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All Journal Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) BIO-EDU: Jurnal Pendidikan Biologi Prosiding University Research Colloquium Jurnal Bakti Untuk Negeri Jurnal Ilmiah Kesehatan Journal of Natural Product for Degenerative Diseases
Eko Mugiyanto
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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AKTIVITAS ANTIOKSIDAN, TOTAL FENOL DAN TOTAL FLAVONOID TANAMAN KEDONDONG (Spondias dulcis Soland ex Park) Veni Haqiqotun Najihah; Eko Mugiyanto; Yulian Wahyu Permadi
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 5 No. 2 (2018)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (550.52 KB) | DOI: 10.22236/farmasains.v5i2.2375

Abstract

Upaya peningkatan dalam pemanfaatan antioksidan alami telah dilakukan melalui uji aktivitas antioksidan serta penentuan total fenolik dan flavonoid dari tanaman kedondong (Spondias dulcis Soland ex Park). Tujuan dari penelitian ini adalah untuk menentukan aktivitas antioksidan, total fenolik dan flavonoid dari ekstrak daun, kulit batang dan daging buah kedondong. Ekstraksi telah dilakukan menggunakan pelarut etanol 96% dengan metode maserasi. Analisis spektrofotometri UV-VIS menunjukkan kandungan total fenolik dan flavonoid daun, kulit batang, dan daging buah kedondong sebesar: (37,400 mg GAE/g ekstrak; 9,145 mg QE/g ekstrak), (85,067 mg GAE/g ekstrak; 6,829 mg QE/g ekstrak) dan (4,067 mg GAE/g ekstrak; 4,597 mg QE/g ekstrak). Hasil menunjukkan bahwa ekstrak daun memiliki aktivitas antioksidan tertinggi dengan nilai IC50 13,687 µg/mL..
PENGARUH PENAMBAHAN EKSTRAK DAUN SIRSAK (Annona muricata L.)TERHADAP PROFIL FARMAKOKINETIKA PIROKSIKAM Setyo Tri Raharjo; Dwi Bagus Pambudi; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (382.327 KB)

Abstract

Piroxicam is one of the NSAID drug that common used in inflammation. Utilizing of herbal medicine along with synthetic drugs can lead to certain interactions, especially the occurrence of pharmacokinetic drug profile changes. The aim of this study is to determine the effect of addition of soursop leaf extract againt pharmacokinetic piroxicam profile. The method used was cross sectional using 6 rabbits, the data were analyzed statistically with t-test using SPSS version 21 program. The results showed that the piroxicam treatment had Cmax = 0.650 μg / ml, tmax = 3 hours, t ½ = 0.693 hours, and AUC = 0.597 hours.μg / ml, while on treatment of combination of piroksikam with soursop leaf extract have value of Cmax = 0,683 μg / ml, tmax = 1 hour, t ½ = 0,693 hours, and AUC = 0,652 jam.μg / ml. The result of data analysis using T test showed that there was significant difference in AUC value (p <0,05). These results suggest that the addition of soursop leaf extract may affect the piroxicam pharmacokinetic profile.
SINTESIS PREKURSOR SENYAWA 2-AMINOBUTYRIC ACID (ABA) DENGAN STARTING MATERIAL MONOSODIUM GLUTAMATE (MSG) Dewi Syarifah; Slamet Slamet; Wirasti Wirasti; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.494 KB)

Abstract

The aim of the research is to synthesize the compound of Precursor of ABA from MSG the starting material by structural modification as well as to determine the characteristics and physical properties of the synthesis compound. It was done by modification of chemical structure starting with glutamic acid isolation from MSG. Then it isolate reacted with AlCl3 to obtain the ABA compound precursor. The rendemen was 18.5%, of synthesis identification obtained of white powder, odorless, dissolves in hot water and melt at a temperature of 187-189 0C. The UV-Vis spectrophotometry showed that the synthesis process formed a new compound. Confirm with HPLC analysis.
PERBEDAAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN, DAGING BUAH, DAN BIJI MENGKUDU (Morinda citrifolia L.) DENGAN METODE DPPH (1,1–DIPHENYL-2-PICRYLHYDRAZYL) Muhammad Syifaul Qulub; W Wirasti; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (624.833 KB)

