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All Journal Medicina Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi Jurnal Farmasi Udayana E-Jurnal Medika Udayana Jurnal Veteriner ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Bali Anatomy Journal

I Gusti Ayu Dewi Ratnayanti

Department Of Histology, Faculty Of Medicine, Udayana University, Bali, Indonesia

Author-ID : 252323

Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Veterinary

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Perbedaan Gambaran Histopatologi Granuloma Paru Mencit Setelah Diinfeksi Mycobacterium tuberculosis dan atau Intervensi Silika (THE INFLUENCES OF TIME IN THE HISTOPATHOLOGY OF LUNG GRANULOMA IN MICE AFTER INFECTION OF MYCOBACTERIUM TUBERCULOSIS AND SILI Ni Made Linawati; I Gusti Ngurah Mayun; I Gusti Nyoman Sri Wiryawan; Nyoman Sri Budayanti; Ni Made Mertaniasih; Fedik Abdul Ratam; I Nyoman Wande; I Gusti Ayu Dewi Ratnayanti; Ida Ayu Ika Wahyuniari; I Wayan Sugiritama; I Gusti Kamasan Arijana
Jurnal Veteriner Vol 14 No 1 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.958 KB)

The characteristics of lung tuberculosis is granuloma, which is consisted of lymphocytes andmacrophages that show the interaction between immune cells and M.tb. Granuloma is the organizationprocess which is depend on lymphocytes invasion, adhesion molecules and chemokine fasilitation. Silicosiswhich is caused by silica, can influence granuloma in the lung. The features of granuloma is variationdepend on the elicited agent and immune reaction. The main purpose of this study was to prove thehistopathology differences of mice lung granuloma caused by M.tb infection, silica intervention and bothin 3th and 7th weeks. It was 45 mice Balb-c strain, divided into 3 groups; P1 got M.tb infection with H37Rvstrain 105 perml,P2 got silica intervention with 60 micro litre and, P3 got both of M.tb infection and silica intervention. Termination of each group were held on 3 and 7 weeks of intervention, continued byhistopathology examination. In the histopathology feature, we done semi-quantitative prosedure to measurelung damage by using Dormans scores; perivasculitis, peribronchiolitis, alveolitis and granuloma. Oneway anova to analysis the differences of histopathologycal result among these groups (P< 0,05). Resultshowed the significant differences among these group. In the 3th weeks, we found mild lung damage werehappened in all groups with granuloma, without necrosic (P1 and P2). In the 7th weeks we found severe lungdamage in P3 with necrotic and fibrotic granuloma sign, with necrosis in P1, with fibrotic in P2. Weconcluded the worst lung damage happened in 7th weeks in group which are got M.tb infection and silicaintervention, with granuloma characterictic of necrosic and fibrotic.

Penurunan Kadar Trigliserida pada Tikus Jantan dengan Terapi Growth Hormone (DECREASE OF TRIGLYCERIDE LEVEL IN MALE RAT BY GROWTH HORMONE TREATMENT) I Gusti Ayu Dewi Ratnayanti; I Wayan Sugiritama; Ida Ayu Ika Wahyuniari; Ni Made Linawati; I Gusti Ngurah Mayun; Dewa Ayu Agus Sri Laksemi; I Gusti Ngurah Sri Wiryawan; I Gusti Kamasan Nyoman Arijana
Jurnal Veteriner Vol 14 No 2 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (143.93 KB)

