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All Journal Jurnal Kesehatan Andalas Indonesian Journal of Tropical and Infectious Disease The Indonesian Journal of Public Health Sari Pediatri Health Notions Journal Of Vocational Health Studies Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research JURNAL ILKES (Jurnal Ilmu Kesehatan) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal MID-Z (Midwivery Zigot) Jurnal Ilmiah Kebidanan Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Jurnal Abdi Insani JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL Bioscientia Medicina : Journal of Biomedicine and Translational Research KESANS : International Journal of Health and Science Caring : Jurnal Pengabdian Masyarakat MEDICINUS Jurnal Kebidanan Folia Medica Indonesiana
Bagus Setyoboedi
Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran, Universitas Airlangga - Rumah Sakit Akademik Dr Soetomo Surabaya, Indonesia
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A CASE REPORT OF SUCCESSFUL STEROID TREATMENT IN INFANT WITH EXTRAHEPATIC CHOLESTASIS Bagus Setyoboedi; Rendi Aji Prihaningtyas; Agrasenfani Hadi; Muhammad Nur Alpi Apriansyah; Sjamsul Arief
Journal of Vocational Health Studies Vol. 9 No. 2 (2025): November 2025 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V9.I2.2025.139-145

Abstract

Background: Cholestatic jaundice in infants is a significant healthcare challenge, particularly in regions where access to surgical intervention and liver transplantation is limited. An immunologic mechanism underlies the pathogenesis of biliary atresia leading to fibro-obliteration of the bile ducts. However, the successful management of biliary atresia is often difficult because treatment typically occurs at an advanced stage. Therefore, alternative therapies that can suppress bile duct inflammation are urgently needed. Administering anti-inflammatory drugs such as methylprednisolone to infants in the early stages of cholestasis may provide opportunities to improve outcomes in the limited capacity to perform Kasai surgery and liver transplantation. Purpose: This case report describes the clinical improvement of extrahepatic cholestasis following steroid administration. Case analysis: We report a case of a 24-day-old male infant presenting with clinical symptoms of jaundice and pale stool. Liver biopsy revealed features consistent with extrahepatic obstructive cholestasis characteristic of biliary atresia. The patient was treated with methylprednisolone (a corticosteroid) and ursodeoxycholic acid without surgical intervention. Result: The combination of methylprednisolone and ursodeoxycholic acid normalized liver function tests and led to significant clinical improvement. Both jaundice and pale stools completely resolved within two months of treatment. Conclusion: Steroid therapy may provide clinical benefits for infants with extrahepatic cholestasis, particularly in settings with limited healthcare resources. Steroid administration may play a role in the suppression of the inflammatory process that causes fibrosis and bile duct obliteration in the early stages of the disease.
Outcome and Treatment of Hepatic Epithelioid Hemangioendotheliomas in Child: A Rare Case Report Setyoboedi, Bagus; Prihaningtyas, Rendi Aji; Arief, Sjamsul
Journal of Community Medicine and Public Health Research Vol. 6 No. 2 (2025): Journal Community Medicine and Public Health Research
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jcmphr.v6i2.47474

