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All Journal Journal Pharmaceutical Science and Application (JPSA) Jurnal Farmasi Udayana Jurnal Farmasi Klinik Indonesia Acta Pharmaceutica Indonesia Jurnal Farmasi Sains dan Komunitas JFIOnline Udayana Journal of Social Sciences and Humanities (UJoSSH) Jurnal Ilmiah Medicamento

Luh Putu Febryana Larasanty

Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Udayana

Author-ID : 265494

Humanities Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Pengaruh Pemberian Ekstrak Etanol 70% Daun Singkong (Manihot utilissima Pohl) terhadap Kadar Gula Darah Mencit Jantan Galur Balb/C yang Diinduksi Aloksan N. K Warditiani,; L. P. F Larasanty,; I. Damanik,
Jurnal Farmasi Udayana Vol. 4, No. 1, Tahun 2015
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (107.507 KB)

Tanaman singkong (Manihot utilissima Pohl) merupakan tanaman yang memiliki banyak manfaat dalam kehidupan sehari-hari, khususnya sebagai sumber kalori pangan di Indonesia. Dalam pemanfaatannya, daun singkong hanya digunakan sebagai sayur dan makanan ternak. Sehingga diperlukan cara pengolahan yang baru untuk daun singkong agar manfaat daun singkong dapat dirasakan oleh masyarakat. Daun singkong memiliki berbagai kandungan, salah satunya yaitu flavonoid golongan kuersetin. Penelitian sebelumnya menunjukkan flavonoid golongan kuersetin dalam Aloe vera dan Uncaria gambir Roxb mampu menurunkan kadar glukosa darah mencit yang diinduksi aloksan sehingga diduga flavonoid dalam daun singkong memiliki aktivitas antihiperglikemia. Penelitian ini bertujuan untuk mengetahui kemampuan ekstrak daun singkong (Manihot utilissima Pohl) dalam menurunkan kadar glukosa darah pada mencit jantan galur Balb/C yang diinduksi aloksan. Penelitian ini meliputi beberapa tahapan, yaitu: determinasi, ekstraksi, penetapan kadar air, skrining fitokimia, dan uji aktivitas antihiperglikemia ekstrak daun singkong (Manihot utilissima Pohl). Pengujian dilakukan dengan membagi mencit menjadi 6 kelompok perlakuan, antara lain: kontrol normal, kontrol negatif (CMC Na 0,1%), kontrol positif (metformin 65 mg/kg BB), dan tiga kelompok perlakuan (variasi dosis ekstrak daun singkong (Manihot utilissima Pohl) 12,8 mg/kg BB, 25,6 mg/kg BB, dan 51,3 mg/kg BB) diberikan selama 8 hari. Selanjutnya diukur kadar glukosa darah mencit menggunakan alat glukosa test. Hasil data yang diperoleh kemudian diolah secara statistik. Hasil pengujian menunjukkan bahwa ekstrak daun singkong (Manihot utilissima Pohl) mampu menurunkan kadar glukosa darah (p<0,05), namun kemampuan tersebut tidak sama dengan metformin (p<0,05) dimana metformin memiliki aktivitas antihiperglikemia yang lebih besar.

PHARMACIST PROFESSION STUDENT PERCEPTION ABOUT PHARMACIST ROLE IN PHARMACY, COMMUNITY HEALTH CENTER AND HOSPITAL Luh Putu Febryana Larasanty; Kadek Nadia Marta Dewi; Made Ary Sarasmita
Journal Pharmaceutical Science and Application Vol 2 No 2 (2020): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2020.v02.i02.p06

