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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) IJMS - Indonesian Journal on Medical Science Indonesian Journal of Community Services Jurnal Riset Kefarmasian Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) Pharmademica: Jurnal Kefarmasian dan Gizi JAFP (Jurnal Akademi Farmasi Prayoga) Indonesian Journal on Medical Science (IJMS) Media Farmasi Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Margareta Retno Priamsari
Sekolah Tinggi Ilmu Farmasi Nusaputera
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Pengaruh Jenis Pelarut Terhadap Jumlah Rendemen dan Kadar Total Flavonoid Ekstrak Kulit Buah Markisa Kuning (Passiflora edulis var. flavicarpa) Margareta Retno Priamsari; Catur Hana Kristanti
Indonesian Journal on Medical Science Vol 10 No 1 (2023): IJMS 2023
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55181/ijms.v10i1.416

Abstract

Yellow passion fruit (Passiflora edulis var. flavicarpa) is a perennial plant in the form of a shrub that can spread or spread. Yellow passion fruit peel contains many flavonoid compounds that have potential for antioxidants, anti-inflammatories and antibacterials. The aim of this study was to analyze the effect of the type of solvent on the amount of yield and total flavonoid content of yellow passion fruit peel extract. The extraction method uses remaceration with 96% ethanol and ethyl acetate as solvent. Extract quality control using organoleptic, drying shrinkage, yield calculation and qualitative test of flavonoid compounds. Testing for total flavonoid levels was carried out using the colorimetric method with AlCl3 reagent by UV-Vis spectrophotometry and the wavelength used was 436.4 nm. The standard uses quercetin. The results showed that the yield of yellow passion fruit peel extract with 96% ethanol solvent was 4.43%w/w while ethyl acetate solvent was 2.57%w/w. The total flavonoid content of yellow passion fruit peel extract showed a significant difference (p <0.05) which was analyzed by independent sample t-test, namely with 96% ethanol of 4.23 ± 0.02 mgQE/gram and 13.02 mgQE/gram of ethyl acetate. 89±0.01 mgQE/gram.
Pengaruh Metode Maserasi Konvensional dan Berbantu Gelombang Mikro Terhadap Penapisan Fitokimia dan Standardisasi Ekstrak Peperomia pellucida L. Priamsari, Margareta Retno; Kamila, Iffa; Sawal, Rizky Ardian Hartanto
Indonesian Journal on Medical Science Vol 11 No 2 (2024): IJMS 2024
Publisher : Unit Penelitian dan Pengabdian Masyarakat Politeknik Kesehatan Bhakti Mulial

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70050/ijms.v11i2.465

Abstract

Suruhan (Peperomia pellucida L.) is a medicinal plant with many benefits. The efficacy of medicinal plants is related to the results of phytochemical screening and standardization, which are reflected in the quality of the extracts produced. This study aims to assess the impact of extraction methods on the phytochemical screening profile and standardization of suruhan leaf extract. The samples were extracted using the maceration and microwave assisted extraction (MAE) method with 96% ethanol solvent. Next, phytochemical screening and standardization were carried out on both powder and extract. The data obtained was then analyzed descriptively. The results of phytochemical screening from both the maceration and MAE methods show that suruhan leaf extract contains flavonoids, saponins, phenols, tannins, steroids, triterpenoids and glycosides. The results of standardization of leaf extracts using the maceration method obtained water soluble essence content of 2.15%, ethanol dissolved essence content of 67.31%, drying loss of 9.68%, ash content of 37.2988%, specific gravity of 0.9805 g/mL, and Pb metal contamination 0.000 mg/L. Meanwhile, the results of standardization of the leaf extract ordered by the MAE method obtained a water soluble essence content of 30.06%, an ethanol dissolved essence content of 33.84%, a drying loss of 9.52%, an ash content of 38.1392%, a specific gravity of 0.8273 g/mL , and Pb metal contamination 0.061 mg/L.
ANALISIS PENGARUH PERENDAMAN LARUTAN KULIT SINGKONG (Manihot esculenta Cortex) TERHADAP KANDUNGAN LOGAM BERAT TIMBAL (Pb) DALAM KERANG DARAH (Anadara granosa) Susanti, Maria Mita; Priamsari, Margareta Retno
Media Farmasi Indonesia Vol. 12 No. 2 (2017): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (440.435 KB)

