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Dewi Anggraini
1) Arifin Achmad General Hospital, Riau Province, Pekanbaru, Indonesia 2) Eka Hospital Pekanbaru, Pekanbaru, Indonesia 3) Department Of Microbiology, Faculty Of Medicine, Universitas Riau, Pekanbaru, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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GAMBARAN SKRINING METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) PADA PASIEN ORTOPEDI DI RS X RIAU Dewi Anggraini; Muhammad Ihsan; Maya Savira; Fauzia Andrini Djojosugito; Farah Mardhiyah
Biomedika Vol 13, No 2 (2021): Biomedika Agustus 2021
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v13i2.11875

Abstract

ABSTRAKMethicillin-resistant Staphylococcus aureus (MRSA) adalah strain Staphylococcus aureus yang resisten terhadap antibiotik golongan beta laktam. Pasien karier MRSA dinilai meningkatkan kejadian komplikasi paska operasi pada pasien ortopedi. Penelitian ini bertujuan untuk mengetahui gambaran dan prevalensi skrining MRSA pada pasien ortopedi di Bangsal Bedah RS X Riau.  Metode penelitian ini adalah deskriptif dengan rancangan cross-sectional menggunakan data primer dan sekunder responden.  Penelitian ini dilakukan pada 34 responden di Bangsal Bedah RS X Riau sejak Januari 2019 – Maret 2020.  Persentase responden yang memiliki faktor risiko sebagai karier MRSA yaitu: 5,9% dengan riwayat operasi 3 bulan terakhir; 2,9% dengan riwayat penggunaan antibiotik dalam 6 bulan terakhir, 29,4% dengan luka terbuka akut, 11,8% dengan riwayat rawat inap, 0% dengan riwayat kultur MRSA, dan 17,6% merupakan rujukan rumah sakit lain. Pada responden berisiko tersebut ditemukan kolonisasi Staphylococcus aureus pada 9 orang responden (26%) di bagian nasal anterior dan tidak ditemukan adanya bakteri MRSA (0%). Kesimpulan yang didapat dari penelitian ini adalah tidak ditemukannya bakteri MRSA pada seluruh sampel yang diperiksa. Kata Kunci: MRSA, Ortopedi, Skrining, Staphylococcus aureus..  ABSTRACTMethicillin-resistant Staphylococcus aureus (MRSA) is a strain of Staphylococcus aureus that is resistant to beta-lactam antibiotics. Patients with MRSA carrier are considered to increase the incidence of post-operative complications in orthopedic patients. This study aimed to determine the prevalence and illustration of MRSA screening in orthopedic patients in X Hospital Riau. This research method was descriptive with cross-sectional design using primary and secondary data of respondents. This study was conducted on 34 respondents in surgical ward at X Hospital Riau from January 2019 to March 2020. The percentage of respondents who had risk factors as MRSA carriers were: 5.9% with a history of surgery in the last 3 months; 2.9% with a history of antibiotic use in the last 6 months, 29.4% with an acute open wound, 11.8% with a history of hospitalization, 0% with a history of MRSA culture, and 17.6% a referral to another hospital. Colonization of Staphylococcus aureus was found in 9 respondents (26%) in the anterior part of the nose and no MRSA bacteria were found (0%). The conclusion from this study is that MRSA bacteria were not found in all samples because only a few respondents had risk factors for becoming MRSA carrier. Keywords: MRSA, Orthopedic, Screening, Staphylococcus aureus.
POLA RESISTENSI Staphylococcus KOAGULASE NEGATIF TERHADAP ANTIBIOTIK YANG DIISOLASI DARI KULTUR DARAH NEONATUS TERSANGKA SEPSIS DI INSTALASI PERAWATAN NEONATUS RSUD ARIFIN ACHMAD PROVINSI RIAU PERIODE 01 JANUARI-31 DESEMBER 2014 Karina "; Dewi Anggraini; Nazardi Oyong
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 2 (2015): Wisuda Oktober 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

ABSTRACTNeonatal sepsis is one of several most common causes of neonates mortality in developing countries. Neonatal sepsis is defined as a disseminated disease with positive blood culture during the first month of life. The aim of this study was to find how many cultures presented positive and negative results and also to detect the most common bacterial causes of neonatal sepsis and determination of their sensitivity to antibiotics. This research design using a descriptive study with retrospective approach. The sampling technique is performed by total sapling method adn the amount of sample is 568 blood cultures which 196 reported as positive (34,51%) and 372 reported as negative (65,49%). The most common isolated bacteria were coagulase negative Staphylococcus (29,08%), Burkholderia cepacia (12,76%), Acinetobacter baumanii (9,18%), Klebsiella pneumoniae (8,16%), Escherichia coli (4,08%) and, Enterobacter aerogenes (4,98%). Neonatal sepsis caused by infection of coagulase negative Staphylococcus can be treated by vancomycin, linezolid and tigecycline.Keywords : neonatal sepsis, bacterial pattern, antimicrobial susceptibility, sensitivity, antibiotics.
POLA RESISTENSI Acinetobacter baumannii YANG DIISOLASI DI Intensive Care Unit (ICU) RSUD ARIFIN ACHMAD PROVINSI RIAU PERIODE 1 JANUARI HINGGA 31 DESEMBER 2014 Venty Rahman; Dewi Anggraini; Dina Fauzia
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 2 (2015): Wisuda Oktober 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

ABSTRACTBacterial resistance toward antibiotics occurs when antibiotics have lost their ability to effectively control or kill the growth of the bacteria. Bacterial resistance is a worldwide problem in both developing and developed countries. The purpose of this research is to know A. baumannii pattern and their antibiotics resistance isolated in an Intensive Care Unit of Arifin Achmad General Hospital in Riau Province period 1 January until 31 December 2014. This research used descriptive and retrospective design with the total number of isolates as much as 59 isolates. This study was carried out at Microbiology of the clinical Patologi Laboratory Arifin Achmad General Hospital in Riau Province using a Vitek Compact 2. The most commonly isolated bacteria of sputum culture were A. baumannii 34,7% meanwhile in blood culture A. baumannii was found as much as 1,7%. Resistance pattern showed that A. baumannii bacteria have the resistance against meropenem and the sensitivity were amikasin and tygesiclin.Keywords : Antibiotics, bacteria resistance, Intensive Care Unit, sensitivity.
KORELASI STATUS GIZI DAN DURASI DIARE PADA BALITA DENGAN DIARE AKUT DI RUANG RAWAT INAP ANAK RSUD ARIFIN ACHMAD PROVINSI RIAU Ekky Wibisono; Dedi Satriya Putra; Dewi Anggraini
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 2 (2015): Wisuda Oktober 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

ABSTRACTDiarrhea emerges as the developing countries major cause of mortality and morbidity in children under five years especially in Indonesia. Malnutrition and infection well-known have directionally related. Malnutrition was able to be predisposing factor of infection especially enteric infection. Malnourished children had increased risk to have a worse or longer diarrheal duration more than normal children of nutritional status. This study aimed to describe correlation between nutritional status and diarrheal duration in children under five years of age in the Pediaetric Unit of Arifin Achmad General Hospital of Riau Province. This study was found 30 hospitalized childrens under five years with acute diarrhea whom 53,3% were 0-12 years old, 53,3% were males, 80,0% had normal Z-score, 86,7% with mild dehydration, 93,3% length of stay < 5 days and 53,3% diarrheal duration 4-7 days. Sommer’s d test had shown r = 0,044 and p value = 0,772. There was no significant association between nutritional status and diarrheal duration in hospitalized children under five years of age with acute diarrhea in Arifin Achmad General hospital of Riau ProvinceKeywords: acute diarrhea, children under five years, duration, nutritional status
POLA BAKTERI DAN RESISTENSI ANTIBIOTIK PADA ULKUS DIABETIK GRADE DUA DI RSUD ARIFIN ACHMAD PERIODE 2012 Galuh Tiara Akbar; Jazil Karimi; Dewi Anggraini
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 1, No 2 (2014): Wisuda Oktober Tahun 2014
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

Diabetic ulcer is chronic complication of diabetes melitus shown as connective tissues ulceration and destruction on lower limbs caused by uncontrollable hyperglycaemic of Diabetes melitus patient that lead into peripheral angiopathy and neuropathy so that bacterial infection trauma will easily occur. This research’s goal is to find out bacterial pattern and antibiotic resistance of second grade diabetic ulcer patients that have been hospitalized in General Hospital Arifin Achmad on 2012. 23 comprehensive medical records have been used in this descriptive and retrospective methode of research. From distribution of age category has been found 40-59 years old as the highest percentage (87%). Based on gender has been found female respondents (78,3%) and male respondents (21,7%). Most of patients have been suffered Diabetes melitus for less than 5 years (60,9%) and allowed to went home after treatment (82,6%). Most commonly bacteria that found based on bacterial culture and resistance test was Acinetobacter baumanii (34,8%), Klebsiella pneumoniae (26,2%) and Escherichia coli (17,4%). Amoxicillin and ampicillin have lowest sensitivity (0%), followed by trimethoprim/sulfametoxazole (17,4%) and cefotaxime as well as ciprofloxacin was 21,7%. The highest sensitivity antibiotics was meropenem (100%), imipenem, amikacin, and colistin (95,6%), followed by ertapenem (91,3%).Keywords: diabetic ulcer, bacterial pattern, resistance test, sensitivity, antibiotic
GEJALA PENYERTA PADA BALITA DIARE DENGAN INFEKSI ENTEROPATHOGENIC Escherichia coli (EPEC) DI PUSKESMAS RAWAT INAP KOTA PEKANBARU Citra Ayu Anggreli; Dewi Anggraini; Maya Savira
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 1 (2015): Wisuda Februari 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

ABSTRACTEnteropathogenic Escherichia coli (EPEC) is a major cause of diarrhea in children below 5 years of age in the developing countries. The present study to detect the symptoms EPEC from childhood diarrhea has been done on April 2014 until October 2014. A total of 47 fecal specimens were collected from five hospitality primary health care in Pekanbaru and examination has been done in Microbiology Laboratory of Medical Faculty Riau University. The clinical manifestations are obtained is fever (57.45%), vomiting (46.80%), mucoid stools (36.17%), no symptoms (17.20%) and mild-moderate dehydration (74.46%). Results found that from all of the fecal specimen, 2 (4.35%) samples were positive EPEC. The infants with diarrhea who had positive EPEC experiencing fever and moderate dehydration.Keywords : Diarrhea, infants, hospitality primary health care, Enteropathogenic Escherichia coli
KARAKTERISTIK PADA BALITA DIARE DENGAN INFEKSI ENTEROPATHOGENIC Escherichia coli (EPEC) DI PUSKESMAS RAWAT INAP KOTA PEKANBARU Sabella Gustika Vernanda; Maya Savira; Dewi Anggraini
Jurnal Online Mahasiswa (JOM) Bidang Kedokteran Vol 2, No 1 (2015): Wisuda Februari 2015
Publisher : Jurnal Online Mahasiswa (JOM) Bidang Kedokteran

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Abstract

ABSTRACTDiarrheal diseases remain one of the leading cause of childhood morbidity and mortality in most developing countries, with Enteropathogenic Escherichia coli (EPEC) being one of the most important aetiologic agents of children under-five years diarrhea in many of these countries. In Indonesia especially Pekanbaru, the epidemiology of these EPEC have not been well studied. During the period from April 2014 to September 2014, 47 stool sample were collected from children under-five years with acute diarrhea in the hospitality primary health care in Pekanbaru and the examination has been done in Microbiology Laboratory of Medical Faculty Riau University. The Escherichia coli were isolated and diagnosed by standard microbiological methods. The isolates confirmed to be Esherichia coli were subjected to a slide agglutination test with Escherichia coli polyvalent antisera. This study was a descriptive study using a consecutive sampling method to describe the characterization of Enteropathogenic Escherichia coli (EPEC) infection on children under-five years at the hospitality primary health care in Pekanbaru. Based on gender and age from all specimens that were collected, the diarrhea mostly found in male (59.5%), and in 12-59 months patients (93.6%). Out of the 47 stool samples, 1 isolate (2.2%) were positive for EPEC. The isolate was recovered from the 19 months female.Key words: diarrhea, enteropathogenic Escherichia coli, EPEC, children under-five years, hospitality primary health care
Pola Resistensi Bakteri Penyebab Sepsis Neonatorum di Instalasi Perawatan Neonatus RSUD Arifin Achmad Riau Nazardi Oyong; Dewi Anggraini; Karina Karina
Sari Pediatri Vol 17, No 6 (2016)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (345.24 KB) | DOI: 10.14238/sp17.6.2016.435-40

Abstract

Latar belakang. Sepsis neonatorum masih menjadi kendala utama di bidang pelayanan dan perawatan neonatus. Diperlukanpemberian antibiotik empirik yang tepat dapat menurunkan angka kematian. Namun, terapi empirik yang tepat harus berdasarkanpola resistensi di tempat tersebutTujuan. Mengetahui pola resistensi bakteri dari kultur darah pasien sepsis neonatal.Metode. Desain penelitian deskriptif retrospektif. Semua data hasil kultur dan uji resistensi antibiotik dari spesimen darah neonatustersangka sepsis yang dirawat di Instalasi Perawatan Neonatus RSUD Arifin Achmad Provinsi Riau periode Januari sampai Desember2014 dimasukkan dalam penelitian.Hasil. Didapatkan 568 pemeriksaan kultur darah neonatus yang diduga sepsis, dengan hasil kultur darah positif 196 (34,51%).Mikroorganisme terbanyak yang ditemukan yaitu Coagulase negative Staphylococci (CoNS) (29,08%), Candida sp (15,21%), B. cepacia(12,76%), A. baumanii (9,18%) dan K. pneumoniae (8,16%). Bakteri Gram positif paling sensitif dengan vancomycin dan linezolid,sedangkan bakteri Gram negatif paling sensitif dengan meropenem, amikacin dan tigecycline.Kesimpulan. Hasil kultur darah positif adalah 34,5%. Mikroorganisme yang paling banyak yaitu Coagulase negative Staphylococci,Candida sp, B. cepacia, A. baumanii dan K. pneumoniae. Bakteri Gram positif paling sensitif dengan vancomycin dan linezolid. BakteriGram negatif paling sensitif dengan meropenem, amikacin dan tigecycline
Profil and Evaluation of Resistant Tuberculosis Drug’s Side Effect in Diabetes and Non Diabetes Mellitus Patient at RSUD Arifin Achmad Dani Rosdiana; Dewi Anggraini; Indra Yovi; Marlina Tasril
Jurnal Respirologi Indonesia Vol 40, No 3 (2020)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v40i3.119

Abstract

Backgrounds: Diabetes mellitus (DM) increases the risk of reactivation of tuberculosis included multi-resistant drug tuberculosis (MDR-TB). This situation is threatening Riau province due to the high prevalence of DM. Since 2014 Arifin Achmad Hospital as a referral hospital of MDR-TB management. It’s treatment especially in DM patients, requires an evaluation of both outcome and side effects. This evaluation needs to be compared with non-DM MDR TB patients. The aim of this study was to evaluate and analyse patient’s characteristic, conversion of smear or culture, drugs side effect and treatment outcome. Methods: This is a cross sectional retrospective study in RSUD Arifin Achmad Pekanbaru on April-October 2018. Sample of this study were all patients from 2014 – 2017. This study was divided into 2 groups, namely the DM and non-DM groups, then analysed the differences between the two groups Results: There were 113 MDR TB patients had its treatment, which 61% of the patients were male. Baseline data show 26.5% of MDR TB patients have comorbid DM. The most common side effects were nausea and vomiting (100%) in all subjects. In the MDR TB DM group, we found included: well controlled plasma glucose level was 33.3%, severe side effects was16.7%, conversion in the second month 40% and cured or complete treatment was 30%. Conclusions: As many as 26,5% of MDR TB patients had DM comorbidity. There were no differences in the percentage of drugs side effects, smear conversion in the second month and treatment outcome between MDR TB DM and MDR TB non-DM group. (J Respir Indo. 2020; 40(3): 156-62)
Efficacy of pretomanid-containing regiments for drug-resistant tuberculosis: A systematic review and meta-analysis of clinical trials Simanjuntak, Arya M.; Daenansya, Raehan; Afladhanti, Putri M.; Yovi, Indra; Suyanto, Suyanto; Anggraini, Dewi; Rosdiana, Dani
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.402

Abstract

Concerns regarding the rise of drug-resistant tuberculosis (DR-TB) infections and the need for new drugs with shorter treatment time and fewer side effects have been voiced by the World Health Organization (WHO). The WHO revised its guideline to treat multi-drug resistant tuberculosis (MDR-TB) with a 6-month course of BPaLM (bedaquiline, pretomanid, linezolid and moxifloxacin) in 2022. However, a thorough study and meta-analysis of available evidence is required due to the limited confidence of the evidence confirming the effectiveness of pretomanid-containing regiments. The aim of this systematic review and meta-analysis was to evaluate the effectiveness of pretomanid-containing regiments in treating DR-TB patients. Data from six search engines were searched using inclusion criteria based on the PICOS framework. The keywords of pretomanid and tuberculosis or their alternatives were used. Using RoB2 Cochrane risk-of-bias tool for randomized clinical trials, data were independently extracted and the quality of the data was evaluated. Odds ratio (OR) and heterogeneity tests were used and the findings were presented in ORs and forest plots. A total of four studies with 237 patients was included in the final analysis and 204 (86%) patients had favorable outcome (cured) and 33 (14%) was not cured. Pretomanid-containing regimen (OR: 46.73; 95%CI: 11.76–185.7) and BPaLM/BPaL (OR: 41.67; 95%CI: 8.86–196.73) regimens were associated with favorable outcome (cured). This meta-analysis indicates that the pretomanid-containing regimen and the BPaLM/BPaL regimen could increase the chance to have favorable outcome in DR-TB patients.
Co-Authors Afladhanti, Putri M. Aisyah Elliyanti Amalia, Aisyah Sabrina Atya Nasmah Bet, Anwar Citra Ayu Anggreli Daenansya, Raehan Dani Rosdiana Dedi Satriya Putra Dina Fauzia Dino Irawan Effendi, Dasril Eka Zulya Syahputri Ekky Wibisono Erwin Christianto Erwin Christianto Farah Mardhiyah Fauzia Andrini Galuh Tiara Akbar Gusti Yulindra, Utari Hanifah, Zulfa N. hanifah, zulfa nur Hidayat, Nopian INDRA YOVI Insan Fitriyani Jazil Karimi Karina " Karina Karina Kasih, Rani Rindang Marlina Tasril Maya Savira Muhammad Ihsan Mukhyarjon Nazardi Oyong Nazardi Oyong Nori Purnama Nur Afrainin Syah Pratiwi, Adelia Putri, Yolanda Julia Perel Rachmaliza Rachmaliza Rika Wandari Rita Endriani Riza Yefri Riza Yefri, Riza Ruza Prima Rustam, Ruza Prima Sabella Gustika Vernanda Safari, Dodi Shapira, Vanesya Zahrani Sholihin, Uswathun Hasanah Simanjuntak, Arya M. Simatupang, Elvando Tunggul Mauliate Sony " Sri Indah Indriani Sri Utari Masyitah Suyanto Suyanto Syah, Nur A. Syahputri, Eka Zulya Syam, Shaogi Triani, Zhana Daisya Tuti Restuastuti Venty Rahman Wardana, Rexi Dwi Wijaya, Dewi Yuana Nurulita