Background: Pharmacists play a role as a part of health services both at pharmacies, hospitals and community health centers. Pharmaceutical care was regulated in the Regulation of the Minister of Health of the Republic of Indonesia. In the internship, students of the Pharmacists program Faculty of Mathematics and Natural Sciences, Udayana University can see clearly how the implementation of the role of Pharmacists in the Pharmacy, Hospital and Community Health Center. Objective: This study aims to assess the perceptions (responses) of Pharmacist students on the role of Pharmacists in various pharmacy services. Methods: This study used a one-group posttest only design methods. The population of the study used all of the Pharmacist students who were internship at the Pharmacy, Community Health Center and Hospital. The research instrument used a closed-ended questionnaire about the perceptions of Pharmacist students on the role of Pharmacists in internship locations. Results: The results showed that the role of pharmacists in pharmacies and community health centers was greater in the field of clinical pharmacy services. While in hospitals, pharmacists have a greater role in the field of drug management. Conclusion: Students have a positive perception of the role of pharmacists. There were no significant differences in perceptions of Pharmacist students on the role of Pharmacists in the field of drug management and clinical pharmacy services (p> 0.05). Keywords: pharmacist, pharmaceutical care, perception, role, students

Antihypertensive Drug Use in Patient With Intracerebral Hemorrhage Stroke Luh Putu Febryana Larasanty
Journal Pharmaceutical Science and Application Vol 1 No 1 (2012): Journal Pharmaceutical Science and Application
Publisher : Departement of Pharmacy, Faculty of Mathematic and Natural Science, Udayana University

Intracerebral hemorrhage (ICH) stroke is a type of stroke with the highest mortality rate, with only about 38% of patients who survived for the first year after stroke. Antihypertensive treatment one of the main therapy for reduce the mortality rate in ICH. Based on review from research study journals, peer review journals, guidelines or book about use of antihypertensive drugs in ICH stroke patient and/or hypertensive emergency, uses of nicardipine, labetalol, esmolol and enalapril can be as the first-line therapy to manage acute high blood pressure in intracerebral hemorrhage stroke if there is no contraindication or caution is present. Nicardipine, labetalol, esmolol and enalapril is four agent that reduce blood pressure in a titratable fashion and do not lead increases in intracranial pressure. Hydralazine, sodium nitroprusside and nitroglycerine can be used as alternative agent if nicardipine, labetalol, esmolol and enalapril can not be used in ICH stroke patient. Keywords: Stroke, Intracerebral Hemorrhage, Antihypertensive Agent

