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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) IJMS - Indonesian Journal on Medical Science Indonesian Journal of Community Services Jurnal Riset Kefarmasian Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) Pharmademica: Jurnal Kefarmasian dan Gizi JAFP (Jurnal Akademi Farmasi Prayoga) Indonesian Journal on Medical Science (IJMS) Media Farmasi Indonesia Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Margareta Retno Priamsari
Sekolah Tinggi Ilmu Farmasi Nusaputera
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Studi Fitokimia Kulit Nanas: Pengaruh Metode Pengeringan terhadap Kandungan Flavonoid Ekstrak Etanol: Studi Fitokimia Kulit Nanas: Pengaruh Metode Pengeringan terhadap Kandungan Flavonoid Ekstrak Etanol Wahyuningtiastuti, Ananta; Bulu, Atalia Tamo Ina; Priamsari, Margareta Retno; Solichah, Ayu Ina
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p188-195

Abstract

Food waste refers to discarded food materials at the final stage of the food supply chain. One such waste product with potential for utilization in traditional medicine is pineapple peel (Ananas comosus (L.) Merr.), which contains various secondary metabolites, including flavonoids, alkaloids, saponins, and tannins. Among these metabolites, flavonoids are well-known for their antioxidant properties. This study aimed to compare the total flavonoid content in ethanol extracts of pineapple peel subjected to two different drying methods. The drying methods used were sun drying and oven drying at 50 °C. The dried pineapple peels were extracted using 96% ethanol through the Soxhlet extraction method. Phytochemical constituents were identified through colorimetric reactions and Thin Layer Chromatography (TLC). The total flavonoid content was determined colorimetrically using AlCl₃ reagent and measured by UV-Visible spectrophotometry at a wavelength of 439 nm, with quercetin used as the standard. The results indicated that the extract yields from the sun-dried and oven-dried samples were 5.60% and 5.75% (w/w), respectively. TLC analysis revealed Rf values of 0.85, 0.80, and 0.91. The total flavonoid content in the sun-dried sample was 35.44 ± 0.55 mgQE/g, while that in the oven-dried sample was 25.40 ± 0.98 mgQE/g. Statistical analysis using the Independent Sample t-test demonstrated a significant difference in total flavonoid content between the two drying methods.
Optimasi Formulasi Nanopartikel Gel Ekstrak Etanol Kayu Secang (Caesalpinia Sappan L.) Sebagai Antibakteri Terhadap Propionibacterium Acnes: Optimasi Formulasi Nanopartikel Gel Ekstrak Etanol Kayu Secang (Caesalpinia Sappan L.) Sebagai Antibakteri Terhadap Propionibacterium Acnes Maharani, Zahra Febriana; Akbar, Nanda Dwi; Priamsari, Margareta Retno
PHARMADEMICA : Jurnal Kefarmasian dan Gizi Vol 5 No 1 (2025): April - September
Publisher : LPPM-KI - POLTEKKES PIM (Formerly AKAFARMA-AKFAR PIM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54445/pharmademica.v5i1.80

Abstract

Nanoparticle gel is a colloid consisting of nanometer-sized particles made from cosmetic active ingredients or other materials that are evenly distributed in a gel matrix. The purpose of this study was to determine the antibacterial activity of nanoparticle gel preparations of sappanwood extract against Propionibacterium acnes. The sappanwood extract was extracted by remaceration 70% ethanol then the extract was tested for antibacterial activity at concentrations of 20, 40, 60, and 80% using Nutrient Agar media against P. acnes. The results showed that the minimum inhibitory concentration of sappanwood extract appeared at a concentration of 20%. Spreadability and adhesiveness were 5.90 ± 0.06 and 14.96 ± 0.01, respectively. The results of the statistical analysis test with one sample t-test showed a p value> 0.05 so that the response of spreadability and adhesiveness between predictions was not significantly different from the actual. The optimal formula of sappanwood extract gel nanoparticles has moderate antibacterial activity against P. acnes.
Formulation of Spinach Leaf Extract (Amaranthus tricolor L.) Shampoo and Antifungal Activity Test Against Pityrosporum ovale Priamsari, Margareta Retno; Pinto, Marcia Angelica Vidigal Loi; Akbar, Nanda Dwi
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 22 No. 2 (2025): Jurnal Ilmu Farmasi dan Farmasi Klinis
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v22i2.14276

Abstract

Red spinach leaves contain flavonoid, tannin, alkaloid, saponin and terpenoid that have potential as antifungal compounds. This research is  experimental. The purpose of this reserach is is to find out extract red spinach leaves can inhibit the growth of Pityrosporum ovale and to find out that red spinach leaf extract can be formulated in shampoo. Extraction was carried out using the remaceration method with 70% ethanol solvent and then tested for phytochemical content. Antifungal activity testing of red spinach leaf extract using concentrations of 15; 30; 45; 60 and 75% using the well method with PDA media incubated at 37 for 3x24 hours. The results showed the average inhibition zone activity against Pityrosporum ovale at a concentration of 75% of 19.17 mm statistically showed a significant difference. Formulation of shampoo preparations was carried out on red spinach leaf extract at a concentration of 15% with variations in the formula of Cocamide DEA and CMC-Na. The physical characteristics of the shampoo preparation include organoleeptic test, homogeneity, pH, viscosity, adhesion, spreadability and foam height. The results of testing the antifungal activity of shampoo preparations in formula 1 (17.5 mm); formula 2 (17.83 mm); and formula 3 (16.83 mm), based on statistical tests of antifungal shampoo preparations with a p-value (> 0.05) variations in the concentration of Cocamide DEA and CMC-Na have no significant effect on antifungal activity.
Co-Authors Akbar, Nanda Dwi Aminah, Icha Yuliska Ayu Ina Solichah Bulu, Atalia Tamo Ina Catur Hana Kristanti Dwi Setyonugroho Eka Aprilia Nuraida Icha Yuliska Aminah Kamila, Iffa Maharani, Zahra Febriana Maria Mira Susanti Maria Mita Susanti Nada Kurnia Firdaus Nanda Dwi Akbar Odilia Dea Christina Pinto, Marcia Angelica Vidigal Loi Pitarisa, Agustina Putri Pujiastuti, Anasthasia Putri Marsela Danti Riana Riana, Riana Riana Sesilia Rina Ayu Krismonikawati Sandi Mahesa Yudhantara Sawal, Rizky Ardian Hartanto Sesilia, Riana Setyani, Oky Solichah, Ayu Ina Subarjo, Nonik Triliana Warianti Susanti, Maria Mita Wahyuningtiastuti, Ananta