The use of growth hormone (GH) as cardiovascular disease treatment is still controversial. In thispreliminary study the effect of growth hormone therapy on plasma triglyceride level in dyslipidemia wasexamined. Pre and post control group design study was done using 20 dyslipidemic (total cholesterol >200mg/dL) male rats, age 11–12 month-old. The subjects were divided into four groups, aquadest (P0), GH0.02 IU/day (P1), GH 0.04 IU/day (P2), and GH 0.08 IU/day (P3). All subjects were given high cholesteroldiet for three weeks to achieve dyslipidemic in blood level. Aquadest and GH were injected subcutaneouslyonce daily for two weeks. Triglyceride plasma level was measured on day 22nd and 38th by using colorimetricenzymatic test. The mean of pre test plasma triglyceride level of all groups was 136.30 mg/dL and nosignificant difference was found among the groups (p > 0.05). Growth hormone therapy significantly reducedplasma triglyceride level of P1 by 11.78% (118.82 mg/dL, p < 0.01), P2 by 23.46% (103.41 mg/dL, p < 0.01),and P3 by 35.15% (90.22 mg/dL, p < 0.01). Comparison of post test data amomg the groups showedsignificant difference (p < 0.01). This study show that growth hormone therapy could reduce plasmatriglyceride level in dyslipidemic rat. However, further research is needed to more understand the effect ofthe therapy on cardiovascular diseases.

Effect of single clove garlic on clinical symptoms of photoaging in wistar rats exposed with UV-B Nyoman Pratiwi Hapsari Dewi; I Gusti Ayu Dewi Ratnayanti; I Gusti Kamasan Nyoman Arijana; Ni Made Linawati
Bali Anatomy Journal Vol 2 No 2 (2019): Bali Anatomy Journal (BAJ)
Publisher : Department of Anatomy, Medical Faculty, Universitas Udayana, Bali-Indonesia

Background: Photoaging is a premature aging that occurs on skin due to the ultraviolet light exposure that causes the emergence of clinical symptoms, one of which is wrinkle. One kind of material that can prevent photoaging is antioxidant. A single clove garlic has the highest antioxidant activity compared to the other materials. Aim: This research aimed at investigating the effectivity of single clove garlic in inhibiting the clinical symptom of photoaging. Method: This research was an experimental research, utilizing pre-post-test control group design. The used sample were 30 male wistar rats which were divided into 6 experimental groups. All groups were exposed to UV-B light with the amount of 840 mJ/cm2. Control group (P1) was only exposed to UV-B while the other groups were treated with placebo cream (P2), sunblock (P3), 5% garlic cream (P4), 10% garlic cream (P5) and 20% garlic cream (P6) respectively. The clinical symptom in the form of wrinkle was observed by using dermascope and the observations were categorized based on Glogau Scale. The statistical analysis utilized Wilcoxon and Kruskal Wallis test which was followed by Mann Whitney test. Result: The result of the research showed that there was significant difference on the apparent wrinkle on P1 group and P3, P5 and P6. Meanwhile the comparison between P1, P2 and P4 was not significant. Conclusion: The single clove garlic extract can prevent photoaging and has the similar protective effect for the skin as of sunblock.

Effects of red dragon fruit (Hylocereus polyrhizus) peel on low-density lipoprotein levels in menopause wistar rats Dyta Putri Aryo; I Wayan Sugiritama; I Gusti Nyoman Sri Wiryawan; I Gusti Ayu Dewi Ratnayanti
Bali Anatomy Journal Vol 3 No 1 (2020): Bali Anatomy Journal (BAJ)
Publisher : Department of Anatomy, Medical Faculty, Universitas Udayana, Bali-Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36675/baj.v3i1.37

Background: Estrogen has major role to control LDL levels in woman’s body, therefore if a woman experienced hypoestrogen condition usually during menopause phase, there is an increase of the LDL levels. Anthocyanin has similar structure with isoflavones, which have been widely studied and proven to be estrogenic. One of the food ingredients that is rich in anthocyanin is the peel of red dragon fruit (Hylocereus polyrhizus), so it is hoped that this red dragon fruit peels can be a source of phytoestrogens that can play a role in improving LDL levels in menopausal women. Aim: To determine the effect of red dragon fruit peel (Hylocereus polyrhizus) on Low Density Lipoprotein levels in menopause wistar rats. Method: This study was a purely experimental study with a randomized post-test only control group design with a sample of 27 female wistar rats that had fulfilled the inclusion and exclusion criteria. The study sample was divided into 3 (three) groups with each group consisting of 9 female wistar rats, namely the control group (P0), the ethanol extract of red dragon fruit peels at a dose of 60mg / 200grBB group (P1), and dose 90mg / 200grBB group (P2).Result: There was a significant difference between P0 and P1 so that between P0 and P2, meanwhile comparison between P1 and P2 showed only slight difference. Conclusion: The red dragon peel extract can control LDL levels, therefore it is possible to be a substitute of estrogen endogen in menopausal women.

