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All Journal Majalah Obstetri dan Ginekologi The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) JKM (Jurnal Kebidanan Malahayati) Journal of Health, Education, And Literacy (J-Healt) Biomolecular and Health Science Journal Jurnal Ners Pediomaternal Nursing Journal Majalah Biomorfologi (Biomorphology Journal) JIK (Jurnal Ilmu Kebidanan) Indian Journal of Forensic Medicine & Toxicology INDONESIAN MIDWIFERY HEALTH AND SCIENCES JOURNAL PROFESSIONAL HEALTH JOURNAL
Sri Ratna Dwiningsih
Departemen Obstetri Dan Ginekologi Fakultas Kedokteran Universitas Airlangga Surabaya
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Preoperative TNF-a Reduction in Endometriosis Lesions with Combined Oral Contraceptives Thengkano, Irwanto; Yanuari Primariawan, Relly; Hernaningsih, Yetti; Ratna Dwiningsih, Sri
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 2 April 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i2.2547

Abstract

Background: The goals of endometriosis treatment vary greatly depending on the patient's symptoms and reproductive needs. Hormonal therapy to alleviate pain has generally been shown to have positive effects. Combined Oral Contraceptives (COC) are widely available, relatively affordable, and well-known by the public. Objective: This study aims to compare the effects of COC therapy with two newer endometriosis treatments: oral Dienogest 2 mg and injectable Leuprorelin acetate 3.75 mg on TNF alfa levels in serum and peritoneal fluid. Methods: Forty subjects were divided into four groups: three groups receiving medical therapy—COC (0.03 mg ethinylestradiol and 0.15 mg levonorgestrel, taken one active tablet per day continuously), oral Dienogest 2 mg, and intramuscular Leuprorelin acetate 3.75 mg every four weeks—and a control group of endometriosis patients who had not received any hormonal therapy. Peripheral venous blood samples were taken before surgery, and peritoneal fluid was collected at the start of surgery in the pelvic cavity. TNF alfa levels were analyzed using the ELISA method. Data analysis was performed using the Kruskal-Wallis test with a significance level of 0.05. Results: The Kruskal-Wallis test showed significant differences between treatment groups in TNF alfalevels in peritoneal fluid (p:0.023), specifically between the COC group and the control group, and between the Dienogest group and the control group. Conclusion: Preoperative hormonal therapy for estradiol suppression provides limited benefit in reducing systemic inflammatory agents but is effective locally, as evidenced by reduced TNF alfa levels in the peritoneal fluid after preoperative COC and Dienogest therapy. Keywords: COC, Dienogest, Leuprorelin Acetate, Serum, Peritoneal Fluid, TNF alfa
Liposome-based Nanoparticles Encapsulating Vitamin D3 Attenuate IL-6 and TNF-α in a Menopausal Mouse Model Baskara Wiku Adi Kusuma; Sri Ratna Dwiningsih; Ashon As’adi; Sri Puji Astuti Wahyuningsih
The Indonesian Biomedical Journal Vol 17, No 5 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i5.3796

Abstract

BACKGROUND: Vitamin D3 is an essential regulator of immune function, however its bioavailability is limited. Liposomes as nanocarriers can enhance vitamin D3 absorption and delivery, however the application of liposomal vitamin D3 in postmenopausal remains underexplored, particularly in preclinical models. Estrogen deficiency during menopause promotes immune dysregulation and elevates proinflammatory cytokines, including interleukin (IL)-6 and tumor necrosis factor (TNF)-α. This study was conducted to evaluate the effects of liposomal vitamin D3 supplementation on serum vitamin D3, IL-6, and TNF-α levels in an ovariectomy-induced menopausal mouse model.METHODS: Mice were randomly divided into four groups comprising non-surgical control (N), ovariectomized without treatment (D−), conventional vitamin D3-treated (D+), and liposomal vitamin D3-treated (LD). Treatments were administered daily via oral gavage for two months. Serum vitamin D3, IL-6, and TNF-α levels were measured by enzyme-linked immunosorbent assay (ELISA). IL-6 and TNF-α data were analyzed by ANOVA with Duncan’s post-hoc test, while vitamin D3 data were analyzed using the Brown-Forsythe test with Games-Howell post-hoc test (p<0.01).RESULTS: Ovariectomy significantly decreased vitamin D3 levels and increased IL-6 and TNF-α levels in the D− group. Conventional vitamin D3 supplementation (D+) significantly decreased serum vitamin D3 levels and slightly decreased IL-6 and TNF-α levels. Liposomal vitamin D3 (LD3) significantly increased vitamin D3 levels and decreased TNF-α, only slightly decreasing IL-6. Correlation analysis showed a negative association between serum vitamin D3 levels and both cytokines.CONCLUSION: Administration of vitamin D3 liposomes was able to increase vitamin D3 levels and suppress IL-6 and TNF-α towards normal levels. LD3 offers enhanced bioavailability and anti-inflammatory effects, making it a promising therapeutic strategy for managing menopause-associated inflammation and related systemic disorders.KEYWORDS: menopause, liposomal VD3, inflammation, IL-6, TNF-α
Analisa Hubungan Kualitas Udara (Pm2.5, Pm10, Pm1 Dan No2) Terhadap Angka Kejadian Bayi Berat Badan Lahir Rendah (Bblr) di Surabaya Tahun 2022-2024 Naura Annisa Faradila; Budi Prasetyo; Sulistiawati Sulistiawati; Sri Ratna Dwiningsih; Lalu Muhamad Jaelani
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.51144

