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All Journal Medicina Jurnal Kimia (Journal of Chemistry) Buletin Udayana Mengabdi E-Jurnal Medika Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Neurologico Spinale Medico Chirurgico Bali Anatomy Journal

I Gusti Ayu Dewi Ratnayanti

Department Of Histology, Faculty Of Medicine, Udayana University, Bali, Indonesia

Author-ID : 252323

Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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Java plum (Syzygium cumini) extract cream effect on decreasing the number of sunburn cell on the dorsal skin of male Wistar rat (Rattus norvegicus) exposed to UV-radiation Dinesh Tanabbal; I Gusti Ayu Dewi Ratnayanti; I Gusti Nyoman Sri Wiryawan; I Gusti Kamasan Nyoman Arijana; Ida Ayu Ika Wahyuniari
Neurologico Spinale Medico Chirurgico Vol 3 No 1 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i1.89

Background: The primary acute damage due to UV radiation is keratinocyte apoptosis or sunburn cell. Previous studies showed that antioxidants inhibit UV damage. Java plum (Syzygium cumini) which is found in Indonesia, was known to have a high concentration of antioxidants. This study was aimed to assess the Java plum ethanol extract cream effects on the number of sunburn cells on the dorsal skin of male Wistar rats that exposed to UV-B. Methods This experimental research was a post-test only control group design that was conducted on 30 male rats. Groups were divided into control, placebo, 5%, 10%, and 20% ethanol extract cream concentrations (P1, P2, P3, P4, and P5, respectively). The number of sunburn cell were then observed and recorded based on visual evaluation of the skin biopsy under a light microscope. Results: The mean results of P1, P2, P3, P4, and P5 were 132.67, 98.67, 118.67, 104.00, and 54.67 respectively. The control, placebo, 5%, and 10% ethanol extract cream showed no significant result (p>0.05). In contrast, 20% ethanol extract cream showed a protective effect (p<0.05). Conclusion: Java plum ethanol extract cream with 20% dose could decrease the number of sunburn cells in the skin.

Red dragon fruit (Hylocereus polyrhizhus) in preventing collagen decrease in menopause induced rats skin Eswariy Chandramogan; I Wayan Sugiritama; I Gusti Ayu Dewi Ratnayanti; I Gusti Nyoman Sri Wiryawan; Ida Ayu Ika Wahyuniari
Neurologico Spinale Medico Chirurgico Vol 3 No 1 (2020)
Publisher : Indoscholar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36444/nsmc.v3i1.90

Background: Skin aging in menopause women was due to fewer collagen numbers in cells and antioxidants are necessary for inhibiting the process of skin aging due to oxidative stress. Red dragon fruits which plant in Indonesia was known to have a high concentration of antioxidants. This study aimed to assess the ethanol extract of red dragon fruit skin effects on the number of collagens on the skin of female Wistar rats which has been ovariectomized. Methods: This experimental research was a post-test only control group design that was conducted on 30 female Wistar rats. Groups were divided into control (P0), 5% ethanol extract (P1), and 15% ethanol extract concentrations (P2). The dosage was given orally to the 30 female rats and left for observation for 30 days. The number of collagens was observed and calculated on visual evaluation of the skin biopsy under a light microscope. Results: The result showed a significant difference between treatment groups and control (p<0.05). The number of collagen are higher in P2 (83.03 ±4.84) and P1 (77.26 ±5.06) than P0 (57.73 ±5.04). Conclusion: Ethanol extract of red dragon fruit skin could increase the number of collagen in rat skin.

Topical application of purple cabbage (Brassica oleracea L. var. capitata f. rubra) ethanol cream extract of dermic collagen on male Wistar rats (Rattus norvegicus) exposed to ultraviolet B Komang Jegek Triangga Apsari; I Gusti Ayu Dewi Ratnayanti; I Gusti Komang Nyoman Arijana; I Wayan Sugiritama
Intisari Sains Medis Vol. 11 No. 1 (2020): (Available online: 1 April 2020)
Publisher : DiscoverSys Inc.