Abstract

ABSTRACKMussles blood (Anadara granosa) is a type of shell that is often consumed by Indonesian community. The shells have non selective feeder and sessile filter that relatively high which mean heavy metal content is found in the shell’s body due to the accumulation of the heavy metals. In an effort to reduce heavy metals in mussles blood, it can be done using the utilization of cassava skin waste. Cassava skin can be used as a material of reducing the heavy metal content of Pb (Lead) in mussles because it contains cellulose that can modify the group to produce hydroxyl which can bind Pb metal ions. This research aimed to analyze the effect of soaking of cassava skin solution (Manihot esculenta Cortex) with decreasing level of heavy metal lead (Pb) on mussles blood (Anadara granosa). This was an experimental research with treatment of cassava skin concentration of 1%, 1.5% and 3% and soaking time 10 minutes, 40 minutes and 80 minutes. The independent variables are concentration of cassava skin solution, soaking time and dependent variable in this research is Pb concentration in mussles blood (Anadara granosa). Samples were analyzed using an Atomic Absorption Spectrophotometer (SSA). The data were analyzed using Kendall's Tau test. The results showed that there was influence of decreasing percentage of heavy metal Pb on soaking time (p <0.05) but did not affect to concentration of cassava skin solution (p> 0.05).
Perbandingan Aktivitas Antibakteri Kulit Buah Markisa Kuning (Passiflora edulis van Flavicarpa D.) terhadap Bakteri Bacillus subtilis dan Propionibacterium acnes Priamsari, Margareta Retno; Pitarisa, Agustina Putri; Setyani, Oky; Riana, Riana
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 20, No 2 (2023)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v20i2.8357

Abstract

Kulit buah markisa (Passiflora edulis van Flavicarpa D.) berpotensi sebagai agen antibakteri. Kulit markisa kuning merupakan salah satu varian kulit markisa yang memiliki kandungan senyawa alkaloid yang berpotensi sebagai antibakteri. Tujuan penelitian ini adalah untuk mengetahui aktivitas antibakteri ekstrak etanol kulit buah markisa kuning (EEKBMK) terhadap bakteri Bacillus subtilis dan Propionibacterium acnes.  Ekstraksi dilakukan secara maserasi menggunakan etanol 96%. EEKBMK dilakukan skrining fitokimia dan diuji konsentrasi hambat minimum terhadap bakteri Bacillus subtilis dan Propionibacterium acnes. Uji tersebut dilakukan dengan konsentrasi EEKBMK 0,62, 1,25, 2,5 dan 5% menggunakan metode difusi cakram pada media MHA dan diinkubasi selama 24 jam pada suhu 37°C. Hasil skrining fitokimia dijabarkan secara deskriptif dan hasil KHM dianalisis secara statistik menggunakan one way ANOVA. Skrining fitokimia teridentifikasi EEKBMK mengandung senyawa flavonoid, tanin dan saponin. Hasil pengukuran konsentrasi hambat minimum Ekstrak etanol kulit buah markisa kuning pada konsentrasi 0,62% berbeda bermakna pada bakteri Bacillus subtilis dan Propionibacterium acnes masing-masing sebesar 7,70 ±0,60 mm dan 7,93 ± 0,40. Konsentrasi hambat minimum pada 1,25% EEKBMK menunjukkan tidak adanya perbedaan bermakna pada Bacillus subtilis dan Propionibacterium acnes (p > 0,05). Konsentrasi hambat minimum EEKBMK pada konsentrasi 2,5% dan 5% masing-masing berbeda bermakna pada Bacillus subtilis dan Propionibacterium acnes (p < 0,05). EEKBMK 0,62% memiliki aktivitas antibakteri dengan kategori hambatan sedang.
PENGARUH METODE PENGERINGAN TERHADAP KADAR TOTAL FLAVONOID EKSTRAK ETANOLIK DAUN SINGKIL (Premna corymbosa) Margareta Retno Priamsari; Odilia Dea Christina; Dwi Setyonugroho
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 8 No. 1 (2022): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v8i1.478

Abstract

The leaves of singkil (Premna corymbosa) empirically contain various secondary metabolite compounds, one of which is flavonoids that can be used as asthma medication, antitumor, worm infection, and reduce bad breath. Drying is one of the stages of making simplicia which is done so that simplicia is not damaged. This study aims to determine the effect of drying method on total flavonoid content in singkil leaf extract. The research method used is experimental. The research phase included sampling, plant determination, drying simplicia with oven temperature of 50oC and drying in an open space protected from indirect sunlight, extraction by maceration, phytochemical screening, determination of total flavonoid content. The assay method used was colorimetric using UV-Vis spectrophotometer with AlCl3 reagent and quercetin standard. The calibration curve was made for 5 concentrations, namely 12.5; 15; 17.5; 20; and 22.5 ppm. The absorbance was calculated at a wavelength of 415 nm and the reading was used as a determinant of the total flavonoid content of the singkil leaf extract. The results showed that the simplicia drying method could significantly affect the total levels of singkil leaf extract, with the total flavonoid content of singkil leaf extract using the drying method of 2.27±0.02% while the total flavonoid content of singkil leaf extract using the 50oC oven method was 1, 50±0.02%.
Pengaruh Penambahan Konsentrasi Ekstrak Perasan Lemon (Citrus limon (L.) Terhadap Aktivitas Antioksidan Pada Minuman Teh Bunga Telang (Clitoria ternatea L.) Priamsari, Margareta Retno; Subarjo, Nonik Triliana Warianti; Yudhantara, Sandi Mahesa
Jurnal Farmasi & Sains Indonesia Vol 7 No 2 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no2p56-66