Abstract

Berat Badan Lahir Rendah (BBLR) tetap menjadi masalah kesehatan masyarakat yang penting di Indonesia. Salah satu faktor utama yang berkontribusi adalah polusi udara, terutama di daerah perkotaan seperti Surabaya. Kualitas udara yang buruk akibat emisi kendaraan bermotor, aktivitas industri, dan tempat pembuangan limbah dapat meningkatkan risiko LBW. Studi ini bertujuan untuk mengkaji hubungan antara polusi udara dan insiden LBW di Surabaya. Studi ini menggunakan desain analitik cross-sectional untuk menyelidiki hubungan antara polusi udara dan Berat Badan Lahir Rendah (LBW) di Surabaya. Data sekunder dari pusat kesehatan masyarakat (Puskesmas) dan catatan kualitas udara akan dikumpulkan. Analisis statistik akan dilakukan menggunakan SPSS versi 25 untuk menilai korelasi antara tingkat polusi udara dan insiden LBW. Analisis menunjukkan hubungan yang signifikan antara kualitas udara dan insiden Berat Badan Lahir Rendah (LBW). Paparan terhadap PM2.5 (r = 0.740; p = 0.000), PM10 (r = 0.762; p = 0.000), PM1 (r = 0.605; p = 0.000), dan nitrogen dioksida (NO2) (r = 0.614; p = 0.000) semuanya memiliki korelasi yang kuat dengan insiden LBW. Semua parameter kualitas udara memiliki nilai p < 0.05, menunjukkan hubungan yang signifikan secara statistik dan menyebabkan penolakan hipotesis nol (H1) demi hipotesis alternatif (Hₐ). Kualitas udara di Surabaya menunjukkan tingkat yang baik untuk PM2.5, PM10, dan PM1, tetapi tingkat NO2 yang berbahaya. Insiden LBW di Benowo berfluktuasi, mencapai puncaknya pada tahun 2023. Hubungan yang signifikan antara kualitas udara dan LBW ditemukan, dengan faktor lingkungan berperan.
Co-Authors -, Nur Mulyani Amalia Ramadhani Anak Agung Renjani Kanya Kumari Anindya Marcha Angelina Djianto Annisa Trissatharra Arsana Wiyasa Ashon As’adi Bambang Purwanto Baskara Wiku Adi Kusuma Budi Prasetyo Cicilia Valentine Simamora Darsini, Ninik Dhea Hesty Purwaningrum Diana Rahima Hendy Hendarto HERAWATI, LILIK I'tishom, Reny Ilya Krisnana, Ilya Lalu Muhamad Jaelani Monika Lijuwardi Naura Annisa Faradila Noor Syafaatin Udhma Oktavianti, Anisa Dwi Olvinda Eka Zulfi Pratiwi Dwi Trisnanti Pudji Lestari Putri Lisdiana Rahmawati Rara Yumna Elfrida Ratna Sofaria Munir Ratriana Via Parasti Relly Yanuari Primariawan, Relly Yanuari Rida Eka Setiani SAMSULHADI, SAMSULHADI Sari, Gadis Meinar Siti Khaerunnisa Sofia Al Farizi Sri Puji Astuti Wahyuningsih, Sri Puji Astuti Sudaryanti, Lestari Sulistiawati Sulistiawati Sulistiawati Sulistiawati Thengkano, Irwanto Tri Hartini Yuliawati Tunjungseto, Arif Vienda Leony Agustina Widjiati Widjiati, Widjiati Yetti Hernaningsih Zafirah Delia