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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung JMM (Jurnal Masyarakat Mandiri) Jurnal Kreativitas PKM Indonesian Journal of Community Services Medica Hospitalia Journal of Holistics and Health Sciences (JHHS) Jurnal Pengabdian Masyarakat Kedokteran International Journal of Cell and Biomedical Science
Minidian Fasitasari
Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA) Semarang Jl. Raya Kaligawe KM. 4 PO BOX 1054 Semarang Central Java Indonesia, Phone (+6224) 65833584, Fax. (+6224) 6594366.
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Effect of Nigella sativa on Growth and IGF-1 levels in Rats Prenatally Exposed to Pesticides Wibowo, Joko Wahyu; Fasitasari, Minidian; Yuniarti, Heny; Tanry, Selvina
Majalah Kedokteran Bandung Vol 57, No 1 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3862

Abstract

Nigella sativa contains antioxidants and can potentially improve growth disorders due to prenatal pesticide exposure. Pesticides affect the work of thyroid hormone, insulin, and Insulin-like Growth Factor that play essential roles in the growth and development processes. This study aimed to determine the effect of Nigella sativa supplementation on body weight and IGF-1 levels in mice, with a history of pesticide exposure in the womb. This study was conducted from October 14, 2023 to December 1, 2023 at the laboratory of the Center for Food and Nutrition Studies, Inter-University Center, Gajah Mada University, Indonesia. This experimental study used a cohort design and involved 20 pregnant female rats as the experimental animals. These rats were divided into several groups: K0 (control group with standard feed), K1 (group exposed to pesticides during pregnancy),  and P1 and P2 (group exposed to pesticides. Followed by 10.8 mg/200gBW/day and 21.6 mg/ 200 gBW/day of Nigella sativa after birth, respectively). The pesticide dose used was 10 mg/200gBW/day orally. Anthropometric examinations was conducted at birth, and on day 7, day 14, day 21, and day 28. The examination of IGF-1 levels was performed on day 28 using the ELISA method. Results showed that the mean birth weights (g) of the rats by group were as follows: K0:6.09±0.12; K1:4.03±0.03, P1:4.03±0.02 P2:4.05±0.03. On day 28, the mean body weights (g) were as follows: K0:104.0±1.79; K1:65.17±1.47; P1:92.17 ± 3.19; and P2:102.00±1.41. The mean IGF-1 level (pg/mL) were as follows: K0:23.76±0.68; K1:9.03±0.24, P1:14.94±0.37; and P2:19.51±0.56. The ANOVA test presented a p-value of <0.001. Hence, Nigella sativa supplementation after birth significantly affects body weight and IGF-1 levels in rat model of prenatally exposed to pesticides.
Pendampingan bagi Pasien Polycystic Ovary Syndrome (PCOS) di RSI Sultan Agung Semarang dalam Modifikasi Lifestyle dan Pendekatan Aspek Psikospiritual Fasitasari, Minidian; Aryani, Rini; Samsudin, Samsudin
Jurnal Pengabdian Masyarakat Kedokteran Vol 3, No 1 (2024): Januari
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/abdimasku.3.1.13-26

