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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Jurnal Veteriner Indonesian Journal of Pharmaceutical Science and Technology Communications in Science and Technology JSFK (Jurnal Sains Farmasi & Klinis) ARSHI Veterinary Letters Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Health Sains Jurnal Buana Farma Britain International of Exact Sciences Journal (BIoEx Journal) Indonesian Journal of Biological Pharmacy Jurnal Sylva Lestari Eduvest - Journal of Universal Studies Jurnal Veteriner dan Biomedis Current Biomedicine
Bayu Febram Prasetyo
Sub-Divisi Farmasi Veteriner, Sekolah Kedokteran Hewan Dan Biomedis, IPB University, Bogor, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Journal : Jurnal Buana Farma

 1 
PENGHAMBATAN ENZIM TIROSINASE dan AKTIVITAS ANTIOKSIDAN EKSTRAK BUNGA TELANG (Clitoria ternatea) MENGGUNAKAN METODE DPPH Bayu Febram Prasetyo; Amrozi; Nur Anisa BS
Jurnal Buana Farma Vol. 4 No. 1 (2024): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v4i1.942

Abstract

Clitoria ternatea or known as the butterfly pea is widely used in the health sector due to its efficacy as antidiabetic, anti-inflammatory, antimicrobial, anticancer, analgesic, antipyretic, and antioxidants. The purpose of this research is to examine the antioxidants and tyrosinase inhibitor activities of butterfly pea ethanol extract as well as to identify the phytochemical content. Antioxidants activities are determined by the DPPH method. The results of this study indicates that butterfly pea extract has very weak antioxidant activities with an IC50 value more than 200 ppm. The results of the tyrosinase inhibitor activities showed that the butterfly pea extract did not inhibit the tyrosinase enzyme. Based on the screening phytochemical tests, the chemical components contained in butterfly pea extract are flavonoids, tannins, saponins, and steroids. Bunga telang flower extract has very weak antioxidant activity and tyrosinase inhibitor testing showed antioxidant flower extract by DPPH method. Tyrosinase inhibitor assay results showed white Bungatelang extract has no activity to inhibit tyrosinase enzyme.
AKTIVITAS ANTICAPLAK SEDIAAN SPRAY YANG MENGANDUNG MINYAK ROSEMARY,BERGAMOT DAN CUKA APEL Ath-Thaariq, Affan Aufar; Prasetyo, Bayu Febram; Supriyono
Jurnal Buana Farma Vol. 5 No. 2 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i2.1408

Abstract

Apple cider vinegar and rosemary oil have an acaricidal effect on R. sanguineus ticks. Both ingredients offer health benefits. This study aimed to observe the effect of a spray preparation containing apple cider vinegar and rosemary oil at various concentrations on the mortality of R. sanguineus ticks. The study was conducted from February 2025 to April 2025. It used 75 R. sanguineus ticks, divided into 5 groups, with each group having three repetitions. K1, the negative control, was treated with pure distilled water. K2, the positive control, was treated with Fipronil 3% (Frontline brand). K3 was given bergamot oil 5%, rosemary oil 10%, and apple cider vinegar 5%. K4 was given bergamot oil 5%, rosemary oil 10%, and apple cider vinegar 10%. K5 was given bergamot oil 5%, rosemary oil 10%, and apple cider vinegar 15%. Each treatment group consisted of 5 ticks. Observations were made at 30, 60, 90, 120, and 180 minutes post-contact. The results showed that the group treated with bergamot oil 5%, rosemary oil 10%, and apple cider vinegar 15% achieved a Lethal Time 50 (LT50) at 106 minutes. The conclusion indicates that apple cider vinegar at a concentration of 15% required the least amount of time to kill the ticks
ANTIHIPERPIGMENTASI Hylocereus costaricensis MELALUI INHIBISI TIROSINASE: STUDI NETWORK PHARMACOLOGY DAN MOLECULAR DOCKING Prasetyo, Bayu Febram; Alauddin, Daffa Rizal Dzulfaqaar; Purwono, Rini Madyastuti
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1570

Abstract

Hyperpigmentation was driven by increased melanogenesis and oxidative stress, creating a need for effective and safe depigmenting candidates. This study aimed to identify bioactive compounds from Hylocereus costaricensis, to map hyperpigmentation-related targets and pathways using network pharmacology, and to evaluate the binding potential of selected compounds to a melanogenesis target using molecular docking. The workflow included compound screening and drug-likeness/ADMET evaluation, prediction of compound targets and hyperpigmentation-associated genes, construction of compound–target–disease and protein–protein interaction networks, topological and GO/KEGG enrichment analyses, and docking to TYRP1 (PDB: 5M8O). Five main candidates, namely 2,2-dimethyl-3-phenylpropanoic acid, ferulic acid, o-coumaric acid, p-coumaric acid, and vanillic acid, have met the initial criteria. Network pharmacology highlighted a multi-target mechanism by prioritizing key nodes including AKT1, EGFR, PIK3CA, TYR, and CDK4 and by indicating enriched signaling pathways relevant to pigmentation regulation and oxidative-stress responses. Docking results showed moderate affinities, with binding energies of approximately −6.551 to −6.184 kcal/mol and estimated inhibition constants of 15.779 to 29.315 µM, and 2,2-dimethyl-3-phenylpropanoic acid yielded the best score among the tested ligands. Overall, the integrated network pharmacology–docking strategy provided a rational prioritization of compounds and targets for developing anti-hyperpigmentation agents derived from H. costaricensis; however, the evidence remained preliminary and required further experimental validation and mechanistic confirmation.
Co-Authors Adinda, Nada Affan Zufar Agustin Indrawati Ahmad Kurniawan Alauddin, Daffa Rizal Dzulfaqaar Amanda, Marsha Amrozi Andriyanto Andriyanto ANGGARA ALDOBRATA Anisa Rahma, Anisa Anisa, Rahma Ath-Thaariq, Affan Aufar Aziziah, Nurul Madinah Bachmid, Salma Safitri Baharun, Rasyid Bambang Pontjo Priosoeryanto Bhila, Aisya Salsa Budiono, Novericko Ginger Dedi Rahmat Setiadi Diaz, Fariz Arrachman Dondhin Sajuthi Dondin Sajuthi Eva Harlina Fadia, Sindy Siti Farra Sasmita Fikram, Muhammad Fikri Hanifah Firdausi, Zalfaa Nurr Fitri, Arni Diana Ghazali, Farhan Rizqy Hamidi, Zikri Handri Dwi Agung Hikmarizky, Firda IETJE WIENTARSIH Kasmi, Adinda Zahra Marissa Khamidah, Nabila Nurrisma Lina Noviyanti Sutardi Madyastuti, Rini May, Ng U Mifthadillah, Sekar Ayu Miranti Fardesiana Putri Mufida, Anis Arifatu Muhammad Agung Nulhakim Natawiria, Maria Stella Linda Nur Anisa BS Nurdiansyah, Rio Dwi Haryadi Prayogo, Yanico Hadi Rahmadani, Satria Tegar Rahmalia Dini Hanifa Ramadhaniah, Vetty Rasyid, Baharun Rita Kartika Sari Rizal Arifin Akbari Saragih, Adrian Setyanto Tri Wahyudi SUPRIYONO Upik Kesumawati Hadi Vetnizah Juniantito Wasrin Syafii Winarto, Tytha Nadhifa Wulandari, Nenis Rahma Zheng, Lee Xiang