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All Journal Dental Journal (Majalah Kedokteran Gigi) Jurnal Ilmu Kefarmasian Indonesia Majalah Farmasetika Indonesian Journal of Dental Medicine Sinnun Maxillofacial Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Enrichment: Journal of Multidisciplinary Research and Development
Surboyo, Meircurius Dwi Condro
Faculty Of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Engineering Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Formulasi sediaan blush on bentuk stick menggunakan ekstrak kulit manggis (Garcinia mangostana L) sebagai pewarna alami Benni Iskandar; Rona Syafira; Septi Muharni; Leny Leny; Meircurius Dwi Condro Surboyo; Safri Safri
Majalah Farmasetika Vol 7, No 3 (2022): Vol. 7, No. 3, Tahun 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v7i3.38357

Abstract

Blush on atau perona pipi merupakan salah satu sediaan kosmetika yang digunakan untuk memberikan warna atau menambah estetika pada rias wajah. Perona pipi mengandung pigmen yang rendah hingga tinggi sehingga warna yang dihasilkan cenderung bervariasi. Namun penggunan zat warna sintetik selalu dipergunakan dalam sediaan dan sering menimbulkan terjadinya kerusakan pada kulit. Zat warna alami atau pigmen yang diperoleh dari tumbuhan lebih aman daripada zat warna sintetis. Perona pipi dalam bentuk stick mempunyai keunggulan, tidak seperti perona pipi powder yang mudah hancur, perona pipi stick mudah diaplikasikan karena dikemas seperti tabung putar layaknya lipstik. Tujuan dari penelitian ini adalah memformulasikan ekstrak kulit manggis ke dalam bentuk sediaan blush on/ perona pipi stick dengan variasi konsentrasi 14,18, dan 22%. Kulit manggis yang telah diekstraksi dengan etanol 96% diformulasikan ke dalam bentuk sediaan blush on yang berbentuk stick. Sediaan kemudian diuji homogenitas, organoleptis, penentuan nilai pH, uji oles, uji keretakan dan uji stabilitas sediaan terhadap penyinaran sinar UV yang diukur dengan spektrofotometer. Pada konsentrasi 14% warna yang dihasilkan yaitu warna merah muda, pada konsentrasi 18% memberikan warna merah peach, pada konsentrasi 22% memberikan warna merah kecoklatan. Semua sediaan homogen dan mempunyai pH yang berada dalam pH yang diizinkan untuk sediaan perona pipi. Pada uji stabilitas suhu kamar, sediaan cenderung stabil hingga dilakukan penyinaran selama 24 jam dengan sinar UV, sediaan mengalami perubahan warna yang ditunjukkan dengan adanya perubahan pada absorbansi ketika diukur dengan spektrofotometer. Ekstrak kulit manggis (Garcinia mangostana L.) dapat digunakan sebagai pewarna alami dalam formulasi sediaan perona pipi dan perbedaan konsentrasi menghasilkan perbedaan intensitas warna pada sediaan pewarna pipi. Hasil dari pengujian stabilitas menunjukkan bahwa sediaan perona pipi yang diformulasi menunjukkan adanya perubahan terhadap pengaruh cahaya.
Uji Aktivitas Anti-aging Mikroemulsi Minyak Nilam (Pogostemon cablin Benth.) Benni Iskandar; Raesa Tartilla; Anita Lukman; Leny Leny; Meircurius Dwi Condro Surboyo
Majalah Farmasetika Vol 7, No 1 (2022): Vol. 7, No. 1, Tahun 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v7i1.36464

