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Potensi Ekstrak Akar Kalakai (Stenochlaena palutris Bedd) Sebagai Antihiperlipidemia Yang Diuji Secara In Vivo Rabiatul Adawiyah; Fera Sartika; Fahruddin Arfianto
Journal of Pharmascience Vol. 7 No. 1 (2020): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8075

Abstract

ABSTRAK Tumbuhan kalakai atau sering disebut paku haruan atau pakis  merupakan tumbuhan khas Kalimanatan yang banyak digunakan sebagai tumbuhan obat. Kalakai mengandung beberapa senyawa bioaktif seperti fenolik, flavonoid, alkaloid dan keluarga terpenoid yang efektif sebagai antioksidan.  Tujuan penelitian ini untuk menentukan aktivitas antihiperlipidemia dar i ekstrak akar kalakai yang diuji secara in vivo pada tikus wistar. Metode yang digunakan adalah melakukan uji aktivitas antihiperlipidemia dengan cara memberi perlakuan hewan coba dan melakukan pengukuran kadar trigliserida dan kolesterol total dengan menggunakan Spektrofotometer UV-VIS. Hasil penelitian diketahui bahwa peningkatan dosis dapat meningkatkan aktivitas dari ekstrak akar  kalakai. Semakin meningkatnya dosis,  maka terjadi peningkatan pertemuan antara flavonoid dengan reseptor di permukaan sel, sehingga terjadi peningkatan aktivitas. Aktivitas dari pemberian dosis ke-3 dari kadar trigliserida sebesar 49,8 mg/dl sedangkan untuk kadar kolesterolnya sebesar 41,8 mg/dl pada hasil yang didapat dari ekstrak akar kalakai  mendekati pemberian dari kadar  simvastatin. Berdasarkan hal tersebut, maka ekstrak dengan dosis 400 mg/KgBB memiliki potensi untuk teliti lebih lanjut dan dapat digunakansebagai obat alternatif pada pengobatan hiperlipidemia. Keadaan hiperlipidemia tidak hanya terkait kolesterol, tetapi mencakup kadar trigliserida di dalam darah. Kemampuan suatu obat dalam menurunkan kadar kolesterol sekaligus kadar trigliserida, akan memberikan keuntungan terhadap pengobatan pasien hiperlipidemia. Penggunaan akar kalakai tidak hanya terbatas pada pengobatan karena bahan alam dapat digunakan sebagai pencegah timbulnya penyakit terutama hiperlipidemia yang terjadi pada pasien degeneratif. Kata kunci : Ektrak akar kalakai, In Vivo, Kolesterol, SpektrofotometerUV-VIS, Trigliserida  ABSTRACT Kalakai plants or often called haruan nails or ferns are typical Kalimanatan plants which are widely used as medicinal plants. Kalakai contains several bioactive compounds such as phenolic, flavonoid, alkaloid and terpenoid family which are effective as antioxidants. The purpose of this study was to determine the antihyperlipidemic activity of kalakai root extract which was tested in vivo in Wistar rats. The method used is to test the activity of antihyperlipidemia by giving treatment of experimental animal and to measure levels of triglycerides and total cholesterol using a UV-VIS spectrophotometer. the results of the study note that increasing the dose can increase the activity of the kalakai root extract. As the dose incr eases, there is an increase in the linkage between the flavonoids and receptors on the cell surface, resulting in increased activity . The activity of administering the 3rd dose of triglyceride levels was 49.8 mg/dl whereas for cholesterol levels it was 41.8 mg/dl in the result obtained from the extract of kalakai root approaching the administration of simvastatin levels. Based on this, the extract at a dose of 400mg/kg has the potensial for further scrutiny and can be used as an alternative drug in the treatment of hyperlipidemia. The state of hyperlipidemia is not only related to cholesterol, but includes the level of triglycerides in the blood. The ability of a drug to reduce cholesterol levels as well as triglyceride levels, will provide benefits to the treatm ent of hyperlipidemia patients. The use of kalakai root is not only limited to treatment because natural ingredients can be use d as a prevention of disease, especially hyperlipidemia that occurs in degenerative patients. Keywords: Kalakai root extract, In Vivo, Cholesterol, Triglyceride, UV-VIS Spectrophotometer
Kolaborasi Fakultas Farmasi UMPR dan UPTD Puskesmas Kereng Bangkirai dalam Mewujudkan Kampus Sehat Melalui Cek Kesehatan Gratis Rika Arfiana Safitri; Syahrida Dian Ardhany; Susi Novaryatiin; Halida Suryadini; Guntur Satrio Pratomo; Risqika Yulia Tantri Paramawidhita; Nurul Qamariah; Evi Mulyani; Husna Fauzia; Mohammad Rizki Fadhil Pratama; Rabiatul Adawiyah; Rezqi Handayani; Dewi Sari Mulia
Jurnal Pengabdian Masyarakat Wadah Publikasi Cendekia Vol 3 No 2 (2026): Jurnal Pengabdian Masyarakat WPC
Publisher : CV. Wadah Publikasi Cendekia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63004/jpmwpc.v3i2.1423

