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All Journal Jurnal Kedokteran Brawijaya IPTEK Journal of Proceedings Series Journal of the Medical Sciences (Berkala Ilmu Kedokteran) e-Journal Pustaka Kesehatan Jurnal Keolahragaan Journal of Agromedicine and Medical Sciences Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) UNEJ e-Proceeding Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Al-sihah: The Public Health Science Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Jambura Edu Biosfer Journal Supremasi Hukum: Jurnal Penelitian Hukum Jurnal Rekonstruksi dan Estetik Unram Journal of Community Service (UJCS) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Indonesian Journal of Biomedicine and Clinical Sciences

Ulfa Elfiah

Department Of Plastic Reconstructive And Aesthetic Surgery, Faculty Of Medicine, Universitas Jember, Jember, Indonesia

Author-ID : 2650936

Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Effect of Robusta coffee extract gel on fibroblast and collagen during proliferative phase of IIB degree-burn on Long Evans rats Ulfa Elfiah; Muhammad Fahmi Naufal; Mochammad Amrun Hidayat
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 54, No 3 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005403202201

IIB Degree-burn takes longer to heal because only a small epithelium component remains. It requires a topical agent that can accelerate the wound healing process. One of the wound healing signs is the increased collagen formation as an extracellular matrix produced by fibroblast in the proliferative phase. This study aimed to prove the effect of Robusta coffee extract gel as a topical agent on increasing the number of fibroblasts and collagen density in IIB degree-burn treatment on Long Evans rats. This study used 24 Long Evans rats which were divided into three groups, namely positive control (silver sulfadiazine), negative control (gel base), and treatment group (2.5% of Robusta coffee extract gel). The results showed a higher number of fibroblast (p<0.05) and a denser collagen density (p<0.05) of the Robusta coffee extract gel compared to the control group on day 8 and day 14. These results indicated that the number of fibroblasts and collagen increases that can scavenge free radicals and stimulate the release of cytokines that play a role in increasing fibroblast proliferation. Robusta coffee affects expanding the number of fibroblasts and collagen density to be an alternative topical agent of second-degree burns treatment.

PERLINDUNGAN HUKUM TERHADAP PASIEN COVID-19 PADA PELAYANAN KESEHATAN DI RUMAH SAKIT: SEBUAH LITERATURE REVIEW I Gede Widhiana Suarda; Fendi Setyawan; Ulfa Elfiah
Supremasi Hukum: Jurnal Penelitian Hukum Vol 32 No 1 (2023)
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/jsh.32.1.40-59

Artikel ini merupakan tinjauan literatur awal yang bertujuan untuk menemukan arah penelitian yang tepat terkait dengan perlindungan hukum bagi pasien COVID-19 di Indonesia. Dalam upaya mencapai tujuan tersebut, kajian dalam artikel ini menggunakan metode literatur review dengan mengumpulkan data dari berbagai sumber literatur seperti buku dan jurnal untuk membandingkan hasil penelitian yang satu dengan yang lainnya. Langkah selanjutnya adalah melakukan identifikasi literatur yang relevan dengan topik yang dibahas. Dari proses tersebut, terdapat 6 penelitian yang relevan untuk di-review. Hasil kajian menunjukkan dua kesimpulan. Pertama, topik penelitian tentang perlindungan hukum terhadap pasien COVID-19 pada pelayanan kesehatan di Rumah Sakit merupakan sebuah topik yang perlu diteliti lebih lanjut mengingat topik tersebut belum dibahas dalam penelitian exisiting. Kedua, metode penelitian empiris maupun non doctrinal perlu dilakukan secara holistik dengan subyek utama adalah pasien COVID-19 termasuk para pihak yang berkaitan langsung dengan pelayanan terhadap pasien COVID-19 di rumah sakit, seperti tenaga kesehatan dan juga pihak pimpinan rumah sakit. Dengan demikian, hasil penelitian empiris tentang perlindungan hukum terhadap pasien COVID-19 pada playanan kesehatan di Rumah Sakit akan dapat memperkaya ilmu pengetahuan, baik untuk bidang ilmu-ilmu rumpun kesehatan, hukum, maupun ilmu-ilmu sosial.