Abstract

Penuaan merupakan proses penurunan fungsi fisiologis dan terjadi pada semua organ tubuh manusia, termasuk kulit. Paparan sinar matahari langsung pada kulit mengakibatkan kelebihan radikal bebas dalam tubuh. Radikal bebas dalam tubuh dapat memicu terjadinya penuaan dini. Gejala yang jelas terlihat diantaranya munculnya keriput, kulit kering dan kasar serta timbulnya noda-noda gelap pada kulit. Salah satu upaya mengatasi penuaan adalah dengan antioksidan. Minyak nilam (Pogostemon cablin Benth.) telah terbukti memiliki efek antioksidan. Tujuan penelitian ini adalah menguji aktivitas anti-aging dari sediaan mikroemulsi minyak nilam. Penelitian ini dilakukan dengan membuat sediaan mikroemulsi minyak milam pada konsentrasi 0% (F0), 5% (F1), 10% (F2), dan 15% (F3). Sediaan kemudian diujikan pada kulit punggung tangan sukarelawan dengan menggunakan alat skin analyzer dengan parameter yang diukur meliputi kadar air, kehalusan, besar pori, banyak noda, dan keriput. Pengaplikasian sediaan mikroemulsi pada kulit punggung tangan sebanyak dua kali sehari selama 30 hari. Pengujian dilakukan setiap hari ke-10, ke-20, dan ke-30. Hasil uji aktivitas anti-aging menunjukkan bahwa sediaan mikroemulsi minyak nilam 5% (F1) lebih cepat terjadi pemulihan dalam meningkatkan kadar air, kehalusan kulit, mengecilkan ukuran pori, mengurangi noda dan keriput.
Increase of collagen in diabetes-related traumatic ulcers after the application of liquid smoke coconut shell Meircurius Dwi Condro Surboyo; Ira Arundina; Retno Pudji Rahayu
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 2 (2017): June 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (936.87 KB) | DOI: 10.20473/j.djmkg.v50.i2.p71-75

Abstract

Background: Traumatic ulcers in patients with diabetes mellitus may experience delayed healing despite their diabetic condition being controlled. Liquid smoke coconut shell containing phenolic compounds can potentially accelerate the healing process. One healing process indicator is the increased number of fibroblasts, another being the increased amount of collagen. Purpose: This study aimed to analyze the amount of collagen in traumatic ulcers in diabetics after application of liquid smoke coconut shell. Methods: Alloxan was induced in twenty-four male Wistar rats as models of diabetes mellitus. A traumatic 10 mm ulcer was made along the labial fornix incisive inferior with a round, stainless steel blade before liquid smoke coconut shell and benzydamine hydrochloride (as the control) was administrated once a day. A biopsy of the labial fornix incisive inferior was subsequently performed after the topical application for 5 and 7 days. Histological assessment was conducted to analyze the amount of collagen by means of Masson Trichome staining. Results: Histologically, the topical application of liquid smoke coconut shell for 5 days significantly increased the amount of collagen, higher than that of benzydamine hydrochloride as the control (p=0.006) (p<0.05). Meanwhile, the topical application of liquid smoke coconut shell for 7 days made the concentration of collagen no significantly different from that of benzydamine hydrochloride as the control (p=0.156) (p>0.05). Conclusion: Liquid smoke coconut shell applied for 5 days increase the amount of collagen in traumatic ulcers in diabetic patients.
Clinical appearance of acute pseudomembranous candidiasis in children and the importance of good communication, information and education to patients: A case report Afryla Femilian; Winda Dwi Malinda Masuku; Nurina Febriyanti Ayuningtyas; Diah Savitri Ernawati; Fatma Yasmin Mahdani; Meircurius Dwi Condro Surboyo
Dental Journal (Majalah Kedokteran Gigi) Vol. 55 No. 2 (2022): June 2022
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v55.i2.p105-108