Abstract

Hepatic tumors in children are relatively rare, accounting for 0.5- 2% of all childhood tumors. Hepatic epithelioid haemangioendothelioma (HEH) is a rare vascular tumour. HEH may appear clinically with nonspecific abdominal symptoms. A 9- year-9-month-old boy presented to the paediatric outpatient clinic with sudden right upper abdominal pain, weight loss, loss of appetite, and weakness. Initial physical examination revealed hepatomegaly. Laboratory tests showed anemia and thrombocytopenia. Meanwhile, liver function tests, serum bilirubin, and serum alpha-fetoprotein (AFP) were within normal limits. Abdominal ultrasound showed hepatomegaly with multiple liver nodules involving both lobes, with a maximum diameter of 4.3 cm and hypoechoic lesions. An MSCT scan of the abdomen revealed numerous solid lesions, and the largest of which measured approximately 3 x 4 x 3.5 cm. These lesions were spread across both lobes and appeared hypodense. These findings are consistent with the hypothesis that HEH of the liver originates from both lobes. Supportive therapy with packed red cell transfusion and supplemental oxygen was started. Steroid therapy using prednisolone orally was started. The patient was following up after 2 weeks of treatment and revealed improvement in clinical condition and laboratory. Hepatic epithelioid hemangioendothelioma should be considered when round, multifocal lesions infiltrating the liver are present, and confirmed by a physician and radiologist. Long-term outcomes are uncertain; therefore, early detection, therapy, and appropriate follow-up are needed.
Maternal Mid-Upper Arm Circumference as a Screening Tool to Predict Infant Birth Weight Fathurrachman, Muhammad Rais; Umijati, Sri; Kurniawati, Eighty Mardiyan; Setyoboedi, Bagus
Folia Medica Indonesiana Vol. 59, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study investigated the correlation between maternal mid-upper arm circumference and infant birth weight, aiming to present a different outcome compared to previous research. 2. The study's findings offer data suggesting that mid-upper arm circumference can serve as a screening tool for predicting infant birth weight. Abstract Mid-upper arm circumference (MUAC) is commonly used for assessing chronic energy deficiency in women of childbearing age. The measurement of MUAC during pregnancy mainly serves as early detection of potential low birth weight. However, certain studies have indicated no significant correlation between maternal MUAC and birth weight. Therefore, this study aimed to determine the relationship between maternal nutritional status and infant birth weight. The study used an analytical observational method with a cross-sectional approach, involving a sample of 86 mothers who delivered at Jagir Primary Healthcare Center in Surabaya, Indonesia, between July and December 2019. The participants were selected based on certain inclusion and exclusion criteria. The data were obtained from secondary sources, specifically the medical records of Jagir Primary Healthcare Center. The data were analyzed using the Spearman test, with a 95% confidence interval and a 5% margin of error. Most mothers (86.05%) had good nutritional status, as indicated by a MUAC measurement of ≥23.5 cm. Only 3.49% of infants were born with a low birth weight (<2,500 g), while 1.16% of infants were considered macrosomia (>4,000 g). Although most mothers exhibiting low MUAC did not give birth to infants with low birth weights, the analysis revealed a significant relationship (p=0.035) between maternal MUAC and infant birth weight. In conclusion, maternal MUAC can be utilized as a screening tool to predict infant birth weight because it indicates the condition of muscle tissue and subcutaneous fat, which serve as the mother's energy reserves. However, several variables can also impact infant birth weight, including maternal nutrient intake.
Primary Healthcare Providers' Knowledge on the Early Detection of Biliary Atresia Prihaningtyas, Rendi Aji; Setyoboedi, Bagus; Nesa, Ni Nyoman Metriani; Masturina, Melinda; Utomo, Martono Tri; Arief, Sjamsul
Folia Medica Indonesiana Vol. 60, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. An evaluation is necessary to verify that the knowledge of healthcare providers is sufficient for the early detection of biliary atresia. 2. It is crucial to promote education on prolonged jaundice to ensure early detection of biliary atresia in primary health facilities, as some primary healthcare providers have insufficient knowledge on the subject. Abstract Primary healthcare providers frequently fail to recognize biliary atresia because it closely mimics physiological jaundice. Early detection plays an important role in ensuring the optimal treatment of biliary atresia. Delays in referring to biliary atresia cases remain a problem around the world. The objective of this study was to analyze the knowledge of primary healthcare providers regarding prolonged jaundice as an early sign of biliary atresia. A cross-sectional study was conducted at primary healthcare centers using a self-administered questionnaire. The data were analyzed descriptively with the assistance of IBM SPSS Statistics for Windows, version 21.0 (IBM Corp., Armonk, N.Y., USA). A total of 271 respondents participated in this study, including midwives (63.8%), nurses (24.4%), and medical doctors (8.5%). This study found that 73.8% of the respondents agreed that infants with prolonged jaundice need to undergo a serum bilirubin level assessment. However, 40.2% of the respondents believed that pale stools and dark urine in yellow infants were symptoms of physiological jaundice. Concerning the definition of prolonged jaundice, 209 (77.1%) respondents provided a response indicating more than two weeks. A total of 137 (50.6%) respondents stated that biliary atresia is a disease that must be ruled out first in cases of prolonged jaundice. Nevertheless, 86 (31.7%) and 87 (32.1%) respondents also mentioned that breastfeeding jaundice and breast milk jaundice must be considered as potential causes to be investigated. These results indicated that primary healthcare providers still had limited knowledge regarding cholestasis. Education on prolonged jaundice in primary healthcare centers should be more improved to enhance the early detection of biliary atresia.
Late Diagnosis of Biliary Atresia in an Infant- A Call for Early Cholestasis Screening and Timely Referral Yovani Savitri; Rendi Aji Prihaningtyas; Bagus Setyoboedi; Sjamsul Arief
MEDICINUS Vol. 39 No. 1 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/jqc0w953

