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All Journal Biospecies Jurnal Inovasi Pendidikan Kimia Jurnal Pendidikan Kimia (JPKim) Indonesian Journal of Chemistry VOX EDUKASI: Jurnal Ilmiah Ilmu Pendidikan Jurnal Pengabdian kepada Masyarakat Nusantara Integrated Science Education Journal Journal Evaluation in Education (JEE) Makara Journal of Science Jurnal Karya Abdi Masyarakat Jurnal Ilmiah Ilmu Terapan Universitas Jambi Jurnal Pengabdian Masyarakat Pinang Masak Molekul: Jurnal Ilmiah Kimia Journal of The Indonesian Society of Integrated Chemistry al Kimiya : Jurnal Ilmu Kimia dan Terapan Jurnal Pendidikan MIPA
Harizon Harizon
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Physics Public Health Social Sciences Other

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PENGGUNAAN MODEL PEMBELAJARAN PROJECT BASED LEARNING TERINTEGRASI CHEMO-ENTREPRENEURSHIP DAN HUBUNGANNYA DENGAN LIFE SKILL SISWA DALAM PEMBELAJARAN KIMIA Ishak, Putri Mutiara; Harizon, Harizon; Muhaimin, Muhaimin
Jurnal Inovasi Pendidikan Kimia Vol 15, No 1 (2021): January 2021
Publisher : Universitas Negeri Semarang

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Abstract

This study aims to see how student life skills, especially in vocational skills, after using the integrated CEP PjBL learning model. This study uses an associative method with a quantitative approach. Taking population and samples using total random sampling with the population is also the sample used in the study. Collecting data using instruments including, the CEP integrated project-based LKPD which is used as a practical guide as well as a reference in practicum supervision, the model implementation observation sheet to see the implementation of learning carried out to teach students, the life skills observation sheet used in direct life skills assessment when Available learning, as well as the responsibility of the student questionnaire used to measure students' life skills in learning using the CEP integrated PjBL model. The results showed that learning using the CEP integrated PjBL model was proven to be able to help students develop life skills in the aspect of vocational skills so that students had entrepreneurship. This can be seen from the proportion of students' vocational proficiency, namely 74.89%, where the competitiveness of students in sales and the work ethic possessed by students can be categorized as very good, namely 80.27% and 82.45%. The generic life skills of the students were classified as good with the proportion of 77.18% and the specific life skills of the students were classified as good with the proportion of 73.94%.
Limonoids Isolated from Chisocheton pentandrus (Meliaceae) Stembarks and its Cytotoxicity Towards MCF-7 Breast Cancer Cell Line Runadi, Dudi; Anjari, Intan Hawina; Purnama, Purnama; Nurlelasari, Nurlelasari; Harneti, Desi; Mayanti, Tri; Harizon, Harizon; Hidayat, Ace Tatang; Salam, Supriatno; Azmi, Mohamad Nurul; Supratman, Unang
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

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Abstract

Chisocheton is a large source of limonoids with various pharmacological effects, such as antiviral, antibacterial, antimalarial, antifungal, and cytotoxic activities. This study aimed to isolate, elucidate, and evaluate the cytotoxicity of limonoids from C. pentandrus stembarks. Isolation was carried out using various separation methods including extraction and column chromatography. Spectral data were analyzed by FT-IR, UV, DEPT 135°, 1H, 13C-NMR, and HRTOF-MS and compared with those previously reported to determine the chemical structure.The obtained limonoids were lasiocarpine (1), lasiocarpine B (2), pentandricine (3), and 16β-hydroxydysobinin (4); all of which were successfully isolated from C. pentandrus for the first time. The cytotoxic activity of these limonoids were also evaluated against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells using PrestoBlue method. Lasiocarpine A revealed the strongest cytotoxicity with an IC50 of 42.62 µM in moderate level.
The Sesquiterpenoids from the Stem Bark of Dysoxylum excelsum and Their Cytotoxic Activities against HeLa Cancer Cell Lines Supratman, Unang; Kautsari, Arsi; Naini, Al Arofatus; Riyadi, Sandra Amalia; Mayanti, Tri; Harizon, Harizon; Fajriah, Sofa
Molekul Vol 19 No 1 (2024)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2024.19.1.9406

