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All Journal JURNAL AGRILAND ELSE (Elementary School Education Journal) : Jurnal Pendidikan dan Pembelajaran Sekolah Dasar RAUDHAH Menara Perkebunan Majalah Patologi Indonesia Best Journal (Biology Education, Sains and Technology) Abdimas Toddopuli: Jurnal Pengabdian Pada Masyarakat Cokroaminoto Journal of Primary Education
Aida Farida
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Public Health Social Sciences Other

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Perbedaan Ekspresi PTEN pada Endometrium Normal, Hiperplasia Endometrium dan Endometrioid Carcinoma Suhaili; Heni Maulani,; Aida Farida
Majalah Patologi Indonesia Vol. 28 No. 2, Mei 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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ABSTRAKLatarbelakangHiperplasia endometrium merupakan lesi prekursor terjadinya karsinoma endometrium terutama jenisendometrioid carcinoma. Patogenesis karsinoma endometrium dan perubahan dari normal menjadi keganasanmelibatkan banyak kelainan molekular termasuk PTEN gen penghambat tumor. Hipotesis kami adalah terdapatperbedaan ekspresi PTEN pada hiperplasia endometrium dan endometrioid carcinoma dengan endometriumnomal fase proliferasi.MetodeRancangan penelitian yang digunakan adalah case control. Sampel adalah jaringan endometrium berasal darikuretase, biopsi dan histerektomi. Sampel dibagi menjadi 2 kelompok, kelompok kontrol yaitu endometriumnormal fase proliferasi 25 sampel, dan kelompok kasus terdiri dari 25 endometrium hiperpasia dan 25endometrioid carcinoma. Sampel dilakukan pulasan imunohistokimia dengan antibodi monoklonal PTEN.Imunoreaktifitas PTEN di skor secara semikuantitatif yang dilihat dari persentase luas area dan intensitaspulasan. Perbedaan ekspresi PTEN dianalisa dengan SPSS versi 19.0.HasilTidak ada perbedaan yang bermakna pada ekspresi PTEN antara kelompok kasus dengan kontrol berdasarkanluas area dan intensitas pulasan. Penurunan intensitas ekspresi PTEN terlihat pada mayoritas kasushiperplasia atipik dan endometrioid carcinoma dibandingkan dengan endometrium fase proliferasi. Terlihatkecenderungan intensitas ekspresi PTEN menurun pada hiperplasia endometrium atipik dibandingkanhiperplasia endometrium non atipik.KesimpulanIntensitas pulasan PTEN pada endometrium hiperplasia atipik cenderung lebih menurun dibandingkanhiperplasia non atipik. Hiperplasia atipik yang merupakan lesi prekursor terjadinya endometrioid carcinoma. Halini mengindikasikan kemungkinan besar mutasi PTEN mempunyai peranan penting pada patogenesiskarsinoma endometrium.
Kepadatan CD8 di Lingkungan Mikrotumor pada Subtipe Diffuse Large B Cell Lymphoma Indah Yunalda; Krisna Murt; Aida Farida; Ika Kartika; Erial Bahar
Majalah Patologi Indonesia Vol. 30 No. 2, Mei 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i2.466

Abstract

BackgroundDiffuse Large B Cell Lymphomas (DLBCL) is divided into two subtypes, GCB and non-GCB, which are determined based on Hans'salgorithm. The GCB subtype has a better prognosis than non-GCB. Some studies indicate that the tumor progression wasinfluenced by tumor microenvironment, including CD8+ TILs located both surrounding tumor cells and peripheral. This study aims todetermine the density of CD8+ TILs in the tumor microenvironment of DLBCL subtypes.MethodsA Cross sectional study of 40 samples of DLBCL registered to Department of Anatomical Pathology Faculty of Medicine UniversitasSriwijaya/Dr. Mohammad Hoesin Palembang Hospital from 1st October 2017 to 31st December 2018. All samples were stained usinganti-CD8 antibody, afterward, lymphocytes express CD8 were assessed both in surrounding tumor cells and peripheral. The densityof CD8 in each DLBCL subtype was analyzed statistically using Mann Whitney U Test.ResultsIn this study, non-GCB subtype was found higher in comparison to GCB subtype (72.5%) and the samples was dominated by youngages (75%). Significantly, peripheral CD8 density was higher than that of surrounding tumor cells, both in the GCB (p=0.003) andnon-GCB subtypes (p=0.000).ConclusionIn both subtypes, CD8 density is higher in peripheral than surrounding tumor cells and a high density in surrounding tumor cells willbe followed by an increase in peripheral CD8 density.
Co-Authors Abdul Kahar Akbar, Wawan B. MARAHIMIN MARAHIMIN Damanik, Sanra Hanalide Djoko Santoso Eka Bobby Febrianto, Eka Bobby Erial Bahar Fauzi, M. Amin Friska Anggraini Barus Ghani, Bambang Abdul Hadinata, Rilwan Handoko, Habib HAPPY WIDIASTUTI Hasibuan, Henry Budi Hasibuan, M Arief Hasratuddin Heni Maulani Heni Maulani, Huratio Nelson Ika Kartika Indah Yunalda Irsan Saleh Jisman SINAGA K. PANJAITAN PANJAITAN Krisna Murt Maisarah Makhrani Sari Ginting Memed WIRAMIHARDJA Muhammad Yusuf Dibisono Nurliana NURLIANA NURLIANA Rahmad Dian Soekarno Mismana Putra Suhaili Sulthon Parinduri Tohir, Kurnainy Wahyuda, Nurul Wawan Akbar Winra, Winra