Background: Purple cabbage or also known as red cabbage (Brassica oleracea L. var. capitata f. rubra) contains polyphenols, especially anthocyanin (cyanidin-3-diglucoside-5-glucoside). Anthocyanin has a protective effect against radical oxidative superoxide (ROS). Thus it can prevent skin damage caused by ultraviolet (UV)-B radiation.Aim: The research aims to prove the effectivity of distribution of purple cabbage ethanol cream extract prevented the decrease of dermal collagens on Wistar rats (Rattus norvegicus) exposed to UV-B rays.Method: This research was arranged with the randomize post-test only control group design. 30 rats were divided into 6 groups containing 5 rats each, there are control group (P1) without distribution of any cream, Treatment Group (P2) with a distribution of base cream (placebo), (P3) sunblock 33 SPF, (P4) 5%, (P5) 10 %, and (P6) 20 % smeared by purple cabbage ethanol cream extract. All groups exposed to UV-B with a total dose of 840 mJ/cm2 for 4 weeks. Then a sampling rats skin was done for examining the level of collagen skin with Sirius red staining. The level of collagen was calculated by the percentage of the area of the pixel of collagen and was compared with the pixels of entire dermal tissues.Result: The result demonstrated that the mean of collagens in The First Group/P1 (57.74%) and P2 (60.84%) decreased more significantly than P3 (82.17%), P4 (68.23%), P5 (76.93%), and P6 (84.54%) following UV-B exposure. The Post Hoc result showed that there was no significant difference in the level of collagen in the control group and placebo group and the sunblock group with the purple cabbageâ€™s ethanol cream extract group of 20% (p>0.05).Conclusion: the distribution of purple cabbage ethanol cream extract prevented the decrease of dermal collagens on male Wistar rats skin exposed to UV-B.

Ethanolic extract cream of red cabbage (Brassica oleracea L. var. capitata f.rubra) on the epidermal thickness in Wistar rats (Rattus norvegicus) after ultraviolet-B exposure Yogarani V.C Rajappan; I Gusti Kamasan Arijana; I Wayan Sugiritama; IGA Dewi Ratnayanti
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: UV exposure is related to oxidative stress and also as an essential factor in skin photoaging. Several antioxidants are widely used in preventing skin photoaging by influencing epidermal skin layer. High concentrations of antioxidant properties in red cabbage are known to have these effects. This study aims to determine the role of ethanolic extract cream of red cabbage on the epidermal thickness in Wistar rats after UV-B exposure.Methods: An experimental study was carried out among 25 Wistar rats which divided into 5 groups as follows: P1 as control (only exposed to UB-B), P2 (placebo and UV-B), P3 (5% ethanolic extract cream and UV-B), P4 (10% ethanolic extract cream and UV-B), and P5 (20% ethanolic extract cream and UVB). The UV-B dosage applied for each group was 65 mJ/cm2. The thickness of epidermis is calculated by direct measurement using Image Raster software from basal membrane to stratum corneum. The statistical analyses were performed using SPSS ver. 20.0.Results: There was a significantly different in the epidermal thickness among groups (P < 0.05). The mean of epidermal thickness in the control group (P1) was 36.00Â±1.08 Âµm, followed by 27.66Â±0.87 Âµm in the treatment group I (P2), 26.76Â±1.02 Âµm in the treatment group II (P3), 24.94Â±1.25 Âµm in the treatment group III (P4), and 20.24Â±1.47 Âµm in the treatment group IV (P5).Conclusion: The ethanolic extract cream of red cabbage (Brassica oleracea L.Var. capitata f. rubra) in different doses have a statistically significant impact on the epidermal thickness in Wistar rats after UV-B exposure.

The effect of purple mangosteen (Garcinia mangostana) peel extract on collagen fiber in male Wistar rats after Ultraviolet-B (UV-B) exposure Tarvin Jit Singh Gill; I Gusti Ayu Dewi Ratnayanti; I Gusti Kamasan Nyoman Arijana
Intisari Sains Medis Vol. 9 No. 3 (2018): (Available online: 1 December 2018)
Publisher : DiscoverSys Inc.