Abstract

Background: Oral candidiasis is a common opportunistic infection of the oral cavity caused by an overgrowth of the Candida species, in particular, Candida albicans. The incidence varies depending on age and certain predisposing factors. In the practice of dentistry, doctor-patient communication is an important component. Effective communication between doctor and patient is needed to convey information and educate patients so that treatment can be administered appropriately. Purpose: This case aimed to discuss the clinical appearance of acute pseudomembranous candidiasis (APC) in children and the importance of good communication, information and education of patients. Case: A five-year-old male patient came with his mother on November 6, 2020 complaining of white deposits on the mucosa of the upper and lower lips that had been present for a week. Case management: The diagnosis was defined as a typical APC lesion although the potassium hydroxide (KOH) test showed negative results. Characteristic lesions found in APC are often seen clearly in some cases and treatment can begin immediately. Patients receive the empirical therapy, Nystatin oral suspension 100.000 i.u, and the patient is instructed to maintain optimal oral hygiene care, maintain nutrient intake and book a follow-up consultation. Conclusion: Mistakes in patient preparation procedures in taking supporting examinations will result in false negative/positive results, so communication and education information regarding the preparation of supporting examinations for patients is important to note.
FORMULASI, KARAKTERISASI DAN UJI STABILITAS MIKROEMULSI MINYAK NILAM (Pogostemon cablin Benth.) Benni Iskandar; Anita Lukman; Raesa Tartilla; Meircurius Dwi Condro Surboyo; Leny Leny
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 6 No 2 (2021): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (168.629 KB) | DOI: 10.36387/jiis.v6i2.724

Abstract

Patchouli oil contains patchouli alcohol as the main component which is a tricyclic tertiary alcohol sesquiterpene compound that is insoluble in water. Microemulsion is a droplet dispersion technology that combines an insoluble liquid with another liquid. The role of surfactants in helping the dispersion process of microemulsion formulation is by reducing the interfacial tension. Microemulsion is a supersolvents carrier, so that both hydrophilic and lipophilic can be administered through a microemulsion system. The purpose of this study was to formulate patchouli oil into a stable microemulsion preparation. This research was conducted by making 4 preparations of patchouli oil microemulsion containing 5% (F1), 10% (F2), and 15% (F3) patchouli oil, and microemulsion without patchouli oil (F0). Evaluation of microemulsion preparations includes organoleptic test, pH measurement, density determination, viscosity test, freeze and thaw test, centrifugation test, and particle size analysis. The test results showed that the microemulsion containing 5% patchouli oil had the most stable characteristics compared to other formulas.
Formulasi Dan Uji Aktivitas Anti-Aging Gel Lendir Lidah Buaya (Aloe vera Linn.) Benni Iskandar; Anita Lukman; Okla Elfitri; Safri Safri; Meircurius Dwi Condro Surboyo
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.907

Abstract

Aging is one of the problems that occurs in the skin. The factors cause aging are either free radicals. The use of antioxidants can prevent aging. Mucous Aloe vera known to have an antioxidant effect. The purpose of this study is to get aloe vera gel that stable and has anti-aging effects. This research was conducted by making a gel of aloe vera preparations in three formulas, each with aloe vera mucous of 5% (F1), 15% (F2) and blank (F0). Evaluation of gel preparations includes organoleptic, pH, Stability checks at room and cold temperatures, Scatter test, Adhesion, homogenity, irritation and anti-aging test on the skin of the backs of volunteers using skin analyzer with measured parameters including moisture, evenness, large pores, spot, and wrinkles. Gel was used twice a day for 30 days and was carried out every week. Statistical data were analyzed using the two-way ANOVA and continued with the Tukey test. The results showed that the stable a gel of aloe vera formula was F2 with a aloe vera concentration of 15%. Anti-aging activity test results showed that aloe vera gel preparations 15% (F2) faster recovery in increasing moisture, skin smoothness, shrinking pore size, reducing spot and wrinkles.
Knowledge of orofacial pain in students of the Dental Professional Program Faculty of Dental Medicine, Universitas Airlangga Desvia Nuzela Qurzani Hariyadi; Ari Hapsari Tri Wardani; Saka Winias; Fatma Yasmin Mahdani; Adiastuti Endah Parmadiati; Nurina Febriyanti Ayuningtyas; Meircurius Dwi Condro Surboyo
Dental Journal Vol. 56 No. 1 (2023): March 2023
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i1.p36-40