Abstract

Antioksidan adalah senyawa yang menghambat efek negatif dari radikal bebas, Noni (Morinda citrifolia L) memiliki senyawa fenolik seperti itu. Tujuan dari penelitian ini adalah untuk mengevaluasi perbedaan aktivitas antioksidan daun, daging buah dan ekstrak etanol biji noni Morinda citrifolia L. dengan metode pembilasan radikal bebas DPPH. Uji aktivitas antioksidan diukur dengan spektrofotometri UV-Vis dan data dianalisis dengan ANOVA. Hasil penelitian menunjukkan bahwa daun, daging buah dan ekstrak etanol biji noni Morinda citrifolia L. memiliki total fenolik 47.10 ± 1.73, 18.10 ± 0.00 dan 108.43 ± 1.52 mg GAE / g ekstrak, flavonoid total 15.97 ± 0.03, 3.83 ± 0.15 dan 6.18 ± 0,21 mgQE / g ekstrak., Sementara nilai IC50 374,29 ± 4,14, 442,40 ± 5,78, dan 59,22 ± 0,68 μg / mL, masing-masing. Analisis ANOVA memiliki perbedaan dengan nilai signifikansi (p-value) <0,05.
PENGENALAN OBAT ANTIBIOTIKA PADA PENGURUS CABANG AISYAH BLIGO KABUPATEN PEKALONGAN Slamet Slamet; Wulan Agustin Ningrum; Eko Mugiyanto
Jurnal Bakti untuk Negeri Vol 2 No 2 (2022): JBN
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (132.268 KB)

Abstract

Antibiotics are drugs used by doctors for the treatment of infections caused by microbes such as bacteria. Problems arise in the use of antibiotics that are not correct. Inappropriate use of antibiotics. The use of antibiotics that do not kill bacteria so that bacteria are resistant and antibiotic treatment does not work. The purpose of this community service is to remind you of the correct use of drugs and the consequences if antibiotic treatment is not correct. The method used is a lecture about antibiotics and infectious diseases that often occur in the community. The result of this service is that knowledge about antibiotic drugs and how to use them by Aisyah's caretakers is getting better which is reinforced by a high posttest score compared to the pretest value. The conclusion of the community service to the management of Aisyah's mothers is that their knowledge of antibiotics is getting better and those who have forgotten are reminded of their knowledge of antibiotics and their use.
PENGENALAN OBAT ANTIBIOTIKA PADA PENGURUS CABANG AISYAH BLIGO KABUPATEN PEKALONGAN Slamet Slamet; Wulan Agustin Ningrum; Eko Mugiyanto
Jurnal Bakti untuk Negeri Vol 2 No 2 (2022): JBN
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jbn.v2i2.1107

Abstract

Antibiotics are drugs used by doctors for the treatment of infections caused by microbes such as bacteria. Problems arise in the use of antibiotics that are not correct. Inappropriate use of antibiotics. The use of antibiotics that do not kill bacteria so that bacteria are resistant and antibiotic treatment does not work. The purpose of this community service is to remind you of the correct use of drugs and the consequences if antibiotic treatment is not correct. The method used is a lecture about antibiotics and infectious diseases that often occur in the community. The result of this service is that knowledge about antibiotic drugs and how to use them by Aisyah's caretakers is getting better which is reinforced by a high posttest score compared to the pretest value. The conclusion of the community service to the management of Aisyah's mothers is that their knowledge of antibiotics is getting better and those who have forgotten are reminded of their knowledge of antibiotics and their use.
Identifikasi Variasi Gen yang Bersifat Missense/Nonsense Pada Dermatomyositis Dengan Memanfaatkan Database Genomik Dan Bioinformatik Lalu Muhammad Irham; Anisa Nova Puspitaningrum; Wirawan Adikusuma; Eko Mugiyanto; Ageng Brahmadhi; Gina Noor Djalilah; Rahmat Dani Satria; Firdayani; Abdi Wira Septama
Majalah Farmasi dan Farmakologi Vol. 27 No. 1 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i01.22185