Background: Skin aging can be caused by long-term ultraviolet (UV) exposure that usually called as photoaging. Administered antioxidant substances can delay the photoaging process. Purple mangosteen is known to have abundant antioxidant properties such as xanthones and anthocyanins. This study aims to determine the effect of purple mangosteen peel extract on the collagen fiber in male Wistar rats after UV-B exposure.Methods: An experimental study was conducted among 21 male Wistar rats at Histology Laboratorium, Udayana University from a period of March-October 2017. The samples were divided into 3 groups as follows: control, placebo, and mangosteen extract with 7 rats in each group. Collagen fiber was assessed by using a light microscope with 400 times magnification. Statistical analysis was carried out using SPSS ver. 21 software using one way ANOVA.Results: The study found that percentage of collagen area within control group was 61.94%, placebo group 72.90%, and mangosteen peel extract 73.63%. The mean between-group analyzed using one way ANOVA found that there was a statistically significant difference in mangosteen peel extract than control group (p=0.0000), but not statistically significant if compared with placebo group (p=0.640) on the collagen fiber in male Wistar rats.Conclusion: there was a statistically significant difference in mangosteen peel extract than control group on the thickness of collagen fiber in male Wistar rats after UV-B exposure.

The effect of Euphorbia milii tea and its combination with Propolis on number of glomeruli in M.tb-infected mice: a histopathology study Ruthirar Kalaichelvam; Ni Made Linawati; I Gusti Nyoman Sri Wiryawan; Gede Wirata; I Gusti Ayu Dewi Ratnayanti; I Wayan Sugiritama; Ida Ayu Ika Wahyuniari; I Gusti Kamasan Nyoman Arijana
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Background: The role of both Euphorbia milii and Propolis is to increase the effectiveness in pathological condition of the body part damaged, include renal function in maintaining the homeostasis. That combination into mice which are infected by Mycobacterium tuberculosis will change the total number of glomerulus in the kidney.Aim: The study aims to determine the effect of combination tea from Euphorbia milii and Propolis on the number of the glomerulus in mice infected by M. tb.Method: This study confirmed randomized post-test only control group design consisting of 24 mice divided into six groups (G1-G6). E. milli flowers are obtained from flower plantations, in Ketewel, Gianyar, Bali Province took in fresh and dark red sampling. M. tuberculosis used H37Rv strain (ATCC27294) grown on Middlebrook 7H9 liquid medium for two weeks.Result: It was found that Group 3 and Group 5 from the treatment group has the most significant average number of glomerulus which was 13, followed by Group 2 and Group 6 from the control group has the largest average number of glomerulus which was 12. The differences were not significant between groups with P = 0.463 (P <0.05).Conclusion: The Euphorbia milii tea and its combination with Propolis does not affect histological change on the total number of glomerulus in mice infected with M. tb.

PROFIL KADAR KREATININ DAN ASAM URAT SEBAGAI PENANDA FUNGSI GINJAL PADA PENDUDUK LANSIA DI DESA KETEWEL I.N. Wande; I.G.A.D. Ratnayanti; I.G.K.N. Arijana; N.M. Linawati; P.P.A.P. Dewi
Buletin Udayana Mengabdi Vol 22 No 2 (2023): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/BUM.2023.v22.i02.p06

Background. Elderly is a group of population aged 46 years and over based on the age category according to the Ministry of Health of the Republic of Indonesia 2009. The function of the body's organs of the elderly population will decrease over time, especially kidney function. Several laboratory tests that can be used to assess kidney function are measuring the glomerular filtration rate or measuring levels of non-protein nitrogen such as creatinine and uric acid. Objectives. To determine kidney health in the elderly population in Ketewel Village by measuring blood creatinine and uric acid levels and providing education to keep the kidneys healthy. Implementation method. Elderly residents were given information about free kidney function tests, namely uric acid and blood creatinine, then directed to the Mantra Medika Clinical Laboratory for blood collection to avoid crowds due to the Covid-19 pandemic situation. Examination of blood creatinine and uric acid with the Erba XL100® device. Results. There were 22 elderly residents of Ketewel Village who did free creatinine and blood uric acid test. A total of 11 elderly men and 11 elderly women who participated in this program. The average age of the elderly who underwent examination was 59.95 ± 9.04 years. The mean systolic blood pressure was 127 ± 15 mmHg. The mean diastolic blood pressure was 76 ± 9.5 mmHg. The mean blood creatinine level was 0.95 ± 0.2 mg/dl. The average blood uric acid level was 5.42 ± 0.92 mg/dl. Conclusion. Free examination Creatinine and blood uric acid levels in the elderly population in Ketewel Village are within normal limits which can indicate kidney function of the elderly population is still within normal limits. Keywords: Creatinine, uric acid, elderly, Ketewel Villag