Kesesuaian Informasi Kontraindikasi Obat Gastrointestinal Untuk Pasien Geriatri Pada Berbagai Sumber Informasi Tersier I Made Agus Gelgel Wirasuta; Anak Agung Febi Danuswari; Luh Putu Febriyana Larasanty
Acta Pharmaceutica Indonesia Vol. 39 No. 3 & 4 (2014)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Penggunaan obat gastrointestinal meningkat seiring penurunan fungsi sistem gastrointestinal pada populasi geriatri. Informasi kontraindikasi merupakan salah satu informasi keamanan yang diperlukan bagi pasien geriatri. Informatorium Obat Nasional Indonesia (IONI), Informasi Spesialite Obat (ISO), British National Formulary (BNF), dan Drug Information Handbook (DIH) merupakan sumber informasi tersier yang memuat informasi keamanan penggunaan obat. Penelitian ini bertujuan untuk mengetahui kesesuaian informasi kontraindikasi obat gastrointestinal untuk populasi geriatri pada sumber informasi tersier dengan Beers List sebagai pustaka acuan.Penelitian dilakukan dengan studi kepustakaan pada informasi kontraindikasi penggunaan obat gastrointestinal untuk pasien geriatri pada sumber literatur tersier. Sampel obat gastrointestinal diperoleh dari pendataan pada buku Farmakologi Dasar dan Klinik, diperoleh 20 jenis obat yang informasi keamanan tercantum pada keempat sumber informasi tersier yang digunakan. Informasi kontraindikasi 20 obat tersebut didata pada masing-masing sumber informasi tersier, kemudian dikonfirmasi silang dengan informasi pada Beers List, sehingga diperoleh persentase kesesuaian informasi kontraindikasi pada masing-masing sumber informasi tersier. Hasil penelitian menunjukkan bahwa 20 jenis obat gastrointestinal yang digunakan dalam penelitian tidak dikontraindikasikan untuk populasi geriatri. Informasi pada Beers List juga menyatakan bahwa penggunaan obat tersebut tidak dikontraindikasikan pada populasi geriatri, sehingga informasi kontraindikasi penggunaan obat gastrointestinal pada keempat sumber informasi tersier sesuai dengan informasi yang tercantum pada Beers List.Kata kunci: geriatri, informasi keamanan, obat gastrointestinal.AbstractUses of gastrointestinal drugs was increased as the decline in the function of the gastrointestinal system in the geriatric population. Contraindication information is one of the safety information that is required for geriatric patients. Informatorium Obat Nasional Indonesia (IONI), Informasi Spesialite Obat (ISO), the British National Formulary (BNF), and the Drug Information Handbook (DIH) is a tertiary drug information source that includes information of safety drug use. This study aims is to determine the suitability of the information gastrointestinal drug contraindications to the geriatric population in various tertiary resources with Beers List as its reference library.This research are literature study on the use of contraindicated information of gastrointestinal drugs for geriatric patients at tertiary literature sources. Gastrointestinal drug samples listed from Basic and Clinical Pharmacology book, obtained 20 types of generic drug that safety information contained in the all of tertiary resources are used in this study. Contraindications information of those drug in each tertiary resources, then cross confirmed with the information on Beers List, in order to obtain the percentage of suitability of contraindicated information in each tertiary resources.The results showed that 20 type of gastrointestinal drugs used in this study were not contraindicated in geriatric population. Information on the Beers List also states that the use of the drug is not contraindicated in the geriatric population. It is concluded that the contraindicated information of gastrointestinal drug use in geriatric population in IONI, ISO, DIH and BNF is in accordance with the information listed on the Beers List.Keywords: geriatric, gastrointestinal drug, safety information

Influence of Patient Characteristics on The Type of Insulin Therapy Obtained by Diabetes Type 2 Outpatient in Denpasar Municipality Luh Putu Febrayana Larasanty; I GNA. Dewantara Putra; Rhyce Dewata Sari; Komang Dede Saputra; I GA. Gede Minanjaya; I Made Arya Wiraguna; I Made Wiracana
Udayana Journal of Social Sciences and Humanities Vol 1 No 2 (2017): UJoSSH, September 2017
Publisher : Research and Community Services Institutes of Udayana University

This study aims to investigate the influence of patient characteristics on the choice of insulin therapy in type 2 diabetes mellitus outpatients in Denpasar municipality. This is a descriptive analysis study using the patient's medical records as research material. Patients who meet inclusion and exclusion criteria are being recorded based on their medical records. Characteristics that are taken are age, gender, fasting blood glucose level (FBG), 2-hour postprandial blood glucose level (2-hours PPG) and HbA1c values of patients. Types of insulin therapy gained from patient medical records and drug use report in pharmacy. Characteristics data and type of insulin analyzed using correlation test to determine the effect of the patient characteristics on the selection of insulin therapy. 43 patients became the research subject. Males gendered patients (72.09%) and the patients aged less than 65 years (90.70%) are the dominant characteristics of the research subjects. The average value of FBG of patients is 212 mg / dL; 2-hours PPG 280 mg / dL and HbA1c 10.1%. There is a correlation between sex, age, HbA1c value and FBG with the type of insulin obtained by patients (p <0.05). Based on the results of statistical tests, age and gender have a strong correlation on insulin choice, HbA1c and FBG level has a moderate influence and 2-hours PPG have a weak correlation. Patient characteristics had an influence on the type of insulin choice for diabetes mellitus type 2 outpatient in the Denpasar municipality.

