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All Journal Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal Sistem Kesehatan Padjadjaran Journal of Dentistry Jurnal Kesehatan Tambusai Jurnal EduHealth
Anggun Rafisa
Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Economics, Econometrics & Finance Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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Oral Inflammation and The Role of Cytokine Nuroh Najmi; Faisal Kuswandani; Anggun Rafisa; Felisha Febriane Balafif
Jurnal EduHealth Vol. 14 No. 02 (2023): Periode April-June, 2023
Publisher : Sean Institute

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Abstract

Acute inflammation becomes chronic when inflammation prolongs. Oral inflammation can develop become chronic and can be serious disease. Cytokines are small secreted proteins released by cells have a specific effect on the interactions and communications between cells. Based on studied that cytokine can be one of markers of inflammation. In many diseases cytokines can be biomarkers of inflammation and recently many studies use cytokines as one of the biomarkers in additional examination for their studies
Oral Candida Albicans Colonization In Denture Wearer: A Literature Review Febriane Balafif, Felisha; Rafisa, Anggun; Kuswandani, Faisal; Najmi, Nuroh
Jurnal EduHealth Vol. 15 No. 03 (2024): Jurnal EduHealt (September), Year 2024
Publisher : Sean Institute

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Denture stomatitis is the most prevalent multifactorial, chronic inflammatory oral condition amongs denture wearers. One of the primary roles of dentures in denture stomatitis is their potential to cause irritation and inflammation of the oral tissues. This continuous irritation creates an environment where fungal infections, notably C. albicans. The traumatic factors such as mechanical trauma caused by loose prosthesis can increase the risk of tissue penetration and colonization of Candida species. This literature review aimed to explore the colonization of C. albicans in the denture wearer. The article was conducted of two databases and were limited to the period from 2019 to 2024 with a combination of the following keywords: “oral Candida albicans” "colonization" "denture wearer". The results obtained A total of 243 articles were initially identified through the designated keywords in PubMed and Google scholar. After meticulous removal of duplicate articles and application of the inclusion and exclusion criteria, 7 articles met the study’s eligibility criteria. C. albicans was the predominant species recovered from oral caviproty of both denture wearers and non-denture wearers. C. albicans can not only adhere to the oral mucosa but also can colonize the surface of the acrylic denture when it is poorly maintained. The presence of prosthetic appliances changes the microenvironment of the oral cavity through the facilitation of Candida colonization and proliferation. The biofilm on the denture can enhance its adhesion adding to its virulence. Wearing of a denture has been found to enhance adhesion of C. albicans.
Chemical And Physical Evaluation Of Herbal Artificial Saliva Formulations-Scoping Review kuswandani, Faisal; Febriane Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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Saliva plays an important role in physiological function. Alteration in saliva production results in serious health problems that affect patient oral health-related quality of life (OHRQiL). the purpose of the research was to investigate the chemical and physical evaluation of natural artificial saliva formulations. Methods, the data synthesis protocol for a rapid review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol (PRISMA-P). Electronic databases were searched on articles published in 2004- 2024. evaluating Chemical and physical properties of herbal artificial saliva formulations in preclinical study. Results, Identification from the Science Direct and PubMed databases obtained 332 scientific articles and 3 articles met inclusion criteria. Basella alba Linn. (Ceylon Spinach mucilage) shows non-Newtonian characteristic fluid, similar to normal human saliva. It has antioxidative activity, adhesion inhibition, and non-toxic. Propolis extract and Aloe vera extract showed minimal effect on viscoelastic properties but were still in the range of normal human saliva. Dioscorea batatas (Yam tuber mucilage) viscosity shows non-Newtonian characteristic fluid and antibacterial activity by influenced the enzymatic activity of lysozyme and peroxidase. Conclusion, Chemical and physiological evaluation shows that herbal plant extract has the potential to be used as an artificial saliva constituent. It had a viscosity in the range of normal human saliva with several advantages in terms of pharmacological activity.
Metabolic Disorders And Periodontal Disease: A Scoping Review Of Recent Studies Rafisa, Anggun; Febriane Balafif, Felisha; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 02 (2024): Jurnal eduHealt, Edition April - June , 2024
Publisher : Sean Institute