Abstract

Kesehatan sivitas akademika merupakan faktor krusial dalam mendukung terciptanya lingkungan perguruan tinggi yang produktif dan berdaya saing. Penyakit tidak menular (PTM) sering kali terlambat dideteksi karena banyak kasus baru baru disadari pada tahap lanjut. Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan kesadaran dan kepedulian kesehatan sivitas akademika melalui pemeriksaan kesehatan gratis yang terintegrasi dengan edukasi kesehatan dasar, serta menjaring faktor risiko PTM sejak dini. Metode pelaksanaan program dilakukan secara partisipatif melalui tahapan persiapan, sosialisasi, pendaftaran, pelaksanaan cek kesehatan gratis (registrasi, pengukuran identitas, pemeriksaan tekanan darah dan gula darah sewaktu), edukasi interpersonal melalui konseling meja, tindak lanjut rujukan, serta evaluasi kegiatan. Hasil pelaksanaan menunjukkan adanya peningkatan pengetahuan peserta secara signifikan, di mana rata-rata skor melonjak dari 68,9 pada pre-test menjadi 90,8 pada post-test setelah diberikan edukasi singkat. Berdasarkan hasil skrining fisik terhadap peserta, ditemukan bahwa 65,0% peserta memiliki tekanan darah normal, sedangkan 21,7% mengalami pre-hipertensi, dan 13,3% menderita hipertensi klinis. Untuk parameter kadar gula darah sewaktu (GDS), sebanyak 90,0% peserta berkategori normal dan 10,0% teridentifikasi mengalami hiperglikemia.
Antioxidant Activity Ethanolic Extract of Kalakai Leaf (Stenochlaena Palustris (BURM.F) Bedd) From Central Kalimantan by DPPH Method Rabiatul Adawiyah; Halida Suryadini; Atika Abrar; Husna Fauzia; Faradila Faradila
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.4935

Abstract

The diseases triggered by free radicals in Indonesia are increasing. Free radicals can be neutralized by antioxidants. The main sources of antioxidants are plants or fruits. Kalakai (Stenochlaena palustris (Burm.f.) Bedd.) is one of the typical plants of Kalimantan known for its medicinal properties. The leaves of Kalakai contain compounds such as flavonoids, phenols, tannins, alkaloids, and saponins, which have antioxidant abilities. This research aims to determine the antioxidant activity of Kalakai leaf extract from Central Kalimantan against DPPH free radicals based on the IC50 value. Antioxidant activity was measured using the DPPH method and analyzed using UV-Vis spectrophotometry at a wavelength of 516.6 nm. The results showed that Kalakai leaf extract had moderate antioxidant activity with an IC50 value of 241.547 ppm, while vitamin C as a positive control had strong activity with an IC50 of 10.031 ppm. These findings indicate that Kalakai leaves, although less potent than vitamin C, may serve as a promising natural antioxidant source. The conclusions is kalakai leaf extract exhibits moderate antioxidant activity and holds potential for further development in natural antioxidant applications.
Ethnomedicine and Knowledge Transmission among Dayak Communities in Central Kalimantan: An Ethnographic Inquiry Rabiatul Adawiyah; M. Fatchurahman; Guntur Satrio Pratomo; Ferdiyani Haris; I Gusti Ayu Raya Prajnashwari; Sonia Lomei Wandianti; Salsabina Salsabina; Abid Naufal Adhika Wiratama
Media Publikasi Promosi Kesehatan Indonesia Vol. 9 No. 2 (2026)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/mppki.v9i2.8661

Abstract

Introduction: Traditional medicinal knowledge is central to cultural identity and community well-being among the Dayak communities of Central Kalimantan yet its continuity is increasingly threatened by modernization and declining youth engagement. This study aims to examine how ethnomedicinal knowledge is transmitted practiced and sustained through therapeutic traditions eco spiritual values and intergenerational learning. Methods: A qualitative ethnographic approach was conducted in four regions of Central Kalimantan involving twelve purposively and snowball-selected participants including traditional leaders elders and women healers. This design was chosen to capture culturally embedded meanings that cannot be accessed through quantitative techniques. Data were collected through participant observation in depth interviews and documentation then transcribed verbatim and analyzed using thematic coding procedures. Results: Three major findings emerged. First the transmission of medicinal plant knowledge is weakening as younger generations increasingly rely on biomedical services. Second ritual practices such as offerings prayers and ecological ethics remain central in legitimizing healing and guiding responsible plant harvesting. Third the perceived effectiveness of key plants including kalakai pasak bumi and bajakah is reinforced through lived experiences of vitality and longevity although sustainability is challenged by shifting health preferences and environmental change. Conclusion: Dayak ethnomedicine reflects an integrated system combining therapeutic efficacy cultural identity and ecological stewardship. The findings highlight the importance of eco spiritual practices and intergenerational dynamics in sustaining traditional healing. Strengthening documentation pharmacological validation and youth-focused digital revitalization initiatives is essential for ensuring the resilience of Dayak ethnomedicinal knowledge.