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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Tropical and Infectious Disease CERATA Jurnal Ilmu Farmasi ad-Dawaa : Journal of Pharmaceutical Sciences Community Empowerment Jurnal Farmasi Sains dan Praktis Urecol Journal. Part D: Applied Sciences Prosiding University Research Colloquium Journal of Food and Pharmaceutical Sciences MOTORIK CERATA Borneo Journal of Pharmacy
Agustina Styawan, Anita
Program Studi D3 Farmasi STIKES Muhammadiyah Klaten, Indonesia.
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences

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Perbandingan Kadar Kafein pada Teh Hitam (Camellia Sinensis) yang Diseduh dan Direbus dengan Metode Titrasi Bebas Air Anita Agustina Styawan; Muchson Arrosyid; S Sutaryono
Prosiding University Research Colloquium Proceeding of The 10th University Research Colloquium 2019: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Tanaman teh merupakan minuman paling banyak dikonsumsi masyarakat setelah air. Teh mengandung banyak senyawa yang berkhasiat untuk tubuh seperti kafein. Proses penyeduhan teh dengan waktu dan suhu yang tidak optimum dapat mempengaruhi kandungan kafein didalamnya. Semakin tinggi suhu dan lama waktu penyeduhan, kadar kafein dalam teh semakin meningkat. Dan proses penyeduhan dengan pemanasan dapat memperlebar jarak antar molekul dalam teh. Lebarnya jarak antar molekul dalam teh dapat mempermudah molekul air untuk menembus padatan teh sehingga kafein akan mudah terekstrak dalam pelarut air. Penelitian ini bertujuan untuk menganalisis kadar kafein pada teh hitam yang diseduh dan direbus, kemudian membandingkan kadar kafein pada teh hitam dengan proses penyeduhan diseduh (tanpa pemanasan) dan direbus (dengan pemanasan). Metode penelitian yang digunakan adalah eksperimental. Penelitian ini menggunakan sampel simplisia kering daun teh hitam (Camellia sinensis). Sampel diuji secara kualitatif menggunakan reaksi Murexid. Dianalisis kuantitatif menggunakan Titrasi Bebas Air. Hasil penelitian menunjukkan bahwa secara kualitatif sampel positif mengandung kafein yang ditandai dengan perubahan warna menjadi merah. Secara kuantitatif, kadar kafein pada teh hitam yang diseduh sebesar 10,718% b/v dan kadar kafein pada teh hitam yang direbus sebesar 10,986% b/v. Kesimpulan dari penelitian ini adalah terdapat perbedaan yang signifikan kadar kafein pada teh hitam yang diseduh dan direbus dengan nilai signifikasi 0,034<0,05.
FORMULASI DAN UJI SIFAT FISIS SIRUP EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg Nurul Hidayati; Anita Agustina Styawan; Anggit Khusnul Khotimah
Prosiding University Research Colloquium Proceeding of The 12th University Research Colloquium 2020: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg merupakan salah satu tumbuhan obat tradisional yang banyak dimanfaatkan sebagai alternatif pengobatan untuk berbagai penyakit. Kandungan senyawa flavonoid di dalamnya dapat menurunkan kadar gula darah. Pembuatan sirup ekstrak etanol daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg dapat mempermudah penggunaan dan penutupan rasa pahit pada ekstrak daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi ekstrak etanol daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg terhadap sifat fisis sirup dan untuk mengetahui konsentrasi ekstrak etanol daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg yang menghasilkan sifat fisis sirup yang paling baik. Simplisia diekstraksi menggunakan metode maserasi bertingkat dengan etanol 70%. Ekstrak kental daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg dibuat sirup dalam 3 formula dengan variasi konsentrasi ekstrak, formula 1 (7,5%), formula 2 (15%), dan formula 3 (30%). Sirup diuji sifat fisis dan data dianalisis dengan One Way ANOVA dan dilanjutkan uji LSD (Least Significance Difference). Hasil penelitian menunjukkan peningkatan konsentrasi ekstrak daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg mempengaruhi sifat fisis sirup, yaitu rasa sirup semakin pahit, baunya semakin khas, warnanya semakin pekat, serta peningkatan nilai pH, viskositas, dan waktu tuang. Sirup konsentrasi 15% menghasilkan sifat fisis yang paling baik, yaitu rasa manis, bau khas ekstrak daun sukun (Artocarpus altilis) (Parkinson ex F.A.Zorn) Fosberg, warna coklat, tingkat kejernihan sangat jernih, homogen, nilai pH 4 ± 0, viskositas 2,07 ± 0,06 dPas, serta nilai waktu tuang 2,99 ± 0,04 detik.
IDENTIFIKASI FLAVONOID PADA EKSTRAK ETANOL TEMU MANGGA (Curcuma mangga Val.) METODE EKSTRAKSI MASERASI DAN SOKLETASI SECARA KROMATOGRAFI LAPIS TIPIS Muchson Arrosyid; Anita Agustina Styawan; Selvi Candra Dewi; Rezyana Budi Syahputri
CERATA Jurnal Ilmu Farmasi Vol 14 No 1 (2023)
Publisher : UNIVRSITAS MUHAMMADIYAH KLATEN