Cost Utility of Adjuvant and Neo-Adjuvant Treatment for Breast Cancer: A Systematic Review of Observational Economic Evaluations Study Larasanty, Luh Putu Febryana; Setyawan, Irfanianta Arif; Nurlita, Diah
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.007988

This study aimed to perform a systematic review of an observational cost-utility analysis of adjuvant and neo-adjuvant agents in breast cancer patients. The PRISMA flowchart was used to conduct the literature search and study selection. Through the use of two databases, PubMed and Scopus, a literature search was done. The eligible study was determined based on the established inclusion criteria. To evaluate the quality of the study, Drummond's checklist was used. Data extraction was conducted to assess characteristics, study perspective, cost and outcome measurement, the cost-utility ratio in ICER value, threshold, sensitivity or probability analysis, and the conclusion of the cost-utility study. There was a total of 7 studies included for review. Four studies compared chemotherapy regimens as adjuvant or neoadjuvant and three studies included hormone therapy or targeted therapy as an intervention that compared. Observational characteristic includes the use of cohort methods, and a large number of participants, the comparison is mostly for adjuvant therapy purposes and direct medical cost measured from a payer perspective. Anthracycline-based chemotherapy like the FAC regimen showed potential cost-effectiveness results. The use of targeted therapy (pertuzumab, trastuzumab) and hormonal therapy (goserelin) is associated with better utility outcomes and an increase in cost burden from intervention. Based to the reviewed studies, anthracycline-containing regimens such as FAC may have pharmacoeconomic properties as adjuvant or neo-adjuvant therapy. While the use of the most recent pharmacological drug has the potential to improve utility outcomes, but is associated with an increase in the intervention's cost burden.

Co-Authors Anak Agung Febi Danuswari Antari, N.P.U. Cahyadi, Maria Fiani Cahyadi, Maria Fiani Cia Intania Warnaya Danuswari, Anak Agung Febi Dewa Ayu Swastini G.D. Pranawa Gumi, V. C Gunarsih, H. P. I Dewa Agung Ayu Divacandraningrat I GA. Gede Minanjaya I Gusti Ngurah Agung Dewantara Putra I Made Agus Gelgel Wirasuta I Made Arya Wiraguna I Made Wiracana I N.K. Widjaja I Wayan Martadi Santika I. Damanik, I.M.S. Sapanca I.N.K. Widjaja Ida Ayu Sintya Deviyanthi Juniari N.P.M. Kadek Nadia Marta Dewi Ketut Widyani Astuti Komang Dede Saputra Kosasih, Diah Ayu Nirmala Kosasih, Diah Ayu Nirmala Lestari, N. K. S. Luh Putu Ayu Meryta Made Krisna Adi Jaya Maria Fiani Cahyadi Meilinayanti, Ni Made L. N.K.W Prasminda N.L.P.D. Wulandari N.L.P.U Antari N.M.F Irmayanti N.P. Widiastuti N.P.R.D. Putri Ni Kadek Warditiani Ni Made Ary Sarasmita Ni Made Ayu Wistari Ni Made L. Meilinayanti Ni Made P. Susanti Ni Made Pitri Susanti Ni Made Rai Sudarni Ni Nyoman Abigail Triastuti Ni Nyoman Della Yanti Ni Wayan Wirayanti Nugroho A.E. Nurlita, Diah P.P. Andiani Pramono S. Purnamaningrat, A.A.I.D. Putri, W. S. R.A.D. Puspitasari Rhyce Dewata Sari Samba, N. M. R. A. M Sari, Ni Putu Latsartika Sari, Ni Putu Latsartika Setyawan, Irfanianta Arif Siahaan, T. F. Sudarni, Ni Made Rai Sudarni, Ni Made Rai Sugiarto, R. P. Sukarmini, N. N. F. Udayani N. N. W. Udayani, N. N. W Wayan Risma Iswari Widjaja I N.K. Widjaja I.N.K Widjaja, I N. K. Wijaya N. D. Wistari, Ni Made Ayu Wistari, Ni Made Ayu

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