Abstract

Dermatomyositis merupakan penyakit autoimun yang termasuk jenis idiopatik inflamasi miopati (IIM), penyakit ini dapat mempengaruhi kulit dan otot manusia. Gejala klinis Dermatomyositis pada sebagian besar pasien adalah kelemahan otot tubuh, ruam kulit dan kulit bersisik. Salah satu faktor penyebab Dermatomyositis yang sering dilaporkan adalah faktor genetik. Hingga kini,  penelitian terkait Dermatomyositis masih terbatas pada identifikasi jenis variasi gen yang mempengaruhi, namun tidak melaporkan variasi gen mana yang paling berkontribusi pada Dermatomyositis khususnya yang bersifat missense/nonsense. Sehingga pada penelitian ini kami memanfaatkan database genomik dan analisis bioinformatik  untuk mengidentifikasi variasi gen yang paling berhubungan dengan penyakit Dermatomyositis. Penelitian ini menggunakan beberapa database, termasuk GWAS catalog, PheWAS catalog, HaploReg (v41.), dan GTEx portal. Hasil dari penelitian ini ditemukan bahwa gen ZBP1 berkaitan erat dengan penyakit Dermatomyositis dan menunjukkan ekpresi yang tinggi pada beberapa jaringan seperti paru-paru, lambung, esophagus, kulit, jantung dan otot. Variasi gen berdasarkan frekuensi varian alel (rs59626664, rs60542959, rs2066807, rs1048661, rs745400, rs2305480, rs2305479) terkait Dermatomyositis menunjukkan ekspresi jaringan tertinggi di kulit suprapubic, kulit dibawah lengan, otot rangka, dan esofagus. Penelitian ini menekankan bahwa integrasi database genomik dan analisis bioinformatik menunjukkan variasi gen yang berperan dalam patogenesis Dermatomyositis khususnya yang bersifat missense/nonsense. Kami menyarankan untuk peneliti selanjutnya untuk fokus pada variasi gen tersebut untuk divalidasi di fase klinis khusunya di populasi Indonesia.
PENGARUH PENAMBAHAN EKSTRAK DAUN SIRSAK (Annona muricata L.)TERHADAP PROFIL FARMAKOKINETIKA PIROKSIKAM Setyo Tri Raharjo; Dwi Bagus Pambudi; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Piroxicam is one of the NSAID drug that common used in inflammation. Utilizing of herbal medicine along with synthetic drugs can lead to certain interactions, especially the occurrence of pharmacokinetic drug profile changes. The aim of this study is to determine the effect of addition of soursop leaf extract againt pharmacokinetic piroxicam profile. The method used was cross sectional using 6 rabbits, the data were analyzed statistically with t-test using SPSS version 21 program. The results showed that the piroxicam treatment had Cmax = 0.650 ?g / ml, tmax = 3 hours, t ½ = 0.693 hours, and AUC = 0.597 hours.?g / ml, while on treatment of combination of piroksikam with soursop leaf extract have value of Cmax = 0,683 ?g / ml, tmax = 1 hour, t ½ = 0,693 hours, and AUC = 0,652 jam.?g / ml. The result of data analysis using T test showed that there was significant difference in AUC value (p <0,05). These results suggest that the addition of soursop leaf extract may affect the piroxicam pharmacokinetic profile.
SINTESIS PREKURSOR SENYAWA 2-AMINOBUTYRIC ACID (ABA) DENGAN STARTING MATERIAL MONOSODIUM GLUTAMATE (MSG) Dewi Syarifah; Slamet Slamet; Wirasti Wirasti; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The aim of the research is to synthesize the compound of Precursor of ABA from MSG the starting material by structural modification as well as to determine the characteristics and physical properties of the synthesis compound. It was done by modification of chemical structure starting with glutamic acid isolation from MSG. Then it isolate reacted with AlCl3 to obtain the ABA compound precursor. The rendemen was 18.5%, of synthesis identification obtained of white powder, odorless, dissolves in hot water and melt at a temperature of 187-189 0C. The UV-Vis spectrophotometry showed that the synthesis process formed a new compound. Confirm with HPLC analysis.
PERBEDAAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN, DAGING BUAH, DAN BIJI MENGKUDU (Morinda citrifolia L.) DENGAN METODE DPPH (1,1–DIPHENYL-2-PICRYLHYDRAZYL) Muhammad Syifaul Qulub; W Wirasti; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antioksidan adalah senyawa yang menghambat efek negatif dari radikal bebas, Noni (Morinda citrifolia L) memiliki senyawa fenolik seperti itu. Tujuan dari penelitian ini adalah untuk mengevaluasi perbedaan aktivitas antioksidan daun, daging buah dan ekstrak etanol biji noni Morinda citrifolia L. dengan metode pembilasan radikal bebas DPPH. Uji aktivitas antioksidan diukur dengan spektrofotometri UV-Vis dan data dianalisis dengan ANOVA. Hasil penelitian menunjukkan bahwa daun, daging buah dan ekstrak etanol biji noni Morinda citrifolia L. memiliki total fenolik 47.10 ± 1.73, 18.10 ± 0.00 dan 108.43 ± 1.52 mg GAE / g ekstrak, flavonoid total 15.97 ± 0.03, 3.83 ± 0.15 dan 6.18 ± 0,21 mgQE / g ekstrak., Sementara nilai IC50 374,29 ± 4,14, 442,40 ± 5,78, dan 59,22 ± 0,68 ?g / mL, masing-masing. Analisis ANOVA memiliki perbedaan dengan nilai signifikansi (p-value) <0,05.
Co-Authors Abdi Wira Septama Achmad Vandian Nur, Achmad Vandian Ageng Brahmadhi Ainun Muthoharoh Alfioni Wulandari J.E Ana Yulyana Anisa Nova Puspitaningrum Annisya Maulidia Putri Dewi Syarifah Dwi Bagus Pambudi Dwi Bagus Pambudi Firdayani Gina Noor Djalilah Hilda Fitria Wulandari Khusna Santika Rahmasari Lalu Muhammad Irham Muh. Nur Khoiru Wihadi Muhammad Syifaul Qulub Naila Izza Sabila Novel Umarella Nuniek Nizmah. F Mochtar Rahmat Dani Satria Riska Kurnia Oktaviani Saiful Bahri Setyo Tri Raharjo Slamet Slamet St. Rahmatullah Thanh-Hoa Vo Vanesa Maharani Veni Haqiqotun Najihah W Wirasti Widyastuti Handayani Wirasti Wirasti Wirasti Wirawan Adikusuma Wulan Agustin Ningrum Yuliah Wahyu Permadi Yulian Wahyu Permadi