Abstract

Polycystic Ovary Syndrome (PCOS) merupakan disfungsi endokrin yang sering terjadi pada wanita usia reproduksi. Penyebab tersering terjadinya PCOS adalah penumpukan atau akumulasi lemak visceral yang dapat terjadi pada wanita dengan Indeks Massa Tubuh (IMT) obesitas maupun kurus. Penumpukan lemak yang terjadi akan mengarah pada proses lain yang lebih kompleks, yang apabila tidak ditangani dapat mengarah pada sindrom metabolik hingga risiko penyakit kardiovaksular. Pengobatan bagi pasien PCOS selama ini hanya berfokus pada pengobatan dengan medikamentosa tanpa diimbangi dengan pengaturan nutrisi, olahraga rutin, akibat rendahnya kedisiplinan dan motivasi serta pengetahuan pasien mengenai pengaruh intervensi diet bagi pasien PCOS. Kurangnya dukungan psikospiritual bagi pasien juga menjadi salah satu faktor rendahnya tingkat kepatuhan pasien untuk menjalankan diet seimbang, dan melakukan olahraga rutin. Kegiatan ini bertujuan untuk mengoptimalkan peran Mitra dalam mendampingi pasien PCOS dalam modifikasi lifestyle dan memberikan dukungan psikis serta spiritual bagi pasien PCOS di Rumah Sakit Islam (RSI) Sultan Agung Semarang. Kegiatan yang dilakukan berupa pembentukan dan pelatihan tim fasilitator, seminar untuk pasien PCOS yang diisi dengan pemberian edukasi mengenai PCOS, konseling gizi, olahraga bersama, dan konseling psikospiritual. Selain itu dibentuk komunitas pasien PCOS agar mereka dapat saling mensupport secara berkelanjutan. Hasil dari program ini antara lain: media edukasi berupa leaflet, video, dan tayangan digital signage di RSI Sultan Agung, serta pasien lebih memahami mengenai PCOS, mengikuti kegiatan senam bersama, IMT pasien menjadi lebih ke arah normal, dan terbentuknya komunitas PCOS yang kegiatannya dapat berkelanjutan meskipun program ini sudah selesai. Polycystic Ovary Syndrome (PCOS) is an endocrine dysfunction that often occurs in women of reproductive age. The most common cause of PCOS is the accumulation or accumulation of visceral fat, which can occur in women with a body mass index (BMI) who are obese or thin. The accumulation of fat that occurs will lead to other, more complex processes, which if left untreated can lead to metabolic syndrome and the risk of cardiovascular disease. Treatment for PCOS patients so far has only focused on medical treatment without being balanced with nutrition settings, regular exercise, due to low discipline and motivation as well as patient knowledge about the effect of dietary interventions for PCOS patients. Lack of psychospiritual support for patients is also a factor in the low level of patient adherence to a balanced diet and regular exercise. This activity aims to optimize the role of hospital in assisting PCOS patients in lifestyle modification and providing psychological and spiritual support for PCOS patients at the Sultan Agung Islamic Hospital (RSI) Semarang. Activities carried out in the form of forming and training a facilitators’ team, seminar for PCOS patients filled with providing education about PCOS, nutritional counseling, joint exercise, and psycho-spiritual counseling. In addition, a PCOS patient community was formed so that they could support each other and carry out ongoing activities. The results of this program include: educational media in the form of leaflets, videos, and digital signage shows at RSI Sultan Agung, as well as patients understanding more about PCOS, participating in joint exercise, BMI of patients becoming more normal, and the formation of a PCOS community whose activities can sustainable even after the program has been completed.
UPAYA PENCEGAHAN ANEMIA MELALUI PEMERIKSAAN KESEHATAN DAN STATUS GIZI, SERTA EDUKASI PEMANFAATAN TANAMAN KLOROFIL DAUN KATUK Suparmi, Suparmi; Fasitasari, Minidian; Latifah, Fadzil
JMM (Jurnal Masyarakat Mandiri) Vol 8, No 1 (2024): Februari
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jmm.v8i1.20334