Pengaruh Pemberian Gel Ekstrak Kopi Robusta (Coffea canephora) Terhadap Gambaran Makroskopis dan Mikroskopis Luka Bakar Derajat IIB Pada Tikus Long Evans Ulfa Elfiah; Maidy Frista Rosanti; Fatimatuzzahra Fatimatuzzahra; Mochammad Amrun Hidayat
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 2 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i2.56152

Perawatan luka bakar memerlukan penanganan khusus. Penggunaan sediaan obat topikal seperti silver sulfadiazine serta hydrocolloids yang berfungsi sebagai absorptive dressings merupakan salah satu prosedur terapi yang digunakan untuk mempercepat penyembuhan luka. Perawatan kasus luka bakar di Indonesia masih kurang optimal karena adanya pembatasan biaya perawatan oleh sistem jaminan kesehatan Indonesia, oleh karena itu, perlu adanya alternatif perawatan luka bakar dengan mengembangkan bahan-bahan herbal sebagai dressing topikal seperti ekstrak dari kopi. Tujuan dari penelitian ini ialah untuk membuktikan pengaruh pemberian gel ekstrak kopi robusta (Coffea canephora) terhadap gambaran makroskopis dan mikroskopis luka bakar derajat IIB pada tikus long evans. Metode penelitian yang digunakan adalah true experimental laboratories dengan rancangan post-test only control group design. Tikus sebanyak 24 ekor terbagi menjadi 3 kelompok perlakuan. Kelompok kontrol negatif yaitu diberi basis gel, kelompok positif diberi silver sulfadiazine, dan kelompok perlakuan diberi gel ekstrak kopi robusta 2,5%. Data luas luka bakar, perubahan intensitas warna, dan ketebalan epitel luka bakar yang telah diperoleh selanjutnya diuji secara statistik menggunakan One Way ANOVA maupun Kruskal-Wallis dan dilanjutkan dengan uji Post-Hoc. Hasil penelitian menunjukkan pada kelompok perlakuan terjadi penurunan luas makroskopis (p < 0,05), perbaikan intensitas warna (p < 0,05), dan peningkatan ketebalan epitel (p < 0,05) antara gel ekstrak kopi robusta dibandingkan dengan kelompok kelompok negatif. Kesimpulan penelitian ini adalah bahwa gel ekstrak kopi robusta (Coffea canephora) terbukti memberikan pengaruh terhadap penyembuhan luka baik secara makroskopis maupun mikroskopis sehingga gel ekstrak kopi dapat terus dikembangkan menjadi salah satu alternatif dressing dalam perawatan luka bakar.

ANALISIS KEJADIAN SUMBING BIBIR DAN LANGIT: STUDI DESKRIPTIF BERDASARKAN TINJAUAN GEOGRAFIS Elfiah, Ulfa; Kushariyadi; Wahyudi, Septa S
Jurnal Rekonstruksi dan Estetik Vol. 6 No. 1 (2021): Jurnal Rekonstruksi dan Estetik, Juni 2021
Publisher : Universitas Airlangga

Highlights: Angka kejadian kelainan sumbing bibir dan langit-langit di sepuluh wilayah Jember memiliki angka lebih dari 5 penderita. Profesi orangtua, penggunaan pestisida, dan pencemaran logam berat menjadi faktor resiko terjadinya bibir sumbing dan langit di Jember dimana geografisnya adalah perkebunan dan pertanian. Abstrak: Latar Belakang: Angka kejadian sumbing bibir dan langit-langit masih tinggi di Indonesia sedangkan proses penatalaksanaannya masih belum optimal. Penelitian ini bertujuan untuk melakukan analisis kejadian sumbing bibir dan langit-langit berdasarkan tinjauan geografis sehingga dapat menemukan model penanganan yang tepat untuk mengurangi angka kejadian sumbing bibir dan langit-langit. Metode: Penelitian ini merupakan jenis penelitian deskriptif dengan menggunakan data rekam medis di salah satu rumah sakit di provinsi Jawa Timur Indonesia. Data yang digunakan adalah data penderita sumbing bibir dan langit-langit antara tahun 2017-2020. Data yang diperoleh kemudian dikelompokkan berdasarkan wilayah asal penderita yang kemudian dituangkan dalam sebuah peta untuk memberikan gambaran penyebaran penderita sumbing bibir dan langit-langit. Sedangkan karakteristik penderita seperti angka prevalensi, jenis kelainan dan pekerjaan orang tua ditampilkan dalam bentuk tabel. Hasil: Penelitian menunjukkan bahwa kejadian kelainan sumbing bibir dan langit-langit hampir merata di seluruh wilayah Jember bahkan terdapat sepuluh wilayah yang memiliki angka kejadian lebih dari 5 penderita. Tingginya angka kejadian ini kemungkinan berhubungan dengan faktor-faktor risiko seperti pekerja orang tua sebagai petani, penggunaan pestisida dan pencemaran logam berat yang banyak ditemukan di wilayah Jember yang secara geografis merupakan daerah perkebunan dan pertanian sebagai penyebab kejadian kelainan kongenital ini. Kesimpulan: Pemetaan penderita secara geografis akan memudahkan dalam menentukan prediksi angka kejadian dan faktor resiko terjadinya kelainan sumbing bibir dan langit-langit serta memudahkan dalam membuat sistem penanganan penderita sesuai dengan kondisi wilayah masing-masing penderita.