Abstract

Background: Biliary atresia (BA) is a progressive, fibroinflammatory cholangiopathy and the leading cause of pediatric liver transplantation. Early diagnosis and timely Kasai portoenterostomy (KPE), ideally within the first 45–60 days of life, are critical to preserving native liver function and delaying disease progression. However, in many settings, delayed recognition and referral remain major barriers. Case: A 3-month-and-22-day-old female infant presented with persistent jaundice, acholic stools, and hepatosplenomegaly. Despite the onset of symptoms as early as day 3 of life, referral to a tertiary center was significantly delayed. Laboratory tests showed elevated liver enzymes (aspartate aminotransferase/AST 142 U/l, alanine aminotransferase/ALT 109 U/l, gamma-glutamyl transferase/GGT 1554 U/l, alkaline phosphatase/ALP 572 U/l), total bilirubin 9.84 mg/d, and direct bilirubin 8.31 mg/dl. Two-phase abdominal ultrasonography showed findings consistent with BA, including absence of the gallbladder and a positive triangular cord sign. Liver biopsy showed advanced-stage fibrosis (F3–F4), confirming the diagnosis of BA. Conclusions: Due to the delayed diagnosis and the presence of advanced liver damage, the golden period for effective KPE was missed, making liver transplantation the only definitive treatment option. This case highlights the urgent need for improved screening and early referral systems toenhance outcomes in infants with BA.
INTERVENSI EDUKASI SINGKAT TENTANG ATRESIA BILIER PADA TENAGA KESEHATAN: BUKTI PENINGKATAN PENGETAHUAN DAN KESIAPAN SKRINING DENGAN KARTU WARNA TINJA Setyoboedi, Bagus; Prihaningtyas, Rendi Aji; Savitri, Yovani; Tri Utomo, Martono; Arief, Sjamsul
Jurnal Abdi Insani Vol 12 No 12 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i12.3114

Abstract

Biliary atresia is the most common cause of neonatal cholestasis, characterized by prolonged jaundice, pale stools, and dark-colored urine. Early detection is crucial to prevent further liver damage. However, delayed diagnosis is still frequently encountered, mainly due to the lack of healthcare providers’ knowledge in recognizing the early signs of biliary atresia. This study aimed to determine the significance of a targeted health education intervention in improving knowledge of early detection of biliary atresia among healthcare providers. A quasi-experimental study was conducted at Padangan District General Hospital, Bojonegoro, East Java, using a pre-test/post-test questionnaire design. The health intervention consisted of education on biliary atresia and the introduction of the stool color card as an early detection tool, delivered by a Pediatric gastroenterologist and hepatologist. The Wilcoxon signed-rank test was performed with a significance level of p<0.05.A total of 101 respondents participated, predominantly female (88.1%), with the largest age group being 30–39 years (37.6%). Most respondents had more than five years of work experience (81.2%). The mean knowledge score significantly increased from 86.3 in the pre-test to 93.2 in the post-test (p < 0.001). Prior to the intervention, only 12.9% of respondents scored <70, whereas after the intervention nearly all participants (98%) scored >70. Knowledge regarding early symptoms of biliary atresia, the risks of delayed diagnosis, and the use of the Stool Color Card showed meaningful improvement on early detection of biliary atresia. A health education intervention is effective in improving healthcare providers’ knowledge of early detection of biliary atresia.
SOSIALISASI DAN PENGENALAN KARTU WARNA TINJA: STRATEGI PENINGKATAN PENGETAHUAN TENAGA KESEHATAN DALAM SKRINING ATRESIA BILIER Utomo, Martono Tri; Prihaningtyas, Rendi Aji; Savitri, Yovani; Setyoboedi, Bagus; Arief, Sjamsul
Jurnal Abdi Insani Vol 12 No 12 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i12.3245

