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Characterization of Classic Meningioma with Use of Conventional Magnetic Resonance and Diffusion Tensor Imaging Fatmawati, Heni; Adji, Novan Krisno; Bumi, Candra; Putri, Komang Yunita Wiryaning
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1133

Abstract

Introduction: The conventional magnetic resonance imaging (MRI) method is widely considered ‘with limited success’ in differentiating the meningioma types but may fail to localize the tumor occupation of white-matter fiber bundles accurately. Diffusion tensor imaging (DTI) is considered as an imaging modality that may elucidate the microstructure of brain tumors. We provide characteristics of meningioma using DTI-based-three-dimensional tracing of white matter to portray meningioma in a noninvasive approach and its structural contact to contiguous tumors and elucidate the influence of occupying lesions on white-matter fiber bundles. Case Presentation: A 28-year-old female presented with visuospatial disturbances and persistent headaches for 2 years. Conventional and advanced MRI studies were performed. Diffusion-weighted Images (DWI) and Apparent Diffusion Coefficient (ADC) values were measured in the lesion using routine MRI sequences. Advanced MRI using DTI was also performed. Conventional MRI outcomes showed tumor parenchyma, peritumoral edema, and compression on the circumnavigated brain tissue. There was hyperintense on DW trace image and isointense on ADC map. On T2-weighted image (T2WI) and Fluid-Attenuated Inversion Recovery (FLAIR) images, there was an increased signal intensity that demonstrated an extra-axial lesion, while T1-weighted imaging signals showed hypointensity. DTI fractional anisotropy (FA) marker is an unclear optic radiation in the concerned area, indicating the shift or destruction of the optic radiation. The mean FA values of solid-enhancing areas of meningioma were 0.28 ± 0.17. Mean ADC values (103 mm2/s) were 0.764 ± 0.172. Conclusions: Classic meningioma in this case has low intratumoral FA and high ADC. DTI displayed that intratumoral microscopic water motion is disorganized.
Epidemiology of Pulmonary Tuberculosis in Diabetes Mellitus Patients Syahputri, Siti Ananda Hardita; Mufida, Diana Chusna; Bumi, Candra
Jurnal Kesehatan Vol 14 No 2 (2023): Jurnal Kesehatan
Publisher : Poltekkes Kemenkes Tanjung Karang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jk.v14i2.3963

Abstract

Pulmonary Tuberculosis (pulmonary TB) and Type 2 Diabetes Mellitus (DMT2) are the leading causes of death worldwide. The prevalence of T2DM has increased worldwide as an aging result, urbanization, changes in diet, and reduced physical activity patterns, which have increased obesity. Pulmonary TB and T2DM often occur together and complicate each other during treatment. Pulmonary TB infection-DMT2 appears based on a low immunity state. When the body has low immunity, the reactivation of Mycobacterium tuberculosis bacteria can occur more easily. However, several factors can influence it. This study uses a case-control design. The researcher made observations on the subjects by comparing the case group and the control group. This study had 74 respondents in the case group and 74 respondents in the control group using quota sampling. This study has the results that the factors that influence the incidence of pulmonary TB-DMT2 are smoking behavior 0.000α, age 0.877>α, and alcohol consumption 0.998>α. (α=0.05). The factor that most influences the risk of pulmonary TB-DMT2 is smoking behavior with a wald value of 13.391. This research provides information regarding the problem of pulmonary TB-DMT2 in Jember. To increase public awareness of the risk for Pulmonary TB-DMT2.
Sosialiasi Pencegahan Penuaan Dini Pada Pekerja Perkebunan Desa Pakis Kecamatan Panti Kabupaten Jember 2022 Prasetyowati, Irma; Simanjuntak, Tri Damayanti; Bumi, Candra
UNEJ e-Proceeding 2023: Prosiding Kolokium Pengabdian kepada Masyarakat Fakultas Kesehatan Masyarakat
Publisher : UPT Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Premature Ageing can accelerate the emergence of degenerative diseases. Plantation workers or farmers are a group of workers who are very vulnerable to degenerative diseases and accidents in carrying out their work. This activity aims to socialize the prevention of premature aging among plantation workers. Method: This activity uses the counseling method with the target of plantation workers in Pakis Village, Panti District, Jember Regency. The stages of the activities start from the preparation, implementation, and evaluation of activities. The instrument used is a booklet. Results: The socialization contained definitions of premature aging and emerging degenerative diseases, CERDIK prevention, adherence to using personal protective equipment (PPE) while at work, hand washing with soap (CTPS) behavior, and increased knowledge and behavior paying attention to a healthy and balanced nutritional diet, especially foods that contain antioxidants. Participants actively participate through question and answer. Conclusion: socialization activities to increase the knowledge, understanding, and awareness of plantation workers are crucial to prevent premature aging and degenerative diseases.Keywords: prevention, premature aging, plantation workers
THE IMPLEMENTATION OF ADA SCREENING TOOLS TO DETERMINE THE BLOOD SUGAR TEST FLOW IN POSYANDU LANSIA Winarismasari, Khoirunnisa Yunita; Candra Bumi
Indonesian Journal of Community Health Nursing Vol. 9 No. 1 (2024): FEBRUARY 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijchn.v9i1.46005