Respon Sel Darah Putih tikus BALB/C pada Paparan Radiasi Medan Magnet Extremely Low-Frequency (ELF) Jangka Lama Kurniawan, Aditya; Sudarti, Sudarti; Helianti, Dina; Aziz, Ayu Munawaroh; Elfiah, Ulfa
Jambura Edu Biosfer Journal Vol 6, No 2 (2024): Jambura Edu Biosfer Journal
Publisher : Fakultas MIPA Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34312/jebj.v6i2.28432

Sel darah putih merupakan sel yang sensitif terhadap infeksi dan perubahan lingkungan. Penelitian ini menyelidiki efek paparan jangka panjang terhadap medan Extremely Low-Frequency (ELF-MF) pada 50 Hz dan 100 Î¼T terhadap komposisi leukosit mencit BALB/C, dengan fokus pada neutrofil, monosit, dan limfosit. Dua puluh empat tikus BALB/C jantan dibagi menjadi kelompok kontrol, 15 hari, dan 30 hari paparan, dengan paparan intermiten setiap hari selama 2 jam. Jumlah leukosit dianalisis menggunakan ANOVA satu arah.Hasilnya menunjukkan perubahan signifikan pada populasi leukosit. Jumlah neutrofil meningkat secara progresif setelah 30 hari, yang menunjukkan adanya potensi respons inflamasi. Tingkat monosit menunjukkan dua tahap, awalnya menurun pada hari ke-15 lalu melonjak 82,3% pada hari ke-30, yang menunjukkan aktivasi kekebalan adaptif. Sebaliknya, jumlah limfosit tetap stabil hingga hari ke-15 tetapi menurun secara signifikan sebesar 2,14% pada hari ke-30, yang berpotensi mencerminkan modulasi kekebalan yang diinduksi oleh stres.Temuan ini menyoroti radiasi ELF-MF dapat mengubah dinamika leukosit, kemungkinan dimediasi melalui jalur stres oksidatif dan respons inflamasi yang berkepanjangan. Perubahan ini menggarisbawahi pentingnya penelitian lebih lanjut tentang implikasi kesehatan jangka panjang dari paparan ELF-MF, mengingat meningkatnya prevalensi radiasi elektromagnetik di lingkungan modern.

The Antiallergic Potential of Quercetin Compared With Dexamethasone and Prednisolone against Histamine H1 Receptors in Vernal Keratoconjunctivitis Nugraha Wahyu Cahyana; Ulfa Elfiah; Heni Fatmawati
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 2 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i2.9478

Vernal keratoconjunctivitis is an ophthalmological condition that presents significant challenges, especially in children and adolescents, due to chronic inflammation of the conjunctiva and cornea. This inflammation leads to distressing symptoms such as itching, irritation, and photophobia, which severely impact the quality of life. Traditional treatments for this condition often involve antiallergic medications like dexamethasone, prednisolone, and quercetin. However, understanding the precise mechanisms and comparative effectiveness of these treatments is crucial for improving therapeutic outcomes. In this study, protein structure data for dexamethasone (4UDA), prednisolone (8CC1), and quercetin (1JUH) were sourced from the Protein Data Bank (PDB). The crystal structure of the Histamine H1 Receptor (8X5X) was also retrieved from PDB. In silico modeling was carried out using the Cluspro web server to simulate the interactions between these drugs and the receptor. The analysis revealed that quercetin exhibited the lowest Weighted Score of -1810 in cluster 2, outperforming dexamethasone (-1223) and prednisolone (-1372.4), indicating a higher binding potency to the Histamine H1 Receptor. These findings suggest that quercetin has superior potential compared to dexamethasone and prednisolone for binding to Histamine H1 Receptors in the context of vernal keratoconjunctivitis.