DISTRIBUSI GOLONGAN DARAH ABO-RH SISWA SDN 3 KETEWEL SUKAWATI GIANYAR N.M. Linawati; I.G.K.N. Arijana; I.N. Wande; I.W. Sugiritama; I.G.N.S. Wiryawan; I.G.A.D. Ratnayanti; I.A.I. Wahyuniari; D.A.A.S. Laksmi
Buletin Udayana Mengabdi Vol 21 No 4 (2022): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/BUM.2022.v21.i04.p02

Blood group is one of the identification parameters of a person's identity. Blood group is important to know in relation to medical and non-medical problems. However, there are still many blood group data that are not known to students in Ketewel village. This activity aims to determine the ABO-Rhesus blood group in children at SDN 3 Ketewel. The activity was carried out after coordinating with the Village Head, the headmaster of SDN 3 and also Mantra Medika Clinical Laboratory in Ketewel. Implementation of activities in August 2021 by complying with health protocols during the pandemic of Covid-19. The results of the activity were obtained as many as 65 students consisting of 35 male and 30 female which was 100% positive Rhesus. The distribution of ABO blood typing in male students was 14% A, 25% B, 62% O and 3% AB. Meanwhile, distribution of ABO blood type in female students is 13% A, 33% B and 47% O. From the activity, it can be concluded that the distribution of ABO-Rhesus blood group in SDN 3 Ketewel students is mostly O, the least blood group is AB which were all students Rhesus positive. Keywords: Identification, ABO-Rhesus blood group, SDN 3 Ketewel

MASKER GEL EKSTRAK KULIT MANGGIS MENCEGAH PENINGKATAN UKURAN KELENJAR SEBASEA KULIT TIKUS WISTAR YANG DIPAPAR SINAR UVB Arijana, I Gusti Kamasan Nyoman; Dewi Ratnayanti, I Gusti Ayu; Sri Wiryawan, I Gusti Nyoman; Dewi Wijayanti, Ni Putu Ayu
E-Jurnal Medika Udayana Vol 12 No 5 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i05.P10

Kelemahan daya saing industri kosmetik estetik dalam negeri terhadap produk asing terutama disebabkan kurangnya data ilmiah mengenai efikasi produk untuk mendukung daya jualnya. Salah satu produk kosmetika yang sedang dikembangkan adalah masker gel ekstrak kulit manggis. Penelitian sebelumnya menunjukkan potensi masker ini untuk mencegah penuaan dini kulit akibat sinar matahari. Pada penelitian ini ingin diketahui pengaruhnya terhadap kelenjar sebaseus kulit. Rancangan penelitian eksperimental post test only control group dilakukan pada 27 tikus Wistar yang dipapar sinar UVB 840mJ selama 28 hari. Sampel dibagi ke dalam tiga kelompok, yaitu P0 (kontrol normal), P1 (dipapar sinar UVB dan dioles plasebo), dan P2 (dipapar sinar UVB dan dioles masker). Sampel kulit tikus kemudian diproses untuk pengecatan HE lalu ukuran kelanjar sebaseus dianalisis dengan software image raster. Setelah dilakukan analisis dengan anova satu jalan didapatkan perbedaan bermakna (p<0,05) ukuran kelenjar sebaseus antara kelompok P2 (11,51%) dengan kelompok P0 (3,77%) dan P1 (5,04%), sedangkan P0 dan P1 tidak menunjukkan perbedaan bermakna (p>0,05). Penelitian membuktikan bahwa masker gel ekstrak kulit manggis dapat mencegah peningkatan ukuran kelenjar sebasea akibat paparan sinar matahari. Kata kunci : pembesaran kelenjar sebaseus., UVB., penuaan kulit., masker gel kulit manggis