Abstract

Jaundice in newborns is a common condition, but it is important to distinguish between physiological and pathological forms. One of the main causes of pathological jaundice is cholestasis, with biliary atresia being the most frequent etiology. Biliary atresia is progressive and potentially fatal if treatment is delayed. Early detection is a key to successful therapy; however, limited knowledge among healthcare workers and inadequate screening tools contribute to delayed referrals. This study aimed to improve healthcare workers’ understanding of early detection of biliary atresia through education and introduction of stool color cards at RSUD dr. Sayidiman, Magetan. This study employed a quasi-experimental pre-test–post-test design involving 83 healthcare workers. Educational sessions were delivered by a pediatric gastrohepatology specialist, and participants completed questionnaires before (pre-test) and after (post-test) the intervention. Data were analyzed using the Wilcoxon signed-rank test to assess the improvement in knowledge scores, with statistical significance set at p < 0.05. A total of 83 participants took part, predominantly female (94%) with the largest age group being 30–39 years (43.4%). Most participants had more than 5 years of work experience (79.5%) and held a bachelor’s degree (55.4%). The mean knowledge score increased significantly from 90 in the pre-test to 95.3 in the post-test (p < 0.001). Socialization and introduction of stool color cards effectively improve healthcare workers’ knowledge regarding early detection of biliary atresia.
The The Relationship Between Parental Income and the Role of Parental or Babysitter Care on the Incidence of Stunting Rahma Fadila, Zakiya Nur; Sulistiawati, Sulistiawati; Setyoboedi, Bagus
Jurnal KESANS : Kesehatan dan Sains Vol 5 No 3 (2025): KESANS: International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54543/kesans.v5i3.507

Abstract

Introduction: Nutrition plays a crucial role in child growth and development. In Indonesia, stunting remains a major public health problem, with a prevalence of 21.5%, influenced by maternal health, socioeconomic conditions, and caregiving practices. Objective: This study aimed to determine the relationship between parental income, parental caregiving, and babysitter caregiving with stunting among children aged 24–59 months in the working area of the Ponggok Community Health Center in 2025. Method: This study employed an observational analytic method with a retrospective case–control design and was not a case report. The population consisted of mothers with toddlers aged 24–59 months. A total of 84 respondents were selected using consecutive sampling, comprising 42 stunted toddlers (case group) and 42 non-stunted toddlers (control group). Stunting status was determined based on height-for-age z-scores (HAZ) according to WHO standards. The independent variables were family income and caregiving roles of parents and babysitters, while the dependent variable was stunting incidence. Data were collected from Maternal and Child Health (KIA) books and structured questionnaires and analyzed using univariate analysis and Chi-Square tests (p < 0.05). Result and Discussion: Parental income was not significantly associated with stunting (p > 0.05), suggesting that income alone may not directly determine child growth outcomes. Factors such as nutrition knowledge, resource allocation, access to health services, and environmental conditions may influence this relationship. Conclusion: In contrast, parental and babysitter caregiving roles showed significant associations with stunting (p < 0.05), highlighting the importance of caregiving quality.
Delayed Referral of a Neonate with Biliary Atresia Presenting as Jaundice: A Case Report Zubaity Ardhanariswari; Rendi Aji Prihaningtyas; Muji Retnaning Rini; Muhammad Faizi; Bagus Setyoboedi
MEDICINUS Vol. 39 No. 4 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/rmdf9491

Abstract

Delayed diagnosis of cholestasis in infant remains a significant health problem. Cholestatic jaundice is a pathological condition that requires immediate treatment, particularly in cases such as biliary atresia. Biliary atresia is a progressivefibroinflammatory process that causes fibrosis in biliary tract, resulting in liver cirrhosis if left untreated. This case report aims to describe the delayed referral of biliary atresia in an infant. Case: A 3-month-old girl presented to a tertiary hospitalwith a chief complaint of jaundice. Jaundice had been present since the second day of life and persisted despite sun exposure and breastfeeding. The mother also reported abdominal distension, yellow-brown urine resembling tea, and palestools. Physical examination revealed hepatosplenomegaly. Laboratory results showed elevated liver enzymes (aspartate aminotransferase [AST] 237.4 U/l, alanine transaminase [ALT] 139 U/l, gamma-glutamyl transferase [GGT] 864 U/l), and cholestasis (total bilirubin 13.90 mg/dl, direct bilirubin 9.80 mg/dl). A two-phase abdominal ultrasound showed a gallbladder with preprandial size approximately 0.87 x 0.93 x 1.76 cm (length x width x height), with no contractility. Liver histopathologyrevealed extrahepatic cholestasis with extensive fibrosis (F3). The patient was diagnosed with biliary atresia and liver fibrosis and was subsequently referred for liver transplantation. Delayed referral of biliary atresia case is associated withpoor prognosis. Increasing awareness and health education among primary health providers, community health workers, and parents are essential for early detection of cholestasis, which can reduce morbidity, mortality, as well as the need for liver transplantation.
Relationship of Parents' Economic Conditions and Parenting Patterns with Children’s Development Fadilla, Anisa Yuniar; Setyoboedi, Bagus
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 10, No 3 (2022): Special Issue
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v10i3.58792