ANALYSIS OF RAT PLATELET COUNT AFTER ELECTRICAL EXPOSURE IN ACUTE AND SUBACUTE PHASE OF BURN INJURY F P H, Fransiska Nooril; Elfiah, Ulfa; Indreswari, Laksmi; Wisudanti, Desie Dwi
Jurnal Rekonstruksi dan Estetik Vol. 4 No. 1 (2019): Jurnal Rekonstruksi dan Estetik, June 2019
Publisher : Universitas Airlangga

Highlights: In the acute phase of electric burn injury, there was a significant change in platelet count. Contrarily, no significant change in platelet count was observed during the subacute phase of electric burn injury. Abstract: Introduction: Electrical burns are one of the causes of important health burdens throughout the world with incidences varying between 4–18% of all burns. In electrical burns, blood vessels are the heavily damaged tissue characterized by endothelial erosion, followed by adhesion and aggregation of platelets to form a hemostatic plug. The screening test for assessing the formation of a hemostatic plug is platelet count. Platelet count monitoring is very important during the resuscitation phase and treatment periods in severe burns, namely in acute and subacute phases of burns. The purpose of this study is to determine and analyze the changes in the platelet count of rats after electrical exposure in the acute and subacute phases of burns. Methods: This is a quasi-experimental study in vivo with post-test-only group design. The control group in this study was not given electrical exposure and the rat's blood was taken directly after the adaptation process. In the other five groups, P1, P2, P3, P4, and P5 were exposed to 140 V for 17 seconds, then their blood was taken for platelet counts on days 0, 3, 7, 10, and 14 post-exposure. Results : The result of this study based on a Post Hoc LSD test showed that there was a change of platelet number after exposure in the acute phase of burn injury and there was no change of platelet number after exposure in the burning subacute phase. Conclusions: Platelet count difference in acute phase of electric burn injury and no difference in platelet count difference in subacute phase of electric burn injury.

A CASE REPORT: RISK OF ELECTRIC INJURY ON DELAYED INITIAL TREATMENT Elfiah, Ulfa; Suryani, Dissa Yulianita
Jurnal Rekonstruksi dan Estetik Vol. 4 No. 1 (2019): Jurnal Rekonstruksi dan Estetik, June 2019
Publisher : Universitas Airlangga

Highlights: Electric injuries are aggressive burns that can lead to severe tissue necrosis, rhabdomyolysis, and a range of complications, including acute kidney injury (AKI). A multidisciplinary approach and early identification of potential complications in electric injury cases are crucial for reducing the risk of Acute Kidney Injury (AKI) and improving patient outcomes. Abstract: Introduction: Electric Injury is a very aggressive burn injury with severe functional and aesthetic consequences caused by progressive and prolonged tissue necrosis. Necrosis that attacks the skeletal muscle can lead to rhabdomyolysis which results in complications if not treated properly. Case Illustration: A complicated case of electric injury in Dr. Soebandi Jember General Hospital, a 26 years old man came to the emergency room with complaints of severe shortness of breath and urinary disorders. The patient had a history of having an electric shock in his right hand when turning on the fan a week prior of admission. The examination showed that the patient had bilateral pulmonary effusion, generalized edema and acute tubular necrosis (ATN) which was characterized by oliguria and even anuria accompanied by hematuria. Other symptoms experienced by patients are anterior uveitis, subconjunctival hemorrhage, and hematemesis. Discussion: Electric injuries can have a wide range of effects on the body, and their management requires a multidisciplinary approach to address the various complications that may arise. Treatment of electric injuries often involves various surgical procedures, including skin grafts, flaps, or amputation, depending on the severity of the injury. Conclusions: Early identification of potential complications in electric injury cases and effective patient follow-up can reduce the risk of Acute Kidney Injury (AKI) occurrence in patients with electric injuries.

A COMBINATION OF CHEEK FLAP, CARTILAGE INSERTION, AND FAT TRANSFER ON POST-TRAUMA LOWER EYELID ECTROPION RECONSTRUCTION Elfiah, Ulfa; Aprinova, Dicky Primadika
Jurnal Rekonstruksi dan Estetik Vol. 9 No. 2 (2024): Jurnal Rekonstruksi dan Estetik, December 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jre.v9i2.59646

Highlights: This study introduces an innovative approach for post-traumatic ectropion reconstruction in children by combining Mustarde rotational cheek flap, cartilage insertion, and fat transfer. This method effectively addresses the challenges of cicatricial ectropion caused by injuries or burns, leading to improved, durable, and cost-effective outcomes in restoring eyelid function and volume. Abstract: Introduction:Ectropion correction surgery is a procedure designed to restore the anterior lamella to its anatomical position. This study aims to propose a combination of cheek flap and fat transfer as a method for post-traumatic ectropion reconstruction surgery. Case Illustration:A 10-year-old girl presented with ectropion caused by scar formation and volume loss in the infraorbital region following a traumatic incident seven years prior. The procedures performed in this case included a Mustarde rotational cheek flap to reconstruct the scar tissue in the infraorbital region that led to the ectropion, pure ear cartilage insertion to repair the damaged tarsal plate or tarsus, and fat transfer to address the volume loss in the infraorbital area. The donor fat was harvested from the inguinal region Discussion: The rationale for using the Mustarde rotational cheek flap, cartilage insertion, and fat transfer was based on the wide donor area, particularly in cases where the vertical dimension exceeds the horizontal dimension. This approach is believed to yield better outcomes compared to other methods, such as skin grafts. In this case, fat transfer was employed to restore the volume lost beneath the scar tissue following trauma. This combination technique is thought to be more durable and to provide superior results compared to alternative methods, while also being economically advantageous. Conclusion: The combination of the Mustarde rotational cheek flap, cartilage insertion, and fat transfer is believed to improve the outcomes of the reconstruction procedure following scar tissue release and correction of volume loss beneath the scar.

