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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Journal of Mathematical and Fundamental Sciences JURNAL FARMASI GALENIKA Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Jurnal Farmasi Galenika
DUDI RUNADI
Faculty Of Pharmacy, University Of Padjadjaran, Jatinangor-Sumedang
Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health

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Limonoids Isolated from Chisocheton pentandrus (Meliaceae) Stembarks and its Cytotoxicity Towards MCF-7 Breast Cancer Cell Line Runadi, Dudi; Anjari, Intan Hawina; Purnama, Purnama; Nurlelasari, Nurlelasari; Harneti, Desi; Mayanti, Tri; Harizon, Harizon; Hidayat, Ace Tatang; Salam, Supriatno; Azmi, Mohamad Nurul; Supratman, Unang
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

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Abstract

Chisocheton is a large source of limonoids with various pharmacological effects, such as antiviral, antibacterial, antimalarial, antifungal, and cytotoxic activities. This study aimed to isolate, elucidate, and evaluate the cytotoxicity of limonoids from C. pentandrus stembarks. Isolation was carried out using various separation methods including extraction and column chromatography. Spectral data were analyzed by FT-IR, UV, DEPT 135°, 1H, 13C-NMR, and HRTOF-MS and compared with those previously reported to determine the chemical structure.The obtained limonoids were lasiocarpine (1), lasiocarpine B (2), pentandricine (3), and 16β-hydroxydysobinin (4); all of which were successfully isolated from C. pentandrus for the first time. The cytotoxic activity of these limonoids were also evaluated against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells using PrestoBlue method. Lasiocarpine A revealed the strongest cytotoxicity with an IC50 of 42.62 µM in moderate level.
Four Azadirone-Type Limonoids from Chisocheton Pentandrus Stem Bark and Their Cytotoxic Acitivity Against Mcf-7 Breast Cancer Cell Lines Supratman, Unang; Runadi, Dudi; Naini, Al Arofatus; Purnama, Purnama; Mayanti, Tri; Harneti, Desi; Nurlelasari, Nurlelasari; Maharani, Rani; Farabi, Kindi; Nafiah, Mohamad Azlan
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.11085

Abstract

ABSTRACT. Limonoid group belongs to triterpenoid that has undergone further oxidation accompanied by the loss of four carbon atoms to form a furan ring in the chain. This limonoid compound is often found in the Chisocheton genus. Limonoid compounds have been known as compounds with high structural variations and this makes limonoids have diverse and interesting activities, including cytotoxic and anticancer. In the course of our continuing study for limonoid constituents that have cytotoxic activity against cancer cell lines, methanol extract of stem bark from the Chisocheton pentandrus plant provides significant activity. The methanol extract was separated using various chromatographic techniques in the normal and reverse stationary phase to produce four azadirone-type limonoid compounds (1-4). The elucidation structure of 1-4 was determined using spectroscopic methods including, UV-Visible, IR, and 1D-NMR as well as optical rotation. All four known compounds were established as trichilenone acetate (1), toonaciliaton C (2), 11α-acetoxiazadiron (3), and 16β-hydroxydisobinine (4). The cytotoxicity of compounds 1-4 was assessed by examination using the resazurin method, which showed that compound 4 was the promising constituent against the MCF-7 cells with an IC50 value of 43.1 µM and was stronger than its positive control. Keywords: Azadirone-type limonoid, Chisocheton pentandrus, cytotoxic activity, Meliaceae.
LARVACIDAL ACTIVITY OF EXTRACT AND ESSENTIAL OIL OF CURCUMA MANGGA RHIZOME (Curcuma mangga VAL.) AGAINST LARVAEAedesaegypti Dudi Runadi
JURNAL FARMASI GALENIKA Vol 2 No 02 (2015): JURNAL FARMASI GALENIKA
Publisher : Universitas Bhakti Kencana

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Dengue Hemorrhagic Fever (DHF) causedby Aedesaegypti is a pestilentdisease. Many people commonlyuselarvacidefromthehazardous syntheticmaterials for preventingthis disease.In this study, larvacidal activity of ethanolextractandessential oil of Curcuma mangga rhizome was investigated.Test solutions prepared by diluting each extract and essential oil in order to obtain100 µg/mL, 50 µg/mL, 10 µg/mL, 5 µg/mL, 1 µg/mL and 0.5 µg/mLconcentrations in 100 ml water.Larvae Aedesaegyptiinstar 3-4 were used in this study.The results of larvacidal test showed that the extract of Curcuma mangga rhizome was not significantly performed the larvacidal activity, whereas the essential oil of Curcuma mangga significantly performed the larvacidal activity with the values of LC50 as 61.025 µg/mL.
Co-Authors Ace Tatang Hidayat Ami Tjitraresmi, Ami Anjari, Intan Hawina ANTI PEBRIANTI MENTARI ARWA ARWA AVANI CHAIRUNNISA Azmi, Mohamad Nurul Desi Harneti Putri Huspa Farabi, Kindi Ferry Ferdiansyah Ferry Ferdiansyah Sofian, Ferry Ferdiansyah GUSTYAN PRATAMA Harizon Harizon Imam Adi Wicaksono Nafiah, Mohamad Azlan Naini, Al Arofatus NIDIAZKA PUSPANEGARA FAUZI Nulelasari Nurlelasari Nurlelasari Nurlelasari Purnama Purnama Purnama Purnama Rani Maharani Rani Maharani Salam, Supriatno SHEILA PRATIWI Sriwidodo Sriwidodo Sucilawati Ridwan Sulistiyaningsih Sulistiyaningsih Supriatno Salam Syifa Afiifah Latief Tri Mayanti Tri Mayanti Unang Supratman Yedi Herdiana, Yedi Yoga Windhu Wardana Yoshihito Shiono Zelika Mega Ramadhania