously injected with 150 µg of purified CIDR1α-PfEMP1 recombinant protein. Injection was conducted thrice with a three-week interval. Blood samples were extracted every two weeks after immunization. IgG and CD4+ concentrations were measured using ELISA. Data were analyzed using the independent T-test and Mann-Whitney test based on the data distribution. IgG and CD4+ concentrations increased along with the injection frequency. Significant differences between the control and treatment groups were observed in IgG concentrations after all injections and CD4+ level only after secondary II immunization (p<0.05). In conclusion, the CIDR1α-PfEMP1 recombinant protein induces humoral and cellular immune responses through increased IgG and CD4+ concentrations, making it a potential malaria vaccine candidate.
Antibacterial Activity of Robusta Instant Coffee Powder Against Acidogenic and Aciduric Species of Streptococcus mutans Bacteria Lestari, Pujiana Endah; Susilawati, I Dewa Ayu; Harmono, Happy; Dewanti, I Dewa Ayu Ratna; Masari, Al; Nailufar, Khanun; Morauli, Fatricia
BIOEDUKASI Vol 22 No. 3 (2024)
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI FAKULTAS KEGURUAN DAN ILMU PENDIDIKAN UNIVERSITAS JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/bioedu.v22i3.50812

Abstract

Streptococcus mutans is a major species that causes dental caries due to its acidogenic and aciduric properties. Coffee beans contain several compounds, such as caffeine, phenols, tannins, trigonelline, chlorogenic acid, and caffeic acid, which are known for their antibacterial properties. Robusta instant coffee powder is a stable product that is not easily contaminated with bacteria, fungi, and yeast. It is a zero-waste and soluble material. This study aimed to analyze the antibacterial activity of robusta instant coffee powder (RICP) against S. mutans. The antibacterial activity of RICP against S. mutans was tested using three antimicrobial susceptibility tests: 1) disk diffusion method, 2) minimum inhibitory concentrations (MIC), and 3) minimum bactericidal concentration (MBC). The results of the disk diffusion method test showed that the RICP concentration of 0.2 g/mL to 0.8 g/mL against S. mutans had an inhibition zone of 31.14 mm to 42.01 mm. MIC and MBC values of RICP against S. mutans were both 0.0313 g/mL. In conclusion, robusta instant coffee powder (RICP) demonstrates antibacterial activity against the acidogenic and aciduric S. mutans bacteria.
THE ENHANCEMENT OF GLASS IONOMER CEMENT HARDNESS BY ADDING GOURAMI SCALES POWDER NANOPARTICLES Erawati Wulandari; Nadie Fatimatuzzahro; I Dewa Ayu Ratna Dewanti; Anita Faizah
Journal of Vocational Health Studies Vol. 8 No. 3 (2025): March 2025 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V8.I3.2025.206-210

Abstract

Background: Material hardness in dentistry is used as a measuring tool to determine the ability of a restoration material to withstand the compressive force of masticatory. The hardness of Glass Ionomer Cement (GIC) is a mechanical property related to the abrasion and compressive strength of the GIC. If the material’s hardness is low, it results in low material resistance and causes a fracture. Therefore, it is necessary to add materials that contain hydroxyapatite (HA), which can increase the hardness of GIC, as in gourami fish scales. Purpose: This research aims to determine the influence of adding Gourami Fish Scale Powder (GFSP) nanoparticles to GIC hardness. Method: The twenty five sample is in tablet form and divided into five sample groups, namely G0: GIC without the addition of GFSP, G1: GIC powder + 0.5% GFSP, G2: GIC powder + 1.5% GFSP, G3: GIC powder + 2.5% GFSP, G4: GIC powder + 3.5% GFSP. Hardness test was using Vickers Hardness Tester. Data were analyzed using a One Way ANOVA test. Result: The average values of the hardness results from lowest to highest were the G0 (55.5 ± 2.70 VHN), G1 (56.9 ± 3.36 VHN), G2 (63.7 ± 7.73 VHN), G3 (66.3 ± 1.44 VHN), and G4 (70.1 ± 4.72 VHN), while the One Way ANOVA test results were significant among all groups (p-value < 0.05). Conclusion: The addition of GFSP nanoparticles increased GIC hardness. The highest hardness value was obtained by adding 3.5% GFSP nanoparticles.
Co-Authors Anita Faizah Banun Kusumawardani Budi Yuwono Budi Yuwono Depi Praharani Dheamira Rosida Dyah Setyorini Erawati Wulandari Erma Sulistyaningsih Farah Rachmah Aulia Wardani Fiona Budi Amarta Domini Happy Harmono Hestieyonini Hadnyanawati I Dewa Ayu Susilawat I Dewa Ayu Susilawati Imania Zulfa Istinaroh, Nurul Masari, Al Melok Aris Wahyukundari Morauli, Fatricia Muhammad Nurul Amin Nadie Fatimatuzzahro Nailufar, Khanun Narita Ajeng Loviana Nurud Diniyah Nuzulul Hikmah P. Purwanto Pudji Astuti Pujiana Endah Pujiana Endah Lestari Purwanto Purwanto , Ristya Widi Endah Lestari Ristya Widi Endah Yani Roedy Budirahardjo Sri Lestari Sumono, Agus Sunana Ageng Hikmawati Sunlip Wibisono Tecky Indriana