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Ekstrak Daun Kenikir (Cosmos caudatus Kunth.) dengan Variasi Metode Ekstraksi sebagai Penangkal Radikal Bebas ABTS: Kenikir Leaf Extract (Cosmos caudatus Kunth.) with Variations in Extraction Methods as an Antidote to Free Radicals ABTS Utami, Yuri Pratiwi; Mubarak, Fhahri; Imrawati, Imrawati; Jariah, Ainun; Mangosa, Grace Pretty
Jurnal Sains dan Kesehatan Vol. 7 No. 4 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i4.2448

Abstract

Cosmos caudatus Kunth. is a plant that has secondary metabolites that are antioxidant. This study aims to determine the antioxidant activity of the ethanol extract of kenikir leaves which was extracted using a variety of extraction methods with the radical antidote ABTS. Samples of kenikir leaves were processed until they became simple and then extracted using three methods, namely maceration, percolation and digestion. The extracts obtained were subjected to phytochemical screening and the antioxidant activity of the ethanol extract of kenikir leaves was tested using UV-Vis spectrophotometry using the ABTS method (2,2 azinobis (3-ethylbenzothyiazoline-6-sulfonic acid). In testing the antioxidant activity of kenikir leaves, the results showed that the extract using the maceration method had antioxidant activity with an IC50 of 166,962 µg/mL, the extract using the digestion method IC50 84,117 µg/mL and the ethanol percolation extract of kenikir leaves 113,901 µg/mL, with quarcetin. as a positive control with an IC50 of 90.566 µg/mL. This study concluded that extracts with a variety of extraction methods had antioxidant activity, namely digestion (strong), percolation (medium), and maceration (weak). Keywords:          Cosmos caudatus Kunth., extraction, antioxidant, ABTS   Abstrak Kenikir (Cosmos caudatus Kunth.) merupakan tanaman yang memiliki metabolit sekunder yang bersifat antioksidan. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari ekstrak etanol daun kenikir yang diekstraksi menggunakan variasi metode ekstraksi dengan penangkal radikal ABTS. Sampel daun kenikir diolah hingga menjadi simplisia kemudian dilakukan ekstraksi dengan tiga metode yaitu maserasi, perkolasi dan digesti. Ekstrak yang diperoleh dilakukan skrining fitokimia dan pengujian aktivitas antioksidan ekstrak etanol daun kenikir dilakukan menggunakan spektrofotometri UV-Vis dengan menggunakan metode ABTS (2,2 azinobis (3-ethylbenzothyiazoline-6-sulfonic acid). Pengujian aktivitas antioksidan daun kenikir diperoleh hasil bahwa ekstrak dengan metode maserasi memiliki aktivitas antioksidan dengan IC50 166,962 µg/mL, ekstrak metode digesti IC50 84,117 µg/mL dan ekstrak perkolasi etanol daun kenikir 113,901 µg/mL, dengan kuarsetin sebagai kontrol positif dengan IC50 90,566 µg/mL. Penelitian ini menyimpulkan bahwa ekstrak dengan variasi metode ekstraksi memiliki aktivitas antioksidan yaitu digesti (kuat), perkolasi (sedang), dan maserasi (lemah). Kata Kunci:         Kenikir,  eksraksi, antioksidan, ABTS
Uji Aktivitas Antibakteri Dan Uji Toksisitas In Vitro Fraksi N-Butanol Daun Sawo Duren (Chrysophyllum cainito L.) Agiel, Fadillah Maryam Bau; Mubarak, Fhahri; Wahyuddin, Nurzadrina; Mus, Suwahyuni
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.1020

