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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Jurnal Kreativitas PKM Indonesian Journal of Community Services Medica Hospitalia Journal of Holistics and Health Sciences (JHHS) Jurnal Pengabdian Masyarakat Kedokteran International Journal of Cell and Biomedical Science
Minidian Fasitasari
Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Jl. Raya Kaligawe KM. 4 PO BOX 1054 Semarang Central Java Indonesia, Phone (+6224) 65833584, Fax. (+6224) 6594366.
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Effect of Nigella sativa on Growth and IGF-1 levels in Rats Prenatally Exposed to Pesticides Wibowo, Joko Wahyu; Fasitasari, Minidian; Yuniarti, Heny; Tanry, Selvina
Majalah Kedokteran Bandung Vol 57, No 1 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3862

Abstract

Nigella sativa contains antioxidants and can potentially improve growth disorders due to prenatal pesticide exposure. Pesticides affect the work of thyroid hormone, insulin, and Insulin-like Growth Factor that play essential roles in the growth and development processes. This study aimed to determine the effect of Nigella sativa supplementation on body weight and IGF-1 levels in mice, with a history of pesticide exposure in the womb. This study was conducted from October 14, 2023 to December 1, 2023 at the laboratory of the Center for Food and Nutrition Studies, Inter-University Center, Gajah Mada University, Indonesia. This experimental study used a cohort design and involved 20 pregnant female rats as the experimental animals. These rats were divided into several groups: K0 (control group with standard feed), K1 (group exposed to pesticides during pregnancy),  and P1 and P2 (group exposed to pesticides. Followed by 10.8 mg/200gBW/day and 21.6 mg/ 200 gBW/day of Nigella sativa after birth, respectively). The pesticide dose used was 10 mg/200gBW/day orally. Anthropometric examinations was conducted at birth, and on day 7, day 14, day 21, and day 28. The examination of IGF-1 levels was performed on day 28 using the ELISA method. Results showed that the mean birth weights (g) of the rats by group were as follows: K0:6.09±0.12; K1:4.03±0.03, P1:4.03±0.02 P2:4.05±0.03. On day 28, the mean body weights (g) were as follows: K0:104.0±1.79; K1:65.17±1.47; P1:92.17 ± 3.19; and P2:102.00±1.41. The mean IGF-1 level (pg/mL) were as follows: K0:23.76±0.68; K1:9.03±0.24, P1:14.94±0.37; and P2:19.51±0.56. The ANOVA test presented a p-value of <0.001. Hence, Nigella sativa supplementation after birth significantly affects body weight and IGF-1 levels in rat model of prenatally exposed to pesticides.
Pendampingan bagi Pasien Polycystic Ovary Syndrome (PCOS) di RSI Sultan Agung Semarang dalam Modifikasi Lifestyle dan Pendekatan Aspek Psikospiritual Fasitasari, Minidian; Aryani, Rini; Samsudin, Samsudin
Jurnal Pengabdian Masyarakat Kedokteran Vol 3, No 1 (2024): Januari
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/abdimasku.3.1.13-26

Abstract

Polycystic Ovary Syndrome (PCOS) merupakan disfungsi endokrin yang sering terjadi pada wanita usia reproduksi. Penyebab tersering terjadinya PCOS adalah penumpukan atau akumulasi lemak visceral yang dapat terjadi pada wanita dengan Indeks Massa Tubuh (IMT) obesitas maupun kurus. Penumpukan lemak yang terjadi akan mengarah pada proses lain yang lebih kompleks, yang apabila tidak ditangani dapat mengarah pada sindrom metabolik hingga risiko penyakit kardiovaksular. Pengobatan bagi pasien PCOS selama ini hanya berfokus pada pengobatan dengan medikamentosa tanpa diimbangi dengan pengaturan nutrisi, olahraga rutin, akibat rendahnya kedisiplinan dan motivasi serta pengetahuan pasien mengenai pengaruh intervensi diet bagi pasien PCOS. Kurangnya dukungan psikospiritual bagi pasien juga menjadi salah satu faktor rendahnya tingkat kepatuhan pasien untuk menjalankan diet seimbang, dan melakukan olahraga rutin. Kegiatan ini bertujuan untuk mengoptimalkan peran Mitra dalam mendampingi pasien PCOS dalam modifikasi lifestyle dan memberikan dukungan psikis serta spiritual bagi pasien PCOS di Rumah Sakit Islam (RSI) Sultan Agung Semarang. Kegiatan yang dilakukan berupa pembentukan dan pelatihan tim fasilitator, seminar untuk pasien PCOS yang diisi dengan pemberian edukasi mengenai PCOS, konseling gizi, olahraga bersama, dan konseling psikospiritual. Selain itu dibentuk komunitas pasien PCOS agar mereka dapat saling mensupport secara berkelanjutan. Hasil dari program ini antara lain: media edukasi berupa leaflet, video, dan tayangan digital signage di RSI Sultan Agung, serta pasien lebih memahami mengenai PCOS, mengikuti kegiatan senam bersama, IMT pasien menjadi lebih ke arah normal, dan terbentuknya komunitas PCOS yang kegiatannya dapat berkelanjutan meskipun program ini sudah selesai. Polycystic Ovary Syndrome (PCOS) is an endocrine dysfunction that often occurs in women of reproductive age. The most common cause of PCOS is the accumulation or accumulation of visceral fat, which can occur in women with a body mass index (BMI) who are obese or thin. The accumulation of fat that occurs will lead to other, more complex processes, which if left untreated can lead to metabolic syndrome and the risk of cardiovascular disease. Treatment for PCOS patients so far has only focused on medical treatment without being balanced with nutrition settings, regular exercise, due to low discipline and motivation as well as patient knowledge about the effect of dietary interventions for PCOS patients. Lack of psychospiritual support for patients is also a factor in the low level of patient adherence to a balanced diet and regular exercise. This activity aims to optimize the role of hospital in assisting PCOS patients in lifestyle modification and providing psychological and spiritual support for PCOS patients at the Sultan Agung Islamic Hospital (RSI) Semarang. Activities carried out in the form of forming and training a facilitators’ team, seminar for PCOS patients filled with providing education about PCOS, nutritional counseling, joint exercise, and psycho-spiritual counseling. In addition, a PCOS patient community was formed so that they could support each other and carry out ongoing activities. The results of this program include: educational media in the form of leaflets, videos, and digital signage shows at RSI Sultan Agung, as well as patients understanding more about PCOS, participating in joint exercise, BMI of patients becoming more normal, and the formation of a PCOS community whose activities can sustainable even after the program has been completed.
Co-Authors Adhitya Putra Widyantoro, Adhitya Putra Agung Putra Amalina, Nur Dina Aryani, Rini Athatsaniya, Mazaya Denta Chodidjah Chodidjah Danis Pertiwi Fadzil Latifah, Fadzil Hadi Sarosa Ibrahim, Sugeng Ika Rosdiana Joko Wahyu Wibowo Makarim, Fadli Rizal Masfiyah Masfiyah Muhammad Aziz Nur Anna Chalimah Sadyah Pudjowati, Saras Purwaningsih, Hesti Rahayu Rochady Setianto Samsudin Samsudin Siti Thomas Zulaikhah Sri Mulyono Sri Priyantini Suparmi Suparmi Susanto, Mujib Akhis Syaifulloh, Moh Tanry, Selvina Titiek Sumarawati Ulfah Dian Indrayani Vikawati, Nura Eky Yasin, Muhammad Fatah Yuniarti, Heny