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The bidirectional relationship between periodontal disease and metabolic disorders is of particular concern, as these conditions may exacerbate each other through shared inflammatory pathways and metabolic disturbances. This scoping review aims to comprehensively explore the current body of literature on the interconnection between metabolic disorders and periodontal disease. A comprehensive literature search was conducted across databases, such as PubMed and Scopus. This review included studies that focusing on the relationship between metabolic disorders and periodontal disease, as well as articles written in English and published between 2019 and 2024. Non-peer-reviewed articles, articles that were not available in full text, and animal studies were excluded. A total 186 studies met the inclusion and exclusion criteria and were included in the review. Only 2.2% of the studies employed an experimental design, while a substantial majority (77.4%) utilized observational methodologies The majority of the research (72.0%) focused on adults, with a relatively small proportion (16.1%) dedicated to children and adolescents. Research focusing on specific populations, such as women with obesity or gestational diabetes, was limited (7.5%). This review identified a significant gap in intervention studies specifically targeting metabolic disorders to improve periodontal outcomes. Furthermore, it underscores the need for more focused research on vulnerable populations such as children, adolescents, and pregnant women.
SIRT1 As A Novel Therapeutic Target For Periodontitis: A Rapid Review kuswandani, Faisal; Febriane Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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SIRT1 plays a pivotal role in regulating a multitude of biological processes, including cellular metabolism, aging, DNA repair, inflammation, and oxidative stress. evidence suggesting a potential association between SIRT1 activity and periodontal health including periodontitis. This article aims to explore the immunobiological functions of SIRT1 in the initiation and progression of periodontitis. This comprehensive review utilized the PubMed and Cochrane Library databases to collate studies from December 2024 to December 2024. Arround 53 studies were screened and 5 studies were deemed suitable for analyses. Evidence based revealed that, SIRT1 levels elevated after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. Conclussion, clinical studies shows that SIRT1's potential as a biomarker and therapeutic target. Elevated SIRT1 levels after periodontal treatment and its involvement in anti-inflammatory pathways suggest its beneficial role in managing periodontitis. However, Prospective studies are necessary to deepen our understanding of their role in the pathophysiology of periodontitis and their potential clinical applications.
A Review Of IL-17 Relation With Microbiome In Metabolic Disorder Najmi, Nuroh; Kuswandani , Faisal; Rafisa, Anggun; Falisha Febriane Balafif
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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The relationship between IL-17 and the microbiome remains an area requiring extensive research. IL-17, a pro-inflammatory cytokine, plays a crucial role in immune function, particularly in its interactions with the microbiome, especially within the intestinal digestive system. In metabolic diseases linked to inflammation, this connection underscores the importance of understanding cytokine activity and the microbiome's response within the body. In this literature review, three articles were retrieved from a single database, exploring the relationship between IL-17, metabolic diseases, and the microbiome.
Dietary Vitamin D in Periodontal Diseases: A Scoping Review of Interventions and Assessments Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Vitamin D has gained significant attention for its potential role in periodontal health. This scoping review investigates the evidence on dietary vitamin D interventions and assessments in periodontal diseases, examining their impact on periodontal outcomes and identifying research gaps. Using the PRISMA for Scoping Reviews protocols, data were sourced from PubMed and Scopus, including studies focused on dietary vitamin D interventions in periodontal diseases. Exclusions were non-peer-reviewed articles, reviews, animal studies, and inaccessible full-text articles. A total of 22 studies were included: 11 experimental and 11 observational. Among experimental studies, vitamin D supplementation (n=7) was the most common intervention. Observational studies employed various dietary assessment methods, including 24-hour dietary recall (n=2), food frequency questionnaires (FFQ) (n=3), dietary supplement intake (n=3), and combined methods (n=3). Experimental findings suggest that vitamin D supplementation may enhance periodontal health, particularly when paired with non-surgical treatments. Mixed findings from observational studies and limited research on surgical contexts underscore the complexity of establishing definitive conclusions. These findings emphasize the need for standardized methodologies and further investigation to better understand the role of vitamin D in periodontal health.
Potential Protein Receptors in Enterococcus faecalis as Antibacterial and Anti-Biofilm Target Therapy in Endodontic treatment: A Review kuswandani, Faisal; Balafif, Felisha; Najmi, Nuroh; Rafisa, Anggun
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Abstract