Abstract

Abstrak: Katuk (Sauropus androgynus) merupakan salah satu tanaman obat tradisional yang banyak ditanam di taman obat tradisional keluarga (TOGA) di Indonesia. Akan tetapi, pemanfaatan daun katuk sebagai suplemen untuk mencegah anemia masih perlu ditingkatkan. Pengabdian masyarakat ini bertujuan untuk meningkatkan pengetahuan tentang pencegahan anemia dengan pemanfaatan daun katuk bagi warga Perumahan Sembungharjo Permai (RW 8) Sembungharjo, Semarang. Selain itu juga dilaksanakan pemeriksaan kesehatan dan status gizi untuk mengetahui Indeks Masa Tubuh (IMT), tekanan darah, kadar hemoglobin (Hb). Evaluasi peningkatan pengetahuan masyarakat setelah penyuluhan dieveluasi menggunakan kuesioner. Kegiatan diikuti oleh warga RW VIII yang terdiri dari 72 orang, 55,6% perempuan dan 44,4% laki-laki, dengan rentang usia terbanyak 41-50 tahun. Masyarakat sangat antusias dalam mengikuti senam jantung sehat yang dipimpin oleh instruktur. Hasil pemeriksaan status kesehatan berdasarkan IMT menunjukkan bahwa 38.57% peserta memiliki IMT kategori obesitas dan 35.71% kategori IMT normal. Berdasarkan hasil tekanan darah sebanyak 50.91% peserta dalam kategori pra hipertensi, dimana rerata kadar Hb peserta sebesar 12.2 g/dL (9.5-14.0 g/dL) termasuk dalam kategori normal. Rerata tingkat pengetahuan peserta edukasi tentang nutrisi dan manfaat daun katuk untuk anemia sebesar 63.4%. Edukasi tentang penggunaan daun katuk diharapkan dapat meningkatkan upaya pencegahan anemia dengan memanfaatkan tanaman obat keluarga (TOGA) yang ditanam di sekitar rumah.Abstract: Katuk (Sauropus androgynus) is a traditional medicinal plants, particularly in Indonesia's planted family medicine gardens (TOGA). Nevertheless, utilizing katuk leaves as a supplementary measure for anemia prevention should be explored in more efforts. Community service aims to enhance endeavors to prevent anemia utilizing katuk leaves among the residents of Sembungharjo Permai Housing (RW 8) in Semarang. Furthermore, a comprehensive assessment of health and nutrition is conducted to ascertain the Body Mass Index (BMI), blood pressure, and hemoglobin (Hb) levels. Assessment of enhanced public knowledge following education conducted using a questionnaire. The inhabitants of RW VIII participated in the event, with 72 individuals. Among the attendees, 55.6% were women and 44.4% were males. Notably, the age group with the highest representation was individuals between 41 and 50, accounting for 48.6% of the participants. The community exhibited high enthusiasm in their active engagement with the healthy heart workout, which the teacher expertly facilitated. The findings from the health status assessment utilizing the BMI indicated that 38.57% of the individuals surveyed fell into the obese classification. In comparison, 35.71% were categorized as having a normal BMI. According to the findings from the blood pressure measurements, it was observed that 50.91% of the participants fell under the pre-hypertension classification. Additionally, the participants' average Hb level was also determined. The typical range for the category in question is 12.2 g/dL, with a reference range of 9.5-14.0 g/dL. The educational participants' degree of knowledge regarding the nutrition and benefits of katuk leaves for anemia was 63.4%. The dissemination of knowledge about the utilization of katuk leaves is anticipated to enhance endeavors in anemia prevention through the utilization of familial medicinal plants (TOGA) cultivated in the vicinity of residential dwellings.
The Role of Nutritional Therapy in Supporting PCOS Therapy in Undergoing a Pregnancy Program Yuniarti, Heny; Aryani, Rini; Fasitasari, Minidian
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i2.38304

Abstract

Polycystic ovary syndrome (PCOS) is an endocrine disorder of the female reproductive organs. Providing nutritional therapy to women suffering from PCOS who are undergoing a pregnancy program is important because it really supports the success of the therapy, and not all PCOS sufferers receive the nutritional therapy they need. A 21-year-old woman diagnosed with PCOS, primary infertility for 3.5 years, and obesity was referred by a specialist in obstetrics and gynecology to the clinical nutrition clinic at RSI Sultan Agung Semarang for consultation on treating obesity. The patient has been married for more than three years and has a history of irregular menstruation. Patients are given pharmacotherapy therapy in the form of orlistat and non-pharmacotherapy with reduced calories and physical activity. The results of the study showed a weight loss of 6 kg over three months and a decrease in Body Mass Index. In the Omron Karada Scan HBF 375 Bio Impedance Analyzer (BIA) examination, it was found that there was a decrease in total body fat, a decrease in visceral fat, and an increase in body age (Body Age), and the patient was declared pregnant in the fourth month while undergoing nutritional therapy. Nutritional therapy helps reduce BMI, improve lipid profiles and insulin resistance, and supports the success of therapy in PCOS sufferers who are undergoing a pregnancy program.
Co-Authors Adhitya Putra Widyantoro, Adhitya Putra Agung Putra Amalina, Nur Dina Aryani, Rini Athatsaniya, Mazaya Denta Chodidjah Chodidjah Danis Pertiwi Fadzil Latifah, Fadzil Hadi Sarosa Ibrahim, Sugeng Ika Rosdiana Joko Wahyu Wibowo Makarim, Fadli Rizal Masfiyah Masfiyah Muhammad Aziz Nur Anna Chalimah Sadyah Pudjowati, Saras Purwaningsih, Hesti Rahayu Rochady Setianto Samsudin Samsudin Siti Thomas Zulaikhah Sri Mulyono Sri Priyantini Suparmi Suparmi Susanto, Mujib Akhis Syaifulloh, Moh Tanry, Selvina Titiek Sumarawati Ulfah Dian Indrayani Vikawati, Nura Eky Yasin, Muhammad Fatah Yuniarti, Heny