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Abstract

Temu mangga merupakan salah satu keluarga Zingeberaceae, memiliki kandungan metabolit sekunder seperti flavonoid. Temu mangga (Curcuma mangga Val.) berkhasiat sebagai pereda sakit maag, diare, penghilang nyeri haid, mengobati jerawat dan bisul, serta menambah nafsu makan. Selain itu, temu mangga diduga memiliki aktivitas antioksidan karena adanya senyawa fenolik dan flavonoid yang terkandung di dalamnya. Tujuan penelitian ini untuk mengetahui jenis senyawa flavonoid yang terdapat dalam rimpang temu mangga (Curcuma mangga Val.). Ekstraksi dilakukan dua tahap yaitu tahap maserasi dan sokletasi tahap menggunakan pelarut yang sama yaitu etanol 70%. Identifikasi flavonoid ekstrak temu mangga dilakukan menggunakan metode kromatografi lapis tipis (KLT). Bercak lempeng yang memiliki harga Rf dan warna yang sama dengan deteksi awal yaitu kuning kehijauan menunjukkan hasil positif pada ekstrak metode sokletasi dan maserasi. Hasil identifikasi flavonoid pada ekstrak temu mangga (Curcuma mangga Val.) menunjukkan harga Rf ekstraksi secara maserasi sebanyak 0,53 dan hasil dari ekstraksi secara sokletasi sebanyak 0,82. Dari hasil tersebut menunjukkan bahwa terdapat perbedaan antara ekstraksi maserasi dan sokletasi.
Tannin Analysis of Red Roselle Petals (Hibiscus Sabdariffa, L.) using Permanganometry Method Anita Agustina Styawan; Aristhasari Putri; Refida Ramadhani Nur Cholifa
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujas.31

Abstract

Red roselle (Hibiscus sabdariffa L.) is a plant that can be used by the community as traditional medicine. Rosella flower petals contains protein, fat, minerals, alkaloids, flavonoids, and tannins. Red rosella is effective in preventing vertigo, antihypertension, antidiabetic, anticancer, and antioxidants. Tannins are known as one of the active ingredients contained in the petals of red rosella flowers. Tannins are polyphenolic protein. This study aims to determine the levels of tannin in the extract of red rosella flower petals using permanganometry titration. The research method used was observational. This study used a sample of red roselle flower petals. The sample was tested qualitatively using FeCl3 1%. Analyzed quantitatively using permanganometry titration. The results showed that qualitatively the positive sample contained tannins which was marked by a change in color to dark blue dark. Quantitatively the sample was titrated with KMnO4, the tannin content in red roselle flower petals was 13,73 % b/b.
Gel Formulation for Hand Sanitizer from Ethanol Extract of Mulberry Leaf (Morus Alba L.) Sutaryono Sutaryono; Hendra Budiman; Anita Agustina Styawan; Nurul Hidayati; Dayah Ainus
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53017/ujas.37

Abstract

During the Covid 19 pandemic, a handsanitizer product has emerged which functions as a hand washing disinfectant for the prevention of the Covid 19 virus. One of the ingredients that can be made handsanitizer gel is the mulberry plant (Morus alba L.) because it contains many flavonoids which act as antiseptics against bacteria. The research objective was to determine the handsanitizer gel formulation with the concentration of carbopol and propylenglycol which can produce good physical properties. The research design used an experiment, with the mulberry leaf preparation material macerated using 70% ethanol. Mulberry leaf ethanol extract (Morus alba L.) as the active substance and made 3 formulas with variations in the concentration of carbopol: propylenglycol formula I (0.5%: 15%), formula II (1.25%: 12.5%), formula III (2%: 10%). The three formulas were tested for physical properties and analyzed by ANOVA with a confidence level of 95%. The results showed that the handsanitizer gel formulation with carbopol increased viscosity and stickiness, while propylenglycol increased the dispersibility. The 1.25% formula: 12.5% ??produces the best physical properties, with a pH test of 6, a viscosity test of 150 dPas, a spreadability test of 6.5 cm, a sticky power test of 2.39 seconds and a protective power test without red stains.
UJI SIFAT FISIS GEL EKSTRAK ETANOL BATANG BROTOWALI (Tinospora crispa, L) DENGAN VARIASI KONSENTRASI CARBOPOL DAN PROPILENGLIKOL Anisa Dita Rahmawati; Anita Agustina Styawan; Nurul Hidayati
MOTORIK Jurnal Ilmu Kesehatan Vol 13 No 1 (2018): Maret
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/motorik.v13i1.4