Java plum (Syzygium cumini) extract cream effect on decreasing the number of sunburn cell on the dorsal skin of male Wistar rat (Rattus norvegicus) exposed to UV-radiation Dinesh Tanabbal; I Gusti Ayu Dewi Ratnayanti; I Gusti Nyoman Sri Wiryawan; I Gusti Kamasan Nyoman Arijana; Ida Ayu Ika Wahyuniari
Neurologico Spinale Medico Chirurgico Vol 3 No 1 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i1.89

Background: The primary acute damage due to UV radiation is keratinocyte apoptosis or sunburn cell. Previous studies showed that antioxidants inhibit UV damage. Java plum (Syzygium cumini) which is found in Indonesia, was known to have a high concentration of antioxidants. This study was aimed to assess the Java plum ethanol extract cream effects on the number of sunburn cells on the dorsal skin of male Wistar rats that exposed to UV-B. Methods This experimental research was a post-test only control group design that was conducted on 30 male rats. Groups were divided into control, placebo, 5%, 10%, and 20% ethanol extract cream concentrations (P1, P2, P3, P4, and P5, respectively). The number of sunburn cell were then observed and recorded based on visual evaluation of the skin biopsy under a light microscope. Results: The mean results of P1, P2, P3, P4, and P5 were 132.67, 98.67, 118.67, 104.00, and 54.67 respectively. The control, placebo, 5%, and 10% ethanol extract cream showed no significant result (p>0.05). In contrast, 20% ethanol extract cream showed a protective effect (p<0.05). Conclusion: Java plum ethanol extract cream with 20% dose could decrease the number of sunburn cells in the skin.

Red dragon fruit (Hylocereus polyrhizhus) in preventing collagen decrease in menopause induced rats skin Eswariy Chandramogan; I Wayan Sugiritama; I Gusti Ayu Dewi Ratnayanti; I Gusti Nyoman Sri Wiryawan; Ida Ayu Ika Wahyuniari
Neurologico Spinale Medico Chirurgico Vol 3 No 1 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i1.90

Background: Skin aging in menopause women was due to fewer collagen numbers in cells and antioxidants are necessary for inhibiting the process of skin aging due to oxidative stress. Red dragon fruits which plant in Indonesia was known to have a high concentration of antioxidants. This study aimed to assess the ethanol extract of red dragon fruit skin effects on the number of collagens on the skin of female Wistar rats which has been ovariectomized. Methods: This experimental research was a post-test only control group design that was conducted on 30 female Wistar rats. Groups were divided into control (P0), 5% ethanol extract (P1), and 15% ethanol extract concentrations (P2). The dosage was given orally to the 30 female rats and left for observation for 30 days. The number of collagens was observed and calculated on visual evaluation of the skin biopsy under a light microscope. Results: The result showed a significant difference between treatment groups and control (p<0.05). The number of collagen are higher in P2 (83.03 ±4.84) and P1 (77.26 ±5.06) than P0 (57.73 ±5.04). Conclusion: Ethanol extract of red dragon fruit skin could increase the number of collagen in rat skin.