Improving Knowledge of Family Nutrition Fulfillment as an Effort to Prevent Congenital Disorders in Couples of Reproductive Age in Rambipuji District, Jember Elfiah, Ulfa; Shinta Rumastika, Nindya; Surya Wahyudi, Septa; Krisno Adji, Novan; Aisyah Amini, Stefia; Faa'is Artama, Alfila; Nadiyatul Husna, Fella; Sahazra Chakra Firdaussaid, Jihad; Nur Hidayah, Siti
Unram Journal of Community Service Vol. 6 No. 2 (2025): June
Publisher : Pascasarjana Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/ujcs.v6i2.951

The global prevalence of congenital defect reaches 0.992 per 1,000 live births, with a high incidence rate also observed in Jember Regency, particularly in Rambipuji District. Nutrition intake, including protein, is essential to prevent congenital defect, but many sufferers come from families with poor nutritional intake. To prevent congenital defect through education and assistance in planting healthy crops for family nutrition and mapping cases in Jember Regency as a promotive and preventive measure. This study design is a quasi-experimental using pretest and posttest. Participants consisted of 30 married couples aged 14-49 years. The intervention included two educational sessions on congenital defect and the management of healthy crops to be processed into nutritious food. A healthy food recipe book was provided, followed by a cooking demonstration by each participant. The knowledge of couples of reproductive ages increased from pretest to posttest with an average increase of 22.5. Statistical analysis using Wilcoxon showed a significant difference in the knowledge of couples of reproductive ages after the intervention (p=0.000). Providing education and training effectively increases knowledge and skills in managing food for family nutrition among couples of reproductive ages. Similar studies with a larger population can be conducted to review the effectiveness more comprehensively.

Co-Authors Adelia Handoko Aditya Kurniawan Agnellia Maulidya Utami Aisyah Amini, Stefia Annisa Sarfina Djunaedy Aprinova, Dicky Primadika Apryanita, Hudayah Ardhina Mahadica Nugroho Arif Arif Aziz, Ayu Munawaroh Candra Agung Wibisana Cicih Komariah D. S. Perdanakusuma Desie Dwi Wisudanti Diana C. Mufida Dina Helianti Dini Agustina Duriyanto Oesman Dwita Aryadina Rachmawati Elly Nurus Sakinah, Elly Nurus Ema Fawziyah Ulfah ENNY SUSWATI F P H, Fransiska Nooril Faa'is Artama, Alfila Fajar Kurniawan Hidayat Fajar Kurniawan Hidayat Fajar Kurniawan Hidayat, Fajar Kurniawan Fatimatuzzahra Fatimatuzzahra Fatmalia Fhierziandrini Nuzuliana Fendi Setyawan Heni Fatmawati Hilda Nur Achfidawati I Gede Widhiana Suarda Kirana Nadyatara Krisno Adji, Novan Kristianningrum Dian Sofiana Kushariyadi Kushariyadi Kushariyadi Laksmi Indreswari Luh Putu Ratna Sundari Luluk Mauludyahwati M. R. Hutagalung Maidy Frista Rosanti Meytika Fauziah Sugiartanti Misnawi Misnawi Mochammad Amrun Hidayat Mochammad Amrun Hidayat Muhammad A. Shodikin Muhammad Fahmi Naufal Muhammad Izat Fuadi Muhammad Yuda Nugraha Nadiyatul Husna, Fella Nikmatul Maula Nur Rahmadani Novan Krisno Adji Nugraha Wahyu Cahyana Nur Hidayah, Siti Phill T Koesbandriati Ramadhani, Alfiyah Rena Normasari Sahazra Chakra Firdaussaid, Jihad Sheila Rachmania Shinta Rumastika, Nindya Sudarti Sudarti Surya Wahyudi, Septa Suryani, Dissa Yulianita Wahyu Rachmadi Akbar Wahyudi, Septa S Waskito Setiaji Winaspita Aulia Putri Windharto, Agus Wiryaning Putri, Komang Yunita

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