Abstract

Herbal tea is a drink made from leaves or flowers that are processed or processed as is done when making tea. A plant that is useful as herbal tea is the butterfly pea flowers (Clitoria ternatea L). Butterfly pea flowers are a safe and natural source of antioxidants. Lemon fruit (Citrus limon (L.) is another plant that is useful as an antioxidant besides butterfly pea flowers. The high nutritional content of lemon fruit, including vitamin C as an antioxidant. Antioxidants are important substances for  the body to maintain human health. This study aims to determine the effect of adding lemon juice extract concentration on antioxidant activity in butterfly pea flower tea drinks. Butterfly pea flower tea is made by brewing at a temperature of 70⁰C for 5 minutes. Lemon juice is made by squeezing using a lemon squeezer. The concentrations used in lemon juice are 25, 50, 100, 200, and 400 ppm. Testing was carried out using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method and the antioxidant potential was seen from the percentage inhibition value and IC50 using UV-Vis spectrophotometric absorbance measurements. The results in this study were obtained using a linear regression equation. Lemon juice extract on butterfly pea flower tea has an IC50 value of 60.792 ppm, while the value IC50 vitamin C is 3,160 ppm. Lemon juice extract on butterfly pea flower tea is classified as a strong antioxidant. This shows that the addition of lemon juice extract to butterfly pea flower tea has an effect on antioxidant activity. The SPSS results of antioxidant activity in butterfly pea flower tea with the addition of lemon juice extract showed a significant difference with the antioxidant activity of vitamin C namely 0,001 (p<0,05).
Standardisasi dan Skrining Fitokimia Ekstrak Daun Singkil (Premna corymbose) Priamsari, Margareta Retno; Solichah, Ayu Ina; Aminah, Icha Yuliska
Jurnal Farmasi & Sains Indonesia Vol 6 No 1 (2023)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol6no1p76-80

Abstract

Standardization is needed to obtain uniform raw materials that can guarantee the pharmacological effects of singkil plants. Phytochemical screening is the initial stage in a phytochemical research that aims to provide an overview of the class of compounds contained in the plant under study. The purpose of this study was to determine the standardization profile and class of chemical compounds in the ethanol extract of singkil leaves. This type of experimental research. Singkil leaf extraction was carried out by maceration method with 70% ethanol solvent, then followed by standardization test of singkil leaf ethanol extract. The next step is testing phytochemical compounds by identifying alkaloids, flavonoids, saponins, tannins, triterpenoids/steroids through phytochemical screening which are analyzed descriptively.The standardization results showed that the ethanol extract of singkil leaves had a dry shrinkage of 3.43%±1.28% (w/w), the extract content was soluble in water in singkil leaf powder was 20.01%±0.22% (v/w), the water soluble extract content of singkil leaf extract was 19.81 ± 0.22% (v/w), the ethanol soluble extract content of singkil leaf powder was 24.48 ± 0.24 %(v/w), ethanol soluble extract content of singkil leaf extract was 26.88 ± 1.16 %(v/w), specific gravity of singkil leaf extract was 0.91 ± 0.00 %(v/v), and ash content of singkil leaf extract. was 30.40 ± 0.00 %(w/w). The results of phytochemical screening showed that the ethanolic extract of singkil leaves contained flavonoids, tannins, saponins and triterpenoids
Skrining Fitokimia & Aktivitas Antibakteri Ekstrak Bunga Telang (Clitoria ternatea L.) terhadap Bakteri Staphylococcus epidermidis Sesilia, Riana; Priamsari, Margareta Retno; Akbar, Nanda Dwi
Jurnal Farmasi & Sains Indonesia Vol 7 No 1 (2024)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol7no1p232-239