Abstract

Abstract Introduction: The high incidence of undiagnosed diabetes may increase the incidence of T2DM. Therefore, prediabetes screening activities are needed to detect prediabetes cases early to prevent them from developing into T2DM. Methods: A descriptive research analysis with a cross-sectional approach was conducted in Posyandu Lansia in the area of Sumbersari Health Centre, Jember. The population of this study was all people who visited the Sumbersari Health Centre aged 40 years and over. The number of samples obtained as many as 246 with the sampling technique is systematic random sampling. The Data processing was done descriptively and using the ROC (Receiver Operating Characteristic) test to see the results of the diagnostic test of the ADA Diabetes Risk Test instrument at the Sumbersari Health Centre with a random blood sugar test comparison. Results: From a total of 246 subjects, 159 had prediabetes. The sensitivity value at cut point 5 of 66% and specificity of 36% with a PPV value of 38% and NPV of 64%. While at the optimal cut-off point of 4, the sensitivity value is 90%, and the specificity value is 22%, with a PPV value of 40% and NPV of 77%. Moreover, the ROC curve has an AUC value that is statistically considered less effective, with a value of 56%. Conclusion: ADA Diabetes Risk Test shows promising results for prediabetes screening in the Sumbersari population with high sensitivity for determining disease. Keywords: ADA Diabetes Risk Test, Diabetes Mellitus Type 2, Prediabetes,
Tinjauan Sistematik: Hubungan Status Gizi dan Kualitas Hidup pada Lanjut Usia Yusri, Khalisa Nurima; Bumi, Candra
Muhammadiyah Journal of Geriatric Vol 4, No 1 (2023): Muhammadiyah Journal of Geriatric
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24853/mujg.4.1.81-89

Abstract

Peningkatan populasi lanjut usia tidak diikuti dengan kualitas hidupnya. Status gizi menjadi salah satu faktor yang mempengaruhi kualitas hidup lansia dan keseluruhan domainnya. Penelitian ini bertujuan untuk mengetahui hubungan status gizi dengan kualitas hidup pada lansia di seluruh dunia. Penelitian ini menggunakan metode systematic literature review dengan sumber data yang digunakan yakni database Pubmed, Science Direct, Garuda, dan PlosOne dengan kriteria: tahun publikasi dari tahun 2017 hingga 2021, artikel open access dengan semua desain penelitian kuantitatif, berbahasa Inggris atau Indonesia, serta membahas tentang status gizi dan kualitas hidup pada lansia berusia ≥ 60 tahun. Penyeleksian studi dilakukan berdasarkan kata kunci dan kriteria yang telah ditetapkan. Hasil ekstraksi dari 156 artikel, diperoleh 13 artikel membahas hubungan status gizi dan kualitas hidup lansia. Status gizi berhubungan dengan kualitas hidup lansia dengan menyebabkan beberapa dampak seperti: peningkatan kesakitan, kelelahan yang berlebihan, lambatnya kecepatan berjalan, menghambat mobilitas dan menyebabkan gangguan tidur. Lemahnya kondisi fisik menyebabkan lansia mudah mengalami depresi dan kesulitan berinteraksi sosial. Selain itu, tingginya biaya perawatan kesehatan juga berkaitan dengan tingkat kemiskinan dan stres finansial pada lansia. Diketahui pula bahwa status gizi kurang menjadi faktor risiko penyebab terjadinya sindrom frailty yang mampu memperburuk kualitas hidup lansia dalam jangka panjang.
Factors Affecting The Quality of Life of Diabetes Mellitus Type 2 Patients: Literature Review: Quality of live of Diabetes Mellitus Type 2 Rifdatun Nurul Huwaidah Hasan Fahmi; Candra Bumi; Christyana Sandra
INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD) Vol. 4 No. 2 (2022): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
Publisher : STIKes Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36566/ijhsrd/Vol4.Iss2/128

