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All Journal KOMUNITAS: INTERNATIONAL JOURNAL OF INDONESIAN SOCIETY AND CULTURE Media Ilmu Keolahragaan Indonesia International Journal of Education Nexus Kedokteran Translasional Jurnal Keolahragaan Jurnal SPORTIF : Jurnal Penelitian Pembelajaran Wellness And Healthy Magazine Narra J Indonesian Journal of Physical Education and Sport Science (IJPESS) Proceeding ISETH (International Summit on Science, Technology, and Humanity) Prosiding University Research Colloquium Physical Therapy Journal of Indonesia Journal of Social Work and Science Education Jurnal Info Kesehatan
Muchsin Doewes
Faculty of Medicine, Sebelas Maret University
Religion Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Narra J

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Effect of walking and bone joint exercise on enhancing bone remodeling in menopausal women: A randomized controlled trial Pasa, Chusairil; Pamungkasari, Eti P.; Doewes, Muchsin; Purwanto, Bambang; Hartono, Hartono; Cilmiaty, Risya; Dirgahayu, Paramasari
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1321

Abstract

Osteoporosis increases fracture risk and reduces quality of life in menopausal women. Although physical activity, such as walking and bone joint exercise, is known to help maintain bone health, its effectiveness needs further examination. The aim of this study was to analyze the effects of physical activity, in particular walking and bone joint exercise, on enhancing bone remodeling in menopausal women. A randomized controlled trial was conducted among menopausal women and allocated into three groups: walking, bone joint exercise, and control groups. The intervention was provided for eight weeks, with the outcomes measured before and after the intervention. The study assessed five bone remodeling biomarkers: estrogen, parathyroid hormone (PTH), receptor activator of nuclear factor kappa-β ligand (RANKL), tumor necrosis factor-alpha (TNF-α), and bone mineral density (BMD). The paired sample student t-test and ANOVA were used to assess the effects of the interventions. The results indicated that, compared to pre-intervention, both walking and bone joint exercise significantly increased the estrogen (p=0.026 and p=0.023, respectively), decreased RANKL (p=0.019 and p=0.002, respectively), decreased PTH levels (p=0.022 and p=0.048, respectively) and increased the BMD scores (p=0.001 and p<0.001, respectively). In the control group, none of the remodeling biomarkers significantly changed except the mean level of TNF-α, which was increased significantly (p=0.001). This study highlights that structured exercise, such as walking and bone joint exercise, can significantly enhance bone remodeling markers in menopausal women. Therefore, implementing such physical activities into management may provide benefits to menopausal women.
Effect of clove flower extract (Syzygium aromaticum) administration timing on skeletal muscle damage induced by eccentric exercise: An in vivo study Ningrum, Tyas Sari Ratna; Doewes, Muchsin; Indarto, Dono; Cilmiaty, Risya; Kristiyanto, Agus; Widyaningsih, Vitri
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1680

Abstract

Eccentric exercise often leads to oxidative stress, inflammation, and muscle damage that impair athletic performance. To counter these adverse effects, clove flower extract (Syzygium aromaticum) offers promising potential as a natural remedy to promote muscle repair with its potent antioxidant and anti-inflammatory properties. The aim of this study was to assess the effects of clove flower extract administration timing on oxidative stress and inflammatory responses in skeletal muscle damage induced by acute eccentric exercise in mice. This study used a post-test-only control group design, involving 35 male mice (Mus musculus, Balb/c) randomly divided into five groups: a healthy control group (HC) with no exercise and no treatment, a negative control group (NC) with exercise but no treatment, and three treatment groups: T1, T2, and T3 (clove flower extract 24 hours before exercise, immediately after exercise, and 24 hours after exercise, respectively). The treatment groups received a single dose of clove flower extract (500 mg/kg body weight). The skeletal muscle damage of mice was collected for the NADPH oxidase (NOX) and superoxide dismutase (SOD) activities using spectrophotometry, and toll-like receptor 4 (TLR4) and interleukin-8 (IL-8) measurements using enzyme-linked immunosorbent assay (ELISA). Moreover, the skeletal muscle damage was analyzed through the histopathological method. Data were analyzed using one-way analysis of variance (ANOVA) followed by Fisher's least significant difference (LSD) tests as a post hoc test. The result showed that clove flower extract significantly reduced NOX activity (p=0.049) and IL-8 levels (p=0.032), and increased SOD activity (p=0.001) while not significantly affecting the TLR4 levels (p=0.532). Moreover, the results showed a significant reduction in muscle damage (p=0.001). The study highlights that the administration of clove flower extract (500mg/kg bw) can be given 24 hours before, immediately after exercise, or 24 hours after exercise to prevent muscle damage.
Co-Authors . Fadityo . Kisrini . Samigun Abdurrachman, Abdurachman Agus Kristiyanto Alifiyanti Muharramah ANAS KHOLIKUL AMIN, ANAS KHOLIKUL Annisa Marsha Evanti Aprilia, Khalida Nawa Aulia Ramadhani Bambang Purwanto Bhisma Murti Didik Gunawan Tamtomo Dono Indarto Duta Putra Utama, Dimas Ekawati, Febriani Fajar Eti Poncorini Pamungkasari Fajar Ekawati, Febriani Hari Hanggoro, Hari Hartono Hartono Hidayatullah, Muhammad A'raaf Jatmiko Susilo Khoirul Huda Kisrini . M. Furqon Hidayatullah, M. Furqon M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Németh, Zsolt NINGRUM, TYAS SARI RATNA Nugroho, Kristanto Adi Nur Zahratul Jannah Pamungkasari, Eti P. Paramasari Dirgahayu pasa, chusairil Purnama, Siswanta Jaka Restian Gigih sejati, Restian Gigih Risya Cilmiaty, Risya Riza Setya Agrensa Rohma, Noer Sapta Kunta Purnama Savira, Intan Shanti Listyawati Sinu Andhi Jusup, Sinu Andhi Slamet Riyadi Soetrisno Soetrisno SUGIYANTO Syahmirza Indra Lesmana Syetiawinanda, Amriansyah Utama, Dimas Duta Putra Vitri Widyaningsih Wahyuni, Ardianti