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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat JURNAL FARMASI GALENIKA Makara Journal of Science Molekul: Jurnal Ilmiah Kimia
DUDI RUNADI
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Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Four Azadirone-Type Limonoids from Chisocheton Pentandrus Stem Bark and Their Cytotoxic Acitivity Against Mcf-7 Breast Cancer Cell Lines Supratman, Unang; Runadi, Dudi; Naini, Al Arofatus; Purnama, Purnama; Mayanti, Tri; Harneti, Desi; Nurlelasari, Nurlelasari; Maharani, Rani; Farabi, Kindi; Nafiah, Mohamad Azlan
Molekul Vol 19 No 2 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.2.11085

Abstract

ABSTRACT. Limonoid group belongs to triterpenoid that has undergone further oxidation accompanied by the loss of four carbon atoms to form a furan ring in the chain. This limonoid compound is often found in the Chisocheton genus. Limonoid compounds have been known as compounds with high structural variations and this makes limonoids have diverse and interesting activities, including cytotoxic and anticancer. In the course of our continuing study for limonoid constituents that have cytotoxic activity against cancer cell lines, methanol extract of stem bark from the Chisocheton pentandrus plant provides significant activity. The methanol extract was separated using various chromatographic techniques in the normal and reverse stationary phase to produce four azadirone-type limonoid compounds (1-4). The elucidation structure of 1-4 was determined using spectroscopic methods including, UV-Visible, IR, and 1D-NMR as well as optical rotation. All four known compounds were established as trichilenone acetate (1), toonaciliaton C (2), 11α-acetoxiazadiron (3), and 16β-hydroxydisobinine (4). The cytotoxicity of compounds 1-4 was assessed by examination using the resazurin method, which showed that compound 4 was the promising constituent against the MCF-7 cells with an IC50 value of 43.1 µM and was stronger than its positive control. Keywords: Azadirone-type limonoid, Chisocheton pentandrus, cytotoxic activity, Meliaceae.
Co-Authors Ace Tatang Hidayat AMI TJITRARESMI Anjari, Intan Hawina ANTI PEBRIANTI MENTARI ARWA ARWA AVANI CHAIRUNNISA Azmi, Mohamad Nurul Desi Harneti Putri Huspa Farabi, Kindi Ferry Ferdiansyah FERRY FERDIANSYAH SOFIAN GUSTYAN PRATAMA Harizon Harizon Imam Adi Wicaksono Nafiah, Mohamad Azlan Naini, Al Arofatus NIDIAZKA PUSPANEGARA FAUZI Nurlelasari Nurlelasari Purnama Purnama Rani Maharani Salam, Supriatno SHEILA PRATIWI Sriwidodo Sriwidodo Sucilawati Ridwan Sulistiyaningsih Sulistiyaningsih Syifa Afiifah Latief Tri Mayanti Unang Supratman Yedi Herdiana Yoga Windhu Wardana Zelika Mega Ramadhania