Topical application of purple cabbage (Brassica oleracea L. var. capitata f. rubra) ethanol cream extract of dermic collagen on male Wistar rats (Rattus norvegicus) exposed to ultraviolet B Komang Jegek Triangga Apsari; I Gusti Ayu Dewi Ratnayanti; I Gusti Komang Nyoman Arijana; I Wayan Sugiritama
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Purple cabbage or also known as red cabbage (Brassica oleracea L. var. capitata f. rubra) contains polyphenols, especially anthocyanin (cyanidin-3-diglucoside-5-glucoside). Anthocyanin has a protective effect against radical oxidative superoxide (ROS). Thus it can prevent skin damage caused by ultraviolet (UV)-B radiation.Aim: The research aims to prove the effectivity of distribution of purple cabbage ethanol cream extract prevented the decrease of dermal collagens on Wistar rats (Rattus norvegicus) exposed to UV-B rays.Method: This research was arranged with the randomize post-test only control group design. 30 rats were divided into 6 groups containing 5 rats each, there are control group (P1) without distribution of any cream, Treatment Group (P2) with a distribution of base cream (placebo), (P3) sunblock 33 SPF, (P4) 5%, (P5) 10 %, and (P6) 20 % smeared by purple cabbage ethanol cream extract. All groups exposed to UV-B with a total dose of 840 mJ/cm2 for 4 weeks. Then a sampling rats skin was done for examining the level of collagen skin with Sirius red staining. The level of collagen was calculated by the percentage of the area of the pixel of collagen and was compared with the pixels of entire dermal tissues.Result: The result demonstrated that the mean of collagens in The First Group/P1 (57.74%) and P2 (60.84%) decreased more significantly than P3 (82.17%), P4 (68.23%), P5 (76.93%), and P6 (84.54%) following UV-B exposure. The Post Hoc result showed that there was no significant difference in the level of collagen in the control group and placebo group and the sunblock group with the purple cabbageâ€™s ethanol cream extract group of 20% (p>0.05).Conclusion: the distribution of purple cabbage ethanol cream extract prevented the decrease of dermal collagens on male Wistar rats skin exposed to UV-B.

Ethanolic extract cream of red cabbage (Brassica oleracea L. var. capitata f.rubra) on the epidermal thickness in Wistar rats (Rattus norvegicus) after ultraviolet-B exposure Yogarani V.C Rajappan; I Gusti Kamasan Arijana; I Wayan Sugiritama; IGA Dewi Ratnayanti
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: UV exposure is related to oxidative stress and also as an essential factor in skin photoaging. Several antioxidants are widely used in preventing skin photoaging by influencing epidermal skin layer. High concentrations of antioxidant properties in red cabbage are known to have these effects. This study aims to determine the role of ethanolic extract cream of red cabbage on the epidermal thickness in Wistar rats after UV-B exposure.Methods: An experimental study was carried out among 25 Wistar rats which divided into 5 groups as follows: P1 as control (only exposed to UB-B), P2 (placebo and UV-B), P3 (5% ethanolic extract cream and UV-B), P4 (10% ethanolic extract cream and UV-B), and P5 (20% ethanolic extract cream and UVB). The UV-B dosage applied for each group was 65 mJ/cm2. The thickness of epidermis is calculated by direct measurement using Image Raster software from basal membrane to stratum corneum. The statistical analyses were performed using SPSS ver. 20.0.Results: There was a significantly different in the epidermal thickness among groups (P < 0.05). The mean of epidermal thickness in the control group (P1) was 36.00Â±1.08 Âµm, followed by 27.66Â±0.87 Âµm in the treatment group I (P2), 26.76Â±1.02 Âµm in the treatment group II (P3), 24.94Â±1.25 Âµm in the treatment group III (P4), and 20.24Â±1.47 Âµm in the treatment group IV (P5).Conclusion: The ethanolic extract cream of red cabbage (Brassica oleracea L.Var. capitata f. rubra) in different doses have a statistically significant impact on the epidermal thickness in Wistar rats after UV-B exposure.

