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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Prosiding Seminar Nasional Pengabdian Kepada Masyarakat
Lysa Veterini
Department Of Pathology Anatomy, Universitas Nahdlatul Ulama Surabaya
Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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Perbedaan Ekspresi Siklin D1 dan Ki-67 pada Giant Cell Tumor of Bone Jinak dan Ganas Lysa Veterini; Sjahjenny Mustokoweni
Majalah Patologi Indonesia Vol 25 No 1 (2016): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.353 KB)

Abstract

Latar belakang Giant cell tumor of bone (GCTB) merupakan tumor tulang yang jarang. Di RSUD Dr. Soetomo Surabaya didapatkan 21 kasus GCTB, dengan 7 kasus GCTB ganas dan 14 kasus GCTB jinak, dalam rentang waktu 3 tahun periode Januari 2010-Desember 2012. Siklin D1 memiliki peran dalam siklus sel, sedangkan Ki-67 berhubungan dengan proliferasi sel. Tujuan penelitian ini menganalisis perbedaan ekspresi siklin D1 dan Ki-67 pada GCTB jinak dan ganas. Metode Penilaian dilakukan terhadap 21 blok parafin penderita GCTB di RSUD Dr. Soetomo sejak Januari 2010-Desember 2012 dan memenuhi kriteria. Analisis statistik perbedaan masing-masing variabel dengan uji chi-square dan Mann-Whitney. Hasil Ekspresi Ki-67 lebih tinggi pada GCTB ganas dibandingkan dengan GCTB jinak. Ekspresi siklin D1 dan Ki-67 pada GCTB jinak dan ganas menunjukkan terdapat perbedaan bermakna. Kesimpulan Ekspresi siklin D1 dan Ki-67 dapat digunakan untuk membedakan GCTB jinak dan ganas. Kata kunci : giant cell tumor of bone, Ki-67, siklin D1.
Expression of Brain-Derived Neurotrophic Factor in the Brain of Depressed Mice: Systematic Literature Review Nur Azizah AS; Lysa Veterini; Hafid Algristian; Hotimah Masdan Salim
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 5, No 2 (2021)
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v5i2.6354

Abstract

Chronic stress exposure plays a role as a risk factor for depression. In chronic stress, there is prunning of nerve cell dendrites so that depression becomes irreversible. Depression is caused by low serotonin (5-HT2) neurotransmitters in the postsynaptic cleft. Recent findings in experimental animals indicate that serotonergic preparations are required to increase serotonin levels in the synapse opening, thereby triggering the formation of new dendrites to make depression reversible. The different results when these preparations create resistance in cases of chronic depression and actually increase the risk of uncomfortable and even fatal side effects with long-term use. This Systematic Literature Review uses the PubMed and Google Scholar databases for the period 2015-2020. A total of 322 articles at the beginning of identification and those that met the inclusion criteria in this study were six articles. The results of data extraction showed that the depression condition caused by various stressors resulted in BDNF levels in the hippocampus decreased significantly by p≤0.005. Based on the literature study, it was concluded that in depressive conditions, BDNF levels in the brain decreased.
Sosialisasi Tentang Sifat Penyakit COVID-19 yang Baru Diketahui di Pondok Pesantren Zainul Hasan Genggong Lysa Veterini; Fariska Zata Amani; Prima Surya Ardiansyah
PROSIDING SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT UNIVERSITAS NAHDLATUL ULAMA SURABAYA Vol. 1 No. 1 (2022): Prosiding Seminar Nasional Pengabdian Kepada Masyarakat : Perguruan Tinggi Meng
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (709.949 KB) | DOI: 10.33086/snpm.v1i1.908

Abstract

Covid masih menjadi masalah sampai sekarang, terakhir pada Juli 2021 lalu Indonesia telah dihantam gelombang kedua Covid. Walaupun pencegahan mengenai Covid masih relatif sama, namun protokol kesehatan dirasa semakin mengendur. Perlu dilakukan upaya sosialisasi kembali untuk mengembalikan kewaspadaan masyarakat, dalam hal ini dalam lingkungan Pondok Pesantren Zainul Hasan Genggong. Pengabdian masyarakat ini menggunakan metode webinar online tentang sifat Covid yang baru diketahui, diselingi pretest dan posttest. Selesainya webinar online, tanya jawab, serta pretest dan posttest diharapkan menaikan pengetahuan peserta webinar mengenai Covid. Terdapat peningkatan pengetahuan mengenai sifat Covid terbaru diharapkan bisa menjadi bekal para santri untuk menyebarkan pengetahuannya kepada masyarakat di sekitar.
The Relationship between Area of Necrosis with Degree of Lymphocytes Infiltration in Breast Rattus norvegicus Induced by DMBA Ainiyah Fairus; Aufar Zimamuz Zaman Al Hajiri; Hidayatul Ulya; Syihabuddin Farid; Lysa Veterini; Mohammad Nasir
Sriwijaya Journal of Medicine Vol. 5 No. 1 (2022): Vol 5, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/SJM.v5i1.126

Abstract

Breast cancer is one of the leading causes of death in women in the world. According to WHO, the incidence of breast cancer is about 2.1 million. The high mortality rate is often influenced by various reasons, one of which is the prognosis in patients. The level of lymphocyte infiltration in tumor cell tissue has been shown to correlate with a better prognosis in patients, while necrotic tissue found in breast cancer often shows worse prognostic value. To determine the relationship between the area of necrosis with the degree of infiltration of lymphocytes in the breast of Rattus norvegicus induced by DMBA. Method: True experimental study with post-test only controlled group design method using 40 Wistar strains of female (Rattus norvegicus) mice 12-13 weeks old. The technique for taking uses simple random sampling. Examining 2 variables, namely the dependent variable area of necrosis and the independent variable degree of lymphocyte infiltration. The treated group is injected with subcutaneous DMBA 10 mg/Kg BW between the two lower nipples during the middle of the fifth week with a three-week interval of administration to reach 14 times the total administration. Cancer tissue is taken in the fifth week. Data are analyzed by the Spearman test. Results: This study shows no relationship (P> 0.05) between the area of necrosis with the degree of lymphocyte infiltration. Conclusions: There is no relationship the area of necrosis with the degree of lymphocytes infiltration in breast Rattus norvegicus Induced by DMBA.
Co-Authors Ainiyah Fairus Algristian, Hafid Aufar Zimamuz Zaman Al Hajiri Fariska Zata Amani Hidayatul Ulya Mohammad Nasir Nur Azizah AS Prima Surya Ardiansyah Salim, Hotimah Masdan Sjahjenny Mustokoweni, Sjahjenny Syihabuddin Farid