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All Journal Jurnal Kedokteran Brawijaya IPTEK Journal of Proceedings Series Journal of the Medical Sciences (Berkala Ilmu Kedokteran) e-Journal Pustaka Kesehatan Jurnal Keolahragaan Journal of Agromedicine and Medical Sciences Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) UNEJ e-Proceeding Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Al-sihah: The Public Health Science Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Supremasi Hukum: Jurnal Penelitian Hukum Jurnal Rekonstruksi dan Estetik Unram Journal of Community Service (UJCS) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Public Health and Preventive Medicine Archive Indonesian Journal of Biomedicine and Clinical Sciences
Ulfa Elfiah
Department Of Plastic Reconstructive And Aesthetic Surgery, Faculty Of Medicine, Universitas Jember, Jember, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Effect of oyster mushroom powder on total leukocyte during inflammatory and proliferative phases of the wound healing process of third-degree burns model in Wistar rat (Rattus norvegicus) Elfiah, Ulfa; Mochammad Amrun Hidayat; Elly Nurus Sakinah; Candra Agung Wibisana; Ramadhani, Alfiyah; Apryanita, Hudayah
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.24919

Abstract

Burn wounds are challenging to treat because they often heal slowly and are susceptible to complications. The inflammatory phase plays an essential role in the repair process. However, prolonged inflammation can delay tissue healing. The total leukocyte count is an important parameter to evaluate the process, as it reflects the balance between inflammation and the initiation of tissue regeneration. Oyster mushrooms (Pleurotus ostreatus) contain β-glucans and phenolic compounds with anti-inflammatory and antioxidant properties, which may help regulate leukocyte activity and promote wound healing. This study aimed to evaluate the effect of oyster mushroom powder on total leukocyte counts during burn wound healing in Rattus norvegicus. Twenty-seven healthy male rats aged 2-3 mo were randomly divided into 3 groups, with 9 rats in each group. The negative control group received aquadest, the positive control group received bovine serum albumin, and the treatment group received 10% oyster mushroom powder. All groups received identical topical wound management with 1% silver sulfadiazine ointment to prevent infection and maintain a moist wound environment during healing. Blood samples were collected on days 0, 4, 8, and 12 after burn induction, and leukocyte counts were measured. The results showed that the treatment group consistently had lower leukocyte counts compared with control groups. On day 0, the treatment group had significantly lower leukocyte levels compared with the negative control (p = 0.019). On day 8, leukocyte counts in the treatment group were also significantly lower than the positive control (p = 0.030). By day 12, all groups showed a decrease, but the treatment group demonstrated the most gradual and stable reduction over time. In conclusion, oyster mushroom powder reduces leukocyte levels and supported a more controlled inflammatory phase, allowing faster progression to proliferation and improved burn wound healing.
Association between body shape index and body mass index with knee osteoarthritis: a case control study Anik Nurmalikah; Ulfa Elfiah; Nindya Shinta Rumastika; Yuli Hermansyah; Dwita Aryadina Rachmawati
Public Health and Preventive Medicine Archive Vol. 13 No. 1 (2025)
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53638/phpma.2025.v13.i1.p04

Abstract

Background and purpose: Being overweight or obese, which can be determined using the body mass index (BMI), is one of the risk factors for knee osteoarthritis (KOA). Whilst, body shape index (BSI) is considered as more accurate indicator, hence, this study aims to assess correlation of BSI and BMI with KOA. Methods: This study employed a case control design conducted in Jenggawah Village, East Java. Samples were randomly taken from the social service program of the Faculty of Medicine, University of Jember which conducted on June 18, 2023, included 30 KOA patients and 30 non-KOA patients who met the inclusion and exclusion criteria. The instruments used were Omni Calculator and KOA clinical criteria sheet. The statistical analysis used the Spearman Rank correlation test with a significance level of p<0.05. Results: The statistical analysis revealed a significant, moderate, and direct correlation between BSI and KOA (p=0.002; r=0.391). On the other hand, BMI showed an insignificant, very weak, and inverse correlation with KOA (p=0.432; r=-0.103). BSI values indicate low amount of skeletal muscle mass with increased visceral or abdominal adiposity. BMI only assesses overweight, while BSI can represent central adiposity, which also affects KOA. Conclusion: The study concludes that BSI is related to the incidence of KOA, while BMI is not related to the incidence of KOA in Jenggawah Village, Jember Regency. Future research could use a cohort plan to validate whether BMI and BSI can predict the incidence of KOA.
Efficacy and safety of 100% TCA CROSS for atrophic acne scar: A systematic review Satmoko, Valentino Yosarian; Elfiah, Ulfa; Aziz, Ayu Munawaroh
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art9

