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All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Global Medical and Health Communication The Indonesian Biomedical Journal Jurnal Sistem Kesehatan JPPPF (Jurnal Penelitian dan Pengembangan Pendidikan Fisika) Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Abdimas Kartika Wijayakusuma Jurnal Ilmiah Ilmu Terapan Universitas Jambi
Budi Handono
Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran RSUP Dr. Hasan Sadikin Bandung
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : The Indonesian Biomedical Journal

 1 
Correlation of Maternal Serum Hepcidin, Soluble Transferrin Receptor (sTfR) and Cholecalciferol with Third Trimester Anemia: Findings from A Nested Case-control Study on A Pregnancy Cohort Raden Tina Dewi Judistiani; Sefty Mariany Samosir; Setyorini Irianti; Benny Hasan Purwara; Budi Setiabudiawan; Johannes Cornelius Mose; Budi Handono
The Indonesian Biomedical Journal Vol 12, No 4 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i4.1252

Abstract

BACKGROUND: Cholecalciferol, hepcidin, and soluble transferrin receptor (sTfR) interaction play an essential role in iron hemostasis. Anemia in pregnancy contributes to morbidity and mortality both for the mother and baby. In this study, we assessed the correlation between hepcidin, sTfR and cholecalciferol in third trimester maternal anemia. We aimed to find the cut-off for hepcidin and sTfR.METHODS: A case-control study involving 56 pregnant women in each anemia and healthy group was nested on a previous larger cohort study in Indonesia. Serum hepcidin, sTfR and cholecalciferol level were measured by enzyme-linked immunosorbent assay (ELISA) method.RESULTS: Serum hepcidin and sTfR level were significantly higher in case group, while serum cholecalciferol level has no difference between the two groups. New cut-off points were found for hepcidin (<15.93 ng/mL) and sTfR level (>2234.45 ng/mL). Low level of hepcidin (OR=5.32) and high level of sTfR (OR=8.28) increase the risk of anemia. High level of sTfR (adjusted OR=4.725; CI 95%=1.730-12.904; p=0.02) was the most important factor contributes to anemia, followed by the low level of hepcidin (adjusted OR=3.677; CI 95%=1.363-9917; p=0.01).CONCLUSION: The high level of sTfR is the most important factor related to anemia in the third trimester, followed by the low level of hepcidin. Low cholecalciferol level tends to favor the incident of anemia. The new cut-off point of third trimester sTfR and third trimester hepcidin were established in this study and may be useful for risk assessment and treatment monitoring for anemia in pregnancy.KEYWORDS: anemia, cholecalciferol, hepcidin, pregnancy, soluble transferrin receptor
MMP-9 Level Comparation between Spontaneous Abortion and Normal Pregnancy Aloysius Suryawan; Johanes C Mose; Budi Handono
The Indonesian Biomedical Journal Vol 4, No 3 (2012)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v4i3.178

Abstract

BACKGROUND: Abortion remains a problem in the obstetric care as it is one of the causes of maternal and fetal death. Bleeding or miscarriage threat in the first trimester comprises 20% to 25% of all pregnant women, and 50% of them will end as spontaneous abortion. The major cause of maternal death in abortion is hemorrhage. Some recent studies have indicated that MMP-9 is important in the process of embryo implantation into the endometrium and spontaneous abortion occurs when there is an overwhelming increase of MMP-9. This data indicate the importance of a further research to elucidate the role of MMP-9 in spontaneous abortion.METHODS: This was a cross sectional study, included 70 pregnant women with gestational age <20 weeks who came for examination and treatment at the Department of Obstetrics and Gynecology, Medical Faculty of Padjadjaran University/Hasan Sadikin Hospital, Bandung. RESULTS: There were differences in the MMP-9 levels in spontaneous abortion compared to normal pregnancy and MMP-9 had a cut-off point >1221.7 with the sensitivity of 48.6% specificity of 80%, and accuracy of 60.9%.SUMMARY: The MMP-9 level in spontaneous abortion was higher than in normal pregnancy.KEYWORDS: MMP-9, spontaneous abortion, normal pregnancy
Co-Authors Adhi Pribadi Adhi Pribadi Ahmad Farried Akhmad Yogi Pramatirta, Akhmad Yogi Aloysius Suryawan Amran Amrullah Anabela, Lisa Milena Andi Kurniadi, Andi Anita Deborah Anwar Anita Rachmawati Anita Rachmawati Aziz, Muhammad Alamsyah Benny Hasan Purwara Budi Setiabudiawan Dany Hilmanto Dewi Maharsita Sri Prajanta Putri Dewi Marhaeni Diah Herawati Dewi Retno Wulandari Dini Hidayat Dodi Suardi Dyaz, Iqbal Edwin Armawan Erfiandi, Febia Faried, Leri S Farried, Ahmad Firman Fuad Wirakusumah Galih Apriadi Gita Indah Triyanti Gita Indah Triyanti, Gita Indah Hadi Susiarno Hanindya, Yovita Hanom Husni Syam Herlambang Herlambang Herlambang Herman Susanto Herry Aktyar Matondang Hiroyuki Kuwanto Idham Rizali Saleh Indra Gazali Indria Astuti Intan Renata Silitonga, Intan Renata Irene Leha Johanes C. Mose Johanes Cornelius Mose Johannes Cornelius Mose Jusuf S. Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Jusuf Sulaeman Effendi Kuwanto, Hiroyuki Lani Gumilang Lasma R. Pohan, Lasma R. Leri S Faried Lestari, Indiyah Linasari, Desy Lulu Eva Rakhmilla, Lulu Eva M. Rizkar Arev Sukarsa Magnadi Yogi Rahma Nazila Maghfiratul Abrar Nazila Maghfiratul Abrar, Nazila Maghfiratul Nugrahani, Annisa Dewi Pajajaran, Badar Muhammad Prihatni, Delita Raden Tina Dewi Judistiani Ramdhan, Muhammad Raihan Ritonga, Mulyanusa Amrullah Sefty Mariany Samosir Setyorini Irianti Sofie R. Krisnadi Sumawan, Herman Sunjaya, Deni i Kurniad Supahar, Supahar Suryawan, Alfonsus Zeus Susiarno, Hadi Tan, Zaki Miftah Nalalindra Teuku Kyan Nuryasin Tita Husnitawati Madjid Tono Djuwantono Wiryawan Permadi Yordian, Kendry Savira Zaenudin, Aditya Rifandi Zukhruf, Naura Zulvayanti Zulvayanti