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Objectives: Patients with type 2 diabetes mellitus (T2DM) had experienced physical and psychological complications that affect their daily life, and contribute to poor the quality of life. This study aims to determine the factors that affect the quality of life of people withT2DM based on the SF-36 questionnaire, to improve the factors that can be changed to improve the quality of life of people with T2DM. Methods: This literature review search from 3 databases used including google scholar, PubMed, and the garuda portal with the year of publication of the article in 2015-2021. Some of the literature states similar factors that affect the quality of life of people with T2DM.. Results: Factors that affect the quality of life of people with T2DM, include age, gender, education, complications, and duration of diabetes. Influence is given aspect or the overall value of quality of life Conclusion: The education factor can be improved with the intervention given by peers, so that they can manage T2DM well, and have an impact on improving the quality of life of T2DM patients.
Bibiliometrics Menggunakan Analisis R-Bibiloshiny Resistensi Insulin pada Obesitas Kelompok Dewasa Database Scopus (2019-2025) Krish Naufal Anugrah Robby; Rachmad Gusti Irwansyah; Leersia Yusi Ratnawati; Candra Bumi; Irma Prasetyowati; Isa Ma’rufi; Dedek Sutinbuk; Farida Wahyu Ningtyias; Anita Dewi Prahastuti Sujoso; Dewi Rokhmah; Ida Srisurani Wiji Astuti
Jurnal Kesehatan Amanah Vol. 8 No. 2 (2024): Jurnal Kesehatan Amanah
Publisher : Universitas Muhammadiyah Manado

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57214/jka.v8i2.678

Abstract

contributing to the global burden of type 2 diabetes, cardiovascular diseases, and other metabolic complications. This bibliometric study aims to analyze trends, thematic focuses, and collaborations in scientific publications related to insulin resistance in adult obesity, utilizing data from the Scopus database covering the period from 2019 to 2025. Bibliometric tools such as RStudio, Biblioshiny, and VoS Viewer were employed to extract and visualize findings from 8,037 publications. The results reveal that research activity peaked in 2021, followed by a decline in subsequent years. Dominant keywords, such as "insulin resistance," "obesity," and "metabolic syndrome," highlight the clinical and metabolic focus of current research. Biomolecular markers, such as "glycated hemoglobin" and the "triglyceride-glucose index," reflect a growing interest in more precise diagnostic tools. The United States, China, and Italy emerged as major contributors, with journals like Nutrients and Frontiers in Endocrinology leading in publications. Despite significant progress, there remains a considerable gap, particularly in exploring the role of epigenetics and the microbiota in insulin resistance. Additionally, cross-disciplinary collaboration and participation from institutions in developing countries remain limited. This study emphasizes the importance of global, interdisciplinary efforts to address these gaps and drive innovation in interventions, providing a foundation for future research aimed at reducing the impact of insulin resistance in adult obesity.
OPTIMASI KOMBINASI KAYU SECANG, JAHE, DAN STEVIA DALAM MENINGKATKAN KANDUNGAN TOTAL FENOL: OPTIMASI KOMBINASI KAYU SECANG, JAHE, DAN STEVIA DALAM MENINGKATKAN KANDUNGAN TOTAL FENOL Arum, Mentari Sekar; Bumi, Candra; Mualimin, Lulus; Mujayanah, Ani Rosa Putri Ayu
JURNAL BIOSENSE Vol 8 No 3 (2025): Edisi Juli 2025
Publisher : Program Studi Biologi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas PGRI Banyuwangi, Jalan Ikan Tongkol No 01, Telp (0333) 421593, 428592 Banyuwangi 68416