Abstract

Batang brotowali (Tinospora crispa, L) merupakan tanaman yang mengandung flavonoid sebesar 0,52% (Desmiaty dkk, 2014). Ekstrak etanol batang brotowali diformulasikan dalam bentuk sediaan gel untuk mempermudah penggunaanya. Formulasi gel membutuhkan carbopol sebagai basis pembentuk gel dan propilenglikol sebagai humektan yang berperan untuk meningkatkan kelembaban. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi carbopol dan propilenglikol terhadap sifat fisis gel ekstrak batang brotowali. Gel dibuat dalam lima formula dengan perbandingan konsentrasi carbopol : propilenglikol, yaitu Formula I (0,5% : 7,5%), Formula II (1,25% :11,25%), Formula III (2% : 15%), Formula IV (0,5% : 15%), Formula V (2% : 7,5%) dan dilakukan uji sifat fisis gel. Uji sifat fisis gel meliputi uji organoleptis, homogenitas, pH, daya sebar, viskositas, daya lengket, dan daya proteksi. Data yang diperoleh dianalisis secara statistik dengan analisis varian (ANOVA) satu jalan dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa semakin tinggi konsentrasi carbopol meningkatkan viskositas dan daya lengket dan semakin tinggi konsentrasi propilenglikol meningkatkan daya sebar gel. Kesimpulan dari penelitian ini adalah variasi konsentrasi carbopol dan propilenglikol dapat mempengaruhi sifat fisis gel ekstrak etanol batang brotowali. Konsentrasi carbopol dan propilenglikol yang dapat menghasilkan sifat fisis yang baik adalah 1,25% : 11,25% yaitu pada Formula II.
ANALISIS KANDUNGAN ASAM RETINOAT PADA SEDIAAN KRIM MALAM YANG BEREDAR DI TOKO X KOTA KLATEN DENGAN SPEKTROFOTOMETRI UV-Vis Anita Agustina Styawan; Choiril Hana Mustofa; Yenni Kusuma Wardhan
MOTORIK Jurnal Ilmu Kesehatan Vol 15 No 1 (2020): Maret
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/motorik.v15i1.39

Abstract

Whitening cosmetics are cosmetics that contain an active whitening ingredient to brighten the skin. Retinoic acid is prohibited from being used in whitening creams because it can cause dry, burning, carcinogenic and teratogenic skin. The purpose of this study was to determine the levels of retinoic acid contained in night creams. The sample in this study were 5 night cream products circulating in Klaten City X Store. This study was conducted to determine the content of retinoic acid in night creams using thin layer chromatography (TLC). Five positive samples contained retinoic acid by giving dark green spots and the concentration was determined by UV-Vis spectrophotometry. The results of this study indicate that in 5 samples of night cream circulating in Store X in the City of Klaten all positive for retinoic acid, that is, the average for sample A was 0.021%; sample B 0.014%; sample C 0.016%; sample D 0.025% and sample E 0.023%. Keywords: Retinoic Acid, Whitening Cream, UV-Vis Spectrophotometry
Analisis Logam Merkuri (Hg) dalam Krim Pemutih Herbal Temulawak (Curcuma zanthorrhiza) dengan Metode Mercury Analyzer Anita Agustina Styawan; Lenny Apriyaningsih; Dwi Joko Yulianto
CERATA Jurnal Ilmu Farmasi Vol 10 No 1 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v10i1.68

