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All Journal PROSIDING SEMINAR NASIONAL Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Jurnal Kesehatan Masyarakat JIK- JURNAL ILMU KESEHATAN Jurnal Abdimas Mahakam Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan Pena : Jurnal Ilmu Pengetahuan dan Teknologi Jurnal Suara Pengabdian 45 Physical Therapy Journal of Indonesia Journal Research Midwifery Politeknik Tegal Bhamada: Jurnal Ilmu dan Teknologi Kesehatan (E-Journal) JABI: Jurnal Abdimas Bhakti Indonesia The Indonesian Journal of Health Science
Natiqotul Fatkhiyah
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Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Early screening diagnostic test in adolescents with a family history of thalassemia Fatkhiyah, Natiqotul; Kartini, Apoina; Nugraheni, Sri Achadi; Margawati, Ani; Himawan, Fatchurrozak
Physical Therapy Journal of Indonesia Vol. 7 No. 1 (2026): Inpress January-June 2026
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v7i1.346

Abstract

Background: Thalassemia is a major public health concern in Indonesia, particularly in families with a known history of the ailment. This study aimed to assess the validity, reliability, sensitivity, and specificity of a thalassemia screening instrument that included a questionnaire and a scoring model. Methods: A cross-sectional study was conducted in Tegal, Central Java (November 2024–April 2025), involving 64 adolescents aged 10–24 years from extended families with a history of thalassemia, selected through purposive sampling. Inclusion criteria included willingness to participate, ability to communicate, and signed informed consent, while exclusion criteria included incomplete participation, other blood disorders, medical complications, or withdrawal. Screening consisted of a structured questionnaire and physical examination (score 0–8), followed by CBC and HbA2 testing. Statistical analyses included the Kolmogorov–Smirnov test, chi-square tests, Pearson or Spearman correlations, and diagnostic accuracy measures (sensitivity, specificity, PPV, NPV) using a 2×2 table. Results: The screening instrument showed a sensitivity of 76.5%, a specificity of 85.6%, and an AUC of 0.76. It demonstrated acceptable internal consistency and significant construct validity, indicating moderate diagnostic accuracy for identifying thalassemia trait. Conclusion: The screening tool established in this study was appropriate for teenagers with a family history of thalassemia and had modest diagnostic performance. Integration into existing public health systems is both achievable and recommended.
Co-Authors Adrestia Rifki Naharani Ani Margawati Apoina Kartini Arifin Dwi Atmaja Fauziah, Hafidha Firman Hidayat Hadiningsih, Tri Agustina Himawan, Fatchurrozak Iis Annisa M Kodijah - Kodijah Kodijah Masturoh Masturoh Masturoh Masturoh Masturoh, Masturoh Ramadhan Putra Satria Rejeki, Sri Tanjung Risnanto Risnanto Sania Alifatimah Siswati . Siswati Siswati Siswati Siswati Sri Achadi Nugraheni Sri Tanjung Rejeki Sri Tanjung Rejeki Suparjo Suparjo Tri Agustina Hadiningsih Wahyuningsih, Rina Febri Yuni Fitriani Yuni Fitriani Yuni Fitriani, Yuni