Abstract

Sesquiterpenoids belong to a group of terpenoid compounds with interesting structures that are abundant in natural products especially in higher plants. Sesquiterpenoids have a wide variety of bioactivities with great potential cytotoxic activity. The species Dysoxylum excelsum belongs to the Meliaceae family known as higher plant, but only a few sesquiterpenoids have been reported particularly for their cytotoxic activity. Therefore, this research aims to isolate and elucidate the sesquiterpenoids structure from D. excelsum stem bark and examines their cytotoxicity against HeLa cervical cancer cells. Through various column chromatography separations, four known sesquiterpenes namely β-caryophyllene oxide (1), caryophyllenol II (2), humulene dioxide A (3), and guai-6-en-10β-ol (4) were acquired from the n-hexane extract. Compounds 1-4 were isolated for the first time from D. excelsum species. The sesquiterpenoid structures were elucidated according to Nuclear Magnetic Resonance, Infrared, and HR-TOF-MS analysis. The cytotoxicity compounds 1-4 was determined against HeLa cervical cancer cells by examination with the PrestoBlue method and compound 3 exhibited the most potent cytotoxicity with an IC50 value of 160.74 µM. Keywords: cytotoxic activity, Dysoxylum excelsum, HeLa, Meliaceae, sesquiterpenoid.
Socialization and Training on Making Instruments for Arguing Skills Students in Madrasah Aliyah School Yusnidar, Yusnidar; Harizon, Harizon; Haryanto, Haryanto; Astalini, Astalini; Darmaji, Darmaji; Suryati, Sri; Salsabilla Nurma Yahya, Gita
Integrated Science Education Journal Vol 5 No 3 (2024): September
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/isej.v5i3.1117

Abstract

Research objectives: The objectives of this study are to introduce and improve teachers' ability in designing student argumentation assessment instruments in measuring students' level of understanding in learning. Ultimately, it will help students develop good and correct argumentation skills during the learning process. Methodology: The method used in this study is a quantitative method. In using this method, the researcher uses a research design in the form of a questionnaire. By combining this method and design, the research results will be obtained in the form of numbers. The subjects in this study were teachers at Mtss Al-Hidayah. Kebon IX. The results of this study will later become a reference for how this research is conducted and what conclusions can be obtained from the implementation of this research. Main Findings: In the research related to the implementation and application of argumentation instruments, it was found that more than 50% of teachers agreed to implement this argumentation ability instrument. It is seen that teachers strongly agree with the existence of argumentation ability instruments. Teachers are interested and also want to try the argumentation skills instrument. Novelty/Originality of this study: This study is rarely conducted and this study is also quite interesting. From the discussion session, there are still many teachers who do not know about the existence of this argumentation ability instrument. Teachers are interested in implementing this argumentation ability instrument not only in science learning, but also in other subjects.
Diskaprod: Dissemination and Creation of Basic Process Skills Assessment Instruments in Science Learning Darmaji, Darmaji; Astalini, Astalini; Kurniawan, Dwi Agus; Yusnidar, Yusnidar; Harizon, Harizon; Pramitha, Sarah; Afrialdi, Raden Muhammad
Integrated Science Education Journal Vol 5 No 3 (2024): September
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/isej.v5i3.1118