Abstract

Telang flowers contain secondary metabolite compounds that have benefits as antibacterial or antiseptic compounds including flavonoids, tannins, alkaloids and saponins. This research was an experimental research. Telang flower extract was obtained using 70% ethanol solvent by remaceration method then it tested like phytochemical content. Antibacterial activity testing with variaty concentrations media MHA (Mueller Hinton Agar) 15, 30, 45, 60, and 75% against Staphylococcus epidermidis. The positive control was Klindamycin. The obtained data were analyzed by Statistical Package for the Social Sciences (SPSS). The results shown that telang flower extract with concentrations 15, 30, 45, 60 and 75% had an average inhibition zone activity against Staphylococcus epidermidis were respectively 4.45 (15%); 4.63 (30%); 4.35 (45%); 5.47 (65%); and 7.02 mm (75%). The SPSS results show that the p value is <0.05 at the 95% confidence level, which indicates that there is a significant difference in antibacterial activity between butterfly pea flower extracts between concentrations of 15, 30, 45, 60, and 75%. Post hoc tests using LSD showed that there was a difference in antibacterial activity between concentrations of 75% and concentrations of 15, 30, 45, and 60%, but there was no difference in antibacterial activity between concentrations of 15, 30, 45, and 60%.Minimal inhibitor concentration of telang flower extract was obtained at 15%
Studi Fitokimia Kulit Nanas: Pengaruh Metode Pengeringan terhadap Kandungan Flavonoid Ekstrak Etanol: Studi Fitokimia Kulit Nanas: Pengaruh Metode Pengeringan terhadap Kandungan Flavonoid Ekstrak Etanol Wahyuningtiastuti, Ananta; Bulu, Atalia Tamo Ina; Priamsari, Margareta Retno; Solichah, Ayu Ina
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p188-195

Abstract

Food waste refers to discarded food materials at the final stage of the food supply chain. One such waste product with potential for utilization in traditional medicine is pineapple peel (Ananas comosus (L.) Merr.), which contains various secondary metabolites, including flavonoids, alkaloids, saponins, and tannins. Among these metabolites, flavonoids are well-known for their antioxidant properties. This study aimed to compare the total flavonoid content in ethanol extracts of pineapple peel subjected to two different drying methods. The drying methods used were sun drying and oven drying at 50 °C. The dried pineapple peels were extracted using 96% ethanol through the Soxhlet extraction method. Phytochemical constituents were identified through colorimetric reactions and Thin Layer Chromatography (TLC). The total flavonoid content was determined colorimetrically using AlCl₃ reagent and measured by UV-Visible spectrophotometry at a wavelength of 439 nm, with quercetin used as the standard. The results indicated that the extract yields from the sun-dried and oven-dried samples were 5.60% and 5.75% (w/w), respectively. TLC analysis revealed Rf values of 0.85, 0.80, and 0.91. The total flavonoid content in the sun-dried sample was 35.44 ± 0.55 mgQE/g, while that in the oven-dried sample was 25.40 ± 0.98 mgQE/g. Statistical analysis using the Independent Sample t-test demonstrated a significant difference in total flavonoid content between the two drying methods.
Optimasi Formulasi Nanopartikel Gel Ekstrak Etanol Kayu Secang (Caesalpinia Sappan L.) Sebagai Antibakteri Terhadap Propionibacterium Acnes: Optimasi Formulasi Nanopartikel Gel Ekstrak Etanol Kayu Secang (Caesalpinia Sappan L.) Sebagai Antibakteri Terhadap Propionibacterium Acnes Maharani, Zahra Febriana; Akbar, Nanda Dwi; Priamsari, Margareta Retno
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.80

Abstract

Nanoparticle gel is a colloid consisting of nanometer-sized particles made from cosmetic active ingredients or other materials that are evenly distributed in a gel matrix. The purpose of this study was to determine the antibacterial activity of nanoparticle gel preparations of sappanwood extract against Propionibacterium acnes. The sappanwood extract was extracted by remaceration 70% ethanol then the extract was tested for antibacterial activity at concentrations of 20, 40, 60, and 80% using Nutrient Agar media against P. acnes. The results showed that the minimum inhibitory concentration of sappanwood extract appeared at a concentration of 20%. Spreadability and adhesiveness were 5.90 ± 0.06 and 14.96 ± 0.01, respectively. The results of the statistical analysis test with one sample t-test showed a p value> 0.05 so that the response of spreadability and adhesiveness between predictions was not significantly different from the actual. The optimal formula of sappanwood extract gel nanoparticles has moderate antibacterial activity against P. acnes.
Co-Authors Akbar, Nanda Dwi Aminah, Icha Yuliska Ayu Ina Solichah Bulu, Atalia Tamo Ina Catur Hana Kristanti Dwi Setyonugroho Eka Aprilia Nuraida Icha Yuliska Aminah Kamila, Iffa Maharani, Zahra Febriana Maria Mira Susanti Maria Mita Susanti Nada Kurnia Firdaus Nanda Dwi Akbar Odilia Dea Christina Pinto, Marcia Angelica Vidigal Loi Pitarisa, Agustina Putri Pujiastuti, Anasthasia Putri Marsela Danti Riana Riana, Riana Riana Sesilia Rina Ayu Krismonikawati Sandi Mahesa Yudhantara Sawal, Rizky Ardian Hartanto Sesilia, Riana Setyani, Oky Solichah, Ayu Ina Subarjo, Nonik Triliana Warianti Susanti, Maria Mita Wahyuningtiastuti, Ananta Wibowo, Agastia Cicilia