E. Faecalis  is responsible for 80−90% of hospital-acquired enterococcal infections and failed endodontic tretment. The emergence of E. Faecalis  multidrug resistance including to common endodontic medication and its ability to form biofilms have significantly complicated its clinical management. Thereby the development of novel antibacterial and antibiofilm agents is essential. Identifying and targeting key proteins is critical for drug discovery and development. This review aims to provide a brief information about potential protein receptors in E. Faecalis  that could serve as targets for antibacterial and antibiofilm therapies.
Dental Biofilm Formation: A Scoping Review Febriane Balafif, Felisha; Anggun Rafisa; Faisal Kuswandani; Nuroh Najmi
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Abstract

Dental biofilm is a structured microbial community that adheres to the tooth surface and becomes embedded within a self-produced extracellular matrix. This matrix, rich in polysaccharides, proteins, and nucleic acids, enables microorganisms to survive environmental stresses and contributes to the onset of oral diseases such as caries and periodontitis. The purpose of this scoping review is to determine current knowledge the dental biofilm formation. The articles published from 2020 until 2025 were searched for using the keywords: "dental and biofilm and formation" in the PubMed, ScienceDirect, and Google scholar databases. Using PRISMA-Scr, existing articles were chosen based on inclusion and exclusion criteria. There were five articles found that were suitable for review. The data presented in the article vary according to the study's location, purpose, method, and samples. The major classes of extracellular polymeric substances that form the matrix are common to most biofilms and comprise carbohydrates, proteins, nucleic acids, and cell wall polymers, such as peptidoglycans and lipids. Several unique resistance mechanisms make biofilms particularly tough to manage. Biofilm bacteria employ multiple defense mechanisms, such as capsule protection, efflux pumps, membrane modifications, genetic adaptations, quorum sensing, metabolic dormancy, and stress responses, making them highly resistant to treatment and contributing to persistent infections.
Effectiveness of Vitamin C Supplementation in Periodontal Therapy Rafisa, Anggun; Sovira, Gita Dwi Jiwanda
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Abstract

Periodontal disease is a chronic inflammatory condition initiated by microbial dysbiosis and driven by host immune responses, notably the overproduction of reactive oxygen species (ROS), which contribute to tissue damage. Vitamin C (ascorbic acid), a potent antioxidant, plays a role in collagen synthesis and immune regulation. Several studies have proposed vitamin C as an adjunct in periodontal therapy, yet its effectiveness remains unclear. This systematic review aims to evaluate the effect of vitamin C supplementation on clinical periodontal parameters in patients with periodontal disease. A comprehensive literature search was conducted in PubMed and Scopus for randomized controlled trials (RCTs) published between January 2015 and June 2025. Included studies investigated vitamin C supplementation in patients with periodontal disease without systemic conditions, pregnancy, lactation, or medication use. Studies involving vitamin C in combination with other nutrients without a separate vitamin C-only group were excluded. Data extraction and analysis followed the PRISMA guidelines. Four RCTs met the inclusion criteria. Significant clinical improvements were observed in periodontal parameters following non-surgical periodontal therapy (NSPT). However, the addition of vitamin C supplementation alone did not consistently provide significant improvements beyond NSPT alone. One study showed greater improvements when vitamin C was combined with melatonin, and another suggested potential benefits from guava—a natural source of vitamin C and polyphenols—over synthetic vitamin C. Current evidence suggests that while vitamin C supplementation may offer modest anti-inflammatory and antioxidant benefits, it does not consistently enhance clinical outcomes in periodontal therapy when used alone.
Co-Authors Ahmad Yani ahmad yani Asty Samiaty Setiawan, Asty Samiaty Balafif, Felisa Febriane Balafif, Felisha Balafif, Felisha Febriane Chandra, Angievel Cucu Zubaedah Cucu Zubaedah Dahlia Salsa Farhani Dewi Marhaeni Diah Herawati Fairuz, Anargya Alfa Faisal Kuswandani Faisal Kuswandani Falisha Febriane Balafif Febriane Balafif, Felisa Febriane Balafif, Felisha Felisha Febriane Balafif Gilang Yubiliana, Gilang Gita Dwi Jiwanda Sovira Kuswandani , Faisal Mochammad Rodian Nabila Anisha Nani Murniati Nuroh Najmi Nuroh Najmi Nuroh Najmi Rasmi Rikmasari Rosita Aisyah Sri Tjahajawati Sri Tjahajawati Sri Tjahajawati Sri Tjahajawati, Sri