Abstract

Purpose of the Study: This research aimed to identify and analyze the outcomes of the DISKAPROD program, specifically focusing on assessing the effectiveness and quality of instruments used to measure students' basic process skills in schools. The study also sought to determine teacher perceptions regarding the program's impact on improving student learning outcomes. Methodology: A descriptive quantitative method was applied. The study population consisted of all teachers at the Al-Hidayah Foundation Kebon IX Muaro Jambi, with 21 teachers selected via purposive sampling. Data collection was conducted using questionnaires and interviews, while data analysis involved descriptive statistical tests to evaluate the teachers’ perceptions and responses to the program. Main Findings: The findings revealed strong teacher support for the DISKAPROD program. A significant 57.1% of the teachers expressed agreement with its implementation, and 76.1% provided a positive response to the program’s impact. These results suggest widespread approval and recognition of the program’s effectiveness in enhancing the measurement of student process skills, indicating the potential for broader adoption. Novelty/Originality of this Study: This study introduces a fresh approach by highlighting the critical role of teacher-developed assessment tools in accurately measuring student learning outcomes. The integration of the DISKAPROD program into the curriculum is presented as a novel and effective method for improving science education, particularly at the Mts level. By emphasizing the practical application of assessment instruments, this research contributes to ongoing efforts to refine educational practices and foster student skill development in scientific inquiry.
Pelatihan Pembuatan Hypermedia Pop Up Digital Sebagai Sumber Belajar Alternatif Dalam Penerapan Kurikulum Merdeka Asmiyunda, Asmiyunda; Harizon, Harizon; Dewi, Fatria; Sanova, Aulia; Ekaputra, Firdiawan
Jurnal Pengabdian Masyarakat Pinang Masak Vol. 4 No. 2 (2023): Desember 2023
Publisher : Fakultas Sains dan Teknologi, Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/jpm.v4i2.28212

Abstract

Pengabdian pada masyarakat (PPM) menjadi salah satu Tri Dharma Perguruan Tinggi yang dilaksanakan dosen. Kegiatan PPM program studi Pendidikan Kimia FKIP Universitas Jambi dilaksanakan dalam bentuk peningkatan kompetensi bagi masyarakat di SMAN 5 Muaro Jambi dalam bentuk pelatihan pembuatan bahan ajar Hypermedia Pop Up Digital. Kegiatan ini bertujuan untuk meningkatkan kemampuan para guru mata pelajaran dalam membuat referensi sumber belajar dalam menerapkan kurikulum merdeka. Kegiatan PPM dilaksanakan dengan metode presentasi, demonstrasi, diskusi dan kegiatan mandiri. Diharapkan kegiatan PPM yang dilaksanakan bermanfaat bagi guru dalam melaksanakan kurikulum merdeka sedangkan bagi dosen dapat mengembangkan dan membagikan hasil pemikiran dan penelitiannya kepada masyarakat (guru) melalui kegiatan PPM. Capaian kegiatan PPM ini berupa peningkatan kualitas pemahaman dan keterampilan para guru dalam membuat bahan ajar berupa Hypermedia Pop Up Digital dalam mengimplementasikan kurikulum merdeka. Berdasarkan hasil angket yang telah diberikan kepada peserta pelatihan diketahui bahwa 88% mengalami peningkatan pengetahuan terkait bahan ajar inovatif yang disampaikan dan 100% menyatakan kegiatan pelatihan yang dilaksanakan bermanfaat bagi guru dalam kegiatan pembelajaran.
IDENTIFICATION OF ACTIVE COMPOUNDS AND FORMULATION AS AN ANTISEPTIC MOUTHWASH FROM THE PLANT Cassia fistula L. AS A PREVENTIVE MEASURE AGAINST DENTAL AND ORAL DISEASES CAUSED BY THE BACTERIA Enterococcus faecalis Romundza, Febbry; Harizon, Harizon
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.38474

Abstract

A compound with the molecular formula C15H24O has been identified as Caryophyllenol-II through analysis using HR-TOF-MS, IR, and NMR spectroscopy. The ¹³C-NMR spectrum indicates that this compound is a bicyclic sesquiterpenoid, characterized mainly by the presence of a hydroxyl group replacing an epoxide ring and the addition of an olefinic bond. The relationship between the compounds analyzed from Cassia fistula L. and their antibacterial activity against Enterococcus faecalis can be explained through the identification of bioactive compounds with specific mechanisms to inhibit or kill the bacteria. Compounds from Cassia fistula L. have significant potential as an antibacterial agent against Enterococcus faecalis, particularly through membrane disruption and bacterial enzyme inhibition mechanisms. Further research on their role, either individually or in combination with other compounds, could support the development of C. fistula-based antiseptic products, such as mouthwash, for the prevention and treatment of oral and dental diseases. Additionally, this research explores the antibacterial potential of Cassia fistula L. in developing an antiseptic mouthwash. Extracts from Cassia fistula L. are known to contain active compounds such as flavonoids, alkaloids, and tannins, which demonstrate effectiveness against Enterococcus faecalis, as a primary cause of dental and oral infections. The mouthwash formulation based on this extract was tested in vitro and proposed as a natural and safer alternative compared to synthetic chemical-based products for the prevention of dental and oral infections. This study indicates the significant potential of Cassia fistula L. in supporting oral health through effective antiseptic products. These findings support the use of traditional medicinal plants like Cassia fistula L. as a source of active compounds for the development of effective natural antiseptics and have the potential to reduce dependence on synthetic antiseptics while also promoting economic empowerment through simple industries.
Pelatihan Pengembangan Media Pembelajaran Interaktif Berbasis Multimedia Sebagai Upaya Meningkatkan Kompetensi Profesionalisme dan Kreativitas Guru-Guru SMA Muaro Jambi Afrida, Afrida; Harizon, Harizon; Bakar, Abu; Sanova, Aulia
Jurnal Karya Abdi Masyarakat Vol. 2 No. 1 (2018): Jurnal Karya Abdi Masyarakat
Publisher : LPPM Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (475.148 KB) | DOI: 10.22437/jkam.v2i1.5426

Abstract

Saat ini media pembelajaran multimedia berbasis teknologi informasi dan komunikasi (TIK) telah banyak dalam proses pembelajaran sebagai bentuk pengembangan media pembelajaran yang interaktif dan dapat menarik minat, perhatian dan motivasi belajar bagi para peserta didik. Namun yang menjadi salah kendala adalah kurang dikuasainya teknologi pengembangan multimedia pembelajaran berbasis TIK oleh para pengajar. Oleh karena itu diperlukan suatu kegiatan guna meningkatkan kualitas profesional dan kreativitas guru dalam mengembangkan multimedia.Metode yang digunakan dalam kegiatan ini demonstrasi dan praktek pembuatan multimedia menggunakan software 3D Pageflip Professional serta penugasan bagi guru-guru untuk membuat sebuah media pembelajaran hasil kreativitas peserta dan di akhir kegiatan para peserta akan diberikan penilaian hasil evaluasi produk dan respon peserta terhadap kebermanfaatan kegiatan. Berdasarkan hasil pengamatan, bahwa para guru rata-rata memiliki kemampuan yang sangat baik dengan skor 89,63 dalam memahami urgensi pengembangan media pembelajaran, mampu membuat media pembelajaran, mengenal fungsi program, dapat memasukkan teks dan menyisipkan objek movie, sound dan gambar ke ruang template 3D Pageflip Professional. Selanjutnya berdasar hasil angket, rata-rata guru memberikan tanggapan yang sangat baik dengan skor sebesar 82,67 karena melalui kegiatan ini para peserta memperoleh manfaat berupa pengetahuan tentang operasionalisasi program dan uji kreativitas guru dalam membuat desain pengembangan media sebagai bahan ajar.
IDENTIFICATION OF ACTIVE COMPOUNDS AND FORMULATION AS AN ANTISEPTIC MOUTHWASH FROM THE PLANT Cassia fistula L. AS A PREVENTIVE MEASURE AGAINST DENTAL AND ORAL DISEASES CAUSED BY THE BACTERIA Enterococcus faecalis Romundza, Febbry; Harizon, Harizon
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol. 11 No. 2 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i2.38474

Abstract

A compound with the molecular formula C15H24O has been identified as Caryophyllenol-II through analysis using HR-TOF-MS, IR, and NMR spectroscopy. The ¹³C-NMR spectrum indicates that this compound is a bicyclic sesquiterpenoid, characterized mainly by the presence of a hydroxyl group replacing an epoxide ring and the addition of an olefinic bond. The relationship between the compounds analyzed from Cassia fistula L. and their antibacterial activity against Enterococcus faecalis can be explained through the identification of bioactive compounds with specific mechanisms to inhibit or kill the bacteria. Compounds from Cassia fistula L. have significant potential as an antibacterial agent against Enterococcus faecalis, particularly through membrane disruption and bacterial enzyme inhibition mechanisms. Further research on their role, either individually or in combination with other compounds, could support the development of C. fistula-based antiseptic products, such as mouthwash, for the prevention and treatment of oral and dental diseases. Additionally, this research explores the antibacterial potential of Cassia fistula L. in developing an antiseptic mouthwash. Extracts from Cassia fistula L. are known to contain active compounds such as flavonoids, alkaloids, and tannins, which demonstrate effectiveness against Enterococcus faecalis, as a primary cause of dental and oral infections. The mouthwash formulation based on this extract was tested in vitro and proposed as a natural and safer alternative compared to synthetic chemical-based products for the prevention of dental and oral infections. This study indicates the significant potential of Cassia fistula L. in supporting oral health through effective antiseptic products. These findings support the use of traditional medicinal plants like Cassia fistula L. as a source of active compounds for the development of effective natural antiseptics and have the potential to reduce dependence on synthetic antiseptics while also promoting economic empowerment through simple industries.
Extraction and Characterization of Phenolic Compounds from the Stem Bark of Sonneratia caseolaris (Lythraceae) and Their Potential Antibacterial Activity Harizon, Harizon; Kurnia, Dikdik; Sumiarsa, Dadan; Herlina, Tati; Sinaga, Siska Elisahbet; Shiono, Yoshihito; Azmi, Mohamad Nurul; Supratman, Unang
Indonesian Journal of Chemistry Vol 25, No 2 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.98976

Abstract

The ethyl acetate fraction separated from the stembark of Sonneratia caseolaris retrieved three phenolic compounds, including quercetin-3-O-glucoside (1), quercetin (2), and 1-O-(2,4-dihydroxybenzoyl)-β-D-glucopyranose (3). For the first time, compounds 1 and 3 were discovered from Sonneratia genus. Data from various spectroscopic techniques, including mass spectroscopy and one- and two-dimensional NMR, were used to identify their chemical structures. Antibacterial activity has also been assessed for all compounds against Staphylococcus aureus ATCC 25175 and Streptococcus mutans ATCC 6538. Compounds 1–3 displayed varying levels of antibacterial activity against S. aureus and S. mutans. However, all compounds exhibited lower efficacy compared to the control, with their minimum inhibitory concentration (MIC) values ranging from 71.25 to greater than 100 µg/mL. This study provides a foundation for optimizing S. caseolaris phenolic compounds as antibacterial agents and highlights the need for comparative studies within the Sonneratia genus to identify potent bioactive candidates through structural modification or synergistic approaches.
Co-Authors Abu Bakar Ace Tatang Hidayat Afrialdi, Raden Muhammad Afrida Afrida Anjari, Intan Hawina Asmiyunda, Asmiyunda Astalini Astalini Aulia Sanova Azmi, Mohamad Nurul Dadan Sumiarsa Darmaji Darmaji Desi Harneti Putri Huspa Dewi, Fatria Dikdik Kurnia DUDI RUNADI Firdiawan Ekaputra Fuldiaratman Haryanto Haryanto Husni Sabil Ishak, Putri Mutiara Isramiharti Isramiharti Kautsari, Arsi Khalid, M. Hafiz Kholid, Idkhom Kittiwutthisakdi, Kowit Kurniawan, Dwi Agus Lativa Sari, Luluk Luluk Lativa Sari Muhaimin Muhaimin Muhammad Haris Effendi Hasibuan Mujahidawati, Mujahidawati Naini, Al Arofatus novferma, novferma Nurlelasari Nurlelasari Oktavia, Sri Wina Pramitha, Sarah Purnama Purnama Romundza, Febbry Sahara Sahara Salam, Supriatno Salsabilla Nurma Yahya, Gita Sandra Amalia Riyadi Shiono, Yoshihito Sinaga, Siska Elisahbet Sofa Fajriah Suryati, Sri Syaiful . Tati Herlina Tri Mayanti TRIANI, ELZA Umam, M Afifuddin Khotibul Unang Supratman Yusnidar Yusnidar