Abstract

Acne scars result from impaired healing following skin inflammation, with atrophic acne scars accounting for 98% of cases. Although various treatments are commonly used, no gold-standard therapy exists. Chemical reconstruction of skin scars using 100% trichloroacetic acid (100% TCA CROSS) has emerged as a novel intervention for atrophic acne scars. However, evidence supporting its efficacy and safety remains limited, necessitating further evaluation. This systematic review was conducted in accordance with PRISMA and SWiM guidelines. Literature searches were performed in PubMed, Cochrane Library, Google Scholar, and ScienceDirect. Studies were included if they involved patients with atrophic acne scars and utilized 100% TCA CROSS as the intervention, with comparators comprising other acne scar treatments. The primary outcome was efficacy, and the secondary outcome was safety. Only randomized controlled trials (RCTs) were included. Two independent reviewers assessed risk of bias, extracted data, and conducted qualitative analysis. Six studies met the eligibility criteria, with comparators including CO2 laser pinpoint irradiation, microneedling, percutaneous collagen induction dermaroller, platelet-rich plasma (PRP) injection, and PRP injection with needling. One study favored the comparator, while five studies demonstrated no clear difference. Within-group analyses indicated improvements following 100% TCA CROSS. No severe complications were reported. Meta-analysis was not performed due to heterogeneity in outcome measures. In summary, 100% TCA CROSS appears effective and safe for atrophic acne scars.
Pengaruh Pemberian Gel Ekstrak Kopi Robusta (Coffea canephora) Terhadap Gambaran Makroskopis dan Mikroskopis Luka Bakar Derajat IIB Pada Tikus Long Evans Elfiah, Ulfa; Rosanti, Maidy Frista; Fatimatuzzahra, Fatimatuzzahra; Hidayat, Mochammad Amrun
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 2 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i2.56152

Abstract

Perawatan luka bakar memerlukan penanganan khusus. Penggunaan sediaan obat topikal seperti silver sulfadiazine serta hydrocolloids yang berfungsi sebagai absorptive dressings merupakan salah satu prosedur terapi yang digunakan untuk mempercepat penyembuhan luka. Perawatan kasus luka bakar di Indonesia masih kurang optimal karena adanya pembatasan biaya perawatan oleh sistem jaminan kesehatan Indonesia, oleh karena itu, perlu adanya alternatif perawatan luka bakar dengan mengembangkan bahan-bahan herbal sebagai dressing topikal seperti ekstrak dari kopi. Tujuan dari penelitian ini ialah untuk membuktikan pengaruh pemberian gel ekstrak kopi robusta (Coffea canephora) terhadap gambaran makroskopis dan mikroskopis luka bakar derajat IIB pada tikus long evans. Metode penelitian yang digunakan adalah true experimental laboratories dengan rancangan post-test only control group design. Tikus sebanyak 24 ekor terbagi menjadi 3 kelompok perlakuan. Kelompok kontrol negatif yaitu diberi basis gel, kelompok positif diberi silver sulfadiazine, dan kelompok perlakuan diberi gel ekstrak kopi robusta 2,5%. Data luas luka bakar, perubahan intensitas warna, dan ketebalan epitel luka bakar yang telah diperoleh selanjutnya diuji secara statistik menggunakan One Way ANOVA maupun Kruskal-Wallis dan dilanjutkan dengan uji Post-Hoc. Hasil penelitian menunjukkan pada kelompok perlakuan terjadi penurunan luas makroskopis (p < 0,05), perbaikan intensitas warna (p < 0,05), dan peningkatan ketebalan epitel (p < 0,05) antara gel ekstrak kopi robusta dibandingkan dengan kelompok kelompok negatif. Kesimpulan penelitian ini adalah bahwa gel ekstrak kopi robusta (Coffea canephora) terbukti memberikan pengaruh terhadap penyembuhan luka baik secara makroskopis maupun mikroskopis sehingga gel ekstrak kopi dapat terus dikembangkan menjadi salah satu alternatif dressing dalam perawatan luka bakar.
Co-Authors Adelia Handoko Agnellia Maulidya Utami Aisyah Amini, Stefia Anik Nurmalikah Annisa Sarfina Djunaedy Aprinova, Dicky Primadika Apryanita, Hudayah Ardhina Mahadica Nugroho Arif Arif Aziz, Ayu Munawaroh Candra Agung Wibisana Cicih Komariah D. S. Perdanakusuma Desie Dwi Wisudanti Diana C. Mufida Dini Agustina Duriyanto Oesman Dwita Aryadina Rachmawati Elly Nurus Sakinah, Elly Nurus Ema Fawziyah Ulfah ENNY SUSWATI F P H, Fransiska Nooril Faa'is Artama, Alfila Fajar Kurniawan Hidayat Fajar Kurniawan Hidayat Fajar Kurniawan Hidayat, Fajar Kurniawan Fatimatuzzahra Fatimatuzzahra Fatmalia Fhierziandrini Nuzuliana Fendi Setyawan Heni Fatmawati Hilda Nur Achfidawati I Gede Widhiana Suarda Kirana Nadyatara Krisno Adji, Novan Kristianningrum Dian Sofiana Kushariyadi Kushariyadi Kushariyadi Laksmi Indreswari Luh Putu Ratna Sundari Luluk Mauludyahwati M. R. Hutagalung Meytika Fauziah Sugiartanti Misnawi Misnawi Mochammad Amrun Hidayat Mochammad Amrun Hidayat Muhammad A. Shodikin Muhammad Fahmi Naufal Muhammad Izat Fuadi Muhammad Yuda Nugraha Nadiyatul Husna, Fella Nikmatul Maula Nur Rahmadani Nindya Shinta Rumastika Novan Krisno Adji Nugraha Wahyu Cahyana Nur Hidayah, Siti Phill T Koesbandriati Ramadhani, Alfiyah Rena Normasari Rosanti, Maidy Frista Sahazra Chakra Firdaussaid, Jihad Satmoko, Valentino Yosarian Sheila Rachmania Shinta Rumastika, Nindya Surya Wahyudi, Septa Suryani, Dissa Yulianita Wahyu Rachmadi Akbar Wahyudi, Septa S Waskito Setiaji Winaspita Aulia Putri Windharto, Agus Wiryaning Putri, Komang Yunita Yuli Hermansyah