The effect of purple mangosteen (Garcinia mangostana) peel extract on collagen fiber in male Wistar rats after Ultraviolet-B (UV-B) exposure Tarvin Jit Singh Gill; I Gusti Ayu Dewi Ratnayanti; I Gusti Kamasan Nyoman Arijana
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: Skin aging can be caused by long-term ultraviolet (UV) exposure that usually called as photoaging. Administered antioxidant substances can delay the photoaging process. Purple mangosteen is known to have abundant antioxidant properties such as xanthones and anthocyanins. This study aims to determine the effect of purple mangosteen peel extract on the collagen fiber in male Wistar rats after UV-B exposure.Methods: An experimental study was conducted among 21 male Wistar rats at Histology Laboratorium, Udayana University from a period of March-October 2017. The samples were divided into 3 groups as follows: control, placebo, and mangosteen extract with 7 rats in each group. Collagen fiber was assessed by using a light microscope with 400 times magnification. Statistical analysis was carried out using SPSS ver. 21 software using one way ANOVA.Results: The study found that percentage of collagen area within control group was 61.94%, placebo group 72.90%, and mangosteen peel extract 73.63%. The mean between-group analyzed using one way ANOVA found that there was a statistically significant difference in mangosteen peel extract than control group (p=0.0000), but not statistically significant if compared with placebo group (p=0.640) on the collagen fiber in male Wistar rats.Conclusion: there was a statistically significant difference in mangosteen peel extract than control group on the thickness of collagen fiber in male Wistar rats after UV-B exposure.

The effect of Euphorbia milii tea and its combination with Propolis on number of glomeruli in M.tb-infected mice: a histopathology study Ruthirar Kalaichelvam; Ni Made Linawati; I Gusti Nyoman Sri Wiryawan; Gede Wirata; I Gusti Ayu Dewi Ratnayanti; I Wayan Sugiritama; Ida Ayu Ika Wahyuniari; I Gusti Kamasan Nyoman Arijana
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: The role of both Euphorbia milii and Propolis is to increase the effectiveness in pathological condition of the body part damaged, include renal function in maintaining the homeostasis. That combination into mice which are infected by Mycobacterium tuberculosis will change the total number of glomerulus in the kidney.Aim: The study aims to determine the effect of combination tea from Euphorbia milii and Propolis on the number of the glomerulus in mice infected by M. tb.Method: This study confirmed randomized post-test only control group design consisting of 24 mice divided into six groups (G1-G6). E. milli flowers are obtained from flower plantations, in Ketewel, Gianyar, Bali Province took in fresh and dark red sampling. M. tuberculosis used H37Rv strain (ATCC27294) grown on Middlebrook 7H9 liquid medium for two weeks.Result: It was found that Group 3 and Group 5 from the treatment group has the most significant average number of glomerulus which was 13, followed by Group 2 and Group 6 from the control group has the largest average number of glomerulus which was 12. The differences were not significant between groups with P = 0.463 (P <0.05).Conclusion: The Euphorbia milii tea and its combination with Propolis does not affect histological change on the total number of glomerulus in mice infected with M. tb.

Co-Authors A. A. D. Lestari Arijana, IGK Nyoman C.M.A. Putri, D.A.A.S. Laksmi Dewa Ayu Agus Sri Laksmi Dewi Wijayanti, Ni Putu Ayu Dinesh Tanabbal Dyta Putri Aryo Eswariy Chandramogan Fedik Abdul Ratam Gede Wirata Hernowo, Elliana Freya I A. G. Pradnyani I Dewa Ayu Eka Widiari Putri I Dewa Ayu Inten Primayanti I Dewa Gede Angga Triadi Nata I G. A. P. Y. Artha I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Nyoman Wande I Wayan Sugiritama I.G.N.S. Wiryawan I.N. Wande I.W. Sugiritama Joshua Ezra Ronaldo Bayak K. Widnyani Astuti Komang Jegek Triangga Apsari Linawati N.M M.A. Wardhana Mayun G.N N. P. A. D. Wijayanti N.M. Linawati N.P.A.D. Wijayanti Ni Made Linawati Ni Made Mertaniasih Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Sriwidyani NKA Maya Damayanti Nyoman Pratiwi Hapsari Dewi P.P.A.P. Dewi Ruthirar Kalaichelvam Tarvin Jit Singh Gill Yogarani V.C Rajappan Z. Aini,

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