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/biosense.v8i3.5540

Abstract

Tanaman herbal telah lama dimanfaatkan dalam pengobatan tradisional karena kandungan senyawa bioaktifnya, terutama fenol yang berfungsi sebagai antioksidan alami. Di antara tanaman tersebut, kayu secang (Caesalpinia sappan), jahe (Zingiber officinale), dan stevia (Stevia rebaudiana) dikenal memiliki potensi aktivitas antioksidan. Penelitian ini bertujuan untuk mengoptimasi kombinasi ketiga bahan tersebut guna meningkatkan kandungan total fenol dalam formulasi minuman herbal. Pendekatan eksperimen menggunakan metode Response Surface Methodology (RSM) dengan rancangan Central Composite Design (CCD). Proses ekstraksi dilakukan melalui metode infusa pada suhu terkendali, dan kandungan fenol dianalisis menggunakan metode Folin-Ciocalteu dengan spektrofotometer UV-Vis. Hasil analisis statistik menunjukkan bahwa kayu secang memberikan pengaruh kuadratik yang sangat signifikan (p < 0,0001) terhadap peningkatan kadar fenol, sedangkan jahe dan stevia tidak menunjukkan pengaruh yang signifikan baik secara individu maupun interaksi. Model regresi yang dihasilkan signifikan (p = 0,0014) dan sesuai dengan data eksperimen. Grafik kontur menunjukkan bahwa kombinasi konsentrasi menengah antara kayu secang dan jahe menghasilkan kadar fenol tertinggi. Sementara itu, stevia lebih berperan sebagai pemanis alami tanpa kontribusi signifikan terhadap senyawa fenolik. Hasil ini menunjukkan bahwa pengoptimalan proporsi kayu secang dan jahe dapat secara signifikan meningkatkan potensi antioksidan minuman herbal, serta mendukung pengembangan produk fungsional berbasis bahan alami lokal.
The relationship between maternal factors and pregnancy weight gain with the incidence of stunting in toddlers East Java Province Suwardi, Regantia Happy; Bumi, Candra; Prasetyowati, Irma
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 13 ISSUE 4, 2025
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2025.13(4).276-284