PENGARUH PEMBERIAN EKSTRAK KULIT BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) SEBAGAI FITOESTROGEN TERHADAP STEATOSIS HEPAR TIKUS MODEL MENOPAUSE Hernowo, Elliana Freya; Arijana, IGK Nyoman; Sugiritama, I Wayan; Ratnayanti, IGA Dewi
E-Jurnal Medika Udayana Vol 12 No 6 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i06.P17

Latar belakang: Wanita menopause akan mengalami penurunan hormon estrogen. Hormon estrogen diketahui memiliki sifat hepatoprotektif yang mampu mencegah terjadinya perlemakan pada hepar. Penurunan kadar estrogen bisa digantikan dengan senyawa fitoestrogen. Kulit buah naga merah (Hylocereus polyrhizus) diketahui memiliki banyak kandungan antosianin yang terbukti memiliki aktivitas sebagai fitoestrogen. Tujuan: Mengetahui adakah perubahan steatosis hepar tikus model menopause dengan pemberian ekstrak etanol kulit buah Hylocereus Polyrhizus. Metode: Penelitian ini merupakan penelitian randomized post-test control group design dengan menggunakan tiga kelompok sampel yang sudah melalui prosedur ovariektomi. Ketiga kelompok adalah kelompok P0 sebagai kontrol tanpa intervensi, P1 dengan intervensi ekstrak etanol kulit buah naga merah dosis 60mg/200grBB, dan P2 dengan intervensi ekstrak etanol kulit buah naga merah dosis 90mg/200grBB. Hasil: Didapatkan rerata jumlah sel steatosis per 100 sel hepar tikus model menopause pada kelompok P0, P1, dan P2 adalah 59,1259 ± 10,0087; 53,0435 ± 14,0674; 41,5001 ± 10,5814. Hasil One Way ANOVA menemukan adanya perbedaan yang bermakna dengan nilai p = 0,013. Hasil uji Post Hoc LSD menemukan perbedaan rerata antara kelompok P2 dengan P0 ditemukan bermakna (p = 0,004) dan P2 dengan P1 juga bermakna (p = 0,047). Sedangkan P0 dan P1 tidak bermakna (p = 0,247). Simpulan: Ekstrak etanol kulit buah Hylocereus Polyrhizus memiliki pengaruh terhadap steatosis hepar tikus model menopause. Didapatkan steatosis hepar terendah pada kelompok intervensi 90mg/200grBB. Kata kunci : Hylocereus polyrhizus, steatosis, menopause, fitoestrogen

Co-Authors A. A. D. Lestari Arijana, IGK Nyoman C.M.A. Putri, D.A.A.S. Laksmi Dewa Ayu Agus Sri Laksmi Dewi Wijayanti, Ni Putu Ayu Dinesh Tanabbal Dyta Putri Aryo Eswariy Chandramogan Fedik Abdul Ratam Gede Wirata Hernowo, Elliana Freya I A. G. Pradnyani I Dewa Ayu Eka Widiari Putri I Dewa Ayu Inten Primayanti I Dewa Gede Angga Triadi Nata I G. A. P. Y. Artha I Gusti Kamasan I Gusti Kamasan Arijana I Gusti Kamasan Nyoman Arijana I Gusti Ngurah Mayun I Gusti Nyoman Sri Wiryawan I Nyoman Wande I Wayan Sugiritama I.G.N.S. Wiryawan I.N. Wande I.W. Sugiritama Joshua Ezra Ronaldo Bayak K. Widnyani Astuti Komang Jegek Triangga Apsari Linawati N.M M.A. Wardhana Mayun G.N N. P. A. D. Wijayanti N.M. Linawati N.P.A.D. Wijayanti Ni Made Linawati Ni Made Mertaniasih Ni Nyoman Sri Budayanti Ni Putu Candra Paramita Ni Putu Sriwidyani NKA Maya Damayanti Nyoman Pratiwi Hapsari Dewi P.P.A.P. Dewi Ruthirar Kalaichelvam Tarvin Jit Singh Gill Yogarani V.C Rajappan Z. Aini,

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