Abstract

Temulawak herbal whitening cream is one of the herbal whitening creams containing curcumin rhizome extract containing curcumin, demetoksikurkumin and bidemetoksikurkumin which can reduce hyperpigmentation (the skin becomes too dark). Mercury is a dangerous metal that in even small concentrations can be toxic. The use of mercury in whitening creams can cause a variety of things, ranging from changes in skin color which will eventually cause black spots on the skin, allergies, skin irritation and can be carcinogenic. The results of the study qualitatively indicated that sample A was positive containing mercury marked by an orange-red precipitate. Quantitatively, using Mercury Analyzer in sample A, the levels of mercury were 7,470.52 mg / kg or 7,470.52 ppm. The conclusions indicate that sample A is inappropriate or should not be used because it contains more than 1 mg / kg or 1 ppm of mercury.
Analisis Kandungan Asam Retinoat Pada Sediaan Krim Malam Yang Beredar Di Toko X Kota Klaten Dengan Spektrofotometri UV-Vis Yenni Kusuma Wardhani; Anita Agustina Styawan; Choril Hana Mustofa
CERATA Jurnal Ilmu Farmasi Vol 10 No 2 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v10i2.79

Abstract

Whitening cosmetics are cosmetics that contain an active whitening ingredient to brighten the skin. Retinoic acid is prohibited from being used in whitening creams because it can cause dry, burning, carcinogenic and teratogenic skin. The purpose of this study was to determine the levels of retinoic acid contained in night creams. The sample in this study were 5 night cream products circulating in Klaten City X Store. This study was conducted to determine the content of retinoic acid in night creams using thin layer chromatography (TLC). Five positive samples contained retinoic acid by giving dark green spots and the concentration was determined by UV-Vis spectrophotometry.The results of this study indicate that in 5 samples of night cream circulating in Store X in the City of Klaten all positive for retinoic acid, that is, the average for sample A was 0.021%; sample B 0.014%; sample C 0.016%; sample D 0.025% and sample E 0.023%.
Uji Stabilitas Formula Optimum Masker Gel Peel Off Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) Nurul Hidayati; Anita Agustina Styawan; Ida Naim Muslimah
CERATA Jurnal Ilmu Farmasi Vol 11 No 2 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v11i2.145

Abstract

Mahkota Dewa fruit (Phaleria macrocarpa (Scheff.) Boerl was effective as an anti-acne agent and an optimization formula of Mahkota Dewa fruit extractpeel off gel mask has been carried out but the stability test has not been carried out. This study aims to determine the stability of the optimum formula of Mahkota Dewa fruit extract (Phaleria macrocarpa (Scheff.) Boerl)peel off gel mask. The fruit simplicia of Mahkota Dewa was extracted by soxhletation with 70% ethanol. The thick extract is made into a peel off gel mask with 13.09%PVA and 2.97% HPMC. Stability tests were carried out in 3 cycles using the freeze and thaw method. The evaluations carried out included organoleptic, homogeneity, pH, viscosity, dispersibility, adhesion and drying time. Analyzed data by One Way Anova followed by the LSD (Least Significance Difference) test. The results showed that the peel off gel mask optimization formula stable in storage for 3 cycles which overall meet the requirements of physical properties. The preparation was brown with rose aroma, thick, homogeneous with a pH value of 6 ± 0 and a viscosity value of 400 ± 0. The results of the drying time and spreadability test showed no difference in all cycles. Although the results of the adhesion test showed a significant difference, it was still within the range of good adhesion values.
Co-Authors Abdul Rohman Anggit Khusnul Khotimah Anisa Dita Rahmawati Aristhasari Putri Arrosyid, Muchson Atun Yuliana Awal Prichatin Kusumadewi Choiril Hana Mustofa Choiril Hana Mustofa Choril Hana Mustofa Dayah Ainus Dian Irawati Dian Irawati Dwi Joko Yulianto Emerita Dyah Ayu Purwita Sari Faatin, Salsa Gandis Rohmanti Hari Widada, Hari Hendra Budiman Hendra Budiman Ida Naim Muslimah Khairiyah, Fatikhatun Nissa’ Khotimah, Anggit Khusnul Laelia Dwi Anggraini, Laelia Latifah, Anna Lenny Apriyaningsih Muchson Arrosyid Muchson Arrosyid Muhammad Thesa Ghozali Mustofa, Hana Mustofa, Helmi Nisa, Lia Fakila Nofia Putri Lestari Nurul Hidayati Nurul Hidayati Ocha Ardela Fitria Kresnaya Purwanto Putri Susanti Rahmi Nurhaini, Rahmi Ratna Asmah Susidarti Refida Ramadhani Nur Cholifa Rizky, Alfira Rohmanti, Gandis S Sutaryono Selvi Candra Dewi Septiyanna, Rosemaladewi Sutaryono Sutaryono Sutaryono, S Syahputri, Rezyana Budi Wahyu Anasari Windarsih, Anjar Yenni Kusuma Wardhan Yenni Kusuma Wardhani