Abstract

Background: Orofacial pain is associated with the hard and soft tissues of the head, face, and neck. Knowledge of orofacial pain helps in getting information on clinical symptoms, trigger factors, and risks of orofacial pain, as well as clinical and supportive examinations for identifying the pain. The dental professional students’ knowledge influences the ability to diagnose and decide on an appropriate treatment plan. This knowledge is seen from the intelligence level in obtaining information about orofacial pain. Purpose: To describe the level of knowledge of orofacial pain in the students of the Dental Professional Program, Faculty of Dental Medicine, Universitas Airlangga, based on intelligence level. Methods: This research was a descriptive study. Data was taken using a questionnaire on google form with a simple random sampling data technique and was analyzed using SPSS version 25. Results: The majority understand the general description of postherpetic neuralgia (PHN), as well as the risk factors and triggers (93.4% and 87.8%, respectively) associated with it. Further, 90.6% understand burning mouth syndrome (BMS) and the clinical symptoms of PHN. BMS based on clinical examination and support is understood by 96.1%, and 82.9% know how to manage trigeminal neuralgia (TN). Intelligence level is divided into three categories, namely source of knowledge (55.8% are from lectures, journals, and textbooks), material repetition (77.3% never repeated), and retention of material (65.2% no retention). Conclusion: Students’ knowledge of orofacial pain is good, but the relationship between the level of intelligence and knowledge is not yet known.
Oral field cancerization: Genetic profiling for a prevention strategy for oral potentially malignant disorders Karlina Puspasari; Togu Andrie Simon Pasaribu; Meircurius Dwi Condro Surboyo; Nurina Febriyanti Ayuningtyas; Arvind Babu Rajendra Santosh; Diah Savitri Ernawati
Dental Journal Vol. 56 No. 3 (2023): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i3.p189-196

Abstract

Background: Oral cancer therapy, such as radiation or surgical treatment, has pernicious long-term effects that patients suffer throughout their life, the disability being considerable with delayed diagnosis. It is well known that many oral cancers develop from oral potentially malignant disorders (OPMDs). Patients diagnosed with OPMDs may have an increased risk of developing cancer anywhere in the oral cavity. Early detection and intervention could be essential prevention strategies to inhibit oral cancer progression. OPMDs may not immediately develop into carcinoma. However, this condition provides a “field” of specific abnormalities wherein evolving altered genetic cells can be explained with the “field cancerization” concept. Purpose: This review aims to describe the “field cancerization” concept in oral cancer and OPMD, which is expected to contribute to a better clinical management strategy for oral cancer prevention. Review: “Oral field cancerization” describes oral cancers that develop in multifocal areas of pre-cancerous changes. It can be found as histologically abnormal tissue surrounding the tumor, suggesting that oral cancer often consists of multiple independent lesions. Conclusion: The oral field cancerization concept should prompt healthcare professionals to remind their patients that frequent oral examination with histological studies and molecular testing is mandatory for those at high risk of developing malignancies.
Pomegranate extract mechanism in inhibiting the development of oral cancer: A review Imanu, Sherina Fatwa; Leginis, Shinadilla Naza; Iqbal, Mohammad; Surboyo, Meircurius Dwi Condro
Indonesian Journal of Dental Medicine Vol. 6 No. 1 (2023): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v6i1.2023.37-42