Abstract

Background: Each parent has its own parenting style in parenting which is usually influenced by the background they have, both in terms of education, socio-economics, work, customs and others. The purpose of this study was to analyze the relationship between the economic conditions of parents and parenting on the development of children.Methods: This type of research is quantitative research with a correlational research design. The sample in this study was all the population that met all the inclusion and exclusion criteria with a sampling technique using Total Sampling. The independent variable of this research is child development. The dependent variable studied in this study is the economic condition of parents and the intermediate variable in this study is parenting.Results: The results of this study indicate that there are 62.52% parents with middle economic conditions, 20.83% parents with poor economic conditions and 16.65% parents with affluent economic conditions. For parenting, it was found that 58.3% of parents used democratic parenting, 25% used permissive parenting and 16.7% of parents used authoritarian parenting. In child development, it was found that 70.8% of children had normal development and 29.2% of children had impaired development. The results of the Manova test on the relationship between parents' economic conditions and parenting patterns with child development showed a p-value of 0.650.Conclusion: The data shows that there is no significant relationship between the economic conditions of parents and parenting patterns with child development.
Co-Authors Agrasenfani Hadi Akbas, Ahmad Maulana Ifan Amilia krisdiantini Anggi Sepfana Zizilia Anindya Kusuma Winahyu Annisya Dinda Paramitha Arvelina Novia Damayanti Budiono Budiono Cindy Wahyu Agustina Eighty Mardiyan K, Eighty Enny Karyani, Enny Evi Rokhayati Fadilla, Anisa Yuniar Farahdina Farahdina Farida Triani Fathurrachman, Muhammad Rais Firyal Nadiah Rahmah Gina Noor Djalilah Gondo Mastutik Henry Wicaksono, Henry IDG Ugrasena Ilya Krisnana, Ilya Irawan, Muhammad Irwanto Irwanto Irwanto, Irwanto Jasin, Yayu Dwinita Karina Pharamita Dewi Kuntoro Kuntoro Lasmauli Situmorang Linda Dewanti Mahrus A Rahman, Mahrus A Manika Putri Kunigara Maretha Sukmawardani, Maretha Martono Tri Utomo Masturina, Melinda Maytasya Dwinaqifah Melantika Nur Fitria Syahri Melinda Masturina Muhammad Faizi Muhammad Irawan Muhammad Nur Alpi Apriansyah Muhammad Rais Fathurrachman Muji Retnaning Rini Mukarromah, Nur Nabilah Khansa Nastiti, Prima Hari Nesa, Ni Nyoman Metriani Ni Nyoman Metriani Nesa Ningrum, Astika Gita Nisak Luvi Mega Irawati Nur Mukarromah Octariyandra, Syania Mega Paramitha, Annisya Dinda Pratiwi, Fauziah Prihaningtyas, Rendi Aji Puspa Wardhani Qurrota Ayuni Novia Putri Rachmat Hargono Rahma Fadila, Zakiya Nur Rani Sidaryanti Rendi Aji Prihaningtyas Rendi Aji Prihaningtyas Reny Widayanti Samisatun Maulina, Siti Samsriyaningsih Handayani Savitri, Yovani Situmorang, Lasmauli Sjamsul Arief Sjamsul Arief Sjamsul Arief Sjamsul Arief Sjamsul Arief Sjamsul Arief, Sjamsul Sri Umijati Sulistiawati Sulistiawati Sulistiawati Sulistiawati Syahbani, Primadita Teddy Ontoseno Tiyas Kusumaningrum Ulfa Kholili Utamayasa, I Ketut Alit Viky Nafi&#039;ah Rahma Maulidia Viky Nafi'ah Rahma Maulidia Widati Fatmaningrum Winahyu, Anindya Kusuma Woro Setia Ningtyas Yovani Savitri Zizilia, Anggi Sepfana Zubaity Ardhanariswari