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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Pharmacon Jurnal Wiyata : Penelitian Sains dan Kesehatan Journal of Pharmaceutical and Medicinal Sciences Cendekia Journal of Pharmacy CERATA Jurnal Ilmu Farmasi Jurnal Pengabdian Kesehatan Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Prosiding University Research Colloquium Batik-Mu : Jurnal Pengabdian Masyarakat Jurnal Ilmiah Kesehatan CERATA Medical Sains : Jurnal Ilmiah Kefarmasian
Wirasti
Program Studi S1 Farmasi, Fakultas Ilmu Kesehatan, Universitas Muhammadiyah Pekajangan Pekalongan
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Indonesian anti-inflammation herbs mechanism: mini review Nuniek Nizmah. F Mochtar; Eko Mugiyanto; Wirasti wirasti; Vanesa Maharani; Novel Umarella; Hilda Fitria Wulandari; St. Rahmatullah; Widyastuti Handayani; Dwi Bagus Pambudi; Riska Kurnia Oktaviani; Achmad Vandian Nur; Yuliah Wahyu Permadi; Ainun Muthoharoh; Thanh-Hoa Vo; Muh. Nur Khoiru Wihadi
Jurnal Ilmiah Kesehatan Vol. 16 No. 2 (2023): Jurnal Ilmiah Kesehatan
Publisher : Universitas Muhammadiyah Pekajangan Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48144/jiks.v16i2.1453

Abstract

This mini-review aims to provide an overview of some commonly used anti-inflammatory herbs in Indonesia. Inflammation is a complex physiological response that plays a role in various diseases, and herbal remedies have been used traditionally in Indonesian culture for their potential anti-inflammatory properties. We utilize Portal Garuda as the primary database for searching herbs with anti-inflammatory activity using the keyword "anti-inflamasi”. The selected herbs discussed in this review include turmeric (Curcuma longa), ginger (Zingiber officinale), clove (Syzygium aromaticum), and cinnamon (Cinnamomum sp.). These herbs have been reported to possess anti-inflammatory effects through various mechanisms, such as inhibition of pro-inflammatory enzymes and cytokines, antioxidant activity, and modulation of immune responses. Moreover, these herbs have also demonstrated safety profiles in traditional use. However, further scientific research is needed to elucidate the specific bioactive compounds responsible for their anti-inflammatory effects and to determine the optimal dosages and formulations for therapeutic use. The exploration of Indonesian anti-inflammatory herbs could contribute to the development of natural and affordable options for managing inflammatory conditions, complementing conventional treatments, and promoting overall health and well-being.
Penetapan Kadar Kafein Pada Teh Kering Kemasan Produksi Industri Teh di Pekalongan Rina Widhyani; Khusna Santika Rahmasari; Wirasti; Rini Kristiyanti; Slamet
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v12i1.197

Abstract

Caffeine is one of the main alkaloid compounds in tea. The maximum limit of caffeine compounds in beverage food products based on SNI 01-7152-2006 is 50 mg / serving. Pekalongan has a packaged dry tea industry with a variety of brands, so caffeine content testing is required. This study aims to determine the differences in caffeine content in packaged dry tea produced by the tea industry in Pekalongan which is analyzed and to determine the caffeine content of all brands of tea samples that meet the maximum caffeine content requirements. The method used is the reverse phase High Performance Liquid Chromatography (HPLC) method with octadecyl silica C18 as stationary phase, methanol for HPLC mobile phase with a flow rate of 1 mL / minute and a wavelength of 274 nm. The results showed that there were differences in caffeine content in packaged dry tea produced by the tea industry in Pekalongan. The level of caffeine is 1.753 mg / g (T1), 4,870 mg / g (T2), 5,157 mg / g (T3), 2,394 mg / g (T4), 3,601 mg / g (T5), 3,275 mg / g (T6), 3,900 mg / g (T7), 3,725 mg / g (T8), 7,048 mg / g (T9) and 5,348 mg / g (T10). The ten brands of tea samples in a dose of 5 grams per serving have a caffeine content that meets the maximum limit requirements according to SNI 01-7152-2006, namely 50mg / serving with the highest caffeine content in sample T9. The ten brands of tea samples are safe for consumption
Determination of Phenolic Total, Flavonoid Total, Antioxidant Assay and Inhibition of Xanthine Oxidase Enzyme Activity Kemloko Fruits Extract (Phyllanthus Embilica. L) Wirasti Wirasti; Khusna Santika Rahmasari; Isyti'aroh
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 9 No. 1 (2024)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v9i1.33737