Abstract

ABSTRAKLatar Belakang: Stunting merupakan kondisi gangguan tumbuh kembang balita akibat kekurangan gizi kronis dan penyakit infeksi yang ditandai dengan tinggi badan di bawah batas normal. Pada tahun 2022, prevalensi stunting di Indonesia mencapai 21,6% dan di Jawa Timur mencapai 34,9%. Salah satu faktor yang dapat meningkatkan risiko stunting, kesakitan bahkan kematian pada ibu dan anak yaitu faktor maternal. Faktor maternal stunting meliputi, usia ibu saat hamil, jarak kelahiran, paritas, kenaikan berat badan kehamilan, status gizi ibu, tinggi badan ibu, infeksi, kesehatan mental, IUGR dan kelahiran prematur, dan hipertensi.Tujuan: Tujuan penelitian ini adalah untuk menganalisis hubungan faktor maternal dan kenaikan berat badan kehamilan dengan kejadian stunting pada balita usia 24-59 bulan di Kabupaten Jember.Metode: Jenis penelitian ini adalah observasional analitik dengan desain case control yang dilakukan di 15 Puskesmas Kabupaten Jember pada bulan April-Juli 2024. Sampel penelitian ini adalah 272 balita usia 24-59 bulan yang terdiri dari sampel kasus 136 balita stunting dan sampel kontrol 136 balita tidak stunting dengan responden dari ibu balita. Teknik pemilihan sampel menggunakan cluster random sampling. Data penelitian ini diperoleh dari wawancara menggunakan kuesioner dan studi dokumentasi buku Kesehatan Ibu dan Anak. Selanjutnya, data dianalisis dengan analisis univariat (distribusi frekuensi) dan analisis bivariat dengan uji Chi-square.Hasil: Hasil analisis menggunakan uji chi-square diperoleh hasil terdapat hubungan antara kenaikan berat badan kehamilan dengan kejadian stunting pada balita (p-value = <0,001 dan OR= 4,286 dengan 95% CI (2,556-7,187)). Ibu yang memiliki kenaikan berat badan kehamilan tidak sesuai standar Institute of Medicine (IOM) berpeluang melahirkan anak stunting 4,2 kali lebih besar dibandingkan dengan ibu yang memiliki kenaikan berat badan kehamilan sesuai standar IOM. Tidak terdapat hubungan antara usia ibu saat hamil (p-value= 0,419), jarak kelahiran (p-value= 0,178), dan paritas (p-value= 0,321) dengan kejadian stunting pada balita.Kesimpulan: Kenaikan berat badan kehamilan merupakan faktor risiko stunting pada balita usia 24-59 bulan di Kabupaten Jember. KATA KUNCI: faktor maternal; riwayat kehamilan; stunting ABSTRACT Background: Stunting is a condition of impaired growth and development of toddlers due to chronic malnutrition and infectious diseases characterized by height below the normal limit. In 2022, the prevalence of stunting in Indonesia reached 21.6% and in East Java reached 34.9%. One of the factors that can increase the risk of stunting, illness and even death in mothers and children is the maternal factor. Maternal stunting factors include, maternal age during pregnancy, birth distance, parity, pregnancy weight gain, maternal nutritional status, maternal height, infection, mental health, IUGR and premature birth, and hypertension.Objectives: The purpose of this study is to analyze the relationship between maternal factors and pregnancy weight gain with the incidence of stunting in toddlers aged 24-59 months in Jember Regency.Methods: This type of research is observational analysis with a case control design conducted in 15 Jember Regency Health Centers in April-July 2024. The sample of this study consists of 272 toddlers aged 24-59 months, comprising 136 stunted toddlers as the case sample and 136 non-stunted toddlers as the control sample, with respondents being the mothers of the toddlers. The sample selection technique uses cluster random sampling. The data of this study was obtained from interviews using questionnaires and documentation studies of Maternal and Child Health books. Furthermore, the data was analyzed by univariate analysis (frequency distribution) and bivariate analysis by Chi-square test.Results: The results of the analysis using the Chi-square test showed that there was a relationship between pregnancy weight gain and the incidence of stunting in toddlers (p-value = < 0.001 and OR = 4.286 with 95% CI (2.556-7.187)). Mothers who have pregnancy weight gain that does not meet IOM standards are 4.2 times more likely to give birth to stunted children compared to mothers who have pregnancy weight gain according to IOM standards. There was no relationship between maternal age during pregnancy (p-value=0.419, birth distance (p-value=0.178), and parity (p-value=0.321) with the incidence of stunting in toddlers.Conclusions: Pregnancy weight gain is a risk factor for stunting in toddlers aged 24-59 months in Jember Regency.  KEYWORD: maternal factors; pregnancy history; stunting
Business Sector Engagement in Pentahelix Colaboration for Stunting Reduction: A Qualitative Study in Jember Regency Prasetyowati, Irma; Wahyu Ningtyias, Farida; Ratnawati, Leersia Yusi; Bumi, Candra; Nurika, Globila; Haryanik, Meilinda Alya' Putri
Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Education Vol. 14 No. SI1 (2026): Jurnal Promkes: The Indonesian Journal of Health Promotion and Health Educat
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jpk.V14.ISI1.2026.106-114

Abstract

Background: Stunting is a persistent public health issue in Indonesia, with long-term effects on children's physical and cognitive development. In 2023, Jember Regency recorded the highest stunting prevalence in East Java at 29.7%. Objective: To examine the role of the business sector in efforts to reduce stunting in Jember within the Pentahelix collaboration model. Methods:  This study employed a qualitative case study design using in-depth interviews and focus group discussions. Data were analyzed using Buse, Mays, and Walt’s policy implementation framework (Buse, Mays, & Walt, 2012), which focuses on context, content, process, and actors. This framework was chosen because it provides a comprehensive approach to understanding how policies are implemented through multi-actor collaboration, making it relevant for analyzing the Pentahelix model in stunting reduction efforts. Results: Findings indicate that businesses contribute significantly through Corporate Social Responsibility (CSR) initiatives, including Posyandu activities, nutrition support, and economic empowerment programs for mothers in areas with high rates of stunting. Coordination with health offices is based on local data, ensuring interventions are targeted and effective. The CSR Forum serves as a platform for aligning business efforts with public health goals. Businesses are also engaged in monitoring and evaluation through regular reporting from health facilities. Conclusion: Active engagement of the business sector through CSR initiatives strengthens stunting reduction efforts by supporting government and community programs. Integrating business participation into health promotion practice enhances sustainability, coordination, and long-term impact on child health and nutrition.