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All Journal Jurnal Pendidikan dan Pemberdayaan Masyarakat Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) JURNAL FARMASI GALENIKA Jurnal Farmamedika (Pharmamedica Journal) ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Riset Kefarmasian Indonesia Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal farmasi UIN Alauddin Makassar Diniyah: Jurnal Pendidikan Dasar Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Law, Poliitic and Humanities Media Farmasi Jurnal Novem Medika Farmasi
Nur Ida
Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Islam Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Transportation Other

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Journal : ad-Dawaa : Journal of Pharmaceutical Sciences

 1 
Quality and Release Profile of Captopril from Mucoadhesive Gastroretentive Tablet by Using Matrix Sodium Carboxymethyl Cellulose and Carbopol 934P Isriany Ismail; M. Asrah Hidayah Usman; Nur Ida
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol 3 No 1 (2020)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v3i1.14028

Abstract

Captopril have good absorption in gastric pH and ionized on intestinal pH. It is necessary to keep the drug in the form of molecules in the area of the absoption. The mucoadhesive gastroretensive drug delivery system provides the possibility of controlled release in stomach in a certain amount of time. Research has been conducted to assess the quality and profile of captopril release in of a mucoadhesive gastroretensive tablet. Mucoadhesive tablets (MK) were made in 5 formulas by wet granulation method using carbopol 934P and sodium carboxymethyl cellulose as matrix with ratio 10: 0 (MK1), 0: 10 (MK2), 5: 5 (MK3), 7: 3 (MK4), and 3: 7 (MK5). The parameters which was evaluate were characteristics of granules and tablets and kinetics model of captopril release from tablets in 0,01 N HCl medium. Mucoadhesive tablets had different characteristics for each formula. Mucoadhesive tablets that had good quality and release profile were shown by MK4 and MK5 formula. They had controlled drug release profiles accorded to the Korsmeyer-Peppas and Higuchi kinetics models, respectively.
Co-Authors Ahmad Rusmin R Alfiah Irfayanti, Nur andi nur zam zam Arfiani Arifin Arfiani Arifin Asriana Sultan ayu wandira A Baso Amri Bariun, Hasyim Darma, Darma Deniyati, Deniyati Elwahan, Muhaya Ermina Pakki Halistin, Halistin Hasan, Tahirah Hasdiansyah, Andi Herman, Harfiah Ihwan Ridwan, Ihwan Intan Intan Irfan Hadi Isriany Ismail Isriany Ismail Junuda, Nur Khairun Nisa Khairunnisa Khairunnisa M. Asrah Hidayah Usman M. Natsir Djide M. Rusdi Madilis, Hasan Muhammad Ilham Musdalifah Musdalifah Nur Atika Aqila nurmayanti, sitti Radiatunisa Ridwan, Rais Risna Risna, Risna Rosmiyanti Rosmiyanti Rusli Salama, Salmia Sitti Fauziah Noer Sriyanti Sufriyanto, Sufriyanto Surya Ningsi Tahirah Hasan Yasir, Yasnidar