Abstract

Background: Oral cancer is one of the most aggressive and invasive cancers with high metastatic potential. Oral cancer is cancer with the 11th highest number of cases in the world. Oral cancer is treated with chemotherapy and radiotherapy. However, this therapy causes side effects in the form of damage to normal cells in the surrounding tissue. Pomegranate extract contains polyphenols which may be great for inhibiting the development of oral cancer. Purpose: This article presents a systematic and comprehensive review of the potential of pomegranate extract as a natural product to inhibit the development of oral cancer. Review: Pomegranate extract was obtained by ethanol extraction using maceration method. The main content of pomegranate is polyphenolic compounds such as punicalagin, tannins, flavonoids, and ellagic acid. This compound reduces ATP formation, shortens the subG1 phase, and increases apoptosis. At the microcellular level, pomegranate extract can inhibit the activity of MMP-2 or MMP-9 to produce anti-proliferative, anti-angiogenesis and pro-apoptotic processes of cancer cells at concentrations of 25 and 50 μg/ml. Anti-proliferative and pro-apoptotic effects are produced through mitochondrial damage mechanisms. Exposure after 72 hours can reduce oral cell viability greater than exposure after 24 hours. Conclusion: Pomegranate extract is likely has four mechanisms to oral cancer: inhibiting the invasion, migration and growth of oral cancer cells, increasing oral cancer cell apoptosis and regulating antioxidant genes. So that this material can be used as a candidate for oral cancer therapy.
Single nucleotide polymorphisms: A paradigm in oral disease research Ummer, Hiba; Santosh, Arvind Babu Rajendra; Surboyo, Meircurius Dwi Condro; Chitipothu, Mani Deepthi; Sivanandham, Shamala
Dental Journal Vol. 57 No. 3 (2024): September
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i3.p234-240

Abstract

Background: A higher occurrence of oral cancer is observed in South Asian and Southeast Asian countries when compared with other countries in the world. Cancer, a disease with complex pathophysiology, has been linked to chronic inflammation. Inflammation has been considered an important component of tumor initiation and progression. This is supported by the fact that many cancers arise at the sites of chronic inflammation, but the exact mechanism by which inflammation influences cancer is unknown. Purpose: This review article correlates single nucleotide polymorphisms (SNPs), chronic inflammation, and oral cancer. The article emphasizes the critical role that SNPs play in oral cancer susceptibility, progression, and prognosis. This involves discussing the impact of specific SNPs on oral cancer risk and patient outcomes. Review: Gene polymorphism has been documented in the molecular pathogenesis of various cancers, including oral cancer, and SNPs are the most common form of gene polymorphism. Genetic variation has been documented in the molecular pathogenesis of various cancers, including oral cancer, and SNPs are the most common form of gene polymorphism. SNPs have been documented in inflammatory conditions as well as in various diseases. Conclusion: SNPs have phenotypic consequences and therefore can serve as genetic fingerprints. The upregulation or downregulation of genes is able to drive oral carcinogenesis.
Co-Authors Adiastuti Endah Parmadiati Anita Lukman Anita Lukman Ari Hapsari Tri Wardani Arvind Babu Rajendra Santosh BENNI ISKANDAR Chitipothu, Mani Deepthi Desiana Radithia, Desiana Desvia Nuzela Qurzani Hariyadi Diah Savitri Ernawati Fatma Yasmin Mahdani Femilian, Afryla Hendrayanto, Shalma Maulidya Hening Tuti Hendarti Imanu, Sherina Fatwa Ira Arundina Karlina Puspasari Kuntardjo, Yuhanna Leginis, Shinadilla Naza Leny Leny Leny Leny Leny, Leny Maharani, Annissaqiella Nagoro, Ayu Anggraini Broto Nurina Febriyanti Ayuningtyas Okla Elfitri Pratiwi, Aulya Setyo Puspitasari, Yeni Rachmadanti, Zhafira Khansa Raesa Tartilla Raesa Tartilla Retno Pudji Rahayu Riskayanti, Ni Putu Rona Syafira Safri Safri Safri Safri Saka Winias Santosh, Arvind Babu Rajendra Septi Muharni Sismiyanti, Rossy Sivanandham, Shamala Togu Andrie Simon Pasaribu Ummer, Hiba Winda Dwi Malinda Masuku