Abstract

People use Kemloko Fruits as sweets and some also use it as a herbal medicine to reduce uric acid. The sour-tasting Kemloko fruit contains a lot of ascorbic acid. Ascorbic acid and ingredients contained in it have the effect of preventing or reducing uric acid levels. The aim of this research was to treat the antioxidant effect and inhibitory of the xanthine oxidase enzyme Kemloko Fruit extract, as well as determine the phenolic total and flavonoid total levels. The method used to make Kemloko fruit extract uses maceration with ethanol 96% solvent. The phytochemical screening method uses an in-tube reaction for flavonoid content using the Shinoda test, alkaloids using the Dregendorf reagent, saponins using the foam test and terpenoids/steroids using the Liebermann Burchard reagent. Meanwhile, the methods for determining phenolics and flavonoids total are the colorimetric used spectrophotometry UV-Vis, the DPPH methods for antioxidant assay, and measurenment of inhibiting xanthin oxidase activity using a microplate at a wavelength of 375 nm. Qualitative data produced by the ethanol extract of Kemloko fruit contains tannins, flavonoids, alkaloids, terpenoids, saponins and glycosides. Meanwhile, Quantitative data showed that the phenolic and flavonoid total levels were 1465.63±0.003 mgGAE/g extract and 9.52±0.001 µg/mL, respectively, as well as the IC50 for xanthin oxidase enzyme inhibition of 20.65 µg/mL and the IC50 antioxidant power of 9.49 ±0.0007 µg/mL. Kemloko fruit ethanol extract contains tannins, flavonoids, alkaloids, terpenoids, saponins and glycosides has inhibitor activity against xanthine oxidase and antioxidant is a strong.
EVALUASI KESESUAIAN DOSIS INSULIN PADA PROLANIS BERDASARKAN LITERATUR DI RUMAH SAKIT X TAHUN 2019 Nadliyatul Umah; Ainun Muthoharoh; Wulan Agustin Ningrum; Wirasti Wirasti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 5 No 1 (2020)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v5i1.159

Abstract

Kasus penyakit diabetes melitus di Kabupaten Batang pada urutan dua setelah penyakit hipertensi. Jumlah prevalensi penyakit diabetes melitus sebanyak 17,53%. Kesesuaian dosis insulin sangat diperlukan, apabila tidak sesuai hiperglikemik tidak terkontrol. Tujuan dari penelitian ini yaitu untuk memperoleh gambaran tentang evaluasi kesesuaian dosis insulin pada prolanis selama menjalani perawatan diabetes melitus. Metode yang digunakan yaitu deskriptif retrospektif univariat. Kriteria insklusi yaitu data rekam medik pasien yang mempunyai riwayat diabetes melitus yang menjalani prolanis dan menggunakan insulin. Kriteria eksklusi yaitu rekam medik yang tidak lengkap. Hasil dari evaluasi kesesuaian dosis berdasarkan literatur Standard of Medical Care In Diabetes 2018, Drug Information Handbook 19th Edition (Lacy dkk, 2010), The Renal Drug Handbook, MIMS edisi 17, ISO volume 51 yang sesuai sebanyak 100%, kemudian berdasarkan guideline Comparison of 2 intravenous insulin protocols : glycemia variability in critically ill patients yang sesuai sebanyak 34,1% dan guideline Update On Management Of In-hospital Hyperglycemia yang sesuai sebanyak 27,1%. Hasil dari karakteritik prolanis di RS X yaitu pada kelompok usia 60-74 tahun (lansia) sebanyak 49,4%, jenis kelamin lebih banyak laki-laki yaitu 52,9%, hasil diagnosa pasien prolanis yang paling banyak yaitu diabetes militus komplikasi 52,9%, jenis insulin yang sering diberikan untuk pasien prolanis yaitu novomix 30 flexpen sebanyak 84,7%, dan tingkat kepatuhan pasien prolanis yaitu 100%. Bagi pengguna insulin sebaiknya mengikuti anjuran dari program prolanis dan menjaga pola hidup yang sehat agar terapi insulin berhasil.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BIDARA (ZIZIPHUS MAURITIANA LAMM) DALAM FORMULASI SEDIAAN SABUN CAIR SEBAGAI ANTISEPTIK TERHADAP BAKTERI STAPYLOCOCCUS AUREUS ATCC 25923 Khoirunnisak Khoirunnisak; Wulan Agustin Ningrum; Wirasti Wirasti; St Rahmatullah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 5 No 1 (2020)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v5i1.161

Abstract

Daun bidara (Ziziphus mauritianaLamm) mempunyai senyawa aktif seperti flavonoid, alkaloid, saponin, tanin, steroid dan terpenoid yang berfungsi untuk menghambat pertumbuhan bakteri Staphylococcus aureus. Penelitian ini bertujuan untuk memformulasikan sediaan sabun cair  ekstrak daun bidara (Ziziphus mauritiana Lamm) dan menguji efektifitas antibakteri sediaan sabun cair dengan pemberian ekstrak daun bidara pada formula 1 yaitu 0,3%, formula 2 yaitu 0,5% dan formula 3 yaitu 0,7%. Hasil uji  antibakteri pada formula 1 mempunyai daya hambat 5,0003 mm, formula 2 mempunyai daya hambat sebesar 9,0137 mm dan formula 3 memiliki daya hambat sebesar 12,003 mm terhadap bakteri Staphylococcus aureus. Hasil analisis one way ANOVA pada uji antibakteri dengan nilai sig 0,00< 0,05 menunjukan adanya perbedaan dari masing-masing konsentrasi terhadap pengaruh daya hambat bakteri Staphylococcus aureus.Katakunci : Daun bidara, Sabun cair, Staphylococcus aureus
Co-Authors Achmad Vandian Nur, Achmad Vandian Adelia Fitriani Ahmad Vandian Nur Ainun Muthoharoh Ainun Muthoharoh Antonius Padua Ratu Cut Chiwe Widya Pramesty Dina Salwa Atiqi Dwi Bagus Pambudi Dwi Bagus Pambudi Dwi Bagus Pambudi Dwi Bagus Pambudi Pambudi Eko Mugiyanto Elsa Septiana Khoirunnisa Farahdina Ulfah Fissilmi Kaffah Galuh Surya Cahyaningrum Hilda Fitria Wulandari Hinda Dwi Styani Isyti'aroh Khoirunnisak Khoirunnisak Khusna Santika Rahmasari Khusnul Milatul Khasanah Maryatul Kiptiyah Muh. Nur Khoiru Wihadi Nadia Salsabila Ulfa Nadliyatul Umah Nadliyatul Umah Naila Iva Amalina Putri Sulaiman Ningrum, Wulan Agustin Novasella Novasella Novel Umarella Nuniek Nizmah. F Mochtar Nur Mufidah Nurul Ulva Prayugo Sugeng Rasya Rizqi Kamilah Rina Widhyani Rini Kristiyanti Riska Kurnia Oktaviani Rizkyana Efendi S Slamet Shafira anjelia Siti Nur Agmarina Slamet Slamet Slamet Slamet Slamet, Slamet St Rahmatullah St. Rahmatullah ST. Rahmatullah Thanh-Hoa Vo ulian Wahyu Permadi Urmatul Waznah Vanesa Maharani Widyastuti Handayani Wulan Agustin Ningrum Yuliah Wahyu Permadi Yulian Wahyu Permadi Yulian Wahyu Permadi Yulian Wahyu Permadi Yusi Jayanti