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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Sistem Kesehatan JPPPF (Jurnal Penelitian dan Pengembangan Pendidikan Fisika) Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ilmu Terapan Universitas Jambi
Budi Handono
Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran RSUP Dr. Hasan Sadikin Bandung
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Althea Medical Journal

 1 
Pregnant Human Myometrial 1-41 Cell Viability Test on Vitamin D Administration Aziz, Muhammad Alamsyah; Krisnadi, Sofie Rifayani; Handono, Budi; Setiabudiawan, Budi
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2750

Abstract

Background: Preterm labor is one of the universal causes of perinatal mortality worldwide. One of the causes of preterm labor is uterine muscle integrity problems. Some mechanistic studies show insight into vitamin D activity’s possible role in the injured muscle. This study aimed to determine whether vitamin D can increase muscle cell viability.Methods: This experimental research used human smooth muscle uterine myometrium cell line pregnant human myometrial (PHM) 1-41. The cells were cultured for 24 hours in hypoxia condition, then incubated with several doses of vitamin D. The PHM1-41 cell viability was measured using spectrophotometry. Data analysis was conducted using IBM SPSS 24.0. A p-value <0.05 was considered statistically significant. Results: The result showed that the minimum level of muscle cell viability after vitamin D incubation was with 300 nM administration, and the maximum level was after 10nM (88.57%+4.48 and 96.21%+2.13 respectively).Conclusions: Vitamin D at a specific dose can improve cell availability. The optimal dose to improve cell viability is 10 nM. 
Co-Authors Adhi Pribadi Adhi Pribadi Ahmad Farried Akhmad Yogi Pramatirta, Akhmad Yogi Aloysius Suryawan Amran Amrullah Anabela, Lisa Milena Andi Kurniadi, Andi Anita Deborah Anwar Anita Rachmawati Anita Rachmawati Aziz, Muhammad Alamsyah Benny Hasan Purwara Budi Setiabudiawan Dany Hilmanto Dewi Maharsita Sri Prajanta Putri Dewi Marhaeni Diah Herawati Dewi Retno Wulandari Dini Hidayat Dodi Suardi Dyaz, Iqbal Edwin Armawan Erfiandi, Febia Faried, Leri S Farried, Ahmad Firman Fuad Wirakusumah Galih Apriadi Gita Indah Triyanti Gita Indah Triyanti, Gita Indah Hadi Susiarno Hanindya, Yovita Hanom Husni Syam Herlambang Herlambang Herlambang Herman Susanto Herry Aktyar Matondang Hiroyuki Kuwanto Idham Rizali Saleh Indra Gazali Indria Astuti Intan Renata Silitonga, Intan Renata Irene Leha Johanes C. Mose Johanes Cornelius Mose Johannes Cornelius Mose Jusuf S. Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Kuwanto, Hiroyuki Lani Gumilang Lasma R. Pohan, Lasma R. Leri S Faried Lestari, Indiyah Linasari, Desy Lulu Eva Rakhmilla, Lulu Eva M. Rizkar Arev Sukarsa Magnadi Yogi Rahma Nazila Maghfiratul Abrar Nazila Maghfiratul Abrar, Nazila Maghfiratul Nugrahani, Annisa Dewi Pajajaran, Badar Muhammad Prihatni, Delita Raden Tina Dewi Judistiani Ramdhan, Muhammad Raihan Ritonga, Mulyanusa Amrullah Sefty Mariany Samosir Setyorini Irianti Sofie R. Krisnadi Sumawan, Herman Sunjaya, Deni i Kurniad Supahar, Supahar Suryawan, Alfonsus Zeus Susiarno, Hadi Tan, Zaki Miftah Nalalindra Teuku Kyan Nuryasin Tita Husnitawati Madjid Tono Djuwantono Wiryawan Permadi Yordian, Kendry Savira Zaenudin, Aditya Rifandi Zukhruf, Naura Zulvayanti Zulvayanti