Abstract

Sawo duren memiliki metabolit sekunder seperti flavonoid, alkaloid, saponin, dan fenolik. Tujuan dari penelitian ini adalah untuk mengetahui sifat antibakteri fraksi n-butanol daun sawo duren (Chrysophyllum cainito L) dengan menggunakan difusi cakram dan tingkat toksisitasnya terhadap larva udang Arthemia salina Leach. Dengan pelarut etanol, 300 gram sampel dimaserasi. Kemudian, dalam ekstraksi cair-cair menggunakan pelarut n-butanol, aktivitas antibakteri fraksi n-butanol diuji dengan metode difusi cakram. Zona hambat diperoleh pada konsentrasi 1,25%, 2,5%, dan 5%, masing-masing dengan nilai 7.45 ± 0.0, 9.41 ± 0.1, dan 11.43 ± 0.1. kemudian pada fraksi n-butanol daun sawo duren dengan konsentrasi 2, 4, 6, 8 dan 10 ppm bersama dengan air laut sebagai kontrol. Kemudian, sebagai respons terhadap toksisitas, parameter kematian dihitung setelah 24 jam perlakuan. Hasil fraksi n-butanol dari daun sawo duren memiliki aktivitas antibakteri berspektrum luas dan efek toksisitas, dengan nilai LC50 sebesar 4.39 ppm yang termasuk dalam kategori sangat toksik. Hasil skrining fitokimia fraksi n-butanol menunjukkan bahwa flavanoid, alkaloid, dan fenolik semuanya bersifat positif.
Development and Evaluation of a Stable Topical Cream Formulated with Annona squamosa Seed Extract as a Natural Pediculosis Agent Khairi, Nur; Muslimin, Lukman; Mubarak, Fhahri; Indrisari, Maulita; Fajriansyah, Fajriansyah
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1355-1363

Abstract

Head lice infestation (Pediculosis capitis) remains a global public health concern, exacerbated by growing resistance to conventional pediculicides such as permethrin and malathion. This study aimed to evaluate the pediculicidal activity and formulation stability of a topical cream containing Annona squamosa (sugar apple or srikaya) seed extract as a natural alternative for treating pediculosis. The ethanolic extract of A. squamosa seeds was obtained through maceration, producing a 10.005% yield. Pediculicidal assays were conducted using various extract concentrations (5%, 7.5%, and 10%), followed by formulation of oil-in-water creams with extract concentrations of 7.5%, 10%, and 12.5%. Physical stability tests included assessments of viscosity, pH, spreadability, adhesion, and homogeneity. Results showed a dose–response relationship, with lice mortality increasing from 60% at 5% extract to 87% at 10%. Extract. The formulated creams demonstrated high efficacy—86% to 96% mortality—comparable to 1% permethrin. All formulations maintained acceptable physicochemical properties (pH 4.8–5.5, viscosity within 27,000–47,000 cps) and remained stable after accelerated storage. These findings indicate that A. squamosa seed extract is a potent pediculicidal agent that can be effectively incorporated into a stable topical formulation. The study supports the potential of A. squamosa as a safe, sustainable, and plant-based alternative for managing pediculosis while addressing the challenge of chemical resistance.
Co-Authors - Sri Prilmayanti Awaluddin, - Afrilia Nursal Agiel, Fadillah Maryam Bau Ainun Jariah Aksa, Rahmad Andi puanguce Paluseri Arfan Abu Bakar Astuti Amin Azis, Siti Yuki Oktafitriah Dia Purnawanti Fitriyanti Sami Haijal, Ahmad Hamdayani Lance Abidin Herlina Rante Herlina Rante Imrawati Imrawati Khairi, Nur Khairuddin - Mangosa, Grace Pretty Mar’atun Jannah, Imrawati, Muzakkir Baitz, Maulita Indrisari, Maulita Megawati Megawati Muntasir, Muntasir Mus, Suwahyuni Muslimin, Lukman Natsir Djide Noer Rahman Nursal, Afrilia Nursamsiar Nursamsiar Padang, Dirgaraya Kala’ Purnawanti, Dia Putri, Hera Nur Putri, Pratami Yona Rahmad Aksa Rahman, Nur Fausia Rasdi , Rasdi Reski , Reski Sartini Sartini Sartini Sartini Syamsu Nur Wahyu Hendrarti Wahyuddin